Objective:To explore the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Methods:The literatures on prevention and treatment of gastroint...Objective:To explore the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Methods:The literatures on prevention and treatment of gastrointestinal reaction after chemotherapy with Chinese medicine were searched from CNKI,Wanfang and VIP databases from the establishment of the database to September 2020.After screening,the database was established,and data mining was conducted by using IBM SPSS statistics 20.0 and IBM SPSS modeler 18.0 to summarize the medication rules of traditional Chinese medicine in the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Results:(1)A total of 131 literatures involving 245 traditional Chinese medicines were included for data mining;(2)High frequency drugs include Astragalus membranaceus,liquorice,Poria cocos,Atractylodes macrocephala,Pinellia ternata,Codonopsis pilosula,Ophiopogon japonicus,coix seed,Pericarpium Citri Reticulatae,Radix Glehniae and so on;(3)The traditional Chinese medicine used is mainly tonifying deficiency medicine,resolving phlegm and relieving cough and asthma medicine,diuresis and dampness medicine,heat clearing medicine and antiphlogistic medicine.The medicine tastes bitter and sweet,and has cold and warm properties.The meridian tropism involves liver,lung,stomach,spleen and kidney;(4)Seven core TCM combinations were obtained by cluster analysis,and 24 drug pairs(groups)were obtained by association rule analysis.Conclusion:Through the data mining of traditional Chinese medicine for the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer,we can find out the potential rules of traditional Chinese medicine prescription,and clarify the core Chinese medicine,which is helpful to provide certain reference for the development and research of drugs for the treatment of gastrointestinal reaction and modern clinical practice.展开更多
Objective：To evaluate the objectivity and comprehensiveness of Response Evaluation Criteria of Traditional Chinese Medicine for Solid Tumor（Draft,REC-TCM-ST） in application of Chinese medicine therapeutic effect in...Objective：To evaluate the objectivity and comprehensiveness of Response Evaluation Criteria of Traditional Chinese Medicine for Solid Tumor（Draft,REC-TCM-ST） in application of Chinese medicine therapeutic effect in patients with advanced non-small cell lung cancer（NSCLC）.Methods：A retrospective clinical research was used in 104 NSCLC patients in stages of Ⅲ-Ⅳ,53 cases were in Chinese medicine（CM） group and 51 cases were in Western medicine（WM） group.The therapeutic effect of the two groups was evaluated with both REC-TCM-ST and Response Evaluation Criteria in Solid Tumor（RECIST）.Kaplan-Meier method was used to analyze the survival time.Kappa test method was used to test the consistency of the two kinds of evaluation results.Results：According to REC-TCM-ST,the effective rate on relieving tumor mass in the CM group was significantly lower than that in the WM group（P〈0.05）,but there was no significant difference in tumor-mass stable rate（P〉0.05）;the symptom of weakness in the CM group was improved significantly,indicating better therapeutic effect than that in the WM group（P〈0.01）.Karnofsky score in the CM group was significantly better than that in the WM group（P〈0.01）.In terms of survival conditions,the median survival time and the survival rate of 6 months,1 year and 2 years of the CM group were higher than the WM group.The total effective rate was 9.62%,and the total stable rate was 72.12%for 104 cases according to RECIST;while the total effective rate was 34.62%,and the total