MATRICS成套神经认知测试在青少年双相障碍患者中的心理测量学特征

目的检测MATRICS成套神经认知测试(MCCB)在青少年双相障碍患者中的心理测量学特征,以确定MCCB是否可用于青少年双相障碍患者的认知功能评估。方法按照年龄、性别和受教育程度匹配的原则,纳入青少年双相障碍患者(n=38)、青少年重度抑郁发作患者(n=40)和健康对照组(n=41)。分别在基线期和2周后,对青少年双相障碍患者进行蒙特利尔认知评估量表(MoCA)和MCCB评定,其他研究对象仅接受基线期MCCB评定。采用Cronbach’sα系数评估MCCB内部一致性,使用Pearson相关分析考察重测信度与效标效度,通过协方差分析表示区分效度,使用验证性因子分析探讨MCCB的结构效度。结果(1)在对青少年双相障碍患者的评定结果中,MCCB基线期和2周后重测的Cronbach’sα系数分别为0.784、0.773。(2)青少年双相障碍患者2周后MCCB重测结果显示,MCCB各维度重测信度为0.630~0.812(P均<0.01)。(3)效标效度显示,MoCA的短期记忆维度评分与MCCB的信息处理速度以及言语学习和记忆维度评分均呈正相关(r=0.487、0.522,P<0.05或0.01)。(4)区分效度显示,青少年双相障碍组、青少年重度抑郁发作组和健康对照组在MCCB的信息处理速度、注意/警觉性、工作记忆、言语学习和记忆、视觉学习和记忆以及推理与问题解决能力六个维度的评分中,差异均有统计学意义(F=3.790~7.243,P均<0.01)。(5)探索性因子分析显示,MCCB中存在四个因子,累计方差解释率为71.65%。验证性因子分析提示理想7因子模型结构效度欠佳。结论MCCB在青少年双相障碍患者中具有较好的内部一致性、重测信度以及可接受的效度。

应用RFID的典型样板 International Paper与Matrics的合同成为迄今为止RFID技术领域内最大的单笔订单之一

International Paper是一家世界领先的纸张产品制造商，面向家庭、办公、印刷，出版和工业应用提供包装解决方案。公司始建于1898年、目前在40个国家或地区设有生产厂，员工人数超过90000人，年销售额超过250亿美元。业务的飞速增长促使公司着手改进其仓库跟踪流程，以提高运营效率，改善客户服务质量。

Seismic stability of expansive soil slopes reinforced by anchor cables using a modified horizontal slice method

Earthquake-induced slope failures are common occurrences in engineering practice and pre-stressed anchor cables are an effective technique in maintaining slope stability,especially in areas that are prone to earthquakes.Furthermore,the soil at typical engineering sites also exhibit unsaturated features.Explicit considerations of these factors in slope stability estimations are crucial in producing accurate results.In this study,the seismic responses of expansive soil slopes stabilized by anchor cables is studied in the realm of kinematic limit analysis.A modified horizontal slice method is proposed to semi-analytically formulate the energy balance equation.An illustrative slope is studied to demonstrate the influences of suction,seismic excitations and anchor cables on the slope stability.The results indicate that the stabilizing effect of soil suction relates strongly to the seismic excitation and presents a sine shape as the seismic wave propagates.In higher and steeper slopes,the stabilizing effect of suction is more evident.The critical slip surface tends to be much more shallow as the seismic wave approaches the peak and vice versa.

Swelling behaviors of heterogeneous red-bed mudstone subjected to different vertical stresses

In this study,the axial swelling strain of red-bed mudstone under different vertical stresses are measured by swell-under-load method,and the microstructure of mudstone after hygroscopic swelling is studied by mercury intrusion porosimetry(MIP).The weakening coefficient and Weibull distribution function are introduced into the coupling model of mudstone moisture diffusion-swelling deformation-fracture based on finite-discrete element method(FDEM).The weakening effect of moisture on mudstone's mechanical parameters,as well as the heterogeneity of swelling deformation and stress distribution,is considered.The microcrack behavior and energy evolution of mudstone during hygroscopic swelling deformation under different vertical stresses are studied.The results show that the axial swelling strain of mudstone decreases with increase of the vertical stress.At low vertical stresses,moisture absorption in mudstone leads to formation of cracks caused by hydration-induced expansion.Under high vertical stresses,a muddy sealing zone forms on the mudstone surface,preventing further water infiltration.The simulation results of mudstone swelling deformation also demonstrate that it involves both swelling of the mudstone matrix and swelling caused by crack expansion.Notably,crack expansion plays a dominant role in mudstone swelling.With increasing vertical stress,the cracks in mudstone change from tensile cracks to shear cracks,resulting in a significant reduction in the total number of cracks.While the evolution of mudstone kinetic energy shows similarities under different vertical stresses,the evolution of strain energy varies significantly due to the presence of different types of cracks in the mudstone.The findings provide a theoretical basis for understanding the hygroscopic swelling deformation mechanism of red-bed mudstone at various depths.

