Intra-and interobserver reliability of ocular surface analyzer LacryDiag

AIM:To invastigate intra-and interobserver reliability of interferometry,tear meniscus height(TMH)measurement and meibography(MBG)of an ocular surface analyzer,LacryDiag(Quantel Medical,France).METHODS:Five consecutive measurements and subsequent analysis of interferometry,TMH,and MBG were recorded by two examiners using the LacryDiag.To assess intra-and interobserver reliability,we used Cohen’s kappa for categorical variables(interferometry),or intraclass correlation coefficient for continuous variables(TMH,MBG).RESULTS:Thirty eyes of 30 examinees were included.For both observers,there was excellent intraobserver reliability for MBG(0.955 and 0.970 for observer 1 and 2,respectively).Intraobserver reliability for observer 1 was substantial for interferometry(0.799),and excellent for TMH(0.863).Reliability for observer 2 was moderate for interferometry(0.535)and fair to good for TMH(0.431).Interobserver reliability was poor for interferometry(0.074)and fair to good for TMH(0.680)and MBG(0.414).CONCLUSION:LacryDiag ocular surface analyzer in our study proves to be a reliable noninvasive tool for the evaluation of TMH and MBG.As for interferometry,poor interobserver reliability,fair to good intraobserver reliability for observer 1,and moderate for observer 2,leave room for improvement.

The research progress of an E//B neutral particle analyzer

An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of fast ions in the HL-2A/3 tokamak.The E//B NPA contains three main units,i.e.the stripping unit,the analyzing unit and the detection unit.A gas stripping chamber was adopted as the stripping unit.The results of the simulations and beam tests for the stripping chamber are presented.Parallel electric and magnetic fields provided by a NdFeB permanent magnet and two parallel electric plates were designed and constructed for the analyzing unit.The calibration of the magnetic and electric fields was performed using a 50 kV electron cyclotron resonance ion source(ECRIS)platform.The detection unit consists of 32lutetium-yttrium oxyorthosilicate(LYSO)detector modules arranged in two rows.The response functions ofα,hydrogen ions(H^(+),H_(2)^(+)and H_(3)^(+))andγfor a detector module were measured with^(241)Am,^(137)Cs and^(152)Eu sources together with the 50 kV ECRIS platform.The overall results indicate that the designed E//B NPA device is capable of measuring the intensity of neutral hydrogen and deuteron atoms with energy higher than 20 keV.

The Application of Digital Optical 3D Image Analyzer Evaskin in The Evaluation of Wrinkles

To verify the effectiveness of digital optical 3D image analyzer EvaSKIN in the objective and quantitative evaluation of wrinkles.A total of 115 subjects were recruited,the facial images of the subjects were collected by digital optical 3D image analyzer and manual camera,the changes of crow’s feet with age were analyzed.Pictures obtained by manual photography can be directly used for observation and preliminary grading of wrinkles.However,the requirements for evaluators are high,and the results are prone to errors,which will affect the accuracy of the evaluation.Therefore,skilled raters are needed.Compared with the manual photography method,the digital optical 3D image analyzer EvaSKIN can realize three-dimensional extraction of wrinkles,and obtain the change trend of crow’s feet with age.20~30 years old,wrinkles begin to appear slowly;wrinkles will increase rapidly at the age of 30~50;The length of 50~60 year old wrinkles is basically fixed,the wrinkles develop longitudewise,gradually widen and deepen,and the area,depth and volume increase is obvious,and the skin aging condition is intensified.the digital optical 3D image analyzer EvaSKIN realizes the 3D extraction of wrinkles,quantifies the circumference,area,average depth,maximum depth and volume of wrinkles,realizes the objective and quantitative evaluation of wrinkle state,is more accurate in the measurement of wrinkles,and provides a new instrument and method for the evaluation of wrinkles.it is a perfect and supplement to the traditional evaluation methods,and to a certain extent,it helps the research and development and evaluation institutions of cosmetics to obtain more abundant and three-dimensional data support.

