Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced...Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced inhalational (desflurane, fentanyl) anaesthesia and total intravenous (propofol, fentanyl) anaesthesia. The described method for drug concentration measurement in biologic fluids does not require long-term sample processing before injecting the sample into mass-spectrometer interface, in contrast to chromatographic methods. A hydrophobic membrane was used in the interface to separate anaesthetic agents from biological fluids: inhalational anaesthetic desflurane, hypnotic propofol, analgesic fentanyl. A possibility to use the interface for measurement of desflurane and propofol absolute concentration in blood plasma and cerebrospinal fluid was demonstrated for the study of blood-brain barrier (BBB) properties.展开更多
A simple method to detect mercury ions confined in a Paul trap has been developed by resonant ejection. In this method, frequency of the additional ejection ac voltage is scanned instead of the amplitude of the rf dri...A simple method to detect mercury ions confined in a Paul trap has been developed by resonant ejection. In this method, frequency of the additional ejection ac voltage is scanned instead of the amplitude of the rf drive voltage in conventional methods. It is possible not only to observe the spectra of the secular oscillation of the trapped ions directly, but also to eject the confined ions from the trap mass-selectively.展开更多
We study the effect of intense laser radiation on the surface of silicate glass prior irradiated by gamma radiation. Experimental results show that the gamma radiation with dose 5 × 104 R leads to the degradation...We study the effect of intense laser radiation on the surface of silicate glass prior irradiated by gamma radiation. Experimental results show that the gamma radiation with dose 5 × 104 R leads to the degradation of the surface resistance of this optical dielectric to electromagnetic radiation. Depending on the dose of the radiation the laser radiation can result in either surface erosion or its pronounced cracking. It is also found that the efficiency of the degradation process is determined not only by the radiation dose, but also by the presence of different impurities in the glass.展开更多
文摘Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced inhalational (desflurane, fentanyl) anaesthesia and total intravenous (propofol, fentanyl) anaesthesia. The described method for drug concentration measurement in biologic fluids does not require long-term sample processing before injecting the sample into mass-spectrometer interface, in contrast to chromatographic methods. A hydrophobic membrane was used in the interface to separate anaesthetic agents from biological fluids: inhalational anaesthetic desflurane, hypnotic propofol, analgesic fentanyl. A possibility to use the interface for measurement of desflurane and propofol absolute concentration in blood plasma and cerebrospinal fluid was demonstrated for the study of blood-brain barrier (BBB) properties.
文摘A simple method to detect mercury ions confined in a Paul trap has been developed by resonant ejection. In this method, frequency of the additional ejection ac voltage is scanned instead of the amplitude of the rf drive voltage in conventional methods. It is possible not only to observe the spectra of the secular oscillation of the trapped ions directly, but also to eject the confined ions from the trap mass-selectively.
文摘We study the effect of intense laser radiation on the surface of silicate glass prior irradiated by gamma radiation. Experimental results show that the gamma radiation with dose 5 × 104 R leads to the degradation of the surface resistance of this optical dielectric to electromagnetic radiation. Depending on the dose of the radiation the laser radiation can result in either surface erosion or its pronounced cracking. It is also found that the efficiency of the degradation process is determined not only by the radiation dose, but also by the presence of different impurities in the glass.
