A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM micro...A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes.展开更多
In order to improve the energy output consistency of 3, 3’-diamino-4, 4’-azoxyfurazan(DAAF) in the new insensitive booster and the safety and efficiency in the preparation process, a continuous preparation system of...In order to improve the energy output consistency of 3, 3’-diamino-4, 4’-azoxyfurazan(DAAF) in the new insensitive booster and the safety and efficiency in the preparation process, a continuous preparation system of DAAF from synthesis to spherical coating was designed and established in this paper, which combined ultrasonic micromixing reaction with microdroplet globular template. In the rapid micromixing stage, the microfluidic mixing technology with ultrasonic was used to synergistically strengthen the uniform and rapid mass transfer mixing reaction between raw materials to ensure the uniformity of DAAF particle nucleation-growth, and to prepare high-quality DAAF crystals with uniform structure and morphology and concentrated particle size distribution. In the microdroplet globular template stage, the microfluidic droplet technology was used to form a droplet globular template with uniform size under the shear action of the continuous phase of the dispersed phase solution containing DAAF particles and binder. The size of the droplet template was controlled by adjusting the flow rate ratio between the continuous phase and the dispersed phase. In the droplet globular template, with the diffusion of the solvent in the dispersed phase droplets, the binder precipitates to coat the DAAF into a ball, forming a DAAF microsphere with high sphericity, narrow particle size distribution and good monodispersity. The problem of discontinuity and DAAF particle suspension in the process was solved, and the coating theory under this process was studied. DAAF was coated with different binder formulations of fluororubber(F2604), nitrocellulose(NC) and NC/glycidyl azide polymer(GAP), and the process verification and evaluation of the system were carried out. The balling effects of large, medium and small droplet templates under different binder formulations were studied. The scanning electron microscope(SEM) results show that the three droplet templates under the three binder formulations exhibit good balling effect and narrow particle size distribution. The DAAF microspheres were characterized by powder X-ray diffraction(XRD), differential scanning calorimetry(DSC), thermo-gravimetric(TG) and sensitivity analyzer. The results showed that the crystal structure of DAAF did not change during the process, and the prepared DAAF microspheres had lower decomposition temperature and lower mechanical sensitivity than raw DAAF. The results of detonation parameters show that the coating of DAAF by using the above three binder formulations will not greatly reduce the energy output of DAAF, and has comparable detonation performance to raw DAAF. This study proves an efficient and safe continuous system from synthesis to spherical coating modification of explosives, which provides a new way for the continuous, safe and efficient preparation of spherical explosives.展开更多
Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of microreactors.In this work,the novel curved capillary reactor with different shapes w...Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of microreactors.In this work,the novel curved capillary reactor with different shapes was designed to generate Dean flow,which was used to enhance the liquid-liquid micromixing performance.The Villermaux-Dushman probe reaction was employed to characterize the micromixing performance in different curved capillary microreactors.The effects of experiment parameters such as liquid flow rate,inner diameter,tube length,and curve diameter on micromixing performance were systematically investigated.Under the optimal conditions,the minimum value of the segmentation factor XS was 0.008.It was worth noting that at the low Reynolds number(Re<30),the change of curved shape on the capillary microreactor can significantly improve the micromixing performance with XS reduced by 37.5%.Further,the correlations of segment index XS with dimensionless factor such as Reynolds number or Dean number were developed,which can be used to predict the liquid-liquid micromixing performance in capillary microreactors.展开更多
Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of MOCJMs.Herein,the flow cha...Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of MOCJMs.Herein,the flow characteristics and micromixing performance inside the MOCJM were investigated using experiments and computational fluid dynamics(CFD)simulations based on the Villermaux/Dushman system and the finite-rate/modified eddy-dissipation model.The optimal A value was correlated with the characteristic parameters of MOCJMs to develop a CFD calculation method applicable to the study of the micromixing performance of the MOCJMs.Then the micromixing efficiency was evaluated using the segregation index XS,and the effects of operational and geometric parameters such as mixing flow Reynolds number(ReM),flow ratio(RF),total jet area(ST),the number of jet orifices(n),and outlet configuration on the micromixing efficiency were investigated.It was found that the intensive turbulent region generated by interactions between jets,as well as between jets and crossflows,facilitated rapid reactions.XS decreased with increasing ReM and decreasing RF.Furthermore,MOCJMs with lower ST,four jet orifices,and the narrower outlet configuration demonstrated a better micromixing efficiency.This study contributes to a deeper understanding of the micromixing performance of MOCJMs and provides valuable guidance for their design,optimization,and industrial application.展开更多
