With the advent of plastics and the wide range of fillers that are available have made modifications as precise as the tailored resins themselves. To modify the properties of polymer either by using fillers or by prep...With the advent of plastics and the wide range of fillers that are available have made modifications as precise as the tailored resins themselves. To modify the properties of polymer either by using fillers or by preparation of polymer blends gives rise to new materials with tailored properties. More complex, three-component systems, obtained by the addition of polymeric modifier to polymer filled composites may be of interest. Use of Fly ash cenospheres is very attractive because it is inexpensive and its use can reduce the environmental pollution to a significant extent. In the present study, Poly (Methyl Methacrylate) (PMMA)-Fly ash cenospheres composites were prepared using extrusion followed by Injection molding. The effect of matrix modification with Methyl methacrylate– acrylonitrile -butadiene–styrene (MABS) on the performance of PMMA- Fly ash cenospheres compositions was also, studied. It was found that with the addition of Fly ash cenospheres particulate as filler in PMMA showed marginal reduction in Tensile Strength, % Elongation and Impact strength and improvement in Flexural Strength, Heat Deflection Temperature and Vicat Softening Point. Compared with PMMA-cenospheres composites, the notched Impact Strength of the PMMA/MABS/cenospheres composites showed marginal enhancement in values at higher loading of cenospheres. The optimum performances in mechanical and thermal properties were obtained when the ratio of MABS to cenospheres was 1:2.展开更多
目的:总结MAB21L2基因的变异和临床特点,并与高度同源的MAB21L1基因进行比较。方法:对中山眼科中心临床基因数据库中MAB21L2基因变异患者进行基因型和表型分析,回顾性分析既往文献报道的MAB21L2基因和高度同源基因MAB21L1变异的表型-基...目的:总结MAB21L2基因的变异和临床特点,并与高度同源的MAB21L1基因进行比较。方法:对中山眼科中心临床基因数据库中MAB21L2基因变异患者进行基因型和表型分析,回顾性分析既往文献报道的MAB21L2基因和高度同源基因MAB21L1变异的表型-基因型的关系。结果:在2个小眼畸形家系中发现2个MAB21L2基因杂合变异:先证者1携带已知变异c.151C>G/p.(Arg51Gly),患者双眼小眼畸形伴虹膜脉络膜缺损,伴骨关节屈曲。母亲携带相同杂合变异但表型正常;先证者2携带未报道的变异c.1042G>T/p.(Glu348*),左眼小眼畸形,右眼正常且无全身异常。结合文献回顾发现,在显性遗传模式下,80%的MAB21L2杂合致病变异(20/25)和100%的MAB21L1杂合致病变异(25/25)发生在氨基酸49-52区域,导致小眼无眼或眼缺损异常(microphthalmia,anophthalmia or coloboma,MAC);携带该区域MAB21L2基因杂合突变的患者除MAC外,部分还伴骨骼关节发育异常(12/24,50%);杂合截短变异发生在MAB21L2基因可导致MAC(5/5,100%),而发生在MAB21L1则不致病。结论:在2个小眼畸形家系中发现了MAB21L2基因1个新致病变异和1个已知热点致病变异,通过文献综述比较和总结了MAB21L1和MAB21L2基因的突变频谱以及基因型-表型相互关系,为此类基因缺陷导致遗传病的诊断和鉴别诊断提供依据。展开更多
A collaborative team led by Profs George Fu Gao(高福)and Yan JingHua(严景华)from the Institute of Microbiology,Chinese Academy of Sciences(CAS),reported the identification of neutralizing monoclonal antibodies(MAbs)fr...A collaborative team led by Profs George Fu Gao(高福)and Yan JingHua(严景华)from the Institute of Microbiology,Chinese Academy of Sciences(CAS),reported the identification of neutralizing monoclonal antibodies(MAbs)from a convalescent Rift Valley fever(RVF)patient,which facilitates the development of MAbs-based therapeutics and vaccines against Rift Valley fever virus(RVFV)infection.This work was published in Nature Microbiology(April 1st,2019),with the support from the National Natural Science Foundation of China and the Chinese Academy of Sciences.Drs.Wang QiHui(王奇慧),Chen ZhiHai(陈志海)and Wu Yan(吴燕),as well as Miss Ma Tong(马桐)contributed equally to this work.展开更多
