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Detection of Anticardiolipin Antibody in Systemic Lupus Erythematosus and Its Clinical Significance
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作者 LIANGHong XUShizheng 等 《The Chinese-German Journal of Clinical Oncology》 CAS 2002年第2期107-108,共2页
Objective To determine the frequency and the clinical significance of anticardiolipin antibodies (ACA) in patients with systemic lupus erythematosus( SLE).Methods The serum ACA in 30 patients with SLE and 30 sera from... Objective To determine the frequency and the clinical significance of anticardiolipin antibodies (ACA) in patients with systemic lupus erythematosus( SLE).Methods The serum ACA in 30 patients with SLE and 30 sera from healthy volunteers was detected by the enzyme linked immunosorbend assay (ELISA).Results In normal group the binding index(BI) oflgG, IgM and IgA type of ACA was 1.48 ? 展开更多
关键词 systemic lupus erythematosus anticardiolipin antibody the enzyme linked immunosorbend assay
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Systemic lupus erythematosus therapeutic strategy: From immunotherapy to gut microbiota modulation 被引量:1
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作者 Vitaly Chasov Ekaterina Zmievskaya +6 位作者 Irina Ganeeva Elvina Gilyazova Damir Davletshin Maria Filimonova Aygul Valiullina Anna Kudriaeva Emil Bulatov 《Journal of Biomedical Research》 CAS CSCD 2024年第6期531-546,共16页
Systemic lupus erythematosus(SLE)is characterized by a systemic dysfunction of both the innate and adaptive immune systems,leading to an attack on healthy tissues of the body.During the development of SLE,pathogenic f... Systemic lupus erythematosus(SLE)is characterized by a systemic dysfunction of both the innate and adaptive immune systems,leading to an attack on healthy tissues of the body.During the development of SLE,pathogenic features,such as the formation of autoantibodies against self-nuclear antigens,cause tissue damage including necrosis and fibrosis,with increased expression levels of the typeⅠinterferon-regulated genes.Standard treatments for lupus with immunosuppressants and glucocorticoids are not effective enough but cause side effects.As an alternative,more effective immunotherapies have been developed,including monoclonal and bispecific antibodies that target B cells,T cells,co-stimulatory molecules,cytokines or their receptors,and signaling molecules.Encouraging results have been observed in clinical trials with some of these therapies.Furthermore,a chimeric antigen receptor T cell therapy has emerged as the most effective,safe,and promising treatment option for SLE,as demonstrated by successful pilot studies.Additionally,some emerging evidence suggests that gut microbiota dysbiosis may significantly contribute to the severity of SLE,and the normalization of the gut microbiota through methods such as fecal microbiota transplantation presents new opportunities for effective treatment of SLE. 展开更多
关键词 systemic lupus erythematosus IMMUNOTHERAPY monoclonal antibodies bispecific antibodies chimeric antigen receptor T cell fecal microbiota transplantation
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Bilateral Choroidal Occlusion in Antiphospholipid Syndrome Associated with Systemic Lupus Erythematosus 被引量:1
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作者 Yang Zhang Shunhua Zhang +1 位作者 Ailing Bian Youxin Chen 《Chinese Medical Sciences Journal》 CAS CSCD 2017年第4期269-273,共5页
This article reports a rare case of bilateral choroidal occlusion that occurred in a 24-year-old woman with antiphospholipid syndrome (APS) associated with systemic lupus erythematosus (SLE). This young lady concurred... This article reports a rare case of bilateral choroidal occlusion that occurred in a 24-year-old woman with antiphospholipid syndrome (APS) associated with systemic lupus erythematosus (SLE). This young lady concurred with aorta ventralis thrombosis and bilateral iliac artery occlusion when presented, and experienced a rapid deterioration of vision. She also has a history of recurrent miscarriage. Corticosteroid,immunosuppression and anticoagulation therapy were administered. Patients with APS associated with SLE are at risk for thrombotic phenomena, which may affect the ocular vessels of all sizes, including choroidal vessel.Our case alerts ophthalmologists and rheumatologists that bilateral choroidal occlusion may indeed be developed in patients with APS associated with SLE, and is a potential cause of visual morbidity. 展开更多
