The genetic loci for serum complement components C2, factor B (BF), C4A and C4B are very closely linked to each other, and are shown to be situated within the major histocompatibility complex (MHC)on the short arm of ...The genetic loci for serum complement components C2, factor B (BF), C4A and C4B are very closely linked to each other, and are shown to be situated within the major histocompatibility complex (MHC)on the short arm of the human chromosome 6, between MHC Classes Ⅰ and Ⅱ regions. They are referred to as Class Ⅲ genes of the MHC.展开更多
in this paper, the major Bf allotypes were detected and analyzed from 460 unrelated healthy adults of Han nationality in Guangdong, China with the method and nomenclature of the international Complement Reference Labo...in this paper, the major Bf allotypes were detected and analyzed from 460 unrelated healthy adults of Han nationality in Guangdong, China with the method and nomenclature of the international Complement Reference Laboratory. Four Bf phenotypes of BF SS(79. 13%),BF FF(2. 39%), BF FS(18. 04%), and BF SS07 (0.43%) were found with the allelic frequencies of 0. 8837 for BF*S, 0. 1141 for BF*F and 0. 0022 for BF*S07. The BF phenotype frequency distributions were in agreement with the Hardy-Weinberg equilibrium law. The characteristics of the gene frequency distributions were basically the same with those from Wuhan and Shanghai cities. The distribution of BF allotypes among three major human races and the discrepancies of the rare variants in different areas were discussed.展开更多
文摘The genetic loci for serum complement components C2, factor B (BF), C4A and C4B are very closely linked to each other, and are shown to be situated within the major histocompatibility complex (MHC)on the short arm of the human chromosome 6, between MHC Classes Ⅰ and Ⅱ regions. They are referred to as Class Ⅲ genes of the MHC.
文摘in this paper, the major Bf allotypes were detected and analyzed from 460 unrelated healthy adults of Han nationality in Guangdong, China with the method and nomenclature of the international Complement Reference Laboratory. Four Bf phenotypes of BF SS(79. 13%),BF FF(2. 39%), BF FS(18. 04%), and BF SS07 (0.43%) were found with the allelic frequencies of 0. 8837 for BF*S, 0. 1141 for BF*F and 0. 0022 for BF*S07. The BF phenotype frequency distributions were in agreement with the Hardy-Weinberg equilibrium law. The characteristics of the gene frequency distributions were basically the same with those from Wuhan and Shanghai cities. The distribution of BF allotypes among three major human races and the discrepancies of the rare variants in different areas were discussed.