The emergence of MAX borides as well as MAB phases attracted great attention because of the renewable developments of ternary ceramics and offering great opportunities in potential applications.However,the number of b...The emergence of MAX borides as well as MAB phases attracted great attention because of the renewable developments of ternary ceramics and offering great opportunities in potential applications.However,the number of borides remains limited,and further fundamental descriptions and detailed investigations on various properties are still lacking.In this report,we employ an integrated computational scheme that combines density functional theory with the evolutional algorithm to search for the favorable structures of P-and S-glued ternary borides terminated by Nb metal.We discover that the structures of 212-type,as e.g.Nb_(2)PB_(2)and Nb_(2)SB_(2),belong to the P6m2 space group,while those of 211-type,as e.g.Nb_(2)PB and Nb_(2)SB,prefer to crystallize in the P6_(3)/mmc space group,and the corresponding carbides Nb_(2)PC and Nb_(2)SC are also considered for the sake of completeness and comparative analsys.The predicted Nb_(2)PB_(2),Nb_(2)PB,Nb_(2)SB,Nb_(2)PC and Nb_(2)SC are energetically stable,as revealed by the negative formation energies and by the proposed reaction paths with respect to the most competing phases,as well as dynamically stable,as suggested by the non-imaginary phonon spectra.The thermal conductivities of the six materials show unusual behaviors,particularly for the acoustic and optical contributions,and are accompanied by a strong anisotropy.Most importantly,Nb_(2)PB_(2) is found to be an excellent thermal conductor with a total thermal conductivity of~65 W/(m K),while Nb_(2)SC is found to be an ultra-low thermal conductor,with a total thermal conductivity of~5 W/(m K).These values are clearly outside the currently reported range of thermal conductivities,which makes Nb_(2)PB_(2)and Nb_(2)SC extremely interesting for fundamental research as well as prospective applications with the aid of artificial tunings on the almost independent MB block and the A layer.The discovery of these novel materials is expected to contribute substantially to the rapid development of ternary ceramics and to accelerate attempts in the applicability of MAX phases for heat conduction.展开更多
文摘With the advent of plastics and the wide range of fillers that are available have made modifications as precise as the tailored resins themselves. To modify the properties of polymer either by using fillers or by preparation of polymer blends gives rise to new materials with tailored properties. More complex, three-component systems, obtained by the addition of polymeric modifier to polymer filled composites may be of interest. Use of Fly ash cenospheres is very attractive because it is inexpensive and its use can reduce the environmental pollution to a significant extent. In the present study, Poly (Methyl Methacrylate) (PMMA)-Fly ash cenospheres composites were prepared using extrusion followed by Injection molding. The effect of matrix modification with Methyl methacrylate– acrylonitrile -butadiene–styrene (MABS) on the performance of PMMA- Fly ash cenospheres compositions was also, studied. It was found that with the addition of Fly ash cenospheres particulate as filler in PMMA showed marginal reduction in Tensile Strength, % Elongation and Impact strength and improvement in Flexural Strength, Heat Deflection Temperature and Vicat Softening Point. Compared with PMMA-cenospheres composites, the notched Impact Strength of the PMMA/MABS/cenospheres composites showed marginal enhancement in values at higher loading of cenospheres. The optimum performances in mechanical and thermal properties were obtained when the ratio of MABS to cenospheres was 1:2.