Study on the Hook Effect in the Detection of Beta2-Microglobulin with Different Reagents in Fully Automated Biochemical Analyzers

Objective:To investigate the hook effect in the detection of beta2-microglobulin(β2-MG)with different reagents as well as on two fully automated biochemical analyzers and their solutions.Methods:Using immunoturbidimetric assay forβ2-MG as the research object,β2-MG levels were detected by different concentration gradients ofβ2-microglobulin samples in Liedemann,Mack,and Myriad reagents of three manufacturers on two automatic biochemical analyzers,and the difference of the hook effect was comparatively analyzed.Results:Leadman reagent showed the hook effect on the Beckman AU5800 automated biochemistry analyzer,while both Maccura and Mindray reagents did not show the hook effect.After the experiments,we found the limit value of the pre-zone check of Leadman reagent,and changed the parameters of the instrument,when the limit value of the pre-zone check was reached,the instrument automatically diluted the specimen five times and then detected it again.After changing the parameters of the instrument,the correlation between the three methods of detecting samples of different concentrations was r>0.99.Conclusion:Before selecting the application of immunoturbidimetric reagents,we have to carry out the risk assessment of the hook effect and selectively set the parameters of the pre-zone check based on the highest concentration that may occur in the clinic;for the items that may have the hook effect,we have to selectively set the parameters of the pre-zone check when the ratio of average reaction rate and the immediate reaction rate is at the limit value,and the phenomenon of antigen excess may occur,the instrument will carry out automatic dilution before detection,so as to avoid the issuance of erroneous results of high-value samples due to the hook effect.

索尼正式发布mocopi PC应用程序及移动端Data Analyzer

6月13日,索尼正式对便携动作捕捉产品mocopi发布几项更新,改善创作者基于PC(个人电脑)的工作流程,并将持续拓展PC端更多功能,助力3D内容创作。本次更新内容包括:(1)发布mocopi的Windows版PC应用程序,实现了PC端的动作捕捉,以支持电影、动画制作现场或使用3D虚拟形象进行直播等专业3DCG制作;(2)将mocopi移动应用程序的强大功能带到桌面环境,可以在PC上完成动作捕捉、文件保存、预览和发送等一系列工作,因此无需从智能手机迁移文件到PC,使用外部直播软件可以直接直播mocopi PC应用程序的屏幕。

Design and Analysis of a Network Traffic Analysis Tool: NetFlow Analyzer

A network analyzer can often comprehend many protocols, which enables it to display talks taking place between hosts over a network. A network analyzer analyzes the device or network response and measures for the operator to keep an eye on the network’s or object’s performance in an RF circuit. The purpose of the following research includes analyzing the capabilities of NetFlow analyzer to measure various parts, including filters, mixers, frequency sensitive networks, transistors, and other RF-based instruments. NetFlow Analyzer is a network traffic analyzer that measures the network parameters of electrical networks. Although there are other types of network parameter sets including Y, Z, & H-parameters, these instruments are typically employed to measure S-parameters since transmission & reflection of electrical networks are simple to calculate at high frequencies. These analyzers are widely employed to distinguish between two-port networks, including filters and amplifiers. By allowing the user to view the actual data that is sent over a network, packet by packet, a network analyzer informs you of what is happening there. Also, this research will contain the design model of NetFlow Analyzer that Measurements involving transmission and reflection use. Gain, insertion loss, and transmission coefficient are measured in transmission measurements, whereas return loss, reflection coefficient, impedance, and other variables are measured in reflection measurements. These analyzers’ operational frequencies vary from 1 Hz to 1.5 THz. These analyzers can also be used to examine stability in measurements of open loops, audio components, and ultrasonics.

Smart palm-size optofluidic hematology analyzer for automated imaging-based leukocyte concentration detection

A critical function of flow cytometry is to count the concentration of blood cells,which helps in the diagnosis of certain diseases.However,the bulky nature of commercial flow cytometers makes such tests only available in hospitals or laboratories,hindering the spread of point-of-care testing(POCT),especially in underdeveloped areas.Here,we propose a smart Palm-size Optofluidic Hematology Analyzer based on a miniature fluorescence microscope and a microfluidic platform to lighten the device to improve its portability.This gadget has a dimension of 35×30×80 mm and a mass of 39 g,less than 5%of the weight of commercially available flow cytometers.Additionally,automatic leukocyte concentration detection has been realized through the integration of image processing and leukocyte counting algorithms.We compared the leukocyte concentration measurement between our approach and a hemocytometer using the Passing-Bablok analysis and achieved a correlation coefficient of 0.979.Through Bland-Altman analysis,we obtained the relationship between their differences and mean measurement values and established 95%limits of agreement,ranging from−0.93×10^(3)to 0.94×10^(3)cells/μL.We anticipate that this device can be used widely for monitoring and treating diseases such as HIV and tumors beyond hospitals.

