By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its s...By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its steady-state solution. We also show that the time-dependent queueing size at the departure point converges to the corresponding steady-state queueing size at the departure point.展开更多
To discover new lead compounds for M1 agonists. Ten typical M1 agonists were superimposed to build a M1 agonists 3D-pharmacophore model using distance-comparisons （DISCO） method without the previous knowledge of the...To discover new lead compounds for M1 agonists. Ten typical M1 agonists were superimposed to build a M1 agonists 3D-pharmacophore model using distance-comparisons （DISCO） method without the previous knowledge of the three-dimensional structure of M1 receptor. Virtual screening strategy was used to analyze the Available Chemicals Directory-Screening Compounds （ACD-SC） to identify possible new hits. Twenty-two compounds which fit the pharmacophore model well and are not similar with known M1 agonists were purchased in order to evaluate their M1 receptor agonist activity. One of them shows M1 receptor agonist activity with EC50 of 4.90 μmol/L and maximum response. Multiple of 10.0 which shows it worthy of further study as a new lead compound for M1 agonists.展开更多
In this paper, using the stochastic decomposition and renewal theory we provide the direct method for analysis the departure process of single sever M/G/1 queueing system, and further discuss the departure process of ...In this paper, using the stochastic decomposition and renewal theory we provide the direct method for analysis the departure process of single sever M/G/1 queueing system, and further discuss the departure process of GI/G/1 queueing system. The method provided in this paper is new and concise, which make us see dearly the structure of the departure process of a single server queueing system.展开更多
We study a batch arrival MX/M/1 queue with multiple working vacation. The server serves customers at a lower rate rather than completely stopping service during the service period. Using a quasi upper triangular trans...We study a batch arrival MX/M/1 queue with multiple working vacation. The server serves customers at a lower rate rather than completely stopping service during the service period. Using a quasi upper triangular transition probability matrix of two-dimensional Markov chain and matrix analytic method, the probability generating function (PGF) of the stationary system length distribution is obtained, from which we obtain the stochastic decomposition structure of system length which indicates the relationship with that of the MX/M/1 queue without vacation. Some performance indices are derived by using the PGF of the stationary system length distribution. It is important that we obtain the Laplace Stieltjes transform (LST) of the stationary waiting time distribution. Further, we obtain the mean system length and the mean waiting time. Finally, numerical results for some special cases are presented to show the effects of system parameters.展开更多
In this paper, we study an M/M/1 queue with multiple working vacations under following Bernoulli control policy: at the instants of the completion of a service in vacation, the server will interrupt the vacation and e...In this paper, we study an M/M/1 queue with multiple working vacations under following Bernoulli control policy: at the instants of the completion of a service in vacation, the server will interrupt the vacation and enter regular busy period with probability 1 p (if there are customers in the queue) or continue the vacation with probability p. For this model, we drive the analytic expression of the stationary queue length and demonstrate stochastic decomposition structures of the stationary queue length and waiting time, also we obtain the additional queue length and the additional delay of this model. The results we got agree with the corresponding results for working vacation model with or without vacation interruption if we set p = 0 or p = 1, respectively.展开更多
In this paper, by considering the stochastic proces s of the busy period and the idle period, and introducing the unfinished work as a supplementary variable, a new vector Markov process was presented to study th e M...In this paper, by considering the stochastic proces s of the busy period and the idle period, and introducing the unfinished work as a supplementary variable, a new vector Markov process was presented to study th e M/G/1 queue again. Through establishing and solving the density evolution equa tions, the busy-period distribution, and the stationary distributions of waitin g time and queue length were obtained. In addition, the stability condition of th is queue system was given by means of an imbedded renewal process.展开更多
We consider a variant of M/M/1 where customers arrive singly or in pairs. Each single and one member of each pair is called primary;the other member of each pair is called secondary. Each primary joins the queue upon ...We consider a variant of M/M/1 where customers arrive singly or in pairs. Each single and one member of each pair is called primary;the other member of each pair is called secondary. Each primary joins the queue upon arrival. Each secondary is delayed in a separate area, and joins the queue when “pushed” by the next arriving primary. Thus each secondary joins the queue followed immediately by the next primary. This arrival/delay mechanism appears to be new in queueing theory. Our goal is to obtain the steady-state probability density function (pdf) of the workload, and related quantities of interest. We utilize a typical sample path of the workload process as a physical guide, and simple level crossing theorems, to derive model equations for the steady-state pdf. A potential application is to the processing of electronic signals with error free components and components that require later confirmation before joining the queue. The confirmation is the arrival of the next signal.展开更多
基金supported by the National Natural Science Foundation of China(11371303)Natural Science Foundation of Xinjiang(2012211A023)Science Foundation of Xinjiang University(XY110101)
文摘By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its steady-state solution. We also show that the time-dependent queueing size at the departure point converges to the corresponding steady-state queueing size at the departure point.
基金National Natural Science Foundation of China (Grant No. 30271538)985 program,Ministry of Education of China
文摘To discover new lead compounds for M1 agonists. Ten typical M1 agonists were superimposed to build a M1 agonists 3D-pharmacophore model using distance-comparisons （DISCO） method without the previous knowledge of the three-dimensional structure of M1 receptor. Virtual screening strategy was used to analyze the Available Chemicals Directory-Screening Compounds （ACD-SC） to identify possible new hits. Twenty-two compounds which fit the pharmacophore model well and are not similar with known M1 agonists were purchased in order to evaluate their M1 receptor agonist activity. One of them shows M1 receptor agonist activity with EC50 of 4.90 μmol/L and maximum response. Multiple of 10.0 which shows it worthy of further study as a new lead compound for M1 agonists.
文摘In this paper, using the stochastic decomposition and renewal theory we provide the direct method for analysis the departure process of single sever M/G/1 queueing system, and further discuss the departure process of GI/G/1 queueing system. The method provided in this paper is new and concise, which make us see dearly the structure of the departure process of a single server queueing system.
文摘We study a batch arrival MX/M/1 queue with multiple working vacation. The server serves customers at a lower rate rather than completely stopping service during the service period. Using a quasi upper triangular transition probability matrix of two-dimensional Markov chain and matrix analytic method, the probability generating function (PGF) of the stationary system length distribution is obtained, from which we obtain the stochastic decomposition structure of system length which indicates the relationship with that of the MX/M/1 queue without vacation. Some performance indices are derived by using the PGF of the stationary system length distribution. It is important that we obtain the Laplace Stieltjes transform (LST) of the stationary waiting time distribution. Further, we obtain the mean system length and the mean waiting time. Finally, numerical results for some special cases are presented to show the effects of system parameters.
基金Foundation item： Supported by the National Science Foundation of China（60874083） Supported by the 2011 National Statistical Science Development Funds（2011LY014） Supported by the 2012 Soft Science Devel- opment Funds of Science and Technology Committee of Henan Province（122400450090）
文摘In this paper, we study an M/M/1 queue with multiple working vacations under following Bernoulli control policy: at the instants of the completion of a service in vacation, the server will interrupt the vacation and enter regular busy period with probability 1 p (if there are customers in the queue) or continue the vacation with probability p. For this model, we drive the analytic expression of the stationary queue length and demonstrate stochastic decomposition structures of the stationary queue length and waiting time, also we obtain the additional queue length and the additional delay of this model. The results we got agree with the corresponding results for working vacation model with or without vacation interruption if we set p = 0 or p = 1, respectively.
基金Project supported by the National Natural Science Foundation of China(Grant No.70171059)
文摘In this paper, by considering the stochastic proces s of the busy period and the idle period, and introducing the unfinished work as a supplementary variable, a new vector Markov process was presented to study th e M/G/1 queue again. Through establishing and solving the density evolution equa tions, the busy-period distribution, and the stationary distributions of waitin g time and queue length were obtained. In addition, the stability condition of th is queue system was given by means of an imbedded renewal process.
文摘We consider a variant of M/M/1 where customers arrive singly or in pairs. Each single and one member of each pair is called primary;the other member of each pair is called secondary. Each primary joins the queue upon arrival. Each secondary is delayed in a separate area, and joins the queue when “pushed” by the next arriving primary. Thus each secondary joins the queue followed immediately by the next primary. This arrival/delay mechanism appears to be new in queueing theory. Our goal is to obtain the steady-state probability density function (pdf) of the workload, and related quantities of interest. We utilize a typical sample path of the workload process as a physical guide, and simple level crossing theorems, to derive model equations for the steady-state pdf. A potential application is to the processing of electronic signals with error free components and components that require later confirmation before joining the queue. The confirmation is the arrival of the next signal.
