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EOX和mDCF方案一线治疗晚期或转移性HER2阴性胃癌的疗效对比分析 被引量:3
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作者 曹波 姬乐 樊华 《临床和实验医学杂志》 2016年第17期1679-1682,共4页
目的比较EOX(表阿霉素/奥沙利铂/卡培他滨)和m DCF(多西他赛/顺铂/5-氟尿嘧啶/甲酰四氢叶酸钙)方案一线姑息化疗未经治疗过的晚期人类表皮生长因子受体2(HER2)阴性胃癌的疗效和安全性。方法 158例患者随机分为EOX组(n=79)和m DCF组(n=79... 目的比较EOX(表阿霉素/奥沙利铂/卡培他滨)和m DCF(多西他赛/顺铂/5-氟尿嘧啶/甲酰四氢叶酸钙)方案一线姑息化疗未经治疗过的晚期人类表皮生长因子受体2(HER2)阴性胃癌的疗效和安全性。方法 158例患者随机分为EOX组(n=79)和m DCF组(n=79)。EOX化疗方案:静脉注射表阿霉素,剂量50 mg/m^2;其次是静脉滴注奥沙利铂2 h,剂量130 mg/m^2;口服卡培他滨21 d,剂量625 mg/m^2,每日两次。m DCF方案:第1天静脉滴注多西他赛60 min,剂量40 mg/m^2;其次静脉滴注甲酰四氢叶酸钙120 min,剂量400 mg/m^2;静脉滴注5-氟尿嘧啶,剂量400mg/m^2,持续2 d;静脉滴注顺铂60 min,剂量40 mg/m^2。连续3 d。每周对患者进行体检和血液检测,评价患者临床疗效和毒性反应,记录数据并统计分析。结果 EOX和m DCF方案组中位总生存期分别为8.9个月和11.2个月(P=0.21),中位无进展生存期分别为6.7个月和6.9个月(P=0.34),两年生存率分别为6.3%和22.8%(P<0.05)。EOX组患者比m DCF组患者化疗剂量降低发生率显著增高(34.2%vs.3.8%,P=0.01),而且出现了延迟治疗(86.1%vs.62.0%,P=0.25)。EOX和m DCF方案组患者3~4级毒性反应发生率间无显著性差异(P>0.05)。与m DCF方案相比,EOX方案组患者恶心、血栓、腹痛和3~4级中性粒细胞减少的发生率较高,但是贫血、黏膜炎和外周神经病变的发生率较低。结论 m DCF与EOX方案一线姑息化疗HER2阴性晚期胃癌的疗效和安全性无显著性差异。 展开更多
关键词 胃癌 HER2阴性 化疗 EOX方案 mdcf方案
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MDCF压接式微矩形型电连接器的研制 被引量:2
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作者 刘阳 王娅孋 《物联网技术》 2016年第12期34-36,共3页
文中主要介绍了MDCF压接式微矩形电连接器的研制过程。通过图文阐述了MDCF压接式微矩形电连接器的结构和性能特点,并对研制过程中的关键技术问题作了具体论述。
关键词 微矩形 电连接器 绞线插针 mdcf
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Porous SiC/melamine-derived carbon foam frameworks with excellent electromagnetic wave absorbing capacity 被引量:12
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作者 Xinli YE Zhaofeng CHEN +6 位作者 Sufen AI Bin HOU Junxiong ZHANG Xiaohui LIANG Qianbo ZHOU Hezhou LIU Sheng CUI 《Journal of Advanced Ceramics》 SCIE CSCD 2019年第4期479-488,共10页
Porous three-dimensional Si C/melamine-derived carbon foam(3 D-Si C/MDCF)composite with an original open pore structure was fabricated by the heat treatment of the commercial melamine foam(MF),carbonization of the sta... Porous three-dimensional Si C/melamine-derived carbon foam(3 D-Si C/MDCF)composite with an original open pore structure was fabricated by the heat treatment of the commercial melamine foam(MF),carbonization of the stable MF,and chemical vapor deposition of the ultra-thin Si C coating.Scanning electron microscopy(SEM)and X-ray diffraction(XRD)were employed to detect the microstructure and morphology of the as-prepared composites.The results indicated that the 3 D-Si C/MDCF composites with the coating structure were prepared successfully.The obtained minimum reflection loss was–29.50 d B when the frequency and absorption thickness were 11.36 GHz and 1.75 mm,respectively.Further,a novel strategy was put forward to state that the best microwave absorption property with a thin thickness of 1.65 mm was gained,where the minimum reflection loss was–24.51 d B and the frequency bandwidth was 3.08 GHz.The excellent electromagnetic wave absorption ability resulted from the specific cladding structure,which could change the raw dielectric property to acquire excellent impedance matching.This present work had a certain extend reference meaning for the potential applications of the lightweight wave absorption materials with target functionalities. 展开更多
关键词 three-dimensional SiC/melamine-derived carbon foam(3D-SiC/mdcf) chemical vapor deposition coating structure electromagnetic wave absorption characteristic minimum REFLECTION loss
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