关键词 antiCARDIOLIPIN antiBODIES antiPHOSPHOLIPID antiBODIES choroidal vessels systemic lupus erythematosus
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Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan 被引量:1
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作者 Mariam Gbané-Koné Baly Ouattara +5 位作者 Kouassi Jean Mermoz Djaha Estelle Megne Astrid Nawé Ngandeu Abidou Kawalé Coulibaly Edmond Eti Marcel N’zué Kouakou 《Open Journal of Rheumatology and Autoimmune Diseases》 2015年第2期28-35,共8页
Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients’ files with systemic lupus erythematosus aged 12... Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients’ files with systemic lupus erythematosus aged 12 to 73 years old, who fulfilled the American College of Rheumatology (ACR)’s criteria. Antinuclear autoantibodies (ANA) were searched by indirect immunofluorescence. Anti-DNA native autoantibodies, extractable nuclear anti-antigens autoantibodies (anti-Sm, anti-SSA, anti-SSB and anti-RNP) and anti-phospholipids autoantibodies have been searched by ELISA technic. Results: The most frequent clinical manifestations were: articular damages (86.32%), cutaneous and mucosal lesions (71.79%) and fever (76.67%). Kidney damages have been noticed in 40.17%. Neurologic manifestations have been observed in 36.75%. Pericarditis and pleurisies have been noticed in 22.22% and 11.97% of cases, and anaemia in 86.32% of cases. ANA have been detected in 94.12% of cases, anti-DNA native’s autoantibodies in 73.53% and anti-Sm autoantibodies in 75% of cases. Anti-SSA and anti-SSB autoantibodies were respectively in 75% and 56.25% of cases. Anti-RNP autoantibodies were in all the patients, and anti-phospholipids autoantibodies were in 37.50% of cases. Conclusion: Systemic lupus erythematosus of Ivorian black subject is characterised by high prevalence of autoantibodies, mostly Anti-RNP. 展开更多
关键词 Sub-Saharan Africa systemic lupus erythematosus Extractable Nuclear anti-antigens AUTOantiBODIES anti-Phospholipids AUTOantiBODIES ELISA
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Prevalence of Anti-Cardiolipin and Anti-β2 Glycoprotein Antibodies in Indian Systemic Lupus Erythematosus Patients
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作者 Vandana Pradhan Anjali Rajadhyaksha +3 位作者 Pranaya Joshi Manisha Patwardhan Shruti Dighe Kanjaksha Ghosh 《International Journal of Clinical Medicine》 2011年第3期339-345,共7页
Anti-phospholipid antibodies (APA) like anti-cardiolipin antibodies (ACA) and anti-β2glycoprotien (anti-β2GP) are important cause of venous and arterial thrombosis and other occlusive vascular diseases. The prevalen... Anti-phospholipid antibodies (APA) like anti-cardiolipin antibodies (ACA) and anti-β2glycoprotien (anti-β2GP) are important cause of venous and arterial thrombosis and other occlusive vascular diseases. The prevalence of these antibodies in SLE patients at the time of diagnosis is not known in Indian SLE patients. This study was conducted to evaluate the prevalence of ACA and anti-β2GP autoantibodies in SLE patients and to correlate them with disease activity and immune parameters such as C3, C4 and CRP levels. where 85 SLE patients referred from Rheumatology Department, KEM hospital, Mumbai were studied. SLE disease activity was evaluated by SLE Disease Activity Index (SLEDAI) score at the time of evaluation. All patients studied were in an active stage of disease of which 37.6% patients had renal disorders, which were categorized as Lupus Nephritis (LN) and 62.3% patients did not show any renal manifestations (non-LN). ACA and anti-β2GP autoantibodies, to IgG and IgM subclasses were tested by ELISA. C3, C4 and CRP levels were detected by nephelometer. It was observed that 12.9% patients were IgG-ACA and IgM-ACA positive and ACA positivity was noted more among LN group Anti-β2GP autoantibody positivity was 27.1% for IgG and 31.8% for IgM., IgG-anti-β2GP antibodies were slightly higher in non-LN patients, whereas a higher incidence of IgM-anti-β2GP antibodies were detected in LN patients. Hence detection both ACA and anti-β2GP antibodies along with associated immune parameters were helpful to evaluate their possible association with disease severity in SLE patients. A long term follow up of patients having ACA and anti-β2GP antibodies without thrombotic event is also needed to detect their possible thrombotic event in future along with their clinical presentation. 展开更多
