Background Many studies indicated the human cytochrome P450 2D6 （CYP2D6） gene polymorphism was associated with acute leukemia （AL） susceptibility,however,the results were inconsistent.So we performed this meta-ana...Background Many studies indicated the human cytochrome P450 2D6 （CYP2D6） gene polymorphism was associated with acute leukemia （AL） susceptibility,however,the results were inconsistent.So we performed this meta-analysis to evaluate the relationship between CYP2D6＊3 or CYP2D6＊4 polymorphism and AL susceptibility.Methods We searched PubMed database up to February 20,2013,and finally yielded 9 case-control studies including 1343 cases and 1843 controls which tested the association between CYP2D6＊3 or ＊4 polymorphism and AL.After data extraction,we conducted a meta-analysis using the Comprehensive Meta Analysis software.Results Overall,no significant association between CYP2D6＊3 or ＊4 polymorphism and AL risk was found in this metaanalysis （＋ vs.-：OR=1.13,95% CI=0.79-1.63; ＋/＋ vs.-/-：OR=1.73,95% C/=0.99-3.02;-/＋ vs.-/-：OR=1.03,95% C/=0.68-1.56; （-/＋ and ＋/＋） vs.-/-：OR=1.08,95% C/=0.72-1.63; ＋/＋ vs.（-/＋ and-/-）：OR=1.76,95% C/=0.98-3.17）.Similar results were also been found in stratified subgroup analysis.There was no publication bias.Conclusion CYP2D6＊3 or ＊4 polymorphism might not be associated with AL susceptibility.However,the results need to be further confirmed by well-designed and high quality randomized controlled trials with larger sample sizes.展开更多
文摘Background Many studies indicated the human cytochrome P450 2D6 （CYP2D6） gene polymorphism was associated with acute leukemia （AL） susceptibility,however,the results were inconsistent.So we performed this meta-analysis to evaluate the relationship between CYP2D6＊3 or CYP2D6＊4 polymorphism and AL susceptibility.Methods We searched PubMed database up to February 20,2013,and finally yielded 9 case-control studies including 1343 cases and 1843 controls which tested the association between CYP2D6＊3 or ＊4 polymorphism and AL.After data extraction,we conducted a meta-analysis using the Comprehensive Meta Analysis software.Results Overall,no significant association between CYP2D6＊3 or ＊4 polymorphism and AL risk was found in this metaanalysis （＋ vs.-：OR=1.13,95% CI=0.79-1.63; ＋/＋ vs.-/-：OR=1.73,95% C/=0.99-3.02;-/＋ vs.-/-：OR=1.03,95% C/=0.68-1.56; （-/＋ and ＋/＋） vs.-/-：OR=1.08,95% C/=0.72-1.63; ＋/＋ vs.（-/＋ and-/-）：OR=1.76,95% C/=0.98-3.17）.Similar results were also been found in stratified subgroup analysis.There was no publication bias.Conclusion CYP2D6＊3 or ＊4 polymorphism might not be associated with AL susceptibility.However,the results need to be further confirmed by well-designed and high quality randomized controlled trials with larger sample sizes.
