This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been pu...This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been published,but very few on those generated from a mesh using triangular elements.The use of triangular elements is aimed at extending the application of the approach to any shape of modeled devices.Basic concepts of the approach are presented in the case of electromagnetic devices.The procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB environment are also included.展开更多
This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are the...This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are then presented in the case of electromagnetic devices.A step-by-step procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB and Scilab environments are also included.展开更多
Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the val...Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the valves time periods was well developed. With this model,the mass flow rate and dynamic pressure characteristics of constant volumes controlled by high-speed pneumatic PWM on /off valves was well described. A variable flow rate coefficient model was proposed to substitute for the constant one used in most of the prior works to investigate PWM on /off valves' dynamical pressure response, and a formula for disclosing the inherent relationship among the PWM command signal,static mass flow rate,and sonic conductance of the valve was newly derived.Finally,an extensive set of analytical experimental comparisons were implemented to verify the validity of the proposed mathematica model. With the proposed model, PWM on /off valves' characteristics,such as mass flow rate,step pressure response of the valve control system,mean pressure and ripple amplitude,not only in the linear range,but also in the nonlinear range can be wel predicted; Good agreement between measured and calculated results was obtained,which proved that the model is helpful for designing a control strategy in a closed loop control system.展开更多
1 INTRODUCTIONHemodialysis with ultrafiltration,also called hemodiafiltration(HDF),is a main methodof treatment for patients with chronic renal failure.The HDF procedure providesadequate removals of both small and mid...1 INTRODUCTIONHemodialysis with ultrafiltration,also called hemodiafiltration(HDF),is a main methodof treatment for patients with chronic renal failure.The HDF procedure providesadequate removals of both small and middle molecular weight toxic substamces fromuremic blood,which is not possible by dialysis or ultrafiltration alone.According toclinical experience[1],the HDF procedure is well accepied by the patients,and thetreatment time is reduced by using it.展开更多
The cardiovascular system is characterized by complex interactions between various control mechanisms and physiological processes. Different approaches are used to provide better diagnostics and physiological understa...The cardiovascular system is characterized by complex interactions between various control mechanisms and physiological processes. Different approaches are used to provide better diagnostics and physiological understanding, cardiac prosthesis and medical planning. The mathematical description and modelling of the human cardiovascular system plays nowadays an important role in the comprehension of the genesis and development of cardiovascular disorders by providing computer based simulation of dynamic processes in this system. This paper aims to give an overview on lumped parameter models that have been developed by many researchers all over the world, to simulate the blood flow in systemic arteries. Surveying various references we make a review of different approaches to arterial tree modelling and discuss on the applications of such models.展开更多
The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed paramete...The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed parameters model can depict the winding characteristics accurately,but it requires complex calculations.Lumped parameter model requires less calculations,but its applicable frequency range is not wide.This paper studies the amplitude-frequency characteristics of the lightning wave,compares the transformer modelling methods and finally proposes a modified lumped parameter model,based on the above comparison.The proposed model minimizes the errors provoked by the lumped parameter approximation,and the hyperbolic functions of the distributed parameter model.By this modification it becomes possible to accurately describe the winding characteristics and rapidly obtain the node voltage response.The proposed model can provide theoretical and experimental support to lightning protection of the distribution transformer.展开更多
Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air l...Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air leakage,under controlled air leakage is introduced to earmuff to achieve adjustable attenuations in different signal-to-noise ratios(SNRs)and balance between attenuation and speech intelligibility.This work is to develop an improved lumped parameter model(LPM)to predict earmuff attenuation with consideration of air leakage.Air leakage paths are introduced into conventional LPM without air leakage,and air leakage path impedance is analytically described by Maa’s microperforated tube impedance.Earmuff passive attenuation behavior can be analytically described and analyzed with the improved LPM.Finally,the validity of improved LPM is verified experimentally.The results indicate that the improved LPM can predict earmuff attenuation with air leakage,and air leakage deteriorates earmuff attenuation and turns resonance frequency higher.展开更多
A novel parameter extraction method with rational functions is presented for the 2-πequivalent circuit model of RF CMOS spiral inductors. The final S-parameters simulated by the circuit model closely match experiment...A novel parameter extraction method with rational functions is presented for the 2-πequivalent circuit model of RF CMOS spiral inductors. The final S-parameters simulated by the circuit model closely match experimental data. The extraction strategy is straightforward and can be easily implemented as a CAD tool to model spiral inductors. The resulting circuit models will be very useful for RF circuit designers.展开更多
