Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes.MCPs have a range of structures and biological activities and are wid...Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes.MCPs have a range of structures and biological activities and are widely present in marine species.MCPs also have a small molecular weight,are easily modified,and absorbed by the body.These properties have attracted great interest from researchers studying antioxidant,anti-tumor,and anti-aging activities.MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects.Thus,MCPs have the potential use as anti-cancer adjuvant drugs.Free radicals produced by oxidation are closely related to human aging,cancer,arteriosclerosis,and other diseases,but their relationship with cancer is not well known.In this review,we focus on the antioxidant properties of MCPs in the treatment of cancer,highlighting their antioxidant molecular structure and potential for clinical practice.展开更多
目的:探究胃癌根治术后手术部位感染(surgical site infection,SSI)影响因素及血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP1)、糖类抗原72-4(carbohydrate antigen 72-4,CA72-4)、可溶性白细胞分化抗原-14(soluble ...目的:探究胃癌根治术后手术部位感染(surgical site infection,SSI)影响因素及血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP1)、糖类抗原72-4(carbohydrate antigen 72-4,CA72-4)、可溶性白细胞分化抗原-14(soluble cluster of differentiation antigen-14,sCD14)水平变化意义。方法:选取2017年02月至2021年01月我院150例行胃癌根治术患者作为研究对象,根据患者术后是否出现SSI分为两组,感染组(n=35)与非感染组(n=115)。比较两组患者临床资料、手术前后血清MCP1、CA72-4、sCD14水平,分析胃癌根治术后SSI影响因素。绘制受试者工作特征曲线(receiver operating characteristic curve,ROC),评价胃癌根治术后血清MCP1、CA72-4、sCD14水平对SSI的诊断价值。分析术后血清MCP1、CA72-4、sCD14水平与感染程度(IPS评分)的相关性。比较术后血清MCP1、CA72-4、sCD14高水平与低水平患者病死率。结果:两组患者年龄、手术方式、临床分期、手术时间、糖尿病情况比较,差异有统计学意义(P<0.05)。感染组术后血清MCP1、CA72-4、sCD14水平高于非感染组(P<0.05)。Logistic回归方程结果显示,年龄、临床分期、糖尿病、手术方式、手术时间及术后血清MCP1、CA72-4、sCD14水平均为胃癌根治术后SSI的独立危险因素(P<0.05)。绘制胃癌根治术后血清MCP1、CA72-4、sCD14水平对SSI诊断价值的ROC曲线,结果显示胃癌根治术后血清MCP1、CA72-4、sCD14水平诊断SSI的曲线下面积(area under the curve,AUC)分别为0.804、0.768、0.777。应用Logistic二元回归拟合,构建各指标联合诊断的AUC,结果显示,联合检测的AUC为0.912。胃癌根治术后SSI患者IPS评分为(13.89±6.52)分。Pearson相关性分析可知,胃癌根治术后SSI患者血清MCP1、CA72-4、sCD14水平与感染程度呈正相关关系(P<0.05)。根据术后血清MCP1、CA72-4、sCD14水平分为高水平组与低水平组,术后血清MCP1、CA72-4、sCD14高水平组病死率明显高于低水平组,差异有统计学意义(P<0.05)。结论:胃癌根治术后SSI发病影响因素包括年龄、临床分期、糖尿病、手术方式、手术时间及术后血清MCP1、CA72-4、sCD14水平,且临床检测术后血清MCP1、CA72-4、sCD14水平,在SSI诊断、病情评估及预后预测中具有重要价值。展开更多
基金Projects(22176161,42307521)supported by the National Natural Science Foundation of ChinaProject(U21A20293)supported by the National Natural Science Foundation of China-Hunan Joint Fund+2 种基金Project(2023M742934)supported by the China Postdoctoral Science FoundationProject(CX20220599)supported by the Hunan Provincial Innovation Foundation for Postgraduate,ChinaProject supported by the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province,China。
基金supported by the Central Government Supports Local College Reform and Development Fund Talent Training Projects[Grant Number 2020GSP16]the Heilongjiang Touyan Innovation Team Program[Grant Number 2019HTY078].
文摘Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes.MCPs have a range of structures and biological activities and are widely present in marine species.MCPs also have a small molecular weight,are easily modified,and absorbed by the body.These properties have attracted great interest from researchers studying antioxidant,anti-tumor,and anti-aging activities.MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects.Thus,MCPs have the potential use as anti-cancer adjuvant drugs.Free radicals produced by oxidation are closely related to human aging,cancer,arteriosclerosis,and other diseases,but their relationship with cancer is not well known.In this review,we focus on the antioxidant properties of MCPs in the treatment of cancer,highlighting their antioxidant molecular structure and potential for clinical practice.
文摘目的:探究胃癌根治术后手术部位感染(surgical site infection,SSI)影响因素及血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP1)、糖类抗原72-4(carbohydrate antigen 72-4,CA72-4)、可溶性白细胞分化抗原-14(soluble cluster of differentiation antigen-14,sCD14)水平变化意义。方法:选取2017年02月至2021年01月我院150例行胃癌根治术患者作为研究对象,根据患者术后是否出现SSI分为两组,感染组(n=35)与非感染组(n=115)。比较两组患者临床资料、手术前后血清MCP1、CA72-4、sCD14水平,分析胃癌根治术后SSI影响因素。绘制受试者工作特征曲线(receiver operating characteristic curve,ROC),评价胃癌根治术后血清MCP1、CA72-4、sCD14水平对SSI的诊断价值。分析术后血清MCP1、CA72-4、sCD14水平与感染程度(IPS评分)的相关性。比较术后血清MCP1、CA72-4、sCD14高水平与低水平患者病死率。结果:两组患者年龄、手术方式、临床分期、手术时间、糖尿病情况比较,差异有统计学意义(P<0.05)。感染组术后血清MCP1、CA72-4、sCD14水平高于非感染组(P<0.05)。Logistic回归方程结果显示,年龄、临床分期、糖尿病、手术方式、手术时间及术后血清MCP1、CA72-4、sCD14水平均为胃癌根治术后SSI的独立危险因素(P<0.05)。绘制胃癌根治术后血清MCP1、CA72-4、sCD14水平对SSI诊断价值的ROC曲线,结果显示胃癌根治术后血清MCP1、CA72-4、sCD14水平诊断SSI的曲线下面积(area under the curve,AUC)分别为0.804、0.768、0.777。应用Logistic二元回归拟合,构建各指标联合诊断的AUC,结果显示,联合检测的AUC为0.912。胃癌根治术后SSI患者IPS评分为(13.89±6.52)分。Pearson相关性分析可知,胃癌根治术后SSI患者血清MCP1、CA72-4、sCD14水平与感染程度呈正相关关系(P<0.05)。根据术后血清MCP1、CA72-4、sCD14水平分为高水平组与低水平组,术后血清MCP1、CA72-4、sCD14高水平组病死率明显高于低水平组,差异有统计学意义(P<0.05)。结论:胃癌根治术后SSI发病影响因素包括年龄、临床分期、糖尿病、手术方式、手术时间及术后血清MCP1、CA72-4、sCD14水平,且临床检测术后血清MCP1、CA72-4、sCD14水平,在SSI诊断、病情评估及预后预测中具有重要价值。