关键词 systemic lupus erythematosus (SLE) anti-Cardiolipin antiBODIES (ACA) anti-β2glycoprotein antiBODIES (anti-β2GP) lupus NEPHRITIS (LN) SLE without NEPHRITIS (Non-LN)
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Anti-M<sub>3</sub>Muscarinic Acetylcholine Receptor Antibodies in Systemic Lupus Erythematosus
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作者 Silvia Reina Cecilia Pisoni +3 位作者 Alicia Eimon Carolina Carrizo Roberto Arana Enri Borda 《Pharmacology & Pharmacy》 2015年第1期25-33,共9页
Background: Evidences have shown that anti-M3 muscarinic acetylcholine receptor IgG (anti-M3 mAChR IgG) are clinically useful autoantibody that exert a cholinergic pharmacologic effect binding and interacting with M3 ... Background: Evidences have shown that anti-M3 muscarinic acetylcholine receptor IgG (anti-M3 mAChR IgG) are clinically useful autoantibody that exert a cholinergic pharmacologic effect binding and interacting with M3 mAChR at the level of exocrine gland (salivary and ocular). Aims: The aim of this study was to determine the associations between serum level of anti-M3 mAChR IgG in patients with systemic lupus erythematosus (SLE) and other autoantibodies, serum prostaglandin E2 (PGE2), and clinical manifestations. Methods: Serum autoantibodies against M3 mAChR synthetic peptide were measured by enzyme-linked immuno absorbent assay (ELISA) using, as an antigen, a 25-mer peptide K-R-T-V-P-D-N-Q-C-F-I-Q-F-L-S-N-P-A-V-T-F-G-T-A-I corresponding to the amino acid sequence of the second extracellular loop of the human M3 mAChR. Serum levels of antinuclear antibodies (ANA), anti-Smith (Sm) antibodies, anti-phospholipid (APL) antibodies, and PGE2 were determined by ELISA in patients with SLE. Results: We found significantly enhanced titers of anti-M3 mAChR IgG in sera from SLE patients compared with healthy individuals (control). In addition, serum levels of PGE2 were significantly higher in SLE patients than in control patients and were significantly higher in active than in non-active SLE. No correlation was found with other autoantibodies present in SLE. By contrast, a positive correlation was found between anti-M3 mAChR IgG and PGE2 serum levels in SLE. Conclusions: As anti-M3 mAChR antibodies present in the sera of SLE patients may be another factor in the pathogenesis of this disease, and the increment of PGE2 in the sera of SLE has a modulatory action on the inflammatory process, suggesting that the presence of these autoantibodies against M3 mAChR may contribute to sustained immune deregulation and the strong inflammatory component observed in SLE. 展开更多
关键词 anti-M3 MACHR antiBODIES systemic lupus erythematosus PROSTAGLANDIN E2
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Systemic lupus erythematosus combined with primary hyperfibrinolysis and protein C and protein S deficiency:A case report
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作者 Yi-Xuan Liao Yan-Fei Guo +2 位作者 Yu-Xia Wang Ai-Hua Liu Chun-Li Zhang 《World Journal of Clinical Cases》 SCIE 2021年第8期2008-2014,共7页
BACKGROUND Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by systemic involvement and multiple autoantibodies in the serum.Patients with protein C(PC)and protein S(PS)deficiency are prone to t... BACKGROUND Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by systemic involvement and multiple autoantibodies in the serum.Patients with protein C(PC)and protein S(PS)deficiency are prone to thrombosis.In contrast,patients with primary hyperfibrino-lysis tend to bleed.CASE SUMMARY A 52-year-old female patient with bilateral pleural effusion was diagnosed with"tuberculous pleurisy"and treated with anti-tuberculosis drugs and prednisone.The coagulation-related laboratory results showed decreased fibrinogen,PC activity,PS activity,and antithrombinШactivity.The immune-related laboratory results showed positive antinuclear antibody,anti-Smith antibody,anticardiolipin antibody(ACL),anti-β2-glycoprotein I antibody(aβ2GPI)and direct Coomb’s test and decreased complement 3 and complement 4.Thoracoscopy was performed and bloody pleural fluid was drained.Pathology of the pleural biopsy showed lymphocytes,plasma cells,and a few eosinophils in adipose and fibrous connective tissue.Results of whole exome sequencing of blood showed no genetic mutations suggesting the presence of hereditary hematological diseases.The patient was finally diagnosed with SLE and primary hyperfibrinolysis,and was treated with prednisolone,hydroxychloroquine,and compound cyclophosphamide.CONCLUSION PC and PS deficiency in SLE might be related to ACL and aβ2GPI.SLE and primary hyperfibrinolysis can coexist in one patient,with both a risk of thrombosis and a risk of bleeding. 展开更多
