Continuous glucose monitoring metrics in pregnancy with type 1 diabetes mellitus

Managing diabetes during pregnancy is challenging,given the significant risk it poses for both maternal and foetal health outcomes.While traditional methods involve capillary self-monitoring of blood glucose level monitoring and periodic HbA1c tests,the advent of continuous glucose monitoring(CGM)systems has revolutionized the approach.These devices offer a safe and reliable means of tracking glucose levels in real-time,benefiting both women with diabetes during pregnancy and the healthcare providers.Moreover,CGM systems have shown a low rate of side effects and high feasibility when used in pregnancies complicated by diabetes,especially when paired with continuous subcutaneous insulin infusion pump as hybrid closed loop device.Such a combined approach has been demonstrated to improve overall blood sugar control,lessen the occurrence of preeclampsia and neonatal hypoglycaemia,and minimize the duration of neonatal intensive care unit stays.This paper aims to offer a comprehensive evaluation of CGM metrics specifically tailored for pregnancies impacted by type 1 diabetes mellitus.

Home Monitoring of Estrone-3-Glucuronide (E1-3G) Levels in Two Different Ovarian Stimulation Protocols: A Pilot Study

Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3G in ovarian stimulation and focused on their experimental verification and analysis. Methods: A prospective, observational pilot study was conducted involving 54 patients who underwent 54 cycles of ovarian stimulation. The goal was to establish the growth rate of urinary E1-3G during the course of stimulation and to determine the daily upper and lower limits of growth rates at which stimulation is appropriate and safe. Controlled ovarian stimulation was performed using two different stimulation protocols—an antagonist protocol in 25 cases and a progestin-primed ovarian stimulation protocol (PPOS) in 29 cases, with fixed doses of gonadotropins. From the second day of stimulation, patients self-measured their daily urine E1-3G levels at home using a portable analyzer. In parallel, a standard ultrasound follow-up protocol accompanied by a determination of E2, LH, and P levels was applied to optimally control stimulation. Results: The average daily growth rates in both groups were about 50%. The daily increase in E1-3G for the antagonist protocol ranged from 14% to 79%, while they were 28% to 79% for the PPOS protocol. Conclusion: This is the first study to analyze the dynamics of E1-3G in two different protocols and to estimate the limits of its increase during the entire course of the stimulation. The results confirm our theoretical model for the viability of using urinary E1-3G for monitoring ovarian stimulation.

基于持续扫描式葡萄糖监测系统探讨二甲双胍对青春期T1DM患儿的应用价值

目的基于持续扫描式葡萄糖监测系统探讨二甲双胍联合胰岛素注射液治疗青春期1型糖尿病(T1DM)儿童的疗效。方法2018年1月至2023年5月门诊随访的青春期T1DM儿童99例,48例胰岛素联合盐酸二甲双胍片治疗为观察组,51例单用胰岛素治疗为对照组。比较两组儿童各项临床资料、监测指标及安全性。结果在3个月随访时观察组、对照组平均目标范围内时间(TIR)分别为76.6%±9.1%、65.9%±15.0%,中位高血糖时间(TAR)两组分别为7.0%(3.0%~14.3%)、21.0%(12.0%~29.0%),平均低血糖时间(TBR)两组分别为14.5%±7.1%、10.2%±6.8%,在6个月随访时观察组、对照组平均TIR两组分别为76.0%±8.9%、65.5%±14.3%,中位TAR两组分别为8.0%(3.3%~13.8%)、24.0%(15.0%~29.0%),平均TBR两组分别为14.4%±5.9%、10.0%±6.8%,以上变量两组间差异均有统计学意义(P均<0.05)。观察组两次随访中位胰岛素用量低于对照组。48例观察组患儿两次随访时中位胰岛素用量、中位BMI、平均TIR、平均TBR均高于其基线水平,中位TAR水平低于自身基线水平,以上变量差异均有统计学意义(P均<0.05)。观察组4例(8.33%)出现胃肠道症状,无严重低血糖发生。结论二甲双胍联合胰岛素治疗方案,可以有效提高青春期T1DM儿童TIR。TBR水平增加,并不增加严重低血糖风险,安全性良好。二甲双胍联合胰岛素治疗对青春期T1DM儿童是一种可行的选择。