Hydrocracking is a catalytic reaction process in the petroleum refineries for converting the higher boiling temperature residue of crude oil into a lighter fraction of hydrocarbons such as gasoline and diesel. In this...Hydrocracking is a catalytic reaction process in the petroleum refineries for converting the higher boiling temperature residue of crude oil into a lighter fraction of hydrocarbons such as gasoline and diesel. In this study, a modified continuous lumping kinetic approach is applied to model the hydro-cracking of vacuum gas oil. The model is modified to take into consideration the reactor temperature on the reaction yield distribution. The model is calibrated by maximizing the likelihood function between the modeled and measured data at four different reactor temperatures. Bayesian approach parameter estimation is also applied to obtain the confidence interval of model parameters by considering the uncertainty associated with the measured errors and the model structural errors. Then Monte Carlo simulation is applied to the posterior range of the model parameters to obtain the 95% confidence interval of the model outputs for each individual fraction of the hydrocracking products. A good agreement is observed between the output of the calibrated model and the measured data points. The Bayesian approach based on the Markov Chain Monte Carlo simulation is shown to be efficient to quantify the uncertainty associated with the parameter values of the continuous lumping model.展开更多
Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the c...Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.展开更多
To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compl...To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compliance of the decoupler chamber, effective piston area, fluid inertia and resistance of inertia track and direct-decoupler, are identified by means of experiments and finite element method (FEM). Dynamic behaviors are tested with elastomer test system for purpose of validating PHEM. With incorporation of inertia track and direct-decoupler, PHEM behaves effective and efficient vibration isolation in range of both low and high frequencies. The comparison of the numerical results with the experimental observations shows that the present PHEM achieves fairly good performance for the engine vibration isolation.展开更多
A novel approach to design Internal Model Controller(IMC)is proposed in this paper directly from measuredinput and output plant data,which are assumed to becontaminated by measurement noise.In order to avoidthe compli...A novel approach to design Internal Model Controller(IMC)is proposed in this paper directly from measuredinput and output plant data,which are assumed to becontaminated by measurement noise.In order to avoidthe complicated structure-identification problem inmost cases,two Finite Impulse Response(FIR)modelsare taken to represent the plant model and the internalmodel controller respectively.Taking account of mea-surement noise both in the plant input and its output,anESD based Total Least Squares(TLS)solution is appliedfor the unbiased identification of the plant model and itsinverse model,the latter constitutes the internal modelcontroller according to the principle that the internalmodel controller approximates the inverse dynamics ofthe plant model.Simulations are given for a testifica-tion.展开更多
The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose,...The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator (MACSim), is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria subclavia and arteria axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.展开更多
Large-scale cryogenic air separation units(ASUs),which are widely used in global petrochemical and semiconductor industries,are being developed with high operating elasticity under variable working conditions.Differen...Large-scale cryogenic air separation units(ASUs),which are widely used in global petrochemical and semiconductor industries,are being developed with high operating elasticity under variable working conditions.Different from discrete processes in traditional machinery manufacturing,the ASU process is continuous and involves the compression,adsorption,cooling,condensation,liquefaction,evaporation,and distillation of multiple streams.This feature indicates that thousands of technical parameters in adsorption,heat transfer,and distillation processes are correlated and merged into a large-scale complex system.A lumped parameter model(LPM)of ASU is proposed by lumping the main factors together and simplifying the secondary ones to achieve accurate and fast performance design.On the basis of material and energy conservation laws,the piecewise-lumped parameters are extracted under variable working conditions by using LPM.Takagi–Sugeno(T–S)fuzzy interval detection is recursively utilized to determine whether the critical point is detected or not by using different thresholds.Compared with the traditional method,LPM is particularly suitable for“rough first then precise”modeling by expanding the feasible domain using fuzzy intervals.With LPM,the performance of the air compressor,molecular sieve adsorber,turbo expander,main plate-fin heat exchangers,and packing column of a 100000 Nm3 O2/h large-scale ASU is enhanced to adapt to variable working conditions.The designed value of net power consumption per unit of oxygen production(kW/(Nm3 O2))is reduced by 6.45%.展开更多
This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tum...This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (Ct) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (HCPT), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.展开更多
文摘This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been published,but very few on those generated from a mesh using triangular elements.The use of triangular elements is aimed at extending the application of the approach to any shape of modeled devices.Basic concepts of the approach are presented in the case of electromagnetic devices.The procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB environment are also included.
