探究膜相关RING-CH型蛋白1(membrane-associated Ring-CH Protein 1,MARCH1)基因多态能否显著影响内蒙古白绒山羊的生长性状。通过现代分子遗传学技术检测460只内蒙古白绒山羊MARCH1基因启动子区7-bp位点InDel(insertion/deletion)多态...探究膜相关RING-CH型蛋白1(membrane-associated Ring-CH Protein 1,MARCH1)基因多态能否显著影响内蒙古白绒山羊的生长性状。通过现代分子遗传学技术检测460只内蒙古白绒山羊MARCH1基因启动子区7-bp位点InDel(insertion/deletion)多态性,并利用SPSS 23.0分析软件探究它们与生长性状的相关性。育成羊MARCH1基因启动子7-bp(NC_030813:g.1858696insTAATACG)突变位点DD基因型个体体高均值显著大于ID和II基因型个体(P=0.010),ID基因型个体体长均值显著大于II基因型个体(P=0.036);成年羊该突变位点ID基因型个体管围均值显著大于II基因型个体(P=0.040)。皮尔逊相关分析显示:内蒙古白绒山羊体高、体长和管围与体重性状均存在极显著相关(P<0.01)。MARCH1基因启动子区7-bp位点可作为内蒙古白绒山羊体尺性状的有效分子标记。展开更多
Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase which targets MHC-II, CD86 and various other molecules for degradation. It is one of the most efficient post-translational regulators of antigen present...Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase which targets MHC-II, CD86 and various other molecules for degradation. It is one of the most efficient post-translational regulators of antigen presentation. MARCH1 is expressed in resting immature dendritic cells and B cells but can be induced in other cell types. While activation of most immune cells results in a reduction in MARCH1 gene expression, its anti-inflammatory properties are highlighted by its induction in response to IL-10. Here, we review what is known about the regulation of MARCH1 gene expression in response to IL-10 by various immune cells. We speculate on the role of MARCH1 ininfection, its differential expression pattern and the promise that this E3 ubiquitin ligase holds to influence immune responses and mitigate immune pathologies.展开更多
文摘探究膜相关RING-CH型蛋白1(membrane-associated Ring-CH Protein 1,MARCH1)基因多态能否显著影响内蒙古白绒山羊的生长性状。通过现代分子遗传学技术检测460只内蒙古白绒山羊MARCH1基因启动子区7-bp位点InDel(insertion/deletion)多态性,并利用SPSS 23.0分析软件探究它们与生长性状的相关性。育成羊MARCH1基因启动子7-bp(NC_030813:g.1858696insTAATACG)突变位点DD基因型个体体高均值显著大于ID和II基因型个体(P=0.010),ID基因型个体体长均值显著大于II基因型个体(P=0.036);成年羊该突变位点ID基因型个体管围均值显著大于II基因型个体(P=0.040)。皮尔逊相关分析显示:内蒙古白绒山羊体高、体长和管围与体重性状均存在极显著相关(P<0.01)。MARCH1基因启动子区7-bp位点可作为内蒙古白绒山羊体尺性状的有效分子标记。
文摘Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase which targets MHC-II, CD86 and various other molecules for degradation. It is one of the most efficient post-translational regulators of antigen presentation. MARCH1 is expressed in resting immature dendritic cells and B cells but can be induced in other cell types. While activation of most immune cells results in a reduction in MARCH1 gene expression, its anti-inflammatory properties are highlighted by its induction in response to IL-10. Here, we review what is known about the regulation of MARCH1 gene expression in response to IL-10 by various immune cells. We speculate on the role of MARCH1 ininfection, its differential expression pattern and the promise that this E3 ubiquitin ligase holds to influence immune responses and mitigate immune pathologies.