Perspective of Chinese GF-1 high-resolution satellite data in agricultural remote sensing monitoring

High-resolution satellite data have been playing an important role in agricultural remote sensing monitoring. However, the major data sources of high-resolution images are not owned by China. The cost of large scale use of high resolution imagery data becomes prohibitive. In pace of the launch of the Chinese ＂High Resolution Earth Observation Systems＂, China is able to receive superb high-resolution remotely sensed images （GF series） that equalizes or even surpasses foreign similar satellites in respect of spatial resolution, scanning width and revisit period. This paper provides a perspective of using high resolution remote sensing data from satellite GF-1 for agriculture monitoring. It also assesses the applicability of GF-1 data for agricultural monitoring, and identifies potential applications from regional to national scales. GF-1＇s high resolution （i.e., 2 m/8 m）, high revisit cycle （i.e., 4 days）, and its visible and near-infrared （VNIR） spectral bands enable a continuous, efficient and effective agricultural dynamics monitoring. Thus, it has gradually substituted the foreign data sources for mapping crop planting areas, monitoring crop growth, estimating crop yield, monitoring natural disasters, and supporting precision and facility agriculture in China agricultural remote sensing monitoring system （CHARMS）. However, it is still at the initial stage of GF-1 data application in agricultural remote sensing monitoring. Advanced algorithms for estimating agronomic parameters and soil quality with GF-1 data need to be further investigated, especially for improving the performance of remote sensing monitoring in the fragmented landscapes. In addition, the thematic product series in terms of land cover, crop allocation, crop growth and production are required to be developed in association with other data sources at multiple spatial scales. Despite the advantages, the issues such as low spectrum resolution and image distortion associated with high spatial resolution and wide swath width, might pose challenges for GF-1 data applications and need to be addressed in future agricultural monitoring.

Glucagon-like peptide-1 receptor agonists as a possible intervention to delay the onset of type 1 diabetes:A new horizon

Type 1 diabetes(T1D)is a chronic autoimmune condition that destroys insulinproducing beta cells in the pancreas,leading to insulin deficiency and hyperglycemia.The management of T1D primarily focuses on exogenous insulin replacement to control blood glucose levels.However,this approach does not address the underlying autoimmune process or prevent the progressive loss of beta cells.Recent research has explored the potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)as a novel intervention to modify the disease course and delay the onset of T1D.GLP-1RAs are medications initially developed for treating type 2 diabetes.They exert their effects by enhancing glucose-dependent insulin secretion,suppressing glucagon secretion,and slowing gastric emptying.Emerging evidence suggests that GLP-1RAs may also benefit the treatment of newly diagnosed patients with T1D.This article aims to highlight the potential of GLP-1RAs as an intervention to delay the onset of T1D,possibly through their potential immunomodulatory and anti-inflammatory effects and preservation of beta-cells.This article aims to explore the potential of shifting the paradigm of T1D management from reactive insulin replacement to proactive disease modification,which should open new avenues for preventing and treating T1D,improving the quality of life and long-term outcomes for individuals at risk of T1D.

基于Cat.1技术与阵列式位移计的深基坑监测方法与应用

深基坑开挖的危险系数高,容易引发安全事故,需要采用有效的地质灾害监测系统。为实现深基坑施工阶段变形的有效监测与预警,提出了采用基于Cat.1技术与阵列式位移计的无线自动化监测方法。首先通过与传统的LoRa通信技术对比,分析了Cat.1技术的特点和优势。然后把Cat.1技术与阵列式位移计共同应用于基坑监测,建立了监测系统。最后,以某深基坑监测项目为例,分析了代表性测点的水平位移监测结果。结果表明,所建立的监测系统能够稳定地采集监测数据并上传至监测平台,实时反映基坑测点水平位移变化规律,且监测结果的可解释性高,有助于及时发出预警信号,做好风险防范措施。