stable rate was 84.62%according to REC-TCM-ST,thus there were significant differences between the results of the two criteria（P〈0.01）,and there was also some consistency between them,but not satisfactory.Conclusions：REC-TCM-ST was used to evaluate the therapeutic effect of CM in the treatment of advanced NSCLC,which shows that its evaluation results can better reflect the advantages and disadvantages of CM,and the effectiveness of CM is more objective and comprehensive than RECIST,so REC-TCM-ST is worthy of further improvement and clinical expansion.展开更多
目的 观察针刺配合和胃养血方治疗气血亏虚型肺癌癌因性疲乏的临床疗效。方法 将59例气血亏虚型肺癌癌因性疲乏患者随机分为治疗组(29例)和对照组(30例)。治疗组采用针刺配合和胃养血方治疗,对照组采用假针刺配合和胃养血方治疗。观察...目的 观察针刺配合和胃养血方治疗气血亏虚型肺癌癌因性疲乏的临床疗效。方法 将59例气血亏虚型肺癌癌因性疲乏患者随机分为治疗组(29例)和对照组(30例)。治疗组采用针刺配合和胃养血方治疗,对照组采用假针刺配合和胃养血方治疗。观察两组治疗前后Piper疲乏修订量表(revised Piper fatigue scale,PFS-R)及欧洲癌症研究与治疗组织生存质量核心量表(European Organisation for Research and Treatment of Cancer core quality of life questionnaire, EORTC QLQ-C30)各项评分的变化情况,并比较两组临床疗效。结果 两组治疗后PFS-R各项评分均较同组治疗前显著降低(P<0.05)。治疗组治疗前后PFS-R各项评分差值与对照组比较,差异均具有统计学意义(P<0.05,P<0.01)。治疗组治疗后EORTC QLQ-C30中躯体功能、角色功能、认知功能及疲倦评分均较同组治疗前显著降低(P<0.05)。治疗组治疗后EORTC QLQ-C30中角色功能及疲倦评分均明显低于对照组,差异均具有统计学意义(P<0.05)。治疗组治疗后总有效率为31.0%,对照组为17.2%,两组比较差异无统计学意义(P>0.05)。结论 针刺配合和胃养血方能改善肺癌患者疲乏状态及生活质量。展开更多
目的通过Meta分析评价中医运动疗法对肺癌患者肺功能、运动耐量及生活质量的影响。方法通过计算机检索中国知网、万方、维普、PubMed、Embase、Cochrane Library、Web of Science数据库,检索时间均为建库至2023年4月8日。按照纳入和排...目的通过Meta分析评价中医运动疗法对肺癌患者肺功能、运动耐量及生活质量的影响。方法通过计算机检索中国知网、万方、维普、PubMed、Embase、Cochrane Library、Web of Science数据库,检索时间均为建库至2023年4月8日。按照纳入和排除标准筛选文献、提取数据,使用RevMan5.4.1软件进行Meta分析。结果共纳入11篇文献,共751例肺癌患者。Meta分析结果显示,八段锦组的第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、生活质量高于对照组,6分钟步行距离(6MWD)长于对照组(P<0.05)。六字诀组的FEV1、FVC、FEV1/FVC、生活质量高于对照组(P<0.05)。结论中医运动疗法能够整体改善肺癌患者的肺功能、运动耐量及生活质量,值得临床推广。展开更多
基金National Natural Science Foundation of China(No.81673797)。
文摘Objective:To explore the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Methods:The literatures on prevention and treatment of gastrointestinal reaction after chemotherapy with Chinese medicine were searched from CNKI,Wanfang and VIP databases from the establishment of the database to September 2020.After screening,the database was established,and data mining was conducted by using IBM SPSS statistics 20.0 and IBM SPSS modeler 18.0 to summarize the medication rules of traditional Chinese medicine in the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Results:(1)A total of 131 literatures involving 245 traditional Chinese medicines were included for data mining;(2)High frequency drugs include Astragalus membranaceus,liquorice,Poria cocos,Atractylodes macrocephala,Pinellia ternata,Codonopsis pilosula,Ophiopogon japonicus,coix seed,Pericarpium Citri Reticulatae,Radix Glehniae and so on;(3)The traditional Chinese medicine used is mainly tonifying deficiency medicine,resolving phlegm and relieving cough and asthma medicine,diuresis and dampness medicine,heat clearing medicine and antiphlogistic medicine.The medicine tastes bitter and sweet,and has cold and warm properties.The meridian tropism involves liver,lung,stomach,spleen and kidney;(4)Seven core TCM combinations were obtained by cluster analysis,and 24 drug pairs(groups)were obtained by association rule analysis.Conclusion:Through the data mining of traditional Chinese medicine for the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer,we can find out the potential rules of traditional Chinese medicine prescription,and clarify the core Chinese medicine,which is helpful to provide certain reference for the development and research of drugs for the treatment of gastrointestinal reaction and modern clinical practice.
