A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population

MET tyrosine kinase and its ligand,hepatocyte growth factor（HGF）,play a pivotal role in the activties of tumor cells.A germline missense variant in exon 2 of the MET gene,N375S（rs33917957 A〉G）,may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis.In this study,we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls.Logistic regression analysis was applied to estimate crude and adjusted odds ratios（ORs） and 95% confidence intervals（CIs） for the associations between genotypes and gastric cancer risk.We found that MET N375S variant genotypes（NS/SS） were associated with a significantly decreased risk of gastric cancer（OR = 0.78,95% CI = 0.63-0.96,P = 0.021） compared with the wildtype homozygote（NN）.The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.

染色体1q22 10q23 20p13 8q24区域遗传变异与胃癌易感性的关系研究

目的对染色体1q22,10q23,20p13以及8q24区域与胃癌发病风险有显著关联的点位进行验证研究。方法从河南省人民医院2010年1月至2013年12月接诊患者中选取125例胃癌患者与150例健康体检人群,采集两组对象静脉血,提取DNA,分析染色体1q22 (rs4072037 A>G)、10q23 (rs2274223 A>G)、20p13(rs13042395 C>T)以及8q24 (rs6983267 G>T、rs13281615 G>A、rs445114 C>T)点位与胃病发病风险的关系。结果 rs4072037、rs2274223与胃癌发病风险具有关联;rs4072037风险下降71%(OR=0.71,95%CI 0.62～0.80);rs4072037风险上升41%(OR=1.41,95%CI 1.26～1.57);rs13042395风险上升3%(OR=1.03,95%CI 0.93～1.14);rs6983267风险上升8%(OR=1.08,95%CI0.95～1.22);rs13281615风险上升3%(OR=1.03,95%CI 0.91～1.17);rs445114风险上升0 (OR=1.00,95%CI 0.89～1.13);rs13042395、rs6983267、rs13281615、rs445114四个位点与对照组之间差异对比无统计学意义,故与胃癌发病风险无显著关联。结论 1q22(rs4072037 A>G)、10q23(rs2274223 A>G)两个位点与胃癌易感性有关联。