Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.METHODS The English language medical literature on gut-or gastrointestinal-associated lymphoid tissue(GALT) or "dome" carcinoma of the colon was searched and appraised.RESULTS GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque-or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence.CONCLUSION Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.

进行性胃癌全胃切除术的疗效及淋巴结转移规律的研究(附110例全胃切除分析)

作者分析了1204例胃癌手术,237例施行了全胃切除术,术后满5年者儿0例。文中对手术并发症及切除淋巴结数、转移率、转移淋巴结数及转移度的关系和随访结果进行讨论,认为Ⅱ期以上进行性胃癌,行全胃及胃周围淋巴结清扫,应是胃癌手术的首选术式。

直肠扁桃体18例临床病理分析

目的:探讨直肠扁桃体(RT)的临床病理特征和鉴别诊断。方法:回顾性分析我院2016年1月至2021年7月共18例RT或直肠淋巴样息肉患者的临床及病理资料,并对患者进行随访。结果:18例患者中男4例,女14例;中位年龄55岁。11例为肠镜筛查发现,其他患者因腹痛、腹泻、便秘、腹胀、黑便等症状就诊发现。内镜下RT多呈息肉或息肉样隆起(8例)或黏膜下隆起(8例)。光镜下表现为黏膜固有层和(或)黏膜下层致密的淋巴组织结节样增生,可见大小、形态不一的滤泡结构,免疫组化染色显示滤泡增生的特点。6例EB病毒编码的小RNA原位杂交及4例免疫球蛋白基因重排克隆性检测均为阴性。对患者进行了1~64.5个月的随访,未出现复发。结论:RT是发生在直肠的局限性淋巴组织反应性增生,临床罕见,病因未明,活检标本中与淋巴瘤鉴别有一定困难。因此,建议内镜下发现的直肠局限性隆起病变需完整切除并进行相关病理学检查。