Chaotic mixing in eight different types of micro T-mixer flow has been studied experimentally and numerically. The present experimental study was performed to visualize two-liquid flows in a micro T-mixer with baffles...Chaotic mixing in eight different types of micro T-mixer flow has been studied experimentally and numerically. The present experimental study was performed to visualize two-liquid flows in a micro T-mixer with baffles. The Reynolds number, baffle height and setting angle were varied to investigate their effect on the mixing performance. Three micro T-mixer models were produced, which are several centimeters long and have a rectangular cross-section of few millimeters a side. The mixing of two-liquid was measured using the laser induced fluorescence (LIF) technique. Moreover, three-dimensional numerical simulations were conducted with the open-source CFD solver, OpenFOAM, for the same configuration as used in the experiments to investigate the detailed mechanism of the chaotic mixing. As a result, it was found that the mixing of two-liquid is greatly improved in the micro T-mixer with baffle. The baffle height and setting angle show a significant influence on the mixing performance.展开更多
The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannels for chemical process applications. A comparison among digital model processing applications for 3D prin...The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannels for chemical process applications. A comparison among digital model processing applications for 3D print(slicers) and a print layer thickness analysis were performed. The 3D print fidelity was verified in several devices, including the microchannels’ printing with and without micromixer zones. In order to highlight the 3D print potential in Chemical Engineering, the biodiesel synthesis was also carried out in a millireactor manufactured by 3D printing. The millireactor operated under laminar flow regime with a total flow rate of 75.25 ml·min^-1(increment of about 130 times over traditional microdevices used for biodiesel production).The printed millireactor provided a maximum yield of Ethyl Esters of 73.51% at 40 ℃, ethanol:oil molar ratio of7 and catalyst concentration of 1.25 wt% and residence time about 10 s. As a result of flow rate increment attained in the millireactor, the number of required units for scaling-up the chemical processes is reduced. Using the approach described in the present research, anyone could produce their own millireactor for chemical process in a simple way with the aid of a 3D printer.展开更多
Passive micromixers are preferred over active mixers for many microfluidic applications due to their relative ease in integration into complex systems and operational flexibility.They also incur very low cost of manuf...Passive micromixers are preferred over active mixers for many microfluidic applications due to their relative ease in integration into complex systems and operational flexibility.They also incur very low cost of manufacturing.However,the degree of mixing is comparatively low in passive mixers than active mixers due to the absence of disturbance in the flow by external forces and the inherent laminar nature of microchannel flows.Various designs of complex channel structures and three-dimensional geometries have been investigated in the past to obtain an efficient mixing in passive mixers.But the studies on mixing enhancement with simple planar geometries of passive mixers have been few and limited.The present work aims to investigate the possibility of mixing enhancement by employing simple planar type designs,such as T-mixer and T–T mixer with cylindrical elements placed in the mixing channel.The mixing performance has been evaluated in the Reynolds number range of 6 to700.Numerical results have shown that T–T mixer with cylindrical elements performed significantly well and obtained very good mixing quality over basic T-mixer for the entire range of Reynolds number(6 to 700).The device has also shown better mixing as compared to basic T–T mixer and T-mixer with cylindrical elements.A larger pair of vortices formed in the stagnation area due to the presence of a cylindrical element in the junction.Cylindrical elements downstream caused significant enhancement in mixing due to splitting and recombining action.The size of the cylindrical element in the T–T mixer has been optimized to obtain better mixing performance of the device.Remarkable improvement in mixing quality by T–T mixer with cylindrical elements has been obtained at the expense of small rise in pressure drop as compared to other passive designs considered in this study.Therefore,the current design of T–T mixer with cylindrical elements can act as an effective and simple passive mixing device for various micromixing applications.展开更多
Microchannel reactors are widely used in different fields due to their intensive micromixing and, thus, high masstransfer efficiency. In this work, a single countercurrent-flow microchannel reactor(S-CFMCR) at the siz...Microchannel reactors are widely used in different fields due to their intensive micromixing and, thus, high masstransfer efficiency. In this work, a single countercurrent-flow microchannel reactor(S-CFMCR) at the size of ~1 mm was developed by steel micro-capillary and laser drilling technology. Utilizing the Villermaux/Dushman parallel competing reaction, numerical and experimental studies were carried out to investigate the micromixing performance(expressed as the segregation index XS) of liquids inside S-CFMCR at the low flow velocity regime.The effects of various operating conditions and design parameters of S-CFMCR, e.g., inlet Reynolds number(Re),volumetric flow ratio(R), inlet diameter(d) and outlet length(L), on the quality of micromixing were studied qualitatively. It was found that the micromixing efficiency was enhanced with increasing Re, but weakened with the increase of R. Moreover, d and L also have a significant influence on micromixing. CFD results were in good agreement with experimental data. In addition, the visualization of velocity magnitude, turbulent kinetic energy and concentration distributions of various ions inside S-CFMCR was illustrated as well. Based on the incorporation model, the estimated minimum micromixing time tmof S-CFMCR is ~2 × 10-4s.展开更多