双极化Sentinel-1数据在城市沉降监测中的对比研究

目的 针对地面沉降监测仅考虑VV极化Sentinel-1数据而忽略VH极化数据的问题,方法采用PS-InSAR和SBAS-InSAR技术处理延安新区2018年8月—2021年5月的84景双极化Sentinel-1数据,获取地面沉降信息,对比两种极化的沉降监测结果,探讨VH极化在不同实验方法中的意义,并提出一种双极化时序InSAR融合监测新方法。结果 结果表明,新区大部分区域为较稳定区域,形变速率为-8~8 mm/a,此外,还探测到3个较大的沉降区,分别位于桥儿沟流域、高家沟流域和新区东北部填方区域;Sentinel-1不同极化数据的监测结果相关性较高,形变趋势一致;VV极化数据整体优于VH极化,但部分区域VH极化数据得到的地表形变信息更详细;VV-VH极化PS-InSAR形变监测中,VH极化数据能够有效补充VV极化数据监测结果的不足,使结果更加密集,因此,与单一极化监测结果相比,VV-VH极化PS-InSAR形变监测更加详细地反演了地表变形情况;VV-VH极化SBAS-InSAR形变速率结果比单一极化数据相干性和稳定性更高。结论 基于双极化Sentinel-1数据的时序InSAR融合监测技术可以获得比单一极化数据更好的城市地表形变监测结果。

Design of online control and monitoring software for the CPPF system in the CMS Level-1 trigger upgrade

The concentration preprocessing and fan-out(CPPF) system is one of the electronic subsystems of the upgraded Compact Muon Solenoid(CMS) Level-1 trigger system. It includes, in hardware, eight specially designed CPPF cards, one CMS card called AMC13, one commercial Micro-TCA Carrier HUB(MCH) card, and a MicroTCA shelf. Powerful online software is needed for the system, including providing reliable configuration and monitoring for the hardware, and a graphical interface for executing all actions and publishing monitoring messages.Further, to control and monitor the large amount of homogeneous hardware, the SoftWare Automating conTrol of Common Hardware(SWATCH) concept was proposed and developed. The SWATCH provides a generic structure and is flexible for customization. The structure includes a hardware access library based on the IPbus protocol, which assumes a virtual 32-bit address/32-bit data bus and builds a simple hardware access layer. Furthermore, the structure provides a graphical user interface, which is based on modern web technology and is accessible by web page. The CPPF controlling and monitoring online software was also customized from a common SWATCH cell, and provides afinite state machine(FSM) for configuring the entire CPPF hardware, and five monitoring objects for periodically collecting monitoring data from five main functional modules in the CPPF hardware. This paper introduces the details of the CPPF SWATCH cell development.

基于Sentinel-1和Sentinel-2数据融合的森林林龄反演和动态监测

【目的】在Google Earth Engine(GEE)云平台上借助其强大的计算和数据存储能力,融合多源遥感数据对森林林龄进行遥感反演和动态监测。【方法】融合2017—2023年间Sentinel-1、Sentinel-2及高程数据,通过随机森林(Random forest,RF)分类获取土地覆盖信息,并进一步提取森林的分布和面积,同时构建时间序列植被指数来准确提取森林变化区域。基于森林资源清查数据和融合的多源遥感数据,在GEE上构建RF回归、分类回归树(Cart)以及梯度提升回归树(Gradient tree boost,GTB)3种回归模型,用于杉木组、马尾松组、毛竹林、硬阔叶树组以及其他类树种组的2018年林龄遥感反演,并估算出2017年和2023年的林龄信息,以揭示林龄和龄组在2017—2023年的动态变化情况。【结果】1)2017—2023年,研究区森林面积的整体变化总计113.93 km^(2),此间森林的减少和更新并存,其空间分布特征呈现出明显的区域差异。具体而言,森林面积变化多发生于靠近城区和低海拔地区,且靠近城区的森林面积减少往往不再恢复至森林;2)在5种不同树种组构建的3种模型中,RF回归模型的林龄反演结果最佳,平均R^(2)为0.845,平均RMSE为5.32 a,其中毛竹林反演精度最高,R^(2)为0.863,RMSE为2.411 a;3)2017—2023年,研究区林龄在40 a以下的森林由54.59%减少至51.06%,其中龄组变化最显著为杉木组成熟林,面积增加了38.88%。【结论】在GEE上融合多源遥感数据进行林龄反演和动态监测具有重要的应用潜力,本研究结果可为使用云平台及哨兵系列卫星数据对森林资源长时间序列的林龄反演和动态监测的应用提供参考和借鉴。

Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice:One-year observational study