文摘Objective：To evaluate the objectivity and comprehensiveness of Response Evaluation Criteria of Traditional Chinese Medicine for Solid Tumor（Draft,REC-TCM-ST） in application of Chinese medicine therapeutic effect in patients with advanced non-small cell lung cancer（NSCLC）.Methods：A retrospective clinical research was used in 104 NSCLC patients in stages of Ⅲ-Ⅳ,53 cases were in Chinese medicine（CM） group and 51 cases were in Western medicine（WM） group.The therapeutic effect of the two groups was evaluated with both REC-TCM-ST and Response Evaluation Criteria in Solid Tumor（RECIST）.Kaplan-Meier method was used to analyze the survival time.Kappa test method was used to test the consistency of the two kinds of evaluation results.Results：According to REC-TCM-ST,the effective rate on relieving tumor mass in the CM group was significantly lower than that in the WM group（P〈0.05）,but there was no significant difference in tumor-mass stable rate（P〉0.05）;the symptom of weakness in the CM group was improved significantly,indicating better therapeutic effect than that in the WM group（P〈0.01）.Karnofsky score in the CM group was significantly better than that in the WM group（P〈0.01）.In terms of survival conditions,the median survival time and the survival rate of 6 months,1 year and 2 years of the CM group were higher than the WM group.The total effective rate was 9.62%,and the total stable rate was 72.12%for 104 cases according to RECIST;while the total effective rate was 34.62%,and the total stable rate was 84.62%according to REC-TCM-ST,thus there were significant differences between the results of the two criteria（P〈0.01）,and there was also some consistency between them,but not satisfactory.Conclusions：REC-TCM-ST was used to evaluate the therapeutic effect of CM in the treatment of advanced NSCLC,which shows that its evaluation results can better reflect the advantages and disadvantages of CM,and the effectiveness of CM is more objective and comprehensive than RECIST,so REC-TCM-ST is worthy of further improvement and clinical expansion.
文摘目的 观察针刺配合和胃养血方治疗气血亏虚型肺癌癌因性疲乏的临床疗效。方法 将59例气血亏虚型肺癌癌因性疲乏患者随机分为治疗组(29例)和对照组(30例)。治疗组采用针刺配合和胃养血方治疗,对照组采用假针刺配合和胃养血方治疗。观察两组治疗前后Piper疲乏修订量表(revised Piper fatigue scale,PFS-R)及欧洲癌症研究与治疗组织生存质量核心量表(European Organisation for Research and Treatment of Cancer core quality of life questionnaire, EORTC QLQ-C30)各项评分的变化情况,并比较两组临床疗效。结果 两组治疗后PFS-R各项评分均较同组治疗前显著降低(P<0.05)。治疗组治疗前后PFS-R各项评分差值与对照组比较,差异均具有统计学意义(P<0.05,P<0.01)。治疗组治疗后EORTC QLQ-C30中躯体功能、角色功能、认知功能及疲倦评分均较同组治疗前显著降低(P<0.05)。治疗组治疗后EORTC QLQ-C30中角色功能及疲倦评分均明显低于对照组,差异均具有统计学意义(P<0.05)。治疗组治疗后总有效率为31.0%,对照组为17.2%,两组比较差异无统计学意义(P>0.05)。结论 针刺配合和胃养血方能改善肺癌患者疲乏状态及生活质量。
文摘目的通过Meta分析评价中医运动疗法对肺癌患者肺功能、运动耐量及生活质量的影响。方法通过计算机检索中国知网、万方、维普、PubMed、Embase、Cochrane Library、Web of Science数据库,检索时间均为建库至2023年4月8日。按照纳入和排除标准筛选文献、提取数据,使用RevMan5.4.1软件进行Meta分析。结果共纳入11篇文献,共751例肺癌患者。Meta分析结果显示,八段锦组的第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、生活质量高于对照组,6分钟步行距离(6MWD)长于对照组(P<0.05)。六字诀组的FEV1、FVC、FEV1/FVC、生活质量高于对照组(P<0.05)。结论中医运动疗法能够整体改善肺癌患者的肺功能、运动耐量及生活质量,值得临床推广。