In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter...In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter the micromixer by fluid flows and are actuated by an alternating magnetic field normal to the main flow. An important feature of micromixer which is not considered before by researchers is the particle entrance arrangement into the micromixer. This parameter could effectively affect the micromixer efficiency. There are two general micro magnetic particle entrance arrangements in magnetic bead micromixers: determined position entrance and random position entrance. In the case of determined position entrances, micro magnetic particles enter the micromixer at specific positions of entrance cross section. However, in a random position entrance,particles enter the microchannel with no order. In this study mixing efficiencies of identical magnetic bead micromixers which only differ in particle entrance arrangement are numerically investigated and compared.The results reported in this paper illustrate that the prepared computer code can be one of the most powerful and beneficial tools for the magnetic bead micromixer performance analysis. In addition, the results show that some features of the magnetic bead micromixer are strongly affected by the entrance arrangement of the particles.展开更多
1 INTRODUCTIONIn Part Ⅰ of this study,the physical aspects for micro-and macromixing were outlined,a shrinkage slab model for micromixing was presented and a three-region picturecharacterizing interaction between mic...1 INTRODUCTIONIn Part Ⅰ of this study,the physical aspects for micro-and macromixing were outlined,a shrinkage slab model for micromixing was presented and a three-region picturecharacterizing interaction between micro-and macromixing was sketched.The feed ma-terial from a point source was shown to successively undergo the dispersion,micromixing and macromixing regions before achieving homogeneity on the展开更多
This paper studied a concept of micromixer with a synthetic jet placed at the bottom of a rectangular channel. Due to periodic ejections from and suctions into the channel, the fluids are mixed effectively. To study t...This paper studied a concept of micromixer with a synthetic jet placed at the bottom of a rectangular channel. Due to periodic ejections from and suctions into the channel, the fluids are mixed effectively. To study the effects of the inlet velocity, the jet intensity and frequency, and the jet location on the mixing efficiency, 3-D numerical simulations of the micromixer have been carried out. It has been found that when the jet intensity and the frequency are fixed, the mixing efficiency increases when Re 〈 50, and decreases when Re 〉 50 with the best mixing efficiency achieved at Re = 50. When the ratio of the jet velocity magnitude to the inlet velocity is taken as 10 and the jet frequency is 100 Hz, the mixing index reaches the highest value. It has also been found that to get better mixing efficiency, the orifice of the synthetic jet should be asymmetrically located away from the channel's centerline.展开更多
In this paper,a novel micromixer with complex 3D-shape inner units was put forward and fabricated by metal Additive Manufacturing(AM).The design of the micromixer combined the constraints of selective laser melting te...In this paper,a novel micromixer with complex 3D-shape inner units was put forward and fabricated by metal Additive Manufacturing(AM).The design of the micromixer combined the constraints of selective laser melting technology and the factors to improve mixing efficiency.Villermaux-Dushman reaction system and Compute Fluid Design(CFD)simulation were conducted to investigate the performance and the mechanism of this novel micromixer to improve mixing efficiency.The research found that the best mixing efficiency of this novel micromixer could be gained when the inner units divided fluid into five pieces with a uniform volume.Compared with a conventional micromixer without obstacle in the channel,the micromixer designed in this research achieved higher mixing efficiency and reduce the pressure drop by 10.34%.The mixing behaviour in this novel micromixer was discussed,which mainly contains two types:collisions and swirls.Via collisions,the fluid micro masses would hit each other directly,which broke the boundaries of micro masses and promoted the interchange of species in the whole flow field.In swirls,the fluid micro masses were drawn into thin and long slices,which increased the size of the contact area and enhanced molecule diffusion.Finally,the application scheme of this novel micromixer was briefly discussed.展开更多
1 INTRODUCTION When a fluid is injected into a turbulence field to mix with another fluid,twohomogenization processes take place simultaneously:micromixing(on the molecularscale)and macromixing(on the mixer scale).For...1 INTRODUCTION When a fluid is injected into a turbulence field to mix with another fluid,twohomogenization processes take place simultaneously:micromixing(on the molecularscale)and macromixing(on the mixer scale).For micromixing,three successive stages arerecognized at high Schmidt number(1)turbulent dispersion,in which the original ma-terial lumps are dispersed by turbulence into discrete elements with smallest eddy sizeλ_k;(2)viscous deformation,in which the size of the elements is further展开更多