BACKGROUND In 2016,the Food and Drug Administration approved the first hybrid closed-loop(HCL)insulin delivery system for adults with type 1 diabetes(T1D).There is limited information on the impact of using HCL systems on patient-reported outcomes(PROs)in patients with T1D in real-world clinical practice.In this independent study,we evaluated glycemic parameters and PROs over one year of continuous use of Medtronic’s 670G HCL in real-world clinical practice.AIM To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with T1D.METHODS We evaluated 71 patients with T1D(mean age:45.5±12.1 years;59%females;body weight:83.8±18.7 kg,body mass index:28.7±5.6 kg/m2,A1C:7.6%±0.8%)who were treated with HCL at Joslin Clinic from 2017 to 2019.We measured A1C and percent of glucose time-in-range(%TIR)at baseline and 12 months.We measured percent time in auto mode(%TiAM)for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes management.RESULTS At 12 mo,A1C decreased by 0.3%±0.1%(P=0.001)and%TIR increased by 8.1%±2.5%(P=0.002).The average%TiAM was only 64.3%±32.8%and was not associated with A1C,%TIR or PROs.PROs,provided at baseline and at the end of the study,showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9%(P<0.001).Hypoglycemia fear survey/worry scale decreased significantly by 24.9%(P<0.000);Problem Areas In Diabetes reduced significantly by-17.2%(P=0.002).The emotional burden submodules of dietary diversity score reduced significantly by-44.7%(P=0.001).Furthermore,analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic episodes.WHO-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL system.Finally,analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality,sleep latency,or duration of sleep from baseline to 12 mo.CONCLUSION The use of HCL in real-world clinical practice for one year was associated with significant improvements in A1C,%TIR,physical functioning,hypoglycemia fear,emotional distress,and emotional burden related to diabetes management.However,these changes were not associated with time in auto mode.

Factors influencing the effectiveness of using flash glucose monitoring on glycemic control for type 1 diabetes in Saudi Arabia

BACKGROUND In 2017,35000 Saudi children and adolescents were living with a type 1 diabetes(T1D)diagnosis.Diabetic complications are minimized upon strengthened glycemic regulation.The annual cost of treating diabetic patients with complications was four-fold higher than for patients without complications.The use of flash glucose monitoring(FGM)enables better diabetes treatment and thereby improves glycemic control.Understanding the factors that affect effectiveness of FGM will help enhance the device’s use and management of hospital resources,resulting in improved outcomes.AIM To investigate factors that affect effectiveness of the FGM system for glycated hemoglobin(HbA1c)levels/glycemic control among T1D patients.METHODS A retrospective empirical analysis of T1D patient records from King Abdul-Aziz University Hospital and Prince Sultan Military Medical City was performed.T1D patients who began FGM between 2017 and 2019 were included.RESULTS The data included 195 T1D patients(70 males and 125 females)with a mean age of 23.6±8.1 years.Among them,152 patients used multiple daily injection and 43 used an insulin pump.The difference in HbA1c level from baseline and after using FGM was-0.60±2.10,with a maximum of 4.70 and a minimum of-6.30.There was a statistically significant negative correlation between the independent variables(age,duration of diabetes,level of engagement)and HbA1c.The group with the highest HbA1c mean(9.85)was 18-years-old,while the group with the lowest HbA1c mean(7.87)was 45-years-old.Patients with a low level of engagement(less than six scans per day)had the highest HbA1c mean(9.84),whereas those with a high level of engagement(more than eight scans per day)had the lowest HbA1c mean(8.33).CONCLUSION With proper education,FGM can help people with uncontrolled T1D over the age of 18 years to control their glucose level.

Flood disaster monitoring based on Sentinel-1 data:A case study of Sihu Basin and Huaibei Plain,China

