该文介绍了麻省理工计算生理学实验室、哈佛医学院BID医学中心以及飞利浦医疗合作建立的、开源的、多参数智能重症监护数据库Multiparameter Intelligent Monitoring in Intensive Care II:MIMIC-II,简单介绍了其结构、功能和临床应用...该文介绍了麻省理工计算生理学实验室、哈佛医学院BID医学中心以及飞利浦医疗合作建立的、开源的、多参数智能重症监护数据库Multiparameter Intelligent Monitoring in Intensive Care II:MIMIC-II,简单介绍了其结构、功能和临床应用。基于MIMIC-II临床数据库,开展了ICU脓毒血症病人血压和心率的昼夜节律性研究。该研究发现了脓毒血症患者死亡组和存活组在生理参数昼夜节律性上的显著性差异,解决了使用关系型数据库MIMIC-II开展生理参数昼夜节律性研究的很多技术问题。展开更多
Three complexes of Mn（Ⅱ）with L-amino acid[L-Isoleucine（L-Ile）,L-Methionine（L-Met）,L-Tryptophan（L-Trp）]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses....Three complexes of Mn（Ⅱ）with L-amino acid[L-Isoleucine（L-Ile）,L-Methionine（L-Met）,L-Tryptophan（L-Trp）]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses.The catalytic activity of the three complexes for disproportionation of O2-was determined by NBT method.The result shows that the complexes have a high SOD-like activity,and the KQ values of complexes 1,2 and 3 are 0.78×107mol-1·L·s-1,1.28×107mol-1,and 1.50×107mol-1L·s-1,respectively.展开更多
Two cobalt（Ⅱ） complexes of the Schiff base with morpholino or aza-crown ether pendants, CoL^1 and CoL^2, as mimic hydrolytic metalloenzyme, were used in catalytic hydrolysis of carboxylic ester （PNPP）. The analys...Two cobalt（Ⅱ） complexes of the Schiff base with morpholino or aza-crown ether pendants, CoL^1 and CoL^2, as mimic hydrolytic metalloenzyme, were used in catalytic hydrolysis of carboxylic ester （PNPP）. The analysis of specific absorption spectra of the hydrolytic reaction systems indicates that key intermediates, made up of PNPP and Co（Ⅱ） complexes, have been formed in reaction processes of the PNPP catalytic hydrolysis. The mechanism of PNPP catalytic hydrolysis has been proposed based on the analytic result of specific absorption spectrum. A kinetic mathematical model, applied to the calculation of the kinetic parameter of PNPP catalytic hydrolysis, has been established based on the mechanism proposed. The acid effect of buffer solution, structural effect of the complexes, and effect of temperature on the rate of PNPP hydrolysis catalyzed by the complexes have been also discussed.展开更多
Three novel Schiff base cobalt（Ⅱ） complexes containing benzoaza-15-crown-5, CoL^1, CoL^2 and CoL^3 were synthesized and characterized, and these complexes were used in catalytic hydrolysis of carboxylic ester （PNP...Three novel Schiff base cobalt（Ⅱ） complexes containing benzoaza-15-crown-5, CoL^1, CoL^2 and CoL^3 were synthesized and characterized, and these complexes were used in catalytic hydrolysis of carboxylic ester （PNPP, p-nitrophenyl picolinate） as mimic hydrolytic metalloenzyme. The analysis of specific absorption spectra of the hydrolytic reaction systems indicated that the catalytic hydrolysis involved the key intermediates formed by PNPP with cobalt（Ⅱ） complexes. The CoL^3 bearing the electron withdrawing group shows better catalytic activity due to its stabilization effect on active species MLS^-. The catalytic mechanism of PNPP hydrolysis was also proposed. The kinetic parameter of PNPP catalytic hydrolysis has been calculated and the activation energy for the catalytic hydrolysis is 43.69, 39.76 and 35.44 kJ·mol^-1, respectively.展开更多
文摘该文介绍了麻省理工计算生理学实验室、哈佛医学院BID医学中心以及飞利浦医疗合作建立的、开源的、多参数智能重症监护数据库Multiparameter Intelligent Monitoring in Intensive Care II:MIMIC-II,简单介绍了其结构、功能和临床应用。基于MIMIC-II临床数据库,开展了ICU脓毒血症病人血压和心率的昼夜节律性研究。该研究发现了脓毒血症患者死亡组和存活组在生理参数昼夜节律性上的显著性差异,解决了使用关系型数据库MIMIC-II开展生理参数昼夜节律性研究的很多技术问题。
文摘Three complexes of Mn（Ⅱ）with L-amino acid[L-Isoleucine（L-Ile）,L-Methionine（L-Met）,L-Tryptophan（L-Trp）]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses.The catalytic activity of the three complexes for disproportionation of O2-was determined by NBT method.The result shows that the complexes have a high SOD-like activity,and the KQ values of complexes 1,2 and 3 are 0.78×107mol-1·L·s-1,1.28×107mol-1,and 1.50×107mol-1L·s-1,respectively.
基金Project supported by the Educational Department of Sichuan Government （No.2005D007） and the National Natural Science Foundation of China （Nos.20173038, 20107004）.
文摘Two cobalt（Ⅱ） complexes of the Schiff base with morpholino or aza-crown ether pendants, CoL^1 and CoL^2, as mimic hydrolytic metalloenzyme, were used in catalytic hydrolysis of carboxylic ester （PNPP）. The analysis of specific absorption spectra of the hydrolytic reaction systems indicates that key intermediates, made up of PNPP and Co（Ⅱ） complexes, have been formed in reaction processes of the PNPP catalytic hydrolysis. The mechanism of PNPP catalytic hydrolysis has been proposed based on the analytic result of specific absorption spectrum. A kinetic mathematical model, applied to the calculation of the kinetic parameter of PNPP catalytic hydrolysis, has been established based on the mechanism proposed. The acid effect of buffer solution, structural effect of the complexes, and effect of temperature on the rate of PNPP hydrolysis catalyzed by the complexes have been also discussed.
基金Project supported by the Educational Department of Sichuan Government （No. 2005D007） and the National Natural Science Foundation of China （Nos. 20173038, 20107004）.
文摘Three novel Schiff base cobalt（Ⅱ） complexes containing benzoaza-15-crown-5, CoL^1, CoL^2 and CoL^3 were synthesized and characterized, and these complexes were used in catalytic hydrolysis of carboxylic ester （PNPP, p-nitrophenyl picolinate） as mimic hydrolytic metalloenzyme. The analysis of specific absorption spectra of the hydrolytic reaction systems indicated that the catalytic hydrolysis involved the key intermediates formed by PNPP with cobalt（Ⅱ） complexes. The CoL^3 bearing the electron withdrawing group shows better catalytic activity due to its stabilization effect on active species MLS^-. The catalytic mechanism of PNPP hydrolysis was also proposed. The kinetic parameter of PNPP catalytic hydrolysis has been calculated and the activation energy for the catalytic hydrolysis is 43.69, 39.76 and 35.44 kJ·mol^-1, respectively.