文摘This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are then presented in the case of electromagnetic devices.A step-by-step procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB and Scilab environments are also included.
基金National Natural Science Foundation of China(No.51205362)Zhejiang Provincial National Science Foundation of China(No.LQ12E05017)
文摘Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the valves time periods was well developed. With this model,the mass flow rate and dynamic pressure characteristics of constant volumes controlled by high-speed pneumatic PWM on /off valves was well described. A variable flow rate coefficient model was proposed to substitute for the constant one used in most of the prior works to investigate PWM on /off valves' dynamical pressure response, and a formula for disclosing the inherent relationship among the PWM command signal,static mass flow rate,and sonic conductance of the valve was newly derived.Finally,an extensive set of analytical experimental comparisons were implemented to verify the validity of the proposed mathematica model. With the proposed model, PWM on /off valves' characteristics,such as mass flow rate,step pressure response of the valve control system,mean pressure and ripple amplitude,not only in the linear range,but also in the nonlinear range can be wel predicted; Good agreement between measured and calculated results was obtained,which proved that the model is helpful for designing a control strategy in a closed loop control system.
基金Supported by the Naural Science Foundation(Youth)of Tianjin
文摘1 INTRODUCTIONHemodialysis with ultrafiltration,also called hemodiafiltration(HDF),is a main methodof treatment for patients with chronic renal failure.The HDF procedure providesadequate removals of both small and middle molecular weight toxic substamces fromuremic blood,which is not possible by dialysis or ultrafiltration alone.According toclinical experience[1],the HDF procedure is well accepied by the patients,and thetreatment time is reduced by using it.
文摘The cardiovascular system is characterized by complex interactions between various control mechanisms and physiological processes. Different approaches are used to provide better diagnostics and physiological understanding, cardiac prosthesis and medical planning. The mathematical description and modelling of the human cardiovascular system plays nowadays an important role in the comprehension of the genesis and development of cardiovascular disorders by providing computer based simulation of dynamic processes in this system. This paper aims to give an overview on lumped parameter models that have been developed by many researchers all over the world, to simulate the blood flow in systemic arteries. Surveying various references we make a review of different approaches to arterial tree modelling and discuss on the applications of such models.
基金supported by the National Key Research and Development Plan of China under Grant(2016YFB0900600XXX)
文摘The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed parameters model can depict the winding characteristics accurately,but it requires complex calculations.Lumped parameter model requires less calculations,but its applicable frequency range is not wide.This paper studies the amplitude-frequency characteristics of the lightning wave,compares the transformer modelling methods and finally proposes a modified lumped parameter model,based on the above comparison.The proposed model minimizes the errors provoked by the lumped parameter approximation,and the hyperbolic functions of the distributed parameter model.By this modification it becomes possible to accurately describe the winding characteristics and rapidly obtain the node voltage response.The proposed model can provide theoretical and experimental support to lightning protection of the distribution transformer.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11934009 and 11874216)。
文摘Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air leakage,under controlled air leakage is introduced to earmuff to achieve adjustable attenuations in different signal-to-noise ratios(SNRs)and balance between attenuation and speech intelligibility.This work is to develop an improved lumped parameter model(LPM)to predict earmuff attenuation with consideration of air leakage.Air leakage paths are introduced into conventional LPM without air leakage,and air leakage path impedance is analytically described by Maa’s microperforated tube impedance.Earmuff passive attenuation behavior can be analytically described and analyzed with the improved LPM.Finally,the validity of improved LPM is verified experimentally.The results indicate that the improved LPM can predict earmuff attenuation with air leakage,and air leakage deteriorates earmuff attenuation and turns resonance frequency higher.
文摘A novel parameter extraction method with rational functions is presented for the 2-πequivalent circuit model of RF CMOS spiral inductors. The final S-parameters simulated by the circuit model closely match experimental data. The extraction strategy is straightforward and can be easily implemented as a CAD tool to model spiral inductors. The resulting circuit models will be very useful for RF circuit designers.
