An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol%β-cyclodextrinvia a one-pot multicomponent reaction of aldehyde,dimedone,hydr...An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol%β-cyclodextrinvia a one-pot multicomponent reaction of aldehyde,dimedone,hydrazine hydrate with succinic anhydride/phthalic anhydride in water at 80 ℃ for first time.The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains.The outcome of the screening study showed that compound 6d,6f and7 n exhibited excellent activity against E.coil.Whereas,compound 6f and 6h exhibited excellent activity against P.aeurginosa,and compound 6c,and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S.aureus and B.subtilis when compared with Ampicillin（standard control）.The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs.展开更多
A submerged internal circulating membrane coagulation reactor （MCR） was used to treat surface water to produce drinking water. Polyaluminum chloride （PAC1） was used as coagulant, and a hydrophilic polyvinylidene f...A submerged internal circulating membrane coagulation reactor （MCR） was used to treat surface water to produce drinking water. Polyaluminum chloride （PAC1） was used as coagulant, and a hydrophilic polyvinylidene fluoride （PVDF） submerged hollow fiber microfiltration membrane was employed. The influences of trans-membrane pressure （TMP）, zeta potential （ZP） of the suspended particles in raw water, and KMnO4 dosing on water flux and the removal of turbidity and organic matter were systematically investigated. Continuous bench-scale experiments showed that the permeate quality of the MCR satisfied the requirement for a centralized water supply, according to the Standards for Drinking Water Quality of China （GB B749-2006）, as evaluated by turbidity （〈1 NTU） and total organic carbon （TOC） （〈5 mE/L） measurements. Besides water flux, the removal of turbidity, TOC and dissolved organic carbon （DOC） in the raw water also increased with increasing TMP in the range of 0.01-0.05 MPa. High ZP induced by PAC1, such as 5-9 mY, led to an increase in the number of fine and total particles in the MCR, and consequently caused serious membrane fouling and high permeate turbidity. However, the removal of TOC and DOC increased with increasing ZP. A slightly positive ZP, such as 1-2 mV, corresponding to charge neutralization coagulation, was favorable for membrane fouling control. Moreover, dosing with KMnO4 could further improve the removal of turbidity and DOC, thereby mitigating membrane fouling. The results are helpful for the application of the MCR in producing drinking water and also beneficial to the research and application of other coagulation and membrane separation hybrid processes.展开更多
基金supported by Special Assistance Programme SAP,University Grants Commission,New Delhi,India
文摘An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol%β-cyclodextrinvia a one-pot multicomponent reaction of aldehyde,dimedone,hydrazine hydrate with succinic anhydride/phthalic anhydride in water at 80 ℃ for first time.The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains.The outcome of the screening study showed that compound 6d,6f and7 n exhibited excellent activity against E.coil.Whereas,compound 6f and 6h exhibited excellent activity against P.aeurginosa,and compound 6c,and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S.aureus and B.subtilis when compared with Ampicillin（standard control）.The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs.
基金supported by the Special Funds for Technological Development of Research Institutes from the Ministry of Science and Technology of China(Nos.2012EG111122,2013EG111129,2014EG111126)the Program for Overseas Talents from Beijing Academy of Science and Technology(No.OTP-2013-015)the Six Talent Peaks Program from Jiangsu Province(No.JNHB-012)
文摘A submerged internal circulating membrane coagulation reactor （MCR） was used to treat surface water to produce drinking water. Polyaluminum chloride （PAC1） was used as coagulant, and a hydrophilic polyvinylidene fluoride （PVDF） submerged hollow fiber microfiltration membrane was employed. The influences of trans-membrane pressure （TMP）, zeta potential （ZP） of the suspended particles in raw water, and KMnO4 dosing on water flux and the removal of turbidity and organic matter were systematically investigated. Continuous bench-scale experiments showed that the permeate quality of the MCR satisfied the requirement for a centralized water supply, according to the Standards for Drinking Water Quality of China （GB B749-2006）, as evaluated by turbidity （〈1 NTU） and total organic carbon （TOC） （〈5 mE/L） measurements. Besides water flux, the removal of turbidity, TOC and dissolved organic carbon （DOC） in the raw water also increased with increasing TMP in the range of 0.01-0.05 MPa. High ZP induced by PAC1, such as 5-9 mY, led to an increase in the number of fine and total particles in the MCR, and consequently caused serious membrane fouling and high permeate turbidity. However, the removal of TOC and DOC increased with increasing ZP. A slightly positive ZP, such as 1-2 mV, corresponding to charge neutralization coagulation, was favorable for membrane fouling control. Moreover, dosing with KMnO4 could further improve the removal of turbidity and DOC, thereby mitigating membrane fouling. The results are helpful for the application of the MCR in producing drinking water and also beneficial to the research and application of other coagulation and membrane separation hybrid processes.
