Lupus nephritis （LN） is one of the most severe manifestations of systemic lupus erythematosus （SLE）, which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves mu...Lupus nephritis （LN） is one of the most severe manifestations of systemic lupus erythematosus （SLE）, which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves multiple factors, including genetic predisposition, epigenetic regulation and environmental interaction. Over the last decade, omics-based techniques have been extensively utilized for biomarker screening and a wide variety of variations which are associated with SLE and LN have been identified at the levels of genomics, transcriptomics and proteomics. These studies and discoveries have expanded our understanding of the molecular basis of the disease and are important for identification of potential therapeutic targets for disease prediction and early treat- ment. In this review, we summarize some of the recent studies targeted at the identification of LN-associated biomarkers using genomics and proteomic approaches.展开更多
基金supported by National Institutes of Health(Grant No. P50 CORT AR055503, R01 AR050812 and R03 AR055778)National Natural Science Foundation of China(Grant No. 81070611 and 31100924)
文摘Lupus nephritis （LN） is one of the most severe manifestations of systemic lupus erythematosus （SLE）, which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves multiple factors, including genetic predisposition, epigenetic regulation and environmental interaction. Over the last decade, omics-based techniques have been extensively utilized for biomarker screening and a wide variety of variations which are associated with SLE and LN have been identified at the levels of genomics, transcriptomics and proteomics. These studies and discoveries have expanded our understanding of the molecular basis of the disease and are important for identification of potential therapeutic targets for disease prediction and early treat- ment. In this review, we summarize some of the recent studies targeted at the identification of LN-associated biomarkers using genomics and proteomic approaches.