关键词 systemic lupus erythematosus Primary hyperfibrinolysis antiphospholipid antibody Protein C deficiency Protein S deficiency Case report
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Histone H1/MBP hydrolysing antibodies - novel potential marker in diagnosis of disease severity in systematic lupus erythematosus patients 被引量:1
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作者 Valentyna Chopyak Yaroslav Tolstiak +5 位作者 Iryna Magoryvska Rostyslav Bilyy Rostyslav Bilyy Natalya Korniy Yuriy Kit Rostyslav Stoika 《Health》 2010年第10期1204-1207,共4页
Recently we have shown the presence of catalytically active IgGs, capable to cleave histone H1 and bovine myelin basic protein (MBP), in blood serum of SLE patients. Here we present data that demonstrate the correlati... Recently we have shown the presence of catalytically active IgGs, capable to cleave histone H1 and bovine myelin basic protein (MBP), in blood serum of SLE patients. Here we present data that demonstrate the correlation between a) proteolytic activity towards histone H1 and MBP of IgG-antibodies from blood serum of SLE patients and b) disease severity level in these patients. IgGs were isolated from blood serum by chromatography on protein G-sepharose. Commercial preparations of bovine myelin basic proteins (MBP) and calf thymus histone H1 were used as substrates. Analysis of the proteolytic activity showed that 16 of 38 lgG-preparations (42,1%) obtained from blood serum of SLE patients were capable of cleaving both histone H1 and MBP with different efficiency. It was revealed that the presence in blood serum of lgGs possessing proteolytic activity towards both histone H1 and bMBP closely correlates with manifestation of the disease severity in SLE patients. 展开更多
关键词 System lupus erythematosus PROTEOLYTIC Activity IgG-antibodies Disease Severity
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A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus
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作者 Lai Wang Haoyuan Yin +8 位作者 Jiao Jiang Qilin Li Changxing Gao Wenrui Li Bo Zhang Yue Xin Hongyang Li Ming Zhao Qianjin Lu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第10期4560-4576,共17页
Tripterygium wilfordii Hook F(TWHF)is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus(SLE),with triptolide(TP)as its main active ingredient.However,its side effects also ind... Tripterygium wilfordii Hook F(TWHF)is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus(SLE),with triptolide(TP)as its main active ingredient.However,its side effects also induced by TP,especially hepatotoxicity and reproductive toxicity,largely limit its application in a subset of patients.Monoclonal antibodies(mAbs)developed for the treatment of SLE that deplete B cells by targeting B cell-expressing antigens,such as CD19,have failed in clinical trials,partly due to their poor efficacy in consuming B cells.Here,we report the development of a rationally designed antibody‒drug conjugate(ADC),CD19 mAb-TP conjugate,to alleviate the side effects of TWHF and simultaneously improve the therapeutic efficacy of CD19 mAb.The CD19 mAb-TP conjugate,which was named ADC-TP,selectively depleted B cell subsets both in vitro and in vivo and effectively alleviated disease symptoms in mouse lupus models with enhanced therapeutic efficacy than CD19 mAb and fewer side effects than TP.Our present study proposes a CD19 mAb‒TP conjugate strategy to mitigate the toxicity of TWHF while also enhancing the therapeutical efficacy of CD19 mAbs for the treatment of SLE,providing a feasible method for improving the current agents used for treating SLE. 展开更多
关键词 systemic lupus erythematosus TRIPTOLIDE CD19 antibody‒drug conjugate B cells Reproductive toxicity Synergistic effect Targeted therapy
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Pathogenesis of Neuropsychiatric Syndromes of Systemic Lupus Erythematosus
