An efficient electrocatalyst is indispensable to significantly reduce energy consumption and accelerate the conversion efficiency of water splitting.In this work,the honeycomb-like porous MoCo alloy on nitrogen-doped ...An efficient electrocatalyst is indispensable to significantly reduce energy consumption and accelerate the conversion efficiency of water splitting.In this work,the honeycomb-like porous MoCo alloy on nitrogen-doped three-dimensional(3D)porous graphene substrate(Mo_(0.3)Co_(0.7)@NPG)has been synthesized from the annealing of layered double hydroxide(MoCo-LDH@NPG).Especially,the Mo_(0.3)Co_(0.7)@NPG exhibits low hydrogen evolution overpotential of 75 mV(10 mA·cm^(-2))and a Tafel slope of 69.9 mV·dec^(-1),which can be attributed to highly conductive NPG substrate,the unique nanostructure and the synergistic effect of Mo and Co.Moreover,the Mo_(0.3)Co_(0.7)@NPG can maintain the original morphology and high catalytic activity after 50-h stability test.This work proposes a general strategy to synthesize a multi-element alloy on conductive substrates with high porosity for electrocatalytic reaction.展开更多
Molybdenum cofactor(Moco)biosynthesis is linked to c-Jun N-terminal kinase(JNK)signaling in Drosophila through MoaE,a molybdopterin(MPT)synthase subunit that is also acomponent of theAdaTwoAcontaining(ATAC)acetyltrans...Molybdenum cofactor(Moco)biosynthesis is linked to c-Jun N-terminal kinase(JNK)signaling in Drosophila through MoaE,a molybdopterin(MPT)synthase subunit that is also acomponent of theAdaTwoAcontaining(ATAC)acetyltransferasecomplex.Here,weshow thathumanMPTsynthase and ATAC inhibited PKR,a double-stranded RNA-dependent protein kinase,to facilitate translation initiation of iron-responsive mRNA.MPT synthase and ATAC directly interacted with PKR and suppressed latent autophosphorylation of PKR and its downstream phosphorylation of JNK and eukaryotic initiation factor 2a(eIF2a).The suppression of eIF2a phosphorylation via MPT synthase and ATAC prevented sequestration of the guanine nucleotide exchange factor eIF2B,which recycles eIF2-GDP to eIF2-GTP,resulting in the promotion of translation initiation.Indeed,translation of the iron storage protein,ferritin,was reduced in the absence of MPT synthase or ATAC subunits.Thus,MPT synthase and ATAC regulate latent PKR signaling and link transcription and translation initiation.展开更多
Synthetic aperture radar(SAR) is usually sensitive to trajectory deviations that cause serious motion error in the recorded data. In this paper, a coherent range-dependent mapdrift(CRDMD) algorithm is developed to acc...Synthetic aperture radar(SAR) is usually sensitive to trajectory deviations that cause serious motion error in the recorded data. In this paper, a coherent range-dependent mapdrift(CRDMD) algorithm is developed to accommodate the range-variant motion errors. By utilizing the algorithm as an estimate core, robust motion compensation strategy is proposed for unmanned aerial vehicle(UAV) SAR imagery. CRDMD outperforms the conventional map-drift algorithms in both accuracy and efficiency. Real data experiments show that the proposed approach is appropriate for precise motion compensation for UAV SAR.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52272296 and 51502092)the Fundamental Research Funds for the Central Universities(Nos.JKD01211601 and 1222201718002)the National Overseas High-Level Talent Youth Program in China and the Eastern Scholar Project of Shanghai。
文摘An efficient electrocatalyst is indispensable to significantly reduce energy consumption and accelerate the conversion efficiency of water splitting.In this work,the honeycomb-like porous MoCo alloy on nitrogen-doped three-dimensional(3D)porous graphene substrate(Mo_(0.3)Co_(0.7)@NPG)has been synthesized from the annealing of layered double hydroxide(MoCo-LDH@NPG).Especially,the Mo_(0.3)Co_(0.7)@NPG exhibits low hydrogen evolution overpotential of 75 mV(10 mA·cm^(-2))and a Tafel slope of 69.9 mV·dec^(-1),which can be attributed to highly conductive NPG substrate,the unique nanostructure and the synergistic effect of Mo and Co.Moreover,the Mo_(0.3)Co_(0.7)@NPG can maintain the original morphology and high catalytic activity after 50-h stability test.This work proposes a general strategy to synthesize a multi-element alloy on conductive substrates with high porosity for electrocatalytic reaction.
基金supported by private funding fromthe Stowers Institute for Medical Research to the Workman laboratory.
文摘Molybdenum cofactor(Moco)biosynthesis is linked to c-Jun N-terminal kinase(JNK)signaling in Drosophila through MoaE,a molybdopterin(MPT)synthase subunit that is also acomponent of theAdaTwoAcontaining(ATAC)acetyltransferasecomplex.Here,weshow thathumanMPTsynthase and ATAC inhibited PKR,a double-stranded RNA-dependent protein kinase,to facilitate translation initiation of iron-responsive mRNA.MPT synthase and ATAC directly interacted with PKR and suppressed latent autophosphorylation of PKR and its downstream phosphorylation of JNK and eukaryotic initiation factor 2a(eIF2a).The suppression of eIF2a phosphorylation via MPT synthase and ATAC prevented sequestration of the guanine nucleotide exchange factor eIF2B,which recycles eIF2-GDP to eIF2-GTP,resulting in the promotion of translation initiation.Indeed,translation of the iron storage protein,ferritin,was reduced in the absence of MPT synthase or ATAC subunits.Thus,MPT synthase and ATAC regulate latent PKR signaling and link transcription and translation initiation.
基金supported by the Key R&D Program Projects in Hainan Province (ZDY 2019008)the State Key Laboratory of Rail T ransit Engineering Information (SKLK22-08)。
文摘Synthetic aperture radar(SAR) is usually sensitive to trajectory deviations that cause serious motion error in the recorded data. In this paper, a coherent range-dependent mapdrift(CRDMD) algorithm is developed to accommodate the range-variant motion errors. By utilizing the algorithm as an estimate core, robust motion compensation strategy is proposed for unmanned aerial vehicle(UAV) SAR imagery. CRDMD outperforms the conventional map-drift algorithms in both accuracy and efficiency. Real data experiments show that the proposed approach is appropriate for precise motion compensation for UAV SAR.