Electrokinetic(EK)micromixers have been widely studied in the past decade for biochemical applications,biological and chemical analysis,etc.Unfortunately,almost all EK mixers require different electrical conductivity ...Electrokinetic(EK)micromixers have been widely studied in the past decade for biochemical applications,biological and chemical analysis,etc.Unfortunately,almost all EK mixers require different electrical conductivity between the two fluids to be mixed,which has greatly limited their wide applications,in cases where the two streams to be mixed have equivalent electrical conductivity.Here we show that mixing enhancement between two fluids with identical conductivity can be achieved in an EK micromixer with conductive sidewalls,where the electric field is in transverse direction of the flow.The results revealed that the mixing became stronger with increased conductivity value.This mixing method provides a novel and convenient strategy for mixing two liquids with the same or similar electrical conductivity in microfluidic systems,and could potentially serves as a powerful tool for sample preparation in applications such as liquid biopsy,and environmental monitoring,etc.展开更多
Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of mi...Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of micromixer,this paper carries out a high-fidelity numerical simu-lation and a parametrial experimental study on a well-established design.A passive tracer is induced in the numerical simulation to analyze mixing dynamics induced by the staggered herring-bone structures.Three effects are identified to reveal the underlying mechanisms,including folding,stretching,and splitting.To the authors’knowledge,the splitting effect is identified for the first time by the isosurface of the passive tracer,to show the high efficiency of the staggered herring-bone design.The micromixer is then used to synthesize lipid nanoparticles by mixing a mixture of lipid and poly(lactic-co-glycolic acid)(PLGA)solutions with deionized water.Under a wide mass ratio of lipid and PLGA solutions,nanoparticles with good monodispersity are synthesized to reflect the good compatibility of the micromixer and the mixture.In addition,an optimized mass ratio is identified from the parametrical experiment.展开更多
The competitive iodide/iodate reaction scheme was used to ascertain the micromixing in the stirred solid-liquid systems. Two different glass beads from 450 to 1250 μm were tested. The effect of solid particles on rea...The competitive iodide/iodate reaction scheme was used to ascertain the micromixing in the stirred solid-liquid systems. Two different glass beads from 450 to 1250 μm were tested. The effect of solid particles on reaction selectivity with multiple impellers at different feed points has been investigated. It was confirmed that glass beads as a second phase were suitable for the study. The segregation index has changed significantly only for the medium-sized particles at relatively high solid holdups. The cloud formation was clearly observed for the medium-sized particles at a concentration of 12.12 wt. %. When feeding into the clear liquid above the cloud, the value of the segregation index increased significantly. However, in the presence of particles of 1-1.25 mm, the influence on the selectivity was negligible when the agitation speed was increased.展开更多
Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been ...Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been shown to be affected by the shear effect, the shear effect triggering conditions in gasliquid two-phase flow is unclear and the aggregation behavior of nanoparticles under the shear effect is difficult to predict, resulting in uncontrollable physical and chemical properties of nanoparticle aggregates. In this study, a numerical simulation of nanoparticle aggregation in gas-liquid two-phase flow under the shear effect is performed using the CFD-DEM method. Then, the effects of total flow rate,gas-liquid two-phase flow ratio, and particle volume fraction on particle aggregation were analyzed to achieve control of particle aggregation shape and size. Meanwhile, the triggering mechanism of the shear effect and the mechanism of the shear effect on the aggregation of nanoparticles were clarified. The results show that increasing the total flow rate or decreasing the gas-liquid two-phase flow rate ratio can induce the shear effect, which reduces the particle aggregation size and makes the morphology tend to be spherical. Moreover, increasing the particle volume fraction, and total flow rate or decreasing the gas-liquid two-phase flow rate ratio also increases the number of particle collisions and induce interparticle adhesion. Hence, particle adhesion and the shear effect compete with each other and together affect particle aggregation.展开更多
Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential contin...Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃ in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity.展开更多
The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is unde...The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is underscored by the complexity of in vivo tissues,which exhibit heterogeneous structures comprised of diverse cells and matrices.Drawing inspiration from the classical Tesla valve,our study introduces a new concept of micromixers to address this complexity.The innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian fluids.Notably,our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles,which represents a significant improvement over the traditional mixing method.This advance is pivotal for the field of 3D printing and bioprinting,and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues.展开更多
The mechanism of diffusion and mixing in the micro-channel flow was studied numerically and experimentally in detail. Based on the theoretical and computational results, the micro-mixers with high efficiency were desi...The mechanism of diffusion and mixing in the micro-channel flow was studied numerically and experimentally in detail. Based on the theoretical and computational results, the micro-mixers with high efficiency were designed. The conclusions drawn from this thesis are helpful for the practical usage.展开更多
基金the financial support from the National Natural Science Foundation of China(21808059)the Fundamental Research Funds for the Central Universities(JKA01221712).
文摘A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes.
基金National Natural Science Foundation of China(Grant No.22005275)to provide fund for conducting experiments.