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作者 Taku Yoshio Hiroshi Okamoto 《Open Journal of Rheumatology and Autoimmune Diseases》 2015年第2期46-56,共11页
The pathogenesis of neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) is multifactorial and can involve various inflammatory cytokines, autoantibodies such as anti-neuronal antibodies, anti-ribosomal ... The pathogenesis of neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) is multifactorial and can involve various inflammatory cytokines, autoantibodies such as anti-neuronal antibodies, anti-ribosomal P antibodies, anti-NR2 glutamate receptor binding antibodies, anti-Sm antibodies, anti-U1-RNP antibodies and anti-phospholipid antibodies, and immune complexes (IC). Disruption of the blood-brain barrier (BBB) is integral to the neuropathology of SLE. Recently the possibility has been reported that aforementioned autoantibodies in the circulation may be strongly associated with disruption of the BBB. Each of these mechanisms might contribute to the pathogenesis of focal NPSLE (for example, cerebrovascular disease, movement disorders, myelopathy, seizures and cranial neuropathy) or diffuse NPSLE (for example, acute confusional state, psychosis and cognitive dysfunction) to varying degrees. In this review we focus on how the aforementioned autoantibodies, the BBB, IC and cytokines as well as chemokines are associated with the appearance of NPSLE. 展开更多
关键词 NEUROPSYCHIATRIC systemic lupus erythematosus anti-Ribosomal P antiBODIES anti-NR2 Glutamate Receptor Binding antiBODIES INTERLEUKIN-6 Granulocyte-Colony Stimulating Factor The Blood-Brain Barrier
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An atypical presentation of Kikuchi-Fujimoto disease mimicking systemic lupus erythematosus: case report and literature review
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作者 Diane Belder-Preston Catherine-Maude Pound Roman Jurencak 《Open Journal of Pediatrics》 2011年第4期67-71,共5页
Purpose: To report a case of atypical Kikuchi-Fujimoto disease (KFD) that illustrates several overlapping features with systemic lupus erythematosus (SLE). Methods: A case is reported followed by a review of the curre... Purpose: To report a case of atypical Kikuchi-Fujimoto disease (KFD) that illustrates several overlapping features with systemic lupus erythematosus (SLE). Methods: A case is reported followed by a review of the current literature. Case report: A 16-year-old boy with an unusual manifestation of Kikuchi-Fujimoto disease (KFD) is described. The patient presented with fever, weight loss and severe abdominal pain, due to extensive necrotizing retroperitoneal and mesenteric lymphadenopathy. During the course of his illness, he developed several symptoms suggestive of systemic lupus erythematosus (SLE): a pericardial effusion, cotton wool spots on the retina and antibodies against nuclear antigens (ANA), Smith (Sm) and ribonucleoprotein (RNP) antigens. However, no additional features of SLE were found. The patient subsequently fully recovered within two months, without initiation of immunosuppressive therapy. His autoantibodies became negative five months after initial presentation and he remains well at his 23 month follow up visit. Discussion: We hypothesize that the autoantibodies developed by our patient were secondary to self-antigen induced autoimmunity related to his extensive tissue necrosis. Despite initially having clinical features suggestive of SLE, our patient’s full and spontaneous recovery strongly supports the diagnosis of KFD. This illustrates the need for careful diagnosis, in order to avoid unnecessary and potentially toxic treatment with immunosuppressive agents. 展开更多
关键词 Kikuchi-Fujimoto’s Disease RETROPERITONEAL LYMPHADENITIS systemic lupus erythematosus (SLE) antiNUCLEAR antibodies (ANA)
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PRESENCE OF ANTILAMIN ANTIBODIES IN SERA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
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作者 王慧珍 崔京涛 +1 位作者 王晓红 王永潮 《Chinese Medical Sciences Journal》 CAS CSCD 1995年第4期223-225,共3页