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

Effect of degree of saturation on stresses and pore water pressure in the subgrade layer caused by railway track loading

Purpose-The experiments of this study investigated the effect of the subgrade degree of saturation on the value of the stresses generated on the surface and the middle(vertical and lateral stresses).The objectives of this study can be identified by studying the effect of subgrade layer degree of saturation variation,load amplitude and load frequency on the transmitted stresses through the ballast layer to the subgrade layer and the stress distribution inside it and investigating the excess pore water pressure development in the clay layer in the case of a fully saturated subgrade layer and the change in matric suction in the case of an unsaturated subgrade layer.Design/methodology/approach-Thirty-six laboratory experiments were conducted using approximately half-scale replicas of real railways,with an iron box measuring 1.5×1.031.0 m.Inside the box,a 0.5 m thick layer of clay soil representing the base layer was built.Above it is a 0.2 m thick ballast layer made of crushed stone,and on top of that is a 0.8 m long rail line supported by three 0.9 m(0.1×0.1 m)slipper beams.The subgrade layer has been built at the following various saturation levels:100,80,70 and 60%.Experiments were conducted with various frequencies of 1,2 and 4 Hz with load amplitudes of 15,25 and 35 kN.Findings-The results of the study demonstrated that as the subgrade degree of saturation decreased from 100 to 60%,the ratio of stress in the lateral direction to stress in the vertical direction generated in the middle of the subgrade layer decreased as well.On average,this ratio changed from approximately 0.75 to approximately 0.65.Originality/value-The study discovered that as the test proceeded and the number of cycles increased,the value of negative water pressure(matric suction)in the case of unsaturated subgrade soils declined.The frequency of loads had no bearing on the ratio of decline in matric suction values,which was greater under a larger load amplitude than a lower one.As the test progressed(as the number of cycles increased),the matric suction dropped.For larger load amplitudes,there is a greater shift in matric suction.The change in matric suction is greater at higher saturation levels than it is at lower saturation levels.Furthermore,it is seen that the load frequency value has no bearing on how the matric suction changes.For all load frequencies and subgrade layer saturation levels,the track panel settlement rises with the load amplitude.Higher load frequency and saturation levels have a greater impact.

Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient bioactivities.To overcome these limitations,tissue-engineered scaffolds have emerged as a promising alternative.In this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue regeneration.The PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and hydrophilicity.In vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 myoblasts.Moreover,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML injury.Mechanistic insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT pathway.Additionally,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast maturation.These findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

The Jaffa Transform for Hessian Matrix Systems and the Laplace Equation

Hessian matrices are square matrices consisting of all possible combinations of second partial derivatives of a scalar-valued initial function. As such, Hessian matrices may be treated as elementary matrix systems of linear second-order partial differential equations. This paper discusses the Hessian and its applications in optimization, and then proceeds to introduce and derive the notion of the Jaffa Transform, a new linear operator that directly maps a Hessian square matrix space to the initial corresponding scalar field in nth dimensional Euclidean space. The Jaffa Transform is examined, including the properties of the operator, the transform of notable matrices, and the existence of an inverse Jaffa Transform, which is, by definition, the Hessian matrix operator. The Laplace equation is then noted and investigated, particularly, the relation of the Laplace equation to Poisson’s equation, and the theoretical applications and correlations of harmonic functions to Hessian matrices. The paper concludes by introducing and explicating the Jaffa Theorem, a principle that declares the existence of harmonic Jaffa Transforms, which are, essentially, Jaffa Transform solutions to the Laplace partial differential equation.

Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods

Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault.The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging.Efficient pretreatment methods followed by accurate and sensitive detections are necessary.Herein,pretreatment methods for the extraction,enrichment,and preconcentration of BDZs as well as the strategies for their screening,identification,and quantitation developed in the past five years have been reviewed.Moreover,recent advances in various methods are summarized.Characteristics and advantages of each method are encompassed.Future directions of the pretreatment and detection methods for BDZs are also reviewed.