Summer floods occur frequently in many regions of China,affecting economic development and social stability.Remote sensing is a new technique in disaster monitoring.In this study,the Sihu Basin in Hubei Province of China and the Huaibei Plain in Anhui Province of China were selected as the study areas.Thresholds of backscattering coefficients in the decision tree method were calculated with the histogram analysis method,and flood disaster monitoring in the two study areas was conducted with the threshold method using Sentinel-1 satellite images.Through satellite-based flood disaster monitoring,the flooded maps and the areas of expanded water bodies and flooded crops were derived.The satellite-based monitoring maps were derived by comparing the expanded area of images during a flood disaster with that before the disaster.The difference in spatiotemporal distribution of flood disasters in these two regions was analyzed.The results showed that flood disasters in the Sihu Basin occurred frequently in June and July,and flood disasters in the Huaibei Plain mostly occurred in August,with a high interannual vari-ability.Flood disasters in the Sihu Basin were usually widespread,and the affected area was between Changhu and Honghu lakes.The Huaibei Plain was affected by scattered disasters.The annual mean percentages of flooded crop area were 14.91%and 3.74% in the Sihu Basin and Huaibei Plain,respectively.The accuracies of the extracted flooded area in the Sihu Basin in 2016 and 2017 were 96.20% and 95.19%,respectively.

Application of MOS-1b/MESSR data to flood monitoring of Dongting Lake

Taking Dongting Lake district as the studying area and utilizing multi-temporal MOS-lb/MESSR data as remote sensing info source, by the combination operation and ratio transform processing and the image, spectrum and histogram comparison of the MESSR image data of all bands for the flood season and dry season with the ER-DAS IMAGINE system, a classification model was established, which can be used to acquire the spatial distributing information of water bodies. Meanwhile a water depth index model was derived and built, and then a model for detecting the depth of water body based on the non-linear recursive analysis was presented. By the overlay analysis of the classification thematic images based on the model for extracting flood information, the flooding area and distributing information were acquired.

基于GF-1卫星影像的青岛市冬小麦种植面积变化动态监测

为准确获取青岛市冬小麦种植面积及空间分布变化特点,帮助相关部门优化种植结构,合理安排农业生产,研究利用GF-1 WFV卫星遥感影像,选择青岛市2014—2021年冬小麦种植面积遥感提取的最佳时相,采用图像监督分类法提取冬小麦的种植面积,并通过分类后比较法分析小麦种植面积的动态变化。结果表明:2014—2021年青岛市冬小麦的种植面积为21.7万~24.8万hm^(2),2016年小麦种植面积最大,2020年最小,每年冬小麦种植面积波动范围为0.3万~2.7万hm^(2);遥感提取的种植面积与统计部门提供的种植面积误差较小,误差百分率不超过6.5%;小麦与其他地物类型之间相互转换的差异很小,2014—2021年逐年小麦转为其他地物的面积变化范围为8.0万~10.9万hm^(2),其他地物转为小麦的面积变化范围为7.9万~11.4万hm^(2)。

The Impact of the FreeStyle LibreTM Flash Glucose Monitoring System on Glycemic Control in Patients with Diabetes;Observational Multicenter 15-Months Study

Objectives: The study was to determine the impact of using the FreeStyle LibreTM flash glucose monitoring system on glycemic control and the rate of events due to diabetes in people with diabetes from different types and age groups. Methods: a retrospective cohort chart review study was carried out at three centers in the Taif region in the Kingdom of Saudi Arabia: The study was approved by an accredited centralized institutional review board. Paper or electronic medical records were included for individuals of any age with diabetes (type 1, type 2, gestational diabetes) managed with diet, insulin therapy, or/and oral antihyperglycemic medication and/or non-insulin injection therapy. The primary outcome measure was the laboratory HbA1c level as well as reduction. Secondary outcome measures were frequency of severe hypoglycemia, admission to hospital or ER visit related to diabetes complications, and severe hyperglycemia (DKA or HHS). Results: Data was analyzed from 1695 patients. The average HbA1c before using the flash glucose monitoring system was 9.60% ± 1.44% and 3 months HbA1c after using the FreeStyle LibreTM flash glucose monitoring system was 8.70% + 1.45% for a difference of -0.90% ([95% CI -0.92: -0.88];p 65 years, (p-values Conclusion: The benefits of using the FreeStyle LibreTM flash glucose monitoring system are self-evident in reducing HbA1c and events due to hyperglycemia or hypoglycemia.