In this study, we characterized specifically-stained sera from patients with systemic lupus erythematosus (SLE) which had been shown to display the homogeneous or peripheral region of nuclei by indirect immunofluoresc... In this study, we characterized specifically-stained sera from patients with systemic lupus erythematosus (SLE) which had been shown to display the homogeneous or peripheral region of nuclei by indirect immunofluorescence (IIF). By western blotting, we demonstrated that in some cases there was a correlation between the peripheral or homogenous. IIF staining of nuclei by sera from patients with SLE and the presence of autoantibodies to lamins. Here we first report the presence of 2. 2% anti-lamin autoantibodies in the sera among the 174 patients with SLE in China. 展开更多
关键词 antilamin antibody systemic lupus erythematosus
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Clinical value of chemiluminescence method for detection of antinuclear antibody profiles 被引量:1
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作者 Hui-Yao Xiang Xi-Ying Xiang +3 位作者 Ting-Bo Ten Xie Ding Yu-Wen Liu Chun-Hua Luo 《World Journal of Clinical Cases》 SCIE 2023年第28期6688-6697,共10页
BACKGROUND Antinuclear antibodies(ANAs)are crucial in diagnosing autoimmune diseases,mainly systemic lupus erythematosus(SLE).This study aimed to compare the performance of chemiluminescence assay(CLIA)and line immuno... BACKGROUND Antinuclear antibodies(ANAs)are crucial in diagnosing autoimmune diseases,mainly systemic lupus erythematosus(SLE).This study aimed to compare the performance of chemiluminescence assay(CLIA)and line immunoassay(LIA)in detecting ANAs in patients with autoimmune diseases,evaluate their diagnostic accuracy for SLE,and develop a novel diagnostic model using CLIA-detected antibodies for SLE.Specimens from patients with autoimmune diseases and physical examination specimens were collected to parallel detect specific antibodies.Individual antibodies'diagnostic performance and a model combining multiple antibodies were assessed.The findings provide valuable insights into improving the diagnosis of SLE through innovative approaches.AIM To compare the performance of CLIA and LIA in detecting ANAs in patients with autoimmune diseases,assess their accuracy for SLE,and develop a novel diagnostic model using CLIA-detected antibodies for SLE.METHODS Specimens have been obtained from 270 patients with clinically diagnosed autoimmune disorders,as well as 130 physical examination specimens.After that,parallel detection of anti-double-stranded DNA(dsDNA)antibody,anti-histone(Histone)antibody,anti-nucleosome(Nuc)antibody,anti-Smith(Sm)antibody,anti-ribosomal P protein(Rib-P)antibody,anti-sicca syndrome A(Ro60)antibody,anti-sicca syndrome A(Ro52)antibody,anti-sicca syndrome(SSB)antibody,anticentromere protein B(Cenp-B)antibody,anti-DNA topoisomerase 1(Scl-70)antibody,anti-histidyl tRNA synthetase(Jo-1)antibody,and anti-mitochondrial M2(AMA-M2)antibody was performed using CLIA and LIA.The detection rates,compliance rates,and diagnostic performance for SLE were compared between the two methodologies,followed by developing a novel diagnostic model for SLE.RESULTS CLIA and LIA exhibited essentially comparable detection rates for anti-dsDNA antibody,anti-Histone antibody,anti-Nuc antibody,anti-Sm antibody,anti-Rib-P antibody,anti-Ro60 antibody,anti-Ro52 antibody,anti-SSB antibody,anti-Cenp-B antibody,anti-DNAScl-70 antibody,anti-Jo-1 antibody and anti-AMA-M2 antibody(P>0.05).The two methods displayed identical results for the detection of anti-dsDNA antibody,anti-Histone antibody,anti-Nuc antibody,anti-Sm antibody,anti-Ro60 antibody,anti-Ro52 antibody,anti-SSB antibody,anti-Cenp-B antibody,anti-Scl-70 antibody,and anti-AMA-M2 antibody(Kappa>0.7,P<0.05),but showed a moderate agreement for the detection of anti-Rib-P antibody and anti-Jo-1 antibody(Kappa=0.671 and 0.665;P<0.05).In addition,the diagnostic performance of these antibodies detected by both methods was similar for SLE.The diagnostic model's area under the curve values,sensitivity,and specificity,including an anti-dsDNA antibody and an anti-Ro60 antibody detected by CLIA,were 0.997,0.962,and 0.978,respectively.These values were higher than the diagnostic performance of individual antibodies.CONCLUSION CLIA and LIA demonstrated excellent overall consistency in detecting ANA profiles.A diagnostic model based on CLIA-detected antibodies can successfully contribute to developing a novel technique for detecting SLE. 展开更多
关键词 Chemiluminescence assay Immunoblotting antinuclear antibody profile Autoimmune diseases systemic lupus erythematosus Diagnostic model