文摘Hydrocracking is a catalytic reaction process in the petroleum refineries for converting the higher boiling temperature residue of crude oil into a lighter fraction of hydrocarbons such as gasoline and diesel. In this study, a modified continuous lumping kinetic approach is applied to model the hydro-cracking of vacuum gas oil. The model is modified to take into consideration the reactor temperature on the reaction yield distribution. The model is calibrated by maximizing the likelihood function between the modeled and measured data at four different reactor temperatures. Bayesian approach parameter estimation is also applied to obtain the confidence interval of model parameters by considering the uncertainty associated with the measured errors and the model structural errors. Then Monte Carlo simulation is applied to the posterior range of the model parameters to obtain the 95% confidence interval of the model outputs for each individual fraction of the hydrocracking products. A good agreement is observed between the output of the calibrated model and the measured data points. The Bayesian approach based on the Markov Chain Monte Carlo simulation is shown to be efficient to quantify the uncertainty associated with the parameter values of the continuous lumping model.
基金the EU RTN Haemodel Project(contract number HPRN-CT-2002-00270)and by an EPSRC Advanced Research Fellowship.
文摘Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.
基金National Hi-tech Research Development Program of China(863 Program,No.2001AA505000-11)
文摘To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compliance of the decoupler chamber, effective piston area, fluid inertia and resistance of inertia track and direct-decoupler, are identified by means of experiments and finite element method (FEM). Dynamic behaviors are tested with elastomer test system for purpose of validating PHEM. With incorporation of inertia track and direct-decoupler, PHEM behaves effective and efficient vibration isolation in range of both low and high frequencies. The comparison of the numerical results with the experimental observations shows that the present PHEM achieves fairly good performance for the engine vibration isolation.
文摘A novel approach to design Internal Model Controller(IMC)is proposed in this paper directly from measuredinput and output plant data,which are assumed to becontaminated by measurement noise.In order to avoidthe complicated structure-identification problem inmost cases,two Finite Impulse Response(FIR)modelsare taken to represent the plant model and the internalmodel controller respectively.Taking account of mea-surement noise both in the plant input and its output,anESD based Total Least Squares(TLS)solution is appliedfor the unbiased identification of the plant model and itsinverse model,the latter constitutes the internal modelcontroller according to the principle that the internalmodel controller approximates the inverse dynamics ofthe plant model.Simulations are given for a testifica-tion.
文摘The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator (MACSim), is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria subclavia and arteria axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.
基金This work was funded by the National Natural Science Foundation of China(Grant Nos.51775494,51821093,and 51935009)the National Key Research and Development Project(Grant No.2018YFB1700701)Zhejiang Key Research and Development Project(Grant No.2019C01141).
文摘Large-scale cryogenic air separation units(ASUs),which are widely used in global petrochemical and semiconductor industries,are being developed with high operating elasticity under variable working conditions.Different from discrete processes in traditional machinery manufacturing,the ASU process is continuous and involves the compression,adsorption,cooling,condensation,liquefaction,evaporation,and distillation of multiple streams.This feature indicates that thousands of technical parameters in adsorption,heat transfer,and distillation processes are correlated and merged into a large-scale complex system.A lumped parameter model(LPM)of ASU is proposed by lumping the main factors together and simplifying the secondary ones to achieve accurate and fast performance design.On the basis of material and energy conservation laws,the piecewise-lumped parameters are extracted under variable working conditions by using LPM.Takagi–Sugeno(T–S)fuzzy interval detection is recursively utilized to determine whether the critical point is detected or not by using different thresholds.Compared with the traditional method,LPM is particularly suitable for“rough first then precise”modeling by expanding the feasible domain using fuzzy intervals.With LPM,the performance of the air compressor,molecular sieve adsorber,turbo expander,main plate-fin heat exchangers,and packing column of a 100000 Nm3 O2/h large-scale ASU is enhanced to adapt to variable working conditions.The designed value of net power consumption per unit of oxygen production(kW/(Nm3 O2))is reduced by 6.45%.
基金Project suppoted by the National Natural Science Foundation of China (Grant No10372026)the Shanghai Leading Academic Discipline Project (Grant NoB112)
文摘This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (Ct) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (HCPT), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.