提出了一种以软交换为核心完全遵循下一代网络分层结构特点的多媒体会议系统模型,实现了控制、业务与承载相分离。会议应用由业务层的应用服务器、Web服务器和媒体服务器实现,呼叫控制功能由软交换完成,业务媒体流由IP网络承载。实现的...提出了一种以软交换为核心完全遵循下一代网络分层结构特点的多媒体会议系统模型,实现了控制、业务与承载相分离。会议应用由业务层的应用服务器、Web服务器和媒体服务器实现,呼叫控制功能由软交换完成,业务媒体流由IP网络承载。实现的原型系统由基于Tomcat开发的Web服务器、基于MOBICENTS开发的会议服务器、支持MSCML(Media Server Control Markup Language)协议的媒体服务器及软交换组成。经测试说明了系统架构设计的合理性和稳定性。展开更多
Under simulated physiological conditions (pH=7.40), the interaction between non-steroidal anti-inflammatory drug Mobic and lipase was studied by fluorescence spectra, ultraviolet absorption spectra, circular dichroism...Under simulated physiological conditions (pH=7.40), the interaction between non-steroidal anti-inflammatory drug Mobic and lipase was studied by fluorescence spectra, ultraviolet absorption spectra, circular dichroism spectra and computer simulation technique. The experimental results showed that Mobic could quench the fluorescence of lipase by static quenching, and the binding site number is about 1. According to F¨orster’s theory of non-radiation energy transfer, the binding distance between Mobic and lipase was obtained, r<7 nm, which indicated that there was non-radiation energy transfer in the system. The thermodynamic parameters were obtained from van’t Hoff equation, Gibbs free energy -G<0, indicating that the reaction between them was spontaneous,-H<0,-S>0, indicating that hydrophobic force played a major role in the formation of Mobic and lipase complex. The results of synchronous fluorescence spectra, UV spectra and circular dichroism spectra showed that Mobic changed the conformation of lipase. The molecular docking results showed that the binding position of Mobic was close to the active center, indicating that Mobic could change the microenvironment of amino acid residues at the active center of lipase catalysis. The results of docking showed that there was hydrogen bond between Mobic and lipase, so the interaction between Mobic and lipase was driven by hydrophobic interaction and hydrogen bond.展开更多
文摘提出了一种以软交换为核心完全遵循下一代网络分层结构特点的多媒体会议系统模型,实现了控制、业务与承载相分离。会议应用由业务层的应用服务器、Web服务器和媒体服务器实现,呼叫控制功能由软交换完成,业务媒体流由IP网络承载。实现的原型系统由基于Tomcat开发的Web服务器、基于MOBICENTS开发的会议服务器、支持MSCML(Media Server Control Markup Language)协议的媒体服务器及软交换组成。经测试说明了系统架构设计的合理性和稳定性。
文摘Under simulated physiological conditions (pH=7.40), the interaction between non-steroidal anti-inflammatory drug Mobic and lipase was studied by fluorescence spectra, ultraviolet absorption spectra, circular dichroism spectra and computer simulation technique. The experimental results showed that Mobic could quench the fluorescence of lipase by static quenching, and the binding site number is about 1. According to F¨orster’s theory of non-radiation energy transfer, the binding distance between Mobic and lipase was obtained, r<7 nm, which indicated that there was non-radiation energy transfer in the system. The thermodynamic parameters were obtained from van’t Hoff equation, Gibbs free energy -G<0, indicating that the reaction between them was spontaneous,-H<0,-S>0, indicating that hydrophobic force played a major role in the formation of Mobic and lipase complex. The results of synchronous fluorescence spectra, UV spectra and circular dichroism spectra showed that Mobic changed the conformation of lipase. The molecular docking results showed that the binding position of Mobic was close to the active center, indicating that Mobic could change the microenvironment of amino acid residues at the active center of lipase catalysis. The results of docking showed that there was hydrogen bond between Mobic and lipase, so the interaction between Mobic and lipase was driven by hydrophobic interaction and hydrogen bond.