基于Sentinel-1A 数据的土地利用变化监测

广东多云雨天气造成光学遥感数据持续获取困难,合成孔径雷达(SAR)能够弥补光学影像缺失导致的土地利用高频次监测更新不及时、存在监测盲区的问题。哨兵一号(Sentinel-1)卫星数据可在欧洲空间局官网免费下载,虽然成本低、获取容易,但变化检测精度低,实际应用困难,本文提出一种综合Sentinel-1A的强度信息、相位信息和外部高程信息的新增房屋识别方法。首先对SAR影像进行预处理得到后向散射系数图,采用对数比值法对多时相影像构造差异图,再使用阈值分割算法提取变化区域。然后利用复数图像和数字高程模型计算相干系数和坡度,进一步剔除坡度较大和相干性较高的伪变化图斑,得到最终的变化图斑。实验结果表明,在差异图的基础上融合坡度和相干性信息,可得到较为可靠的变化检测结果,总体精度提升约18%,对广东开展高频次土地利用遥感监测工作具有重要意义。

“3+1”订单式人才培养模式实习实践质量监控体系的构建

新疆作为中国能源资源禀赋突出的地区,开展校企协同“3+1”订单式人才培养模式改革试点,有助于高水平应用型人才的培养。新疆理工学院在校企深度合作基础上,开展了校企协同“3+1”订单式人才培养模式的改革与实践,并取得了良好的效果。针对“3+1”校企协同育人模式中实习质量监控体系不健全的问题,通过建立实习准备、实施、总结全过程的质量标准体系,搭建“实习、毕业论文、就业”一体化管理模式,完善“三元协同”的教学质量监控与反馈体系,构建了实习实践教学质量监控体系,经过一轮的实践应用表明质量监控体系的构建和运行对实习质量的提高和人才培养质量的提升获得了良好的效果。

基于多源数据的1∶10000地形图更新与质检技术研究

随着经济社会的不断发展,人们对于基础测绘成果的现势性要求越来越高,因此,探索实现基础测绘快速更新机制尤为重要。传统的基础测绘作业模式存在更新现势性弱、更新周期长等问题,已经越来越无法满足经济社会发展对于地理信息数据的要求。基于此,本文依托实际1∶10 000地形图更新项目,探索将国情监测数据、国土调查数据、电力部门数据用于1∶10 000地形图更新中。同时,为提高1∶10 000地形图成果质量检查的效率,设计成果质量批量检查方案并开发完成相应质检软件。本文提出的1∶10 000地形图生产与更新的技术流程,可为今后1∶10 000地形图生产与更新提供一定借鉴。

融合GF-1和高光谱的内陆水体叶绿素a浓度反演

通过对含叶绿素a水体反射光谱特征分析,融合国产高分卫星和近地高光谱数据开展内陆水体水质遥感监测工作,形成了叶绿素a浓度遥感反演技术方法。利用GF-1遥感数据特征波段,与实测近地高光谱数据进行相关性分析,构建叶绿素a浓度联合反演估计模型,其相关性系数达到0.794。将实测值与预测值进行线性拟合,其拟合优度达到0.7805,两者间均方根误差为2.11,平均相对误差为20.56%,基本满足水库叶绿素a含量遥感反演需求。选取湖南省典型水库,通过标准化分级,监测水库叶绿素a浓度空间分布情况,为后期快速掌握内陆水体污染控制、风险评估等提供技术支撑。

应用持续血糖监测技术评估德谷胰岛素治疗1型糖尿病的效果

目的 应用持续血糖监测(continuous blood glucose monitoring, CGM)评估德谷胰岛素治疗1型糖尿病的效果。方法 选取2023年3月—2024年3月淄博市张店区中医院收治的100例1型糖尿病患者为研究对象,以治疗方法的不同分为甘精组、德谷组,各50例。甘精组以甘精胰岛素治疗,德谷组以德谷胰岛素治疗。比较两组血糖指标、转归情况、治疗效果、不良反应发生情况。结果 治疗后,两组空腹血糖、餐后2 h血糖及糖化血红蛋白水平均低于治疗前,且德谷组低于甘精组,差异有统计学意义(P均<0.05)。德谷组平均血糖波动幅度、日间血糖平均绝对差、血糖标准差、平均血糖以及血糖变异系数低于甘精组,差异有统计学意义(P均<0.05)。德谷组治疗总有效率高于甘精组,差异有统计学意义(P<0.05)。德谷组不良反应发生率低于甘精组,差异有统计学意义(P<0.05)。结论 德谷胰岛素达到的血糖调控效果更为显著,能减少低血糖发生率,降低血糖变异系数,改善1型糖尿病预后。