Proton pitch angle distributions in the Martian induced magnetosphere: A survey of Tianwen-1 Mars Ion and Neutral Particle Analyzer observations

The pitch angle distributions of ions and electrons can be affected by various processes;thus,they can serve as an important indicator of the physical mechanisms driving the dynamics of space plasmas.From observations from the Mars Ion and Neutral Particle Analyzer onboard the Tianwen-1 orbiter,we calculated the pitch angle distributions of protons in the Martian induced magnetosphere by using information from the magnetohydrodynamically simulated magnetic field,and we statistically analyzed the spatial occurrence pattern of different types of pitch angle distributions.Even though no symmetrical features were seen in the dataset,we found the dominance of the field-aligned distribution type over the energy range from 188 to 6232 eV.Maps of the occurrence rate showed the preferential presence of a trapped-like distribution at the lower altitudes of the surveyed nightside region.Although our results are more or less restricted by the adopted magnetic field,they indicate the complexity of the near-Mars proton pitch angle distributions and infer the possibility of wave–particle interactions in the Martian induced magnetosphere.

MATLAB和Simulink发行版2023b增加Simulink Fault Analyzer和Polyspace Test

全球领先的数学计算软件开发商MathWorks推出MATLAB和Simulink产品系列版本2023b(R2023b)。R2023b推出了两款新产品和几项重要更新,它们可为工程师和研究人员提供简化工作流的新功能。Simulink Fault Analyzer支持使用仿真进行系统性故障影响和安全分析。此新产品能够在不修改工程设计的情况下执行故障注入仿真。工程师利用仿真通过特定的系统条件来确定故障时间或触发故障并执行安全分析,如失效模式和影响分析(FMEA)。与Requirements Toolbox配合使用时,Simulink Fault Analyzer可帮助工程师创建和记录故障、危险、故障检测和缓解逻辑及其他工件之间的形式化连接。

语音分析软件Speech Analyzer和Praat在上海市区方言鼻化韵单一化演变研究中的应用

目前我国方言语音演变研究中音位的确定主要以传统意义上的研究方法为多,音位归纳主要凭个人经验。若记音人本身记音能力有限,可能造成记录结果与方言实际读音存在偏差。因此,如果在传统记音方法的基础上,辅以语音分析软件,将使方言语音研究更为精密、客观。以Speech Analyzer和Praat语音分析软件为例,結合上海市区方言鼻化韵单一化,即鼻化韵中前a后ɑ的对立完全消失,发成中A这一语音演变现象,以Speech Analyzer确定鼻化元音位置,以Praat做共振峰分析,为这一语音演变现象的确定提供证据。

使用Thomson Data Analyzer进行专利分析的几点研究

专利分析软件作为专利数据挖掘的工具,可以用作行业趋势分析、技术追踪、竞争对手监视等,目前正得到企业越来越广泛的重视。Thomson DataAnalyzer作为一款基于Derwent世界专利数据库基础上开发的专利分析软件,具有其独特的优势。本文在对TDA软件介绍的基础上,对使用中如何进行数据整理,以及如何进行技术领域分析进行了研究。

Rapid Determination of Lysine Content in Maize Kernel by Amino-acid Analyzer

In this study, nine high-lysine maize kernels and two kernels of common maize hybrid were used as experiment materials, and quantitative determination of lysine contents in high-lysine maize kernels and common maize kernels was carried out using Hitachi L-8900 Automatic Amino-acid Analyzer, to know the effect of the Analyzer in distinguishing the lysine contents between common maize kernels and high-lysine maize kernels. The results showed that the lysine contents of high-lysine maize kernels were among 0.34%-0.42%, while of common maize kernels were a- mong 0.24%-0.25%, and the difference was significant. Compared with other tradi- tional methods, this method is rapid, simple, sensitive, highly reproductive and needs fewer maize kernels, thus it is applicable in maize breeding.