文摘In order to improve the energy output consistency of 3, 3’-diamino-4, 4’-azoxyfurazan(DAAF) in the new insensitive booster and the safety and efficiency in the preparation process, a continuous preparation system of DAAF from synthesis to spherical coating was designed and established in this paper, which combined ultrasonic micromixing reaction with microdroplet globular template. In the rapid micromixing stage, the microfluidic mixing technology with ultrasonic was used to synergistically strengthen the uniform and rapid mass transfer mixing reaction between raw materials to ensure the uniformity of DAAF particle nucleation-growth, and to prepare high-quality DAAF crystals with uniform structure and morphology and concentrated particle size distribution. In the microdroplet globular template stage, the microfluidic droplet technology was used to form a droplet globular template with uniform size under the shear action of the continuous phase of the dispersed phase solution containing DAAF particles and binder. The size of the droplet template was controlled by adjusting the flow rate ratio between the continuous phase and the dispersed phase. In the droplet globular template, with the diffusion of the solvent in the dispersed phase droplets, the binder precipitates to coat the DAAF into a ball, forming a DAAF microsphere with high sphericity, narrow particle size distribution and good monodispersity. The problem of discontinuity and DAAF particle suspension in the process was solved, and the coating theory under this process was studied. DAAF was coated with different binder formulations of fluororubber(F2604), nitrocellulose(NC) and NC/glycidyl azide polymer(GAP), and the process verification and evaluation of the system were carried out. The balling effects of large, medium and small droplet templates under different binder formulations were studied. The scanning electron microscope(SEM) results show that the three droplet templates under the three binder formulations exhibit good balling effect and narrow particle size distribution. The DAAF microspheres were characterized by powder X-ray diffraction(XRD), differential scanning calorimetry(DSC), thermo-gravimetric(TG) and sensitivity analyzer. The results showed that the crystal structure of DAAF did not change during the process, and the prepared DAAF microspheres had lower decomposition temperature and lower mechanical sensitivity than raw DAAF. The results of detonation parameters show that the coating of DAAF by using the above three binder formulations will not greatly reduce the energy output of DAAF, and has comparable detonation performance to raw DAAF. This study proves an efficient and safe continuous system from synthesis to spherical coating modification of explosives, which provides a new way for the continuous, safe and efficient preparation of spherical explosives.
基金supports of National Natural Science Foundation of China(22308057)Outstanding Talent Introduction Funds from Fuzhou University(0040-511175)Fuzhou University Testing Fund of precious apparatus(2023T003).
文摘Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of microreactors.In this work,the novel curved capillary reactor with different shapes was designed to generate Dean flow,which was used to enhance the liquid-liquid micromixing performance.The Villermaux-Dushman probe reaction was employed to characterize the micromixing performance in different curved capillary microreactors.The effects of experiment parameters such as liquid flow rate,inner diameter,tube length,and curve diameter on micromixing performance were systematically investigated.Under the optimal conditions,the minimum value of the segmentation factor XS was 0.008.It was worth noting that at the low Reynolds number(Re<30),the change of curved shape on the capillary microreactor can significantly improve the micromixing performance with XS reduced by 37.5%.Further,the correlations of segment index XS with dimensionless factor such as Reynolds number or Dean number were developed,which can be used to predict the liquid-liquid micromixing performance in capillary microreactors.
基金the financial support from the Shanghai Sailing Program,China(21YF1409500)the National Natural Science Foundation of China(22308100,22308105)+1 种基金the State Key Laboratory of Chemical Engineering(SKL-ChE-23Z01)and the National Science Fund for Distinguished Young Scholars of China(22225804).
文摘Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of MOCJMs.Herein,the flow characteristics and micromixing performance inside the MOCJM were investigated using experiments and computational fluid dynamics(CFD)simulations based on the Villermaux/Dushman system and the finite-rate/modified eddy-dissipation model.The optimal A value was correlated with the characteristic parameters of MOCJMs to develop a CFD calculation method applicable to the study of the micromixing performance of the MOCJMs.Then the micromixing efficiency was evaluated using the segregation index XS,and the effects of operational and geometric parameters such as mixing flow Reynolds number(ReM),flow ratio(RF),total jet area(ST),the number of jet orifices(n),and outlet configuration on the micromixing efficiency were investigated.It was found that the intensive turbulent region generated by interactions between jets,as well as between jets and crossflows,facilitated rapid reactions.XS decreased with increasing ReM and decreasing RF.Furthermore,MOCJMs with lower ST,four jet orifices,and the narrower outlet configuration demonstrated a better micromixing efficiency.This study contributes to a deeper understanding of the micromixing performance of MOCJMs and provides valuable guidance for their design,optimization,and industrial application.