文摘目的:总结MAB21L2基因的变异和临床特点,并与高度同源的MAB21L1基因进行比较。方法:对中山眼科中心临床基因数据库中MAB21L2基因变异患者进行基因型和表型分析,回顾性分析既往文献报道的MAB21L2基因和高度同源基因MAB21L1变异的表型-基因型的关系。结果:在2个小眼畸形家系中发现2个MAB21L2基因杂合变异:先证者1携带已知变异c.151C>G/p.(Arg51Gly),患者双眼小眼畸形伴虹膜脉络膜缺损,伴骨关节屈曲。母亲携带相同杂合变异但表型正常;先证者2携带未报道的变异c.1042G>T/p.(Glu348*),左眼小眼畸形,右眼正常且无全身异常。结合文献回顾发现,在显性遗传模式下,80%的MAB21L2杂合致病变异(20/25)和100%的MAB21L1杂合致病变异(25/25)发生在氨基酸49-52区域,导致小眼无眼或眼缺损异常(microphthalmia,anophthalmia or coloboma,MAC);携带该区域MAB21L2基因杂合突变的患者除MAC外,部分还伴骨骼关节发育异常(12/24,50%);杂合截短变异发生在MAB21L2基因可导致MAC(5/5,100%),而发生在MAB21L1则不致病。结论:在2个小眼畸形家系中发现了MAB21L2基因1个新致病变异和1个已知热点致病变异,通过文献综述比较和总结了MAB21L1和MAB21L2基因的突变频谱以及基因型-表型相互关系,为此类基因缺陷导致遗传病的诊断和鉴别诊断提供依据。
文摘A collaborative team led by Profs George Fu Gao(高福)and Yan JingHua(严景华)from the Institute of Microbiology,Chinese Academy of Sciences(CAS),reported the identification of neutralizing monoclonal antibodies(MAbs)from a convalescent Rift Valley fever(RVF)patient,which facilitates the development of MAbs-based therapeutics and vaccines against Rift Valley fever virus(RVFV)infection.This work was published in Nature Microbiology(April 1st,2019),with the support from the National Natural Science Foundation of China and the Chinese Academy of Sciences.Drs.Wang QiHui(王奇慧),Chen ZhiHai(陈志海)and Wu Yan(吴燕),as well as Miss Ma Tong(马桐)contributed equally to this work.
基金the National Natural Science Foundation of China(No.51902052)partially supported by“the Fundamental Research Funds for the Central Universities”+1 种基金supported by appointments to the JRG program at the APCTP through the Science and Technology Promotion Fund and Lottery Fund of the Korean Government,the Korean Local Governments,Gyeongsangbuk-do Province and Pohang Citypartially funded by the Swedish Research Council through grant agreement no.2018-05973 for providing the facility support on the numerical calculations in this paper。
文摘The emergence of MAX borides as well as MAB phases attracted great attention because of the renewable developments of ternary ceramics and offering great opportunities in potential applications.However,the number of borides remains limited,and further fundamental descriptions and detailed investigations on various properties are still lacking.In this report,we employ an integrated computational scheme that combines density functional theory with the evolutional algorithm to search for the favorable structures of P-and S-glued ternary borides terminated by Nb metal.We discover that the structures of 212-type,as e.g.Nb_(2)PB_(2)and Nb_(2)SB_(2),belong to the P6m2 space group,while those of 211-type,as e.g.Nb_(2)PB and Nb_(2)SB,prefer to crystallize in the P6_(3)/mmc space group,and the corresponding carbides Nb_(2)PC and Nb_(2)SC are also considered for the sake of completeness and comparative analsys.The predicted Nb_(2)PB_(2),Nb_(2)PB,Nb_(2)SB,Nb_(2)PC and Nb_(2)SC are energetically stable,as revealed by the negative formation energies and by the proposed reaction paths with respect to the most competing phases,as well as dynamically stable,as suggested by the non-imaginary phonon spectra.The thermal conductivities of the six materials show unusual behaviors,particularly for the acoustic and optical contributions,and are accompanied by a strong anisotropy.Most importantly,Nb_(2)PB_(2) is found to be an excellent thermal conductor with a total thermal conductivity of~65 W/(m K),while Nb_(2)SC is found to be an ultra-low thermal conductor,with a total thermal conductivity of~5 W/(m K).These values are clearly outside the currently reported range of thermal conductivities,which makes Nb_(2)PB_(2)and Nb_(2)SC extremely interesting for fundamental research as well as prospective applications with the aid of artificial tunings on the almost independent MB block and the A layer.The discovery of these novel materials is expected to contribute substantially to the rapid development of ternary ceramics and to accelerate attempts in the applicability of MAX phases for heat conduction.
