Platycodon grandiflorus polysaccharide(PGP)is one of the main components of P.grandiflorus,but the mechanism of its anti-inflammatory effect has not been fully elucidated.The aim of this study was to evaluate the ther...Platycodon grandiflorus polysaccharide(PGP)is one of the main components of P.grandiflorus,but the mechanism of its anti-inflammatory effect has not been fully elucidated.The aim of this study was to evaluate the therapeutic effect of PGP on mice with dextran sodium sulfate(DSS)-induced ulcerative colitis(UC)and explore the underlying mechanisms.The results showed that PGP treatment inhibited the weight loss of DSS-induced UC mice,increased colon length,and reduced DAI,spleen index,and pathological damage within the colon.PGP also reduced the levels of pro-inflammatory cytokines and inhibited the enhancement of oxidative stress and MPO activity.Meanwhile,PGP restored the levels of Th1,Th2,Th17,and Treg cell-related cytokines and transcription factors in the colon to regulate colonic immunity.Further studies revealed that PGP regulated the balance of colonic immune cells through mesenteric lymphatic circulation.Taken together,PGP exerts anti-inflammatory and anti-oxidant effect and regulates colonic immunity to attenuate DSS-induced UC through mesenteric lymphatic circulation.展开更多
Background: As one of the most commonly performed surgical procedures, circumcision may lead to complications. However, studies on preventing postoperative complications are scarce and still insufficient to draw any c...Background: As one of the most commonly performed surgical procedures, circumcision may lead to complications. However, studies on preventing postoperative complications are scarce and still insufficient to draw any conclusions. This retrospective study aimed to summarize the surgical principles and consideration for preventing complications after circumcision.Methods: We reviewed 28 patients(aged 3–45 years;median age, 24 years) with prepuce hyperplasia or phimosis treated with our modified circumcision technique. In our modified technique, an accurate incision design is made through the stretch test, the stenosis is released, and veins and lymphatic tissues in the fascia are maintained. These surgical details for preventing complications were abbreviated to “ARM.”Results: None of the patients had complications at the 6-month follow-up postoperatively. Only mild prepuce edema was observed, which returned to the normal condition spontaneously within 2–3 weeks. The diameter of the distal penis increased by 0.4 ± 0.1 cm 6 months after the procedure.Conclusion: The “ARM” principle may help surgeons to prevent postoperative complications of circumcision.Maintaining the fascia during the procedure can increase the diameter of the surgical region.展开更多
基金supported by the National Science Foundation of China(No.81874348)the Academic Funding for Top Talents in Disciplines(Specialties)of Anhui Provincial Higher Education Institutes(No.gxbjZD2021056)the Exploratory Fund of Anhui University of Chinese Medicine(No.2021zxts31)。
文摘Platycodon grandiflorus polysaccharide(PGP)is one of the main components of P.grandiflorus,but the mechanism of its anti-inflammatory effect has not been fully elucidated.The aim of this study was to evaluate the therapeutic effect of PGP on mice with dextran sodium sulfate(DSS)-induced ulcerative colitis(UC)and explore the underlying mechanisms.The results showed that PGP treatment inhibited the weight loss of DSS-induced UC mice,increased colon length,and reduced DAI,spleen index,and pathological damage within the colon.PGP also reduced the levels of pro-inflammatory cytokines and inhibited the enhancement of oxidative stress and MPO activity.Meanwhile,PGP restored the levels of Th1,Th2,Th17,and Treg cell-related cytokines and transcription factors in the colon to regulate colonic immunity.Further studies revealed that PGP regulated the balance of colonic immune cells through mesenteric lymphatic circulation.Taken together,PGP exerts anti-inflammatory and anti-oxidant effect and regulates colonic immunity to attenuate DSS-induced UC through mesenteric lymphatic circulation.
文摘Background: As one of the most commonly performed surgical procedures, circumcision may lead to complications. However, studies on preventing postoperative complications are scarce and still insufficient to draw any conclusions. This retrospective study aimed to summarize the surgical principles and consideration for preventing complications after circumcision.Methods: We reviewed 28 patients(aged 3–45 years;median age, 24 years) with prepuce hyperplasia or phimosis treated with our modified circumcision technique. In our modified technique, an accurate incision design is made through the stretch test, the stenosis is released, and veins and lymphatic tissues in the fascia are maintained. These surgical details for preventing complications were abbreviated to “ARM.”Results: None of the patients had complications at the 6-month follow-up postoperatively. Only mild prepuce edema was observed, which returned to the normal condition spontaneously within 2–3 weeks. The diameter of the distal penis increased by 0.4 ± 0.1 cm 6 months after the procedure.Conclusion: The “ARM” principle may help surgeons to prevent postoperative complications of circumcision.Maintaining the fascia during the procedure can increase the diameter of the surgical region.