文摘Chaotic mixing in eight different types of micro T-mixer flow has been studied experimentally and numerically. The present experimental study was performed to visualize two-liquid flows in a micro T-mixer with baffles. The Reynolds number, baffle height and setting angle were varied to investigate their effect on the mixing performance. Three micro T-mixer models were produced, which are several centimeters long and have a rectangular cross-section of few millimeters a side. The mixing of two-liquid was measured using the laser induced fluorescence (LIF) technique. Moreover, three-dimensional numerical simulations were conducted with the open-source CFD solver, OpenFOAM, for the same configuration as used in the experiments to investigate the detailed mechanism of the chaotic mixing. As a result, it was found that the mixing of two-liquid is greatly improved in the micro T-mixer with baffle. The baffle height and setting angle show a significant influence on the mixing performance.
基金the National Postdoctoral Program(PNPD/CAPES)the UNICAMP Scholarship Program+2 种基金FUNCAMP(UNICAMP Foundation)the financial support provided by CNPq(National Council for Scientific and Technological Development,Process404760/2016-3)FAPESP(Sao Paulo Research Foundation,Process 2016/20842-4).
文摘The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannels for chemical process applications. A comparison among digital model processing applications for 3D print(slicers) and a print layer thickness analysis were performed. The 3D print fidelity was verified in several devices, including the microchannels’ printing with and without micromixer zones. In order to highlight the 3D print potential in Chemical Engineering, the biodiesel synthesis was also carried out in a millireactor manufactured by 3D printing. The millireactor operated under laminar flow regime with a total flow rate of 75.25 ml·min^-1(increment of about 130 times over traditional microdevices used for biodiesel production).The printed millireactor provided a maximum yield of Ethyl Esters of 73.51% at 40 ℃, ethanol:oil molar ratio of7 and catalyst concentration of 1.25 wt% and residence time about 10 s. As a result of flow rate increment attained in the millireactor, the number of required units for scaling-up the chemical processes is reduced. Using the approach described in the present research, anyone could produce their own millireactor for chemical process in a simple way with the aid of a 3D printer.
文摘Passive micromixers are preferred over active mixers for many microfluidic applications due to their relative ease in integration into complex systems and operational flexibility.They also incur very low cost of manufacturing.However,the degree of mixing is comparatively low in passive mixers than active mixers due to the absence of disturbance in the flow by external forces and the inherent laminar nature of microchannel flows.Various designs of complex channel structures and three-dimensional geometries have been investigated in the past to obtain an efficient mixing in passive mixers.But the studies on mixing enhancement with simple planar geometries of passive mixers have been few and limited.The present work aims to investigate the possibility of mixing enhancement by employing simple planar type designs,such as T-mixer and T–T mixer with cylindrical elements placed in the mixing channel.The mixing performance has been evaluated in the Reynolds number range of 6 to700.Numerical results have shown that T–T mixer with cylindrical elements performed significantly well and obtained very good mixing quality over basic T-mixer for the entire range of Reynolds number(6 to 700).The device has also shown better mixing as compared to basic T–T mixer and T-mixer with cylindrical elements.A larger pair of vortices formed in the stagnation area due to the presence of a cylindrical element in the junction.Cylindrical elements downstream caused significant enhancement in mixing due to splitting and recombining action.The size of the cylindrical element in the T–T mixer has been optimized to obtain better mixing performance of the device.Remarkable improvement in mixing quality by T–T mixer with cylindrical elements has been obtained at the expense of small rise in pressure drop as compared to other passive designs considered in this study.Therefore,the current design of T–T mixer with cylindrical elements can act as an effective and simple passive mixing device for various micromixing applications.
基金Supported by the National Natural Science Foundation of China(21576012)the National Key Research and Development Program of China(2017YFB0307202)
文摘Microchannel reactors are widely used in different fields due to their intensive micromixing and, thus, high masstransfer efficiency. In this work, a single countercurrent-flow microchannel reactor(S-CFMCR) at the size of ~1 mm was developed by steel micro-capillary and laser drilling technology. Utilizing the Villermaux/Dushman parallel competing reaction, numerical and experimental studies were carried out to investigate the micromixing performance(expressed as the segregation index XS) of liquids inside S-CFMCR at the low flow velocity regime.The effects of various operating conditions and design parameters of S-CFMCR, e.g., inlet Reynolds number(Re),volumetric flow ratio(R), inlet diameter(d) and outlet length(L), on the quality of micromixing were studied qualitatively. It was found that the micromixing efficiency was enhanced with increasing Re, but weakened with the increase of R. Moreover, d and L also have a significant influence on micromixing. CFD results were in good agreement with experimental data. In addition, the visualization of velocity magnitude, turbulent kinetic energy and concentration distributions of various ions inside S-CFMCR was illustrated as well. Based on the incorporation model, the estimated minimum micromixing time tmof S-CFMCR is ~2 × 10-4s.