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Meta-analysis of anti-ribosomal P antibodies in lupus psychosis
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作者 Kim Linz Brian J Miller 《World Journal of Meta-Analysis》 2013年第3期121-129,共9页
AIM: To perform a meta-analysis of the prevalence of anti-ribosomal P (aRP) antibodies in lupus psychosis, and the odds of psychosis in aRP-positive subjects.METHODS: We identifed articles by searching PubMed, Psy... AIM: To perform a meta-analysis of the prevalence of anti-ribosomal P (aRP) antibodies in lupus psychosis, and the odds of psychosis in aRP-positive subjects.METHODS: We identifed articles by searching PubMed, PsychInfo, and ISI, and the reference lists of identifed studies.RESULTS: Twenty-four studies met the inclusion criteria. Positive aRP antibodies were found in 51% (91 of 179 total cases) of cases of lupus psychosis. There was an almost 3.5-fold increased odds of psychosis in aRP-positive patients (OR = 3.46, 95%CI: 1.97-6.09, P 〈 0.001). The population attributable risk percentage was 36% for aRP antibodies.CONCLUSION: aRP antibodies are common in lupus psychosis, although the potential mechanism(s) underlying this association remain unclear. Given the overlap between the clinical presentation and risk factors for lupus psychosis and schizophrenia, further investigation of aRP antibodies in schizophrenia is warranted. 展开更多
关键词 systemic lupus erythematosus PSYCHOSIS AUTOantiBODIES anti-ribosomal P antibodies Metaanalysis
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血清anti-β2GPI、FSTL1、PD-1对系统性红斑狼疮免疫功能、疾病活动度的影响
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作者 王晓娟 邢广栋 《罕少疾病杂志》 2024年第7期142-144,共3页
目的探究血清抗β2糖蛋白I抗体(anti-β2GPI)、卵泡抑素样蛋白(FSTL1)、程序性死亡受体1(PD-1)对系统性红斑狼疮(SLE)患者免疫功能、疾病活动度的影响。方法选取我院2019年1月~2022年6月SLE患者113例作为观察组,另选取同期健康体检者10... 目的探究血清抗β2糖蛋白I抗体(anti-β2GPI)、卵泡抑素样蛋白(FSTL1)、程序性死亡受体1(PD-1)对系统性红斑狼疮(SLE)患者免疫功能、疾病活动度的影响。方法选取我院2019年1月~2022年6月SLE患者113例作为观察组,另选取同期健康体检者105例作为对照组。比较两组、不同疾病活动度患者血清anti-β2GPI、FSTL1、PD-1水平,评价各血清指标与疾病活动度的关系,并根据观察组血清表达水平分为高表达者、低表达者,对比两者免疫功能(CD4+、CD8+、CD4+/CD8+),分析各血清指标与免疫功能相关性。结果观察组血清anti-β2GPI、FSTL1、PD-1高于对照组(P<0.05);血清anti-β2GPI、FSTL1、PD-1高表达患者CD4+、CD4+/CD8+低于低表达患者,CD8+高于低表达患者(P<0.05);血清anti-β2GPI、FSTL1、PD-1与CD4+、CD4+/CD8+呈负相关,与CD8+呈正相关(P<0.05);血清anti-β2GPI、FSTL1、PD-1水平随疾病活动度增加呈升高趋势,且重度活动患者>中度活动患者>轻度活动患者>病情稳定患者(P<0.05);血清anti-β2GPI、FSTL1、PD-1与疾病活动度显著相关(P<0.05)。结论血清anti-β2GPI、FSTL1、PD-1高表达可能参与SLE患者细胞免疫功能紊乱、疾病活动度加重的发生过程。 展开更多
关键词 抗Β2糖蛋白I抗体 卵泡抑素样蛋白 程序性死亡受体1 系统性红斑狼疮 免疫功能 疾病活动度
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联合检测ANuA、Anti-ds-DNA、anti-P和Anti-sm在SLE伴肾损害患者中的诊断价值 被引量:1
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作者 王立鼎 唐晓磊 秦嫚 《分子诊断与治疗杂志》 2023年第1期165-168,共4页
目的 探究抗核小体(ANuA)、抗双链DNA(Anti-ds-DNA)、抗核糖体P蛋白(anti-P)和抗Sm抗体(Anti-sm)联合检测在系统性红斑狼疮(SLE)伴肾损害患者中的诊断价值。方法 选取2019年1月至2022年4月黄山市人民医院收治的SLE患者163例为研究对象,... 目的 探究抗核小体(ANuA)、抗双链DNA(Anti-ds-DNA)、抗核糖体P蛋白(anti-P)和抗Sm抗体(Anti-sm)联合检测在系统性红斑狼疮(SLE)伴肾损害患者中的诊断价值。方法 选取2019年1月至2022年4月黄山市人民医院收治的SLE患者163例为研究对象,根据患者是否合并肾损害分为SLE组(n=55)与SLE伴肾损害组(n=108)。收集两组患者血清进行ANuA、Anti-ds-DNA、anti-P和Anti-sm检测,比较两组上述抗体单一及联合检测的阳性率,并绘制ROC曲线分析上述抗体指标对SLE伴肾损害的诊断价值。结果 SLE组Anti-ds-DNA、Anti-sm抗体单一及联合检测阳性率均高于SLE伴肾损害组,差异均具有统计学意义(χ^(2)=18.360、10.513、8.010,P<0.05);SLE组ANuA、anti-P检测阳性率均低于SLE伴肾损害组,差异均具有统计学意义(χ^(2)=7.094、4.281,P<0.05)。多因素Logistic回归分析显示,ANuA(β=2.284,OR=9.816)、Anti-ds-DNA(β=0.749,OR=2.115)、anti-P(β=1.386,OR=3.999)和Anti-sm(β=0.475,OR=1.608)是SLE伴肾损害的独立影响因素(P<0.05)。ROC曲线显示,ANuA、Anti-ds-DNA、anti-P和Anti-sm四者联合检测时,预测SLE伴肾损害的AUC为0.911,敏感性、特异性分别为89.0%、92.6%,优于单一检测(P<0.05)。结论 ANuA、Anti-ds-DNA、anti-P和Anti-sm都与SLE伴肾损害有关,联合检测ANuA、Anti-ds-DNA、anti-P和Anti-sm对于提高SLE伴肾损害的诊断准确性具有重要价值。 展开更多
关键词 抗核小体抗体 抗双链DNA 抗核糖体P蛋白抗体 sm抗体 系统性红斑狼疮 肾损害
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A successful birth of severe secondary recurrent miscarriage case after a decline of phosphatidylserine-dependent anti-prothrombin antibody by intravenous immunoglobulin administration
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作者 Mika Kanaya Kunihiko Nagasawa +4 位作者 Tsuyoshi Baba Shinichi Ishioka Hideto Yamada Toshiaki Endo Tsuyoshi Saito 《Open Journal of Obstetrics and Gynecology》 2012年第2期156-160,共5页
