A comparison of the adsorption isotherms of caffeine, theophylline and theobromine and the competitive adsorption of the three compounds on a C18 column were investigated. The experimental parameters of the equilibriu...A comparison of the adsorption isotherms of caffeine, theophylline and theobromine and the competitive adsorption of the three compounds on a C18 column were investigated. The experimental parameters of the equilibrium isotherms were estimated by linear and nonlinear regression analyses. The linear equation as a function of the adsorption concentration of the single compound in its solution and the competitive adsorption of a single compound in a mixed solution were then determined. The adsorption equilibrium data were then correlated to the linear, Langmuir, Freundlich, Langmuir-Freundlich and stoichiometric displacement theory for adsorption（SDT-A） isotherm models. The mixed compounds of the three compounds were competitively adsorbed on the C18 particles. The expression of stoichiometric displacement theory for adsorption was found to be more suitable for adsorption of methylxanthines on a C18 column.展开更多
Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanica...Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanically ventilated preterm infants. Evidence for additional short-term benefits on reducing the incidence of bronchopulmonary dysplasia and patent ductus arteriosus has also been suggested. Controversies existamong various neonatal intensive care units in terms of drug efficacy compared to other methylxanthines, dosage regimen, time of initiation, duration of therapy, drug safety and value of therapeutic drug monitoring. In the current review, we will summarize the available evidence for the best practice in using caffeine therapy in preterm infants.展开更多
基金Supported by the Basic Science Research Program Through the National Research Foundation(NRF) of Korea funded by the Ministry of Education, Science and Technology(No.2010-0015731)
文摘A comparison of the adsorption isotherms of caffeine, theophylline and theobromine and the competitive adsorption of the three compounds on a C18 column were investigated. The experimental parameters of the equilibrium isotherms were estimated by linear and nonlinear regression analyses. The linear equation as a function of the adsorption concentration of the single compound in its solution and the competitive adsorption of a single compound in a mixed solution were then determined. The adsorption equilibrium data were then correlated to the linear, Langmuir, Freundlich, Langmuir-Freundlich and stoichiometric displacement theory for adsorption（SDT-A） isotherm models. The mixed compounds of the three compounds were competitively adsorbed on the C18 particles. The expression of stoichiometric displacement theory for adsorption was found to be more suitable for adsorption of methylxanthines on a C18 column.
文摘Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanically ventilated preterm infants. Evidence for additional short-term benefits on reducing the incidence of bronchopulmonary dysplasia and patent ductus arteriosus has also been suggested. Controversies existamong various neonatal intensive care units in terms of drug efficacy compared to other methylxanthines, dosage regimen, time of initiation, duration of therapy, drug safety and value of therapeutic drug monitoring. In the current review, we will summarize the available evidence for the best practice in using caffeine therapy in preterm infants.