PLC Analyzer在多工位快速液压机中的应用

介绍快速液压机工作原理以及PLC Analyzer软件的使用,通过PLC Analyzer软件在多工位快速压机中的使用,实现了对各种信号的数据采集与存储功能,便于分析、解决调试过程中出现的不定期的异常故障,优化了压机调试参数。借助该软件可快速、准确地发现设备故障点,弥补传统PLC无法对瞬时故障信号记录以及判断的缺陷。

MAXM-COULTER全自动血细胞分析仪测定网织红细胞的评价

目的 对MAXM -COULTER全自动血细胞分析仪测定网织红细胞 (RET)效果进行评价。方法 收集临床及正常人血液标本用上述仪器进行测定。结果 批内、批间重复性高值、中值CV3 4 %～ 4 5 % ;低值CV11 4 %～ 16 9%。携带率为 0 %。仪器计数与手工相关性高 (r =0 9646)。测得 10 3例正常人RET均值为0 78%。结论 网织红细胞仪器计数与手工计数相关性高 ,精密度、重复性、稳定性好 。

基于Analyzer的城市水环境设施管理综合分析评估体系构建

本文以城市水环境设施预警监控信息为基础,构建面向行业主管部门的城市水环境设施综合分析评估体系,包括信息上报评价体系、检验合格评价体系、基础建设评价体系和突发事故评价体系,并采用BI技术-analyzer分析软件进行了实现,能够有效降低开发和维护难度。

基于EventLog Analyzer的日志服务器配置

计算机网络是学校基础设施中的核心。服务器与网络设备会产生大量的日志记录,这些日志记录在进行账号行为的审计、留存系统运行信息分析和发现黑客入侵行为方面具有重要作用,但这些日志记录并不能长期存在这些设备中。如何保存并管理这些日志记录以便发挥作用成为网络管理工作的重点。该文介绍通过EventLog Analyzer创建日志服务器的配置过程以及对服务器和网络设备的管理。

Digital Differential Analyzer,Bresenham算法的比较分析

本文主要阐述了Digital Differential Analyzer及Bresenham两类算法原理、伪代码编写、运行速度比较等内容。本文的研究对于计算机图形技术从业人员具有一定借鉴意义及参考价值。

采用库仑滴定法—康宁Chloride Analyzer 925型测定血清氯化物含量

目前人体氯化物测定普遍采用化学滴定法，火焰光度计法。但因这些方法操作繁冗，在分析中易引入较大误差，常常影响实验结果的精确性。近来我们使用美国康宁925型氯化物分析仪采用库仑滴定法测定氯化物含量，获得较为满意的效果。认为该法具有简单、

Aspen Flare System Analyzer在火炬管网设计与分析中的具体应用

火炬气的排放系统设计是一个非常复杂的过程,涉及到各泄放点的背压与管路马赫数的计算。介绍了Aspen Flare System Analyzer模拟软件的特点及应用方法,该软件遵循API的规范要求,通过计算火炬管网中各管段始末点的压力、温度、流速等参数,可有效发现设计中的不合理管径并进行修改。以中东某油田地面工程项目为例,阐述了在工程实际中如何通过该软件进行火炬管网核算。高压火炬管网的核算结果显示,部分安全阀尾管背压和马赫数过大,经软件修改后的尺寸在实际运行中可满足火炬气的排放要求,保证了系统安全。表明了该软件在安全阀的选型和火炬管网的设计工作中的应用价值。

A Self-Powered Breath Analyzer Based on PANI/PVDF Piezo-Gas-Sensing Arrays for Potential Diagnostics Application

The increasing morbidity of internal diseases poses serious threats to human health and quality of life.Exhaled breath analysis is a noninvasive and convenient diagnostic method to improve the cure rate of patients. In this study, a self-powered breath analyzer based on polyaniline/polyvinylidene fluoride(PANI/PVDF) piezogas-sensing arrays has been developed for potential detection of several internal diseases. The device works by converting exhaled breath energy into piezoelectric gassensing signals without any external power sources. The five sensing units in the device have different sensitivities to various gas markers with concentrations ranging from 0 to 600 ppm. The working principle can be attributed to the coupling of the in-pipe gas-flow-induced piezoelectric effect of PVDF and gas-sensing properties of PANI electrodes. In addition, the device demonstrates its use as an ethanol analyzer to roughly mimic fatty liver diagnosis.This new approach can be applied to fabricating new exhaled breath analyzers and promoting the development of self-powered systems.