文摘In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter the micromixer by fluid flows and are actuated by an alternating magnetic field normal to the main flow. An important feature of micromixer which is not considered before by researchers is the particle entrance arrangement into the micromixer. This parameter could effectively affect the micromixer efficiency. There are two general micro magnetic particle entrance arrangements in magnetic bead micromixers: determined position entrance and random position entrance. In the case of determined position entrances, micro magnetic particles enter the micromixer at specific positions of entrance cross section. However, in a random position entrance,particles enter the microchannel with no order. In this study mixing efficiencies of identical magnetic bead micromixers which only differ in particle entrance arrangement are numerically investigated and compared.The results reported in this paper illustrate that the prepared computer code can be one of the most powerful and beneficial tools for the magnetic bead micromixer performance analysis. In addition, the results show that some features of the magnetic bead micromixer are strongly affected by the entrance arrangement of the particles.
基金Supported by the National Natural Science Foundation of China and China Petrochemical Corporation.
文摘1 INTRODUCTIONIn Part Ⅰ of this study,the physical aspects for micro-and macromixing were outlined,a shrinkage slab model for micromixing was presented and a three-region picturecharacterizing interaction between micro-and macromixing was sketched.The feed ma-terial from a point source was shown to successively undergo the dispersion,micromixing and macromixing regions before achieving homogeneity on the
基金the National Natural Science Foundation of China(10372099)
文摘This paper studied a concept of micromixer with a synthetic jet placed at the bottom of a rectangular channel. Due to periodic ejections from and suctions into the channel, the fluids are mixed effectively. To study the effects of the inlet velocity, the jet intensity and frequency, and the jet location on the mixing efficiency, 3-D numerical simulations of the micromixer have been carried out. It has been found that when the jet intensity and the frequency are fixed, the mixing efficiency increases when Re 〈 50, and decreases when Re 〉 50 with the best mixing efficiency achieved at Re = 50. When the ratio of the jet velocity magnitude to the inlet velocity is taken as 10 and the jet frequency is 100 Hz, the mixing index reaches the highest value. It has also been found that to get better mixing efficiency, the orifice of the synthetic jet should be asymmetrically located away from the channel's centerline.
基金supported by the National Natural Science Foundation of China(51775196)Guangdong Province Science and Technology Project(2017B090912003,2017B090911014)+3 种基金High-level Personnel Special Support Plan of Guangdong Province(2016TQ03X289)Guangzhou Star of Pearl River Talent Project(201710010064)the Fundamental Research Funds for the Central Universities(Project Nos.2018ZD30,2019MS060)Guangzhou Science and Technology Project(201704030097).
文摘In this paper,a novel micromixer with complex 3D-shape inner units was put forward and fabricated by metal Additive Manufacturing(AM).The design of the micromixer combined the constraints of selective laser melting technology and the factors to improve mixing efficiency.Villermaux-Dushman reaction system and Compute Fluid Design(CFD)simulation were conducted to investigate the performance and the mechanism of this novel micromixer to improve mixing efficiency.The research found that the best mixing efficiency of this novel micromixer could be gained when the inner units divided fluid into five pieces with a uniform volume.Compared with a conventional micromixer without obstacle in the channel,the micromixer designed in this research achieved higher mixing efficiency and reduce the pressure drop by 10.34%.The mixing behaviour in this novel micromixer was discussed,which mainly contains two types:collisions and swirls.Via collisions,the fluid micro masses would hit each other directly,which broke the boundaries of micro masses and promoted the interchange of species in the whole flow field.In swirls,the fluid micro masses were drawn into thin and long slices,which increased the size of the contact area and enhanced molecule diffusion.Finally,the application scheme of this novel micromixer was briefly discussed.
基金Supported by the National Natural Science Foundation of China and China Petrochemical Corporation.
文摘1 INTRODUCTION When a fluid is injected into a turbulence field to mix with another fluid,twohomogenization processes take place simultaneously:micromixing(on the molecularscale)and macromixing(on the mixer scale).For micromixing,three successive stages arerecognized at high Schmidt number(1)turbulent dispersion,in which the original ma-terial lumps are dispersed by turbulence into discrete elements with smallest eddy sizeλ_k;(2)viscous deformation,in which the size of the elements is further
基金partially supported by the North American Mixing Forum (NAMF), NSF CAREER (CBET-0954977)the National Natural Science Foundation of China(21705055)+1 种基金Science and Technology Development Planning Program of Jilin Province(20190201178JC)Jilin Province Industrial Technology Research and Development Project(2019C048-5)
文摘Electrokinetic(EK)micromixers have been widely studied in the past decade for biochemical applications,biological and chemical analysis,etc.Unfortunately,almost all EK mixers require different electrical conductivity between the two fluids to be mixed,which has greatly limited their wide applications,in cases where the two streams to be mixed have equivalent electrical conductivity.Here we show that mixing enhancement between two fluids with identical conductivity can be achieved in an EK micromixer with conductive sidewalls,where the electric field is in transverse direction of the flow.The results revealed that the mixing became stronger with increased conductivity value.This mixing method provides a novel and convenient strategy for mixing two liquids with the same or similar electrical conductivity in microfluidic systems,and could potentially serves as a powerful tool for sample preparation in applications such as liquid biopsy,and environmental monitoring,etc.
