目的探究m6A甲基化甲基转移酶RNA结合蛋白15(RNA-binding Motif Protein 15,RBM15)与宫颈癌的相关性及临床意义。方法选取2011年1月1日至2018年1月1日期间于皖南医学院第一附属医院进行诊治的宫颈癌病例132例,另选20例正常宫颈组织病例...目的探究m6A甲基化甲基转移酶RNA结合蛋白15(RNA-binding Motif Protein 15,RBM15)与宫颈癌的相关性及临床意义。方法选取2011年1月1日至2018年1月1日期间于皖南医学院第一附属医院进行诊治的宫颈癌病例132例,另选20例正常宫颈组织病例作为对照,共152例,通过免疫组化法检测RBM15在宫颈癌中和正常宫颈中的表达水平,分析其相关性,并研究其表达量与临床分期及临床病理特征之间的关系。结果RBM15在宫颈癌中的阳性表达率56%显著高于正常宫颈0%(P=0.001),且宫颈癌的期别越高,RBM15表达越强(P=0.002)。复发宫颈癌中RBM15的表达也呈现为随期别逐渐上升的趋势(P=0.156)。RBM15的阳性表达与宫颈癌的肿瘤最大径、淋巴结转移、神经侵犯、脉管癌栓有关(P<0.05),而与肿瘤分级、病理类型、发病年龄、鳞状上皮细胞癌抗原(Squamous cell carcinoma antigen,SCCA)无关(P>0.05)。结论RBM15在宫颈癌中呈高表达,且与宫颈癌分期及临床病理特征具有一定的相关性,RBM15表达升高也会造成宫颈癌患者预后不良,这一发现日后有望成为宫颈癌诊治的新靶点。展开更多
The explosion characteristics of M15 methanol-gasoline mixture was experimental test by using FRTA explosion limit instrument.The effect of temperature on the explosion area of the sample was studied.The results show ...The explosion characteristics of M15 methanol-gasoline mixture was experimental test by using FRTA explosion limit instrument.The effect of temperature on the explosion area of the sample was studied.The results show that the lower explosion limit of M15 methanol-gasoline mixture is 1.716%and the upper explosion limit is 11.451%at the initial temperature of 80℃.The lower explosion limit of M15 methanol-gasoline is in the range of 1.711%-1.760%with the initial temperature from 25℃to 100℃,and the upper explosion limit of the sample changes between 11.253%and 11.451%.Considering experimental error and precision,it can be approximated that the temperature has little influence on the explosion area of M15 methanol-gasoline mixture.展开更多
基金Key Research and Development(R&D)Projects of Shanxi Province(No.201903D121028)Special Foundation for Platform Base and Outstanding Talent of Shanxi Province(No.201705D211002)。
文摘The explosion characteristics of M15 methanol-gasoline mixture was experimental test by using FRTA explosion limit instrument.The effect of temperature on the explosion area of the sample was studied.The results show that the lower explosion limit of M15 methanol-gasoline mixture is 1.716%and the upper explosion limit is 11.451%at the initial temperature of 80℃.The lower explosion limit of M15 methanol-gasoline is in the range of 1.711%-1.760%with the initial temperature from 25℃to 100℃,and the upper explosion limit of the sample changes between 11.253%and 11.451%.Considering experimental error and precision,it can be approximated that the temperature has little influence on the explosion area of M15 methanol-gasoline mixture.