A 33 years old woman was referred to our hospital since her sixth pregnancy had been revealed. In fact, at 19 years of age she had diagnosed as having systemic lupus erythematosus without organ failure. In addition, s... A 33 years old woman was referred to our hospital since her sixth pregnancy had been revealed. In fact, at 19 years of age she had diagnosed as having systemic lupus erythematosus without organ failure. In addition, she had a past history of uncontrollable severe pregnancy-induced hypertension occurred during the second pregnancy, resulting in extremely premature delivery and following postpartum HELLP syndrome. It was so severe that we employed administration of dexamethasone and plasma exchange to ameliorate a life-threatening situation. In the course of her recovery it was revealed that she had been complicated with antiphospholipid antibodies, and at the same time we observed that phosphatidylserine-dependent anti-prothrombin antibody IgG levels were declining as her condition was getting better. There-after, she became pregnant three times, but all pregnancies ended in miscarriage despite administration of prednisolone and anticoagulant therapy. Therefore, we realized that her recurrent miscarriages could not be prevented with generally acceptable therapies, so we tried intravenous immunoglobulin shortly after fetal heart beats were detected. In fact, her sixth pregnancy was going well, but we had to terminate it at the 35th week of gestation due to the onset of HELLP syndrome-like condition. However, she could achieve an almost intact pregnancy outcome without neonatal complications or persistently worsening postpartum HELLP syndrome-like condition. Considering the etiologic relation overlapping between systemic lupus erythematosus, antiphospholipid syndrome and recurrent miscarriage, intravenous immunoglobulin can be one of the treatment options for severe secondary recurrent miscarriage, although the evidence of the treatment is always certain. In addition, a decline of phosphatidylserine-dependent anti-prothrombin antibody IgG levels we observed in this case may represent its therapeutic immunomodulatory effects. 展开更多
关键词 antiPHOSPHOLIPID antibody antiPHOSPHOLIPID Syndrome Intravenous IMMUNOGLOBULIN Recurrent MISCARRIAGE systemic lupus erythematosus
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抗Sm抗体阳性系统性红斑狼疮临床特征分析 被引量:16
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作者 李结华 叶冬青 +2 位作者 杨世贵 徐元勇 胡以松 《实用医学杂志》 CAS 2004年第1期20-22,共3页
目的 :探讨抗Sm抗体阳性系统性红斑狼疮 (SLE)的临床特征。方法 :对 2 75例抗Sm抗体阳性SLE患者临床资料进行分析 ,并与 2 90例抗Sm抗体阴性SLE患者临床资料进行比较。结果 :抗Sm抗体阳性SLE患者年龄小、病程短、光敏感、关节炎、口腔... 目的 :探讨抗Sm抗体阳性系统性红斑狼疮 (SLE)的临床特征。方法 :对 2 75例抗Sm抗体阳性SLE患者临床资料进行分析 ,并与 2 90例抗Sm抗体阴性SLE患者临床资料进行比较。结果 :抗Sm抗体阳性SLE患者年龄小、病程短、光敏感、关节炎、口腔溃疡较多见 (P <0 0 5或P <0 0 1) ;血沉快、蛋白尿、补体下降发生率较高 (P <0 0 5或P <0 0 1) ;抗URNP抗体、抗Rib抗体阳性率高 ;抗Sm抗体阳性组与阴性组之间SLEDAI积分差异无显著性 (P >0 0 5 )。结论 :(1)抗Sm抗体阳性SLE患者临床表现明显 ,易被早期诊断。 (2 )抗Sm抗体、抗URNP抗体、抗Rib抗体联合检测 ,可能对SLE诊断意义较大。 (3 )抗Sm抗体水平与疾病活动性无一致关系。 展开更多
关键词 sm抗体阳性 系统性红斑狼疮 临床特征 自身免疫性疾病 诊断
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联合检测抗核小体、抗双链DNA、抗组蛋白和抗Sm抗体在系统性红斑狼疮诊断中的临床意义 被引量:14
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作者 王许娜 边菁 +3 位作者 尹光辉 朱伟涛 孙晓旭 明亮 《中国现代医学杂志》 CAS 北大核心 2015年第14期59-62,共4页
目的探讨抗核小体抗体(Anu A)、抗双链DNA抗体(Anti-ds DNA)、抗组蛋白抗体(AHA)和抗Sm抗体(Anti-Sm)在系统性红斑狼疮(SLE)诊断中的应用价值。方法收集150例SLE患者和120例其他风湿病患者血清,应用蛋白质印迹法对两组患者血清进行Anu A... 目的探讨抗核小体抗体(Anu A)、抗双链DNA抗体(Anti-ds DNA)、抗组蛋白抗体(AHA)和抗Sm抗体(Anti-Sm)在系统性红斑狼疮(SLE)诊断中的应用价值。方法收集150例SLE患者和120例其他风湿病患者血清,应用蛋白质印迹法对两组患者血清进行Anu A、Anti-ds DNA、AHA和Anti-Sm检测,并对结果进行回顾性分析。结果 SLE组中Anu A、Anti-ds DNA、AHA和Anti-Sm的阳性率分别为42.7%、30.0%、49.3%和32.0%,与对照组比较差异有统计学意义(P<0.01)。SLE组4种抗体联合检测中,Anti-Sm+Anti-ds DNA+Anu A的阳性率为12.7%,AHA+Anti-ds DNA+Anu A的阳性率为14.0%,Anti-Sm+Anti-ds DNA+AHA的阳性率为11.3%,AHA+Anti-ds DNA+Anu A+Anti-Sm的阳性率为8.7%,阳性率明显高于对照组,差异有统计学意义(P<0.01)。4种抗体联合检测的特异性和阳性预测值与单项检测相比均升高,敏感性和阴性预测值与单项检测相比均降低。结论 4种抗体的检测对SLE的诊断有重要意义,其联合检测更有利于SLE的诊断和治疗,并且对疗效评估和预后监测有重要价值。 展开更多
关键词 抗核小体抗体 抗双链DNA抗体 抗组蛋白抗体 sm抗体 系统性红斑狼疮
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抗SmD1抗体在诊断系统性红斑狼疮中的意义 被引量:6
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作者 孙乐栋 钟彩梅 +3 位作者 贺凤姣 曾抗 周再高 黄良 《中国皮肤性病学杂志》 CAS 北大核心 2009年第6期330-331,共2页
目的了解抗SmD1抗体在诊断系统性红斑狼疮(SLE)中的特异性和感敏性,探讨其在SLE诊断中的意义。方法取120例SLE患者和230例非SLE患者的血清,并同时进行抗核抗体(间接免疫荧光法)、抗Sm抗体(免疫斑点法)、抗DNA抗体及抗SmD1抗体(免疫印迹... 目的了解抗SmD1抗体在诊断系统性红斑狼疮(SLE)中的特异性和感敏性,探讨其在SLE诊断中的意义。方法取120例SLE患者和230例非SLE患者的血清,并同时进行抗核抗体(间接免疫荧光法)、抗Sm抗体(免疫斑点法)、抗DNA抗体及抗SmD1抗体(免疫印迹法)检测,统计分析其对SLE患者诊断的特异性与敏感性。结果SLE患者抗SmD1抗体的敏感性为69.17%,特异性为97.82%。结论抗SmD1抗体特异性和敏感性均较高,可作为诊断SLE的参考指标,对SLE的诊断具有重要意义。 展开更多
关键词 smD1抗体 红斑狼疮 系统性 自身抗体
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