BACKGROUND The co-existence of Waldenstr?m’s macroglobulinemia(WM) with internodal marginal zone lymphoma(INMZL) is rare and often associated with poor prognosis.CASE SUMMARY We present a Chinese female patient who d...BACKGROUND The co-existence of Waldenstr?m’s macroglobulinemia(WM) with internodal marginal zone lymphoma(INMZL) is rare and often associated with poor prognosis.CASE SUMMARY We present a Chinese female patient who developed secondary light chain amyloidosis due to WM and INMZL and provides opinions on its systemic treatment.A 65-year-old woman was diagnosed with WM 6 years ago and received Bruton tyrosine kinase inhibitor monotherapy for two years.Her INMZL was confirmed due to left cervical lymphadenopathy.The patient presented with oedema in both lower limbs one year ago,and was diagnosed with secondary light chain amyloidosis.Treatment with the BC regimen(rituximab 375 mg/m~2 monthly for 6-8 courses,and bendamustine 90 mg/m~2 per day × 2,monthly for six courses) was initiated,but not tolerated due to toxic side effects.Bortezomibbased therapy was given for two months,including bortezomib,dexamethasone,and zanubrutinb.Oedema in both lower limbs was relieved and treatment efficacy was evaluated as partial remission.CONCLUSION A detailed clinical evaluation and active identification of the aetiology are recommended to avoid missed diagnosis and misdiagnosis.展开更多
Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We...Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We designed the study as a retrospective and examined data gathered from 912 participants with MD.Their data were originally collected by the Finnish M′eni`ere Federation(FMF).The survey data included individual case histories for environmental factors,comorbidities,disease-specific complaints,impact-related questions,cognitive complaints,health-related quality of life(HRQoL),and sense of coherence(SOC).Results:We observed significant differences between those with and without sporadic occurrence,family history,thyroid disorder,and migraine-associated complaints.Family history explained 20%of variability in patient complaints.Patients with a family history of MD whose disease started at younger age experienced balance problems,more severe vertigo spells,more severe vestibular drop attacks(VDA),and less nausea,although they had good SOC.Thyroid disorder explained 14%of variability in patient complaints.MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness,balance problems,greater impact of hearing problems,cognitive complaints,and poor HRQoL.Migraine explained 12%of variability in patients’complaints and was associated with poor SOC and cognitive balance problems.MD patients with both thyroid disorder and migraine used antidepressants more often than other groups.Logistic regression analysis showed comorbidities of ischemic brain disorder(among 7.1%),kidney insufficiency(among 1.2%),and diabetes(among 7.3%)had statistically significant but restricted association with balance and gait problems,VDA,and reduced HRQoL.Conclusions:Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles,including symptoms of cognitive problems.Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD.展开更多
In recent years, increased interest in investigating the accumulation of sized ranged plastic debris has been observed on beaches along coastlines. The abundance and distribution of the 4M’s sized class plastic debri...In recent years, increased interest in investigating the accumulation of sized ranged plastic debris has been observed on beaches along coastlines. The abundance and distribution of the 4M’s sized class plastic debris were quantitatively assessed on five sandy beaches, in Cameroon. Duplicates of 2 × 2 m (4 m<sup>2</sup>) quadrants were sampled in each beach/month with a total of 80 quadrants. Collected plastic samples were washed, sieved and dried. Particles of size, ≥2 mm, were sorted and measured using a 30 cm ruler, and converted to mm. Overall, 12,822 particles by number (530.59 g) with a mean abundance of 40.07 items/m<sup>2</sup> (1.66 g/m<sup>2</sup>) plastic debris was recorded. ANOVA (p = 0.05) shows a linear relationship between the meso- and micro-sized classes with significantly higher abundance recorded in LDB sites. The highest abundance by weight was recorded in August and June numerically. 80% of the plastic particles were between the size range, of 5 - 20 mm by number and 6 - 100 mm by weight. Moreover, in all beaches micro-sized class plastics were dominated by number 42.40% with fragmented debris dominant, in number/weight, 54.86% (25.69%) while meso-sized class plastics were 29.28% dominated by weight, with fragmented debris type, the most prevalence in number and weight as 46.11% (26.18%). On average, color and shape fractions revealed, colored and irregularly shaped plastics were dominant with an abundance of 80.45 ± 18.17 items/m<sup>2</sup> (2.58 ± 0.68 g/m<sup>2</sup>) and 47.24 ± 20.40 items/m<sup>2</sup> (1.39 ± 0.66 g/m<sup>2</sup>). Finally, the 0.0001 g plastic debris was dominant with a concentration, of 33.68 ± 7.23 items/m<sup>2</sup>. The intense use of beaches for recreation and poor waste disposal has increased the potential for plastic contamination.展开更多
The M’s Dream brand pure silk jeans are novel brand name garments developed by the M’s Dream Clothing and Accessories Design Institute. The pure silk jeans are processed from proteinase for the chemical treatment of...The M’s Dream brand pure silk jeans are novel brand name garments developed by the M’s Dream Clothing and Accessories Design Institute. The pure silk jeans are processed from proteinase for the chemical treatment of silk fabrics through mechanical friction. It combines the advantages of pure cotton jeans and pure silks with plump and thick silk surface, and is noted for its展开更多
BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(H.pylori)infection and an elevated risk of carcinogenesis.Cases of early-stage gastric cancer developed in H.pylori...BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(H.pylori)infection and an elevated risk of carcinogenesis.Cases of early-stage gastric cancer developed in H.pylori-negative Ménétrier’s disease are extremely rare.We report a case of early gastric cancer in H.pylori-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected anemia.Contrast-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant rugae.Blood tests showed hypoproteinemia and were negative for serum H.pylori immunoglobulin G antibodies.The 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach.UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s disease.En bloc resection with ESD was performed for diagnosis and treatment.Histology of ESD showed well-differentiated tubular adenocarcinoma.The cancer was confined to the mucosa,and complete curative resection was achieved.Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s disease.Three years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric rugae.CONCLUSION Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and H.pylori-negative Ménétrier’s disease.展开更多
Background: The aim of this study was to identify the prevalence of tinnitus in a sample of people with early stages of Ménière’s disease. Material and methods: A postal survey was sent to 256 patients all ...Background: The aim of this study was to identify the prevalence of tinnitus in a sample of people with early stages of Ménière’s disease. Material and methods: A postal survey was sent to 256 patients all judged to fulfil the criteria of early unilateral Ménière’s disease established by the American Academy of Otolaryngology Committee on Hearing and Equilibrium. Of these 256 patients, 136 had probable Ménière’s disease and 120 had early possible Ménière’s disease. The same questionnaire was mailed and administered to 60 control subjects with no history of vestibular dysfunction. A total of 158 subjects completed the questionnaire. Results: Tinnitus was found in 54 (63%) of the 72 members of the final unilateral vestibular Ménière’s disease group and 61 (85 %) of the 72 members of the final unilateral probable Ménière’s disease group. Conclusion: The prevalence of tinnitus as determined by a questionnaire survey was significantly greater in patients with probable Ménière’s disease than in patients with early vestibular Ménière’s disease or in control subjects. However, the prevalence of tinnitus as determined by a questionnaire survey was significantly greater in patients with early vestibular Ménière’s disease than in control subjects.展开更多
BACKGROUND Ménétrier’s disease is a rare condition characterized by enlarged gastric folds,usually located in the whole body and fundus of the stomach.This report presents an unusual case of localized M...BACKGROUND Ménétrier’s disease is a rare condition characterized by enlarged gastric folds,usually located in the whole body and fundus of the stomach.This report presents an unusual case of localized Ménétrier’s disease elevated by a submucosal lipoma and thus looking like a polypoid mass and causing an episode of upper gastrointestinal bleeding.The mass was successfully removed with endoscopic submucosal dissection.CASE SUMMARY Esophagogastroduodenoscopy was performed on a 76-year-old male patient after an episode of upper gastrointestinal bleeding,manifesting as fatigue and melena.A large polypoid mass(4 cm×1 cm)with enlarged mucosal folds was found in the body of the stomach,between the lesser curvature and posterior wall.A small ulcer at the distal end of the mass was identified as the source of the bleeding.Biopsy was negative for neoplasia.Computed tomography showed a submucosal lesion beneath the affected mucosa,most likely a lipoma.The mass was removed en bloc with tunneling endoscopic submucosal dissection.Final pathology determined that the mass included Ménétrier’s disease and a submucosal lipoma.The patient was scheduled for follow-up esophagogastroduodenoscopy.CONCLUSION Localized Ménétrier’s disease can coexist with a submucosal lipoma creating a polypoid mass with risk of bleeding.展开更多
Following is a summary of an interview given by Zhao Qizheng, director-general of the State Council Information Office (SCIO), to mark the launching of this magazine. In the interview, Zhao elaborated on the current h...Following is a summary of an interview given by Zhao Qizheng, director-general of the State Council Information Office (SCIO), to mark the launching of this magazine. In the interview, Zhao elaborated on the current human rights conditions in China and their developments, why there are differences between the East and West regarding human rights, and China's stand on the issue.展开更多
Ocular manifestations of WaldenstrSm＇s macroglobulinemia have been described in association with the conjunctiva, cornea, uvea, retina, and periocular adnexa. Only rarely have retinal findings, particularly retinal d...Ocular manifestations of WaldenstrSm＇s macroglobulinemia have been described in association with the conjunctiva, cornea, uvea, retina, and periocular adnexa. Only rarely have retinal findings, particularly retinal detachments, been described in the presence of monoclonal hypergammaglobulinemias. This report presents a case of retinal detachment in the presence of Waldenstr6m＇s macroglobulinemia after being treated with Chinese medicine.展开更多
基金Supported by Medical and Health Research Project of Hainan Province,No. 21A200197。
文摘BACKGROUND The co-existence of Waldenstr?m’s macroglobulinemia(WM) with internodal marginal zone lymphoma(INMZL) is rare and often associated with poor prognosis.CASE SUMMARY We present a Chinese female patient who developed secondary light chain amyloidosis due to WM and INMZL and provides opinions on its systemic treatment.A 65-year-old woman was diagnosed with WM 6 years ago and received Bruton tyrosine kinase inhibitor monotherapy for two years.Her INMZL was confirmed due to left cervical lymphadenopathy.The patient presented with oedema in both lower limbs one year ago,and was diagnosed with secondary light chain amyloidosis.Treatment with the BC regimen(rituximab 375 mg/m~2 monthly for 6-8 courses,and bendamustine 90 mg/m~2 per day × 2,monthly for six courses) was initiated,but not tolerated due to toxic side effects.Bortezomibbased therapy was given for two months,including bortezomib,dexamethasone,and zanubrutinb.Oedema in both lower limbs was relieved and treatment efficacy was evaluated as partial remission.CONCLUSION A detailed clinical evaluation and active identification of the aetiology are recommended to avoid missed diagnosis and misdiagnosis.
文摘Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We designed the study as a retrospective and examined data gathered from 912 participants with MD.Their data were originally collected by the Finnish M′eni`ere Federation(FMF).The survey data included individual case histories for environmental factors,comorbidities,disease-specific complaints,impact-related questions,cognitive complaints,health-related quality of life(HRQoL),and sense of coherence(SOC).Results:We observed significant differences between those with and without sporadic occurrence,family history,thyroid disorder,and migraine-associated complaints.Family history explained 20%of variability in patient complaints.Patients with a family history of MD whose disease started at younger age experienced balance problems,more severe vertigo spells,more severe vestibular drop attacks(VDA),and less nausea,although they had good SOC.Thyroid disorder explained 14%of variability in patient complaints.MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness,balance problems,greater impact of hearing problems,cognitive complaints,and poor HRQoL.Migraine explained 12%of variability in patients’complaints and was associated with poor SOC and cognitive balance problems.MD patients with both thyroid disorder and migraine used antidepressants more often than other groups.Logistic regression analysis showed comorbidities of ischemic brain disorder(among 7.1%),kidney insufficiency(among 1.2%),and diabetes(among 7.3%)had statistically significant but restricted association with balance and gait problems,VDA,and reduced HRQoL.Conclusions:Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles,including symptoms of cognitive problems.Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD.
文摘In recent years, increased interest in investigating the accumulation of sized ranged plastic debris has been observed on beaches along coastlines. The abundance and distribution of the 4M’s sized class plastic debris were quantitatively assessed on five sandy beaches, in Cameroon. Duplicates of 2 × 2 m (4 m<sup>2</sup>) quadrants were sampled in each beach/month with a total of 80 quadrants. Collected plastic samples were washed, sieved and dried. Particles of size, ≥2 mm, were sorted and measured using a 30 cm ruler, and converted to mm. Overall, 12,822 particles by number (530.59 g) with a mean abundance of 40.07 items/m<sup>2</sup> (1.66 g/m<sup>2</sup>) plastic debris was recorded. ANOVA (p = 0.05) shows a linear relationship between the meso- and micro-sized classes with significantly higher abundance recorded in LDB sites. The highest abundance by weight was recorded in August and June numerically. 80% of the plastic particles were between the size range, of 5 - 20 mm by number and 6 - 100 mm by weight. Moreover, in all beaches micro-sized class plastics were dominated by number 42.40% with fragmented debris dominant, in number/weight, 54.86% (25.69%) while meso-sized class plastics were 29.28% dominated by weight, with fragmented debris type, the most prevalence in number and weight as 46.11% (26.18%). On average, color and shape fractions revealed, colored and irregularly shaped plastics were dominant with an abundance of 80.45 ± 18.17 items/m<sup>2</sup> (2.58 ± 0.68 g/m<sup>2</sup>) and 47.24 ± 20.40 items/m<sup>2</sup> (1.39 ± 0.66 g/m<sup>2</sup>). Finally, the 0.0001 g plastic debris was dominant with a concentration, of 33.68 ± 7.23 items/m<sup>2</sup>. The intense use of beaches for recreation and poor waste disposal has increased the potential for plastic contamination.
文摘The M’s Dream brand pure silk jeans are novel brand name garments developed by the M’s Dream Clothing and Accessories Design Institute. The pure silk jeans are processed from proteinase for the chemical treatment of silk fabrics through mechanical friction. It combines the advantages of pure cotton jeans and pure silks with plump and thick silk surface, and is noted for its
文摘BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(H.pylori)infection and an elevated risk of carcinogenesis.Cases of early-stage gastric cancer developed in H.pylori-negative Ménétrier’s disease are extremely rare.We report a case of early gastric cancer in H.pylori-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected anemia.Contrast-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant rugae.Blood tests showed hypoproteinemia and were negative for serum H.pylori immunoglobulin G antibodies.The 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach.UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s disease.En bloc resection with ESD was performed for diagnosis and treatment.Histology of ESD showed well-differentiated tubular adenocarcinoma.The cancer was confined to the mucosa,and complete curative resection was achieved.Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s disease.Three years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric rugae.CONCLUSION Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and H.pylori-negative Ménétrier’s disease.
文摘Background: The aim of this study was to identify the prevalence of tinnitus in a sample of people with early stages of Ménière’s disease. Material and methods: A postal survey was sent to 256 patients all judged to fulfil the criteria of early unilateral Ménière’s disease established by the American Academy of Otolaryngology Committee on Hearing and Equilibrium. Of these 256 patients, 136 had probable Ménière’s disease and 120 had early possible Ménière’s disease. The same questionnaire was mailed and administered to 60 control subjects with no history of vestibular dysfunction. A total of 158 subjects completed the questionnaire. Results: Tinnitus was found in 54 (63%) of the 72 members of the final unilateral vestibular Ménière’s disease group and 61 (85 %) of the 72 members of the final unilateral probable Ménière’s disease group. Conclusion: The prevalence of tinnitus as determined by a questionnaire survey was significantly greater in patients with probable Ménière’s disease than in patients with early vestibular Ménière’s disease or in control subjects. However, the prevalence of tinnitus as determined by a questionnaire survey was significantly greater in patients with early vestibular Ménière’s disease than in control subjects.
文摘BACKGROUND Ménétrier’s disease is a rare condition characterized by enlarged gastric folds,usually located in the whole body and fundus of the stomach.This report presents an unusual case of localized Ménétrier’s disease elevated by a submucosal lipoma and thus looking like a polypoid mass and causing an episode of upper gastrointestinal bleeding.The mass was successfully removed with endoscopic submucosal dissection.CASE SUMMARY Esophagogastroduodenoscopy was performed on a 76-year-old male patient after an episode of upper gastrointestinal bleeding,manifesting as fatigue and melena.A large polypoid mass(4 cm×1 cm)with enlarged mucosal folds was found in the body of the stomach,between the lesser curvature and posterior wall.A small ulcer at the distal end of the mass was identified as the source of the bleeding.Biopsy was negative for neoplasia.Computed tomography showed a submucosal lesion beneath the affected mucosa,most likely a lipoma.The mass was removed en bloc with tunneling endoscopic submucosal dissection.Final pathology determined that the mass included Ménétrier’s disease and a submucosal lipoma.The patient was scheduled for follow-up esophagogastroduodenoscopy.CONCLUSION Localized Ménétrier’s disease can coexist with a submucosal lipoma creating a polypoid mass with risk of bleeding.
文摘Following is a summary of an interview given by Zhao Qizheng, director-general of the State Council Information Office (SCIO), to mark the launching of this magazine. In the interview, Zhao elaborated on the current human rights conditions in China and their developments, why there are differences between the East and West regarding human rights, and China's stand on the issue.
文摘Ocular manifestations of WaldenstrSm＇s macroglobulinemia have been described in association with the conjunctiva, cornea, uvea, retina, and periocular adnexa. Only rarely have retinal findings, particularly retinal detachments, been described in the presence of monoclonal hypergammaglobulinemias. This report presents a case of retinal detachment in the presence of Waldenstr6m＇s macroglobulinemia after being treated with Chinese medicine.