基金supported by the National Natural Science Foundation of China(No.11772343)the Beijing Institute of Technology Research Fund Program for Young Scholars.
文摘Staggered herringbone micromixer has shown good efficiency of mixing and performance of synthesizing nanoparticles.To bring a detailed understanding of the mixing dynamics and syn-thesis performance of this kind of micromixer,this paper carries out a high-fidelity numerical simu-lation and a parametrial experimental study on a well-established design.A passive tracer is induced in the numerical simulation to analyze mixing dynamics induced by the staggered herring-bone structures.Three effects are identified to reveal the underlying mechanisms,including folding,stretching,and splitting.To the authors’knowledge,the splitting effect is identified for the first time by the isosurface of the passive tracer,to show the high efficiency of the staggered herring-bone design.The micromixer is then used to synthesize lipid nanoparticles by mixing a mixture of lipid and poly(lactic-co-glycolic acid)(PLGA)solutions with deionized water.Under a wide mass ratio of lipid and PLGA solutions,nanoparticles with good monodispersity are synthesized to reflect the good compatibility of the micromixer and the mixture.In addition,an optimized mass ratio is identified from the parametrical experiment.
文摘The competitive iodide/iodate reaction scheme was used to ascertain the micromixing in the stirred solid-liquid systems. Two different glass beads from 450 to 1250 μm were tested. The effect of solid particles on reaction selectivity with multiple impellers at different feed points has been investigated. It was confirmed that glass beads as a second phase were suitable for the study. The segregation index has changed significantly only for the medium-sized particles at relatively high solid holdups. The cloud formation was clearly observed for the medium-sized particles at a concentration of 12.12 wt. %. When feeding into the clear liquid above the cloud, the value of the segregation index increased significantly. However, in the presence of particles of 1-1.25 mm, the influence on the selectivity was negligible when the agitation speed was increased.
基金supported by the Shanghai Beyond Limits Manufacturing Projectthe National Natural Science Foundation of China(Nos.11502044, U1906233)+2 种基金the Fundamental Research Funds for the Central Universities (No.DUT22JC08)Dalian city supports innovation and entrepreneurship projects for high-level talents (No.2021RD16)Liaoning Province’s Xing Liao Talents Program (No.XLYC2002108)。
文摘Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been shown to be affected by the shear effect, the shear effect triggering conditions in gasliquid two-phase flow is unclear and the aggregation behavior of nanoparticles under the shear effect is difficult to predict, resulting in uncontrollable physical and chemical properties of nanoparticle aggregates. In this study, a numerical simulation of nanoparticle aggregation in gas-liquid two-phase flow under the shear effect is performed using the CFD-DEM method. Then, the effects of total flow rate,gas-liquid two-phase flow ratio, and particle volume fraction on particle aggregation were analyzed to achieve control of particle aggregation shape and size. Meanwhile, the triggering mechanism of the shear effect and the mechanism of the shear effect on the aggregation of nanoparticles were clarified. The results show that increasing the total flow rate or decreasing the gas-liquid two-phase flow rate ratio can induce the shear effect, which reduces the particle aggregation size and makes the morphology tend to be spherical. Moreover, increasing the particle volume fraction, and total flow rate or decreasing the gas-liquid two-phase flow rate ratio also increases the number of particle collisions and induce interparticle adhesion. Hence, particle adhesion and the shear effect compete with each other and together affect particle aggregation.
基金supported by the National Natural Science Foundation of China(No.22278087)。
文摘Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃ in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity.
基金supported by the National Key Research and Development Program of China(No.2018YFA0703000)the National Natural Science Foundation of China(No.52275294).
文摘The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is underscored by the complexity of in vivo tissues,which exhibit heterogeneous structures comprised of diverse cells and matrices.Drawing inspiration from the classical Tesla valve,our study introduces a new concept of micromixers to address this complexity.The innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian fluids.Notably,our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles,which represents a significant improvement over the traditional mixing method.This advance is pivotal for the field of 3D printing and bioprinting,and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues.
文摘The mechanism of diffusion and mixing in the micro-channel flow was studied numerically and experimentally in detail. Based on the theoretical and computational results, the micro-mixers with high efficiency were designed. The conclusions drawn from this thesis are helpful for the practical usage.