This paper aims to determine the possible role of estrogen receptor-β （ERβ） gene Rsal polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited： in vitr...This paper aims to determine the possible role of estrogen receptor-β （ERβ） gene Rsal polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited： in vitro fertilization （IVF） group, including 374 couples who underwent conventional IVF; intracytoplasmic sperm injection （ICSI） group, including 294 couples who underwent an ICSI procedure using ejaculated sperm; and azoospermic group, consisting of 197 couples who underwent ICSI using either testis or epididymis sperm. Rsal polymorphism in the ERβ gene was detected by polymerase chain reaction （PCR）-restriction fragment length polymorphism technique; fertilization and high-quality embryo rates were evaluated for each group. In each group, no significant differences were found in the overall rates of fertilization and high-quality embryos among GG, AG and AA genotypes. However, the proportion of cycles possessing a satisfactory high-quality embryo rate with the AA genotype was significantly lower than that in the wild-type GG genotype from each group. These results demonstrated that sperm possessing the ERβ RsalA genotype may have reduced fertilization ability and decreased early embryonic developmental potential, which could directly or indirectly contribute to the low fertilization rate and early embryonic developmental arrest in some cases.展开更多
Objectives Peroxisome proliferator-activated receptor-γ2（PPARγ2） variant Pro12Ala was demonstrated with risk of coronary heart disease （CHD） and type 2 diabetes mellitus （T2DM）. Another variant C-689T in the p...Objectives Peroxisome proliferator-activated receptor-γ2（PPARγ2） variant Pro12Ala was demonstrated with risk of coronary heart disease （CHD） and type 2 diabetes mellitus （T2DM）. Another variant C-689T in the promoter was reported with lower receptor activity but lack of reports on association between C-689T and CHD or T2DM. Methods A total of 351 subjects without CHD and T2DM （controls） and 125 patients with CHD and T2DM （cases） were enrolled in our case-control study. Polymerase chain reaction-restricted fragments length polymorphism （PCR-RFLP） was used to detect Pro12Ala and C-689T polymorphisms. And effects on CHD merged with T2DM of the two polymorphisms were analyzed in individual and haplotype analyses. Results In the study, Pro12Pro, Pro12Ala and Ala12Ala genotype frequencies were 92.9%, 6.8% and 0.3% in controls; 92.8%, 7.2% and 0.0% in cases respectively whilst CC, CT and TT genotype frequencies were 93.4%, 6.3% and 0.3% in controls; 92.8%, 7.2% and 0.0% in cases respectively. Pro12Ala and C-689T polymorphisms were in strong linkage disequilibrium （D＇=0.81, P=0.000） and the observed haplotype frequency of Pro-C, Pro-T, Ala-C and Ala-T was 0.957, 0.006, 0.008 and 0.028 respectively. No significant associations were detected between the two polymorphisms and CHD merged with T2DM in either individual or haplotype analyses. In subjects with obesity [body mass index （BMI）≥25 kg/m^2], we found that both Pro12Ala and C-689T polymorphisms were associated with BMI. In haplotype analyses, we found that Pro12Ala and C-689T haplotypes had associations with systolic blood pressure in total population, with BMI, waist circle and total cholesterol（TC） in obesity subgroup and with fasting blood glucose and TC in males. Conclusions PPARγ2 Pro12Ala and C-689T polymorphisms and haplotypes affect the profiles of CHD merged with T2DM in Chinese Han people.展开更多
AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to infl...AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection.展开更多
A certain variety of non-switched polynomials provides a uni-figure representation for a wide range of linear functional equations. This is properly adapted for the calculations. We reinterpret from this point of view...A certain variety of non-switched polynomials provides a uni-figure representation for a wide range of linear functional equations. This is properly adapted for the calculations. We reinterpret from this point of view a number of algorithms.展开更多
We consider the preservation property of the homomorphism and tensor product functors for quasi-isomorphisms and equivalences of complexes. Let X and Y be two classes of R-modules with Ext〉I（X,Y） = 0 for each objec...We consider the preservation property of the homomorphism and tensor product functors for quasi-isomorphisms and equivalences of complexes. Let X and Y be two classes of R-modules with Ext〉I（X,Y） = 0 for each object X ∈ X and each object Y ∈ Y. We show that if A,B ∈ C^（R） are X-complexes and U, V ∈ Cr（R） are Y-complexes, then U V Hom（A, U） Hom（A, Y）; A B Hom（B, U） Hom（A, U）. As an application, we give a sufficient condition for the Hom evaluation morphism being invertible.展开更多
Understanding the relationship between genotype and phenotype is a major biological question and being able to predict phenotypes based on molecular genotypes is integral to molecular breeding. Whole- genome duplicati...Understanding the relationship between genotype and phenotype is a major biological question and being able to predict phenotypes based on molecular genotypes is integral to molecular breeding. Whole- genome duplications have shaped the history of all flowering plants and present challenges to elucidating the relationship between genotype and phenotype, especially in neopolyploid species. Although single nucleotide polymorphisms （SNPs） have become popular tools for genetic mapping, discovery and appli- cation of SNPs in polyploids has been difficult. Here, we summarize common experimental approaches to SNP calling, highlighting recent polyploid successes. To examine the impact of software choice on these analyses, we called SNPs among five peanut genotypes using different alignment programs （BWA-mem and Bowtie 2） and variant callers （SAMtools, GATK, and Freebayes）. Alignments produced by Bowtie 2 and BWA-mem and analyzed in SAMtools shared 24.5% concordant SNPs, and SAMtools, GATK, and Freebayes shared 1.4% concordant SNPs. A subsequent analysis of simulated Brassica napus chromosome 1A and 1C genotypes demonstrated that, of