Numerical Solutions of Fractional Variable Order Differential Equations via Using Shifted Legendre Polynomials

In this manuscript,an algorithm for the computation of numerical solutions to some variable order fractional differential equations(FDEs)subject to the boundary and initial conditions is developed.We use shifted Legendre polynomials for the required numerical algorithm to develop some operational matrices.Further,operational matrices are constructed using variable order differentiation and integration.We are finding the operationalmatrices of variable order differentiation and integration by omitting the discretization of data.With the help of aforesaid matrices,considered FDEs are converted to algebraic equations of Sylvester type.Finally,the algebraic equations we get are solved with the help of mathematical software like Matlab or Mathematica to compute numerical solutions.Some examples are given to check the proposed method’s accuracy and graphical representations.Exact and numerical solutions are also compared in the paper for some examples.The efficiency of the method can be enhanced further by increasing the scale level.

Materials Selection of Thermoplastic Matrices of Natural Fibre Composites for Cyclist Helmet Using an Integration of DMAIC Approach in Six Sigma Method Together with Grey Relational Analysis Approach

Natural fibre reinforced polymer composite(NFRPC)materials are gaining popularity in the modern world due to their eco-friendliness,lightweight nature,life-cycle superiority,biodegradability,low cost,and noble mechanical properties.Due to the wide variety of materials available that have comparable attributes and satisfy the requirements of the product design specification,material selection has become a crucial component of design for engineers.This paper discusses the study’s findings in choosing the suitable thermoplastic matrices of Natural Fibre Composites for Cyclist Helmet utilising the DMAIC,and GRA approaches.The results are based on integrating two decision methods implemented utilising two distinct decision-making approaches:qualitative and quantitative.This study suggested thermoplastic polyethylene as a particularly ideal matrix in composite cyclist helmets during the selection process for the best thermoplastic matrices material using the 6σtechnique,with the decision based on the highest performance,the lightest weight,and the most environmentally friendly criteria.The DMAIC and GRA approach significantly influenced the material selection process by offering different tools for each phase.In the future study,selection technique may have been more exhaustive if more information from other factors had been added.

In Vitro Evaluation of Two Tissue Substitutes for Gingival Augmentation

Three-dimensional collagen matrices of porcine origin are being used as substitutes for soft tissue grafts in periodontal plastic surgery in search of aesthetic and natural results. This in vitro study aimed to compare Fibro-Gide® (GeistlichBiomaterials) and Mucoderm® (BotissBiomaterials) matrices during the initial phase of soft tissue formation. For this purpose, samples of 5 × 5 mm were obtained, and then human fibroblasts were plated on them. After 24, 48 and 72 h, cell viability was assessed using an MTT assay, and the secretion of type I collagen, MMP-2, TIMP-1 and TIMP-2 was analyzed by ELISA immunoassay. The control group (C) consisted of cells plated on polystyrene without the matrices. The morphology of the surfaces was also examined using scanning electron microscopy (SEM), as was the average roughness (Ra) of the samples by a profilometer. Topographic analysis revealed that roughness was significantly higher on Mucoderm® than on Fibro-Gide® (p 0.05). The synthesis of type I collagen, MMP-2 and TIMP-1 were significantly higher from cells plated on Fibro-Gide® than on Mucoderm®, in all time points (p ® than on Mucoderm® (p ® induced an increase in type I collagen, MMP-2 and TIMP-1 and TIMP-2.

Stationary Measures of Three-State Quantum Walks with Defect on the One-Dimension Lattice

In this paper, we focus on the space-inhomogeneous three-state on the one-dimension lattice, a one-phase model and a two-phase model include. By using the transfer matrices method by Endo et al., we calculate the stationary measure for initial state concrete eigenvalue. Finally we found the transfer matrices method is more effective for the three-state quantum walks than the method obtained by Kawai et al.

首发青年期广泛性焦虑障碍患者认知功能损害与内分泌的相关研究

目的:探索首发青年期广泛性焦虑障碍(GAD)患者的认知功能特征及其与下丘脑-垂体-肾上腺轴(HPA轴)外周血皮质醇和脑-垂体-甲状腺轴(HPT轴)甲状腺激素水平的相关性。方法:比较31例首发青年期GAD患者(GAD组)与20名健康对照者(对照组)在临床特征、MATRICS共识认知成套测验(MCCB)7个领域的认知功能得分及外周血皮质醇和甲状腺激素浓度的差异及其相关性。结果:GAD组在注意/警觉性、推理及问题解决和视觉学习领域得分低于对照组(P<0.05或P<0.01)。GAD组HAMA总分与皮质醇浓度呈正相关,与MCCB各分量表及总分呈负相关(P<0.05或P<0.01);病程与T4浓度呈负相关(P<0.05);TSH水平与注意/警觉性得分呈负相关(P<0.05)。结论:首发青年期GAD患者存在HPA轴、HPT轴活动的紊乱以及认知功能不同方面的受损。

Second Approximation of the Generalized Planetary Equation Based upon Golden Metric Tensors

In this paper, we consider the Post Einstein Planetary equation of motion. We succeeded in offering a solution using second approximation method, in which we obtained eight exact mathematical solutions that rebel amazing theoretical results. To the order of C-2, two of these exact solutions are reduced to the approximate solutions from the method of successive approximations.

On Unitary N-Dilations for Tuples of Circulant Contractions and von Neumann’s Inequality

We introduce the spectral mapping factorization of tuples of circulant matrices and its matrix version. We prove that every tuple of circulant contractions has a unitary N-dilation. We show that von Neumann’s inequality holds for tuples of circulant contractions. We construct completely contractive homomorphisms over the algebra of complex polynomials defined on .

稳定期精神分裂症患者社会认知功能损害特征及其影响因素的分析

【目的】探讨稳定期精神分裂症患者社会认知功能损害的特征,并对其影响因素进行相关分析,为改善和提高精神分裂症患者社会认知功能提供临床应对策略。【方法】158名稳定期精神分裂症患者及40名健康受试者接受了MATRICS共识认知成套测试(MCCB)以及简明精神病评定量表(BPRS)的评估,收集受试者的一般人口学信息及临床资料,比较精神分裂症患者与健康对照组之间总体认知功能和社会认知功能的差异,探索影响精神分裂症患者社会认知功能的相关因素。【结果】①慢性稳定期精神分裂症患者MCCB总分及其情绪管理因子分均显著低于健康对照组(P<0.05)。②精神分裂症患者的社会认知功能(情绪管理因子)与性别、年龄、敌对猜疑、持续操作及言语流畅显著相关(P<0.05)。【结论】与健康对照组比较,稳定期精神分裂症患者存在社会认知功能和显著的总体认知功能损害;稳定期精神分裂症患者的社会认知功能受性别、年龄、敌对猜疑和神经认知功能(注意力及信息处理速度)影响显著。

双相抑郁与单相抑郁患者认知功能的比较

目的:比较双相抑郁与单相抑郁患者认知功能的异同。方法:选取2017年1月至2018年7月在某院治疗的101例抑郁障碍患者为研究对象。其中,单相抑郁患者52例,设为单抑郁组,双相抑郁患者49例,设为双抑郁组。同时,在健康人群中选取30例设为正常组。所有患者在入院当天接受药物治疗前完成人口学资料及临床特征等一般资料的采集。使用MATRICS成套神经认知功能测验(MCCB)以及Stroop色词测验对患者和健康者进行认知功能的评定。分析检测结果并比较单抑郁组与双抑郁组之间认知功能测验评分的差异。结果:单抑郁组和双抑郁组两组之间的性别、是否伴有精神病性症、年龄、受教育年限、总病程以及疾病发作次数等一般资料的比较无统计学差异(P>0.05);单抑郁组和双抑郁组两组之间的各项认知功能评分均低于正常组(F=38.320,4.685,19.238,15.711,15.514,28.586,22.404,11.991,10.640,16.630,10.478;P<0.01);单抑郁组的Stroop测试2的成绩高于双抑郁组(t=2.107,P<0.05),两组间的其他项目评分无统计学差异(P>0.05)。结论:单相抑郁障碍和双相抑郁障碍患者均存在认知功能受损的情况,且受损模式基本相同。同时,双相抑郁障碍患者的执行功能受损程度比单相抑郁障碍患者更严重。

精神分裂症与双向情感障碍的认知功能对比研究

目的:对比分析精神分裂症与双向情感障碍的认知功能。方法:选择我院2009年1月-2013年5月收诊的精神分裂症患者30例,躁狂状态双向情感障碍患者30例,正常对照者30例,进行神经心理学测验和心理学行为实验来研究精神分裂症患者的认知能力。结果:使用MATRICS共识认知成套测验(MCCB)心理测试鉴别双向情感障碍、精神分裂症准确度较高;MCCB心理测试中包括:连线、言语流畅、持续操作、空间广度、数字序列、言语记忆、视觉记忆、迷宫、情绪管理等相关测验。结论:研究结果表明,MCCB心理测试可以有效的反映精神分裂症、双向情感障碍患者的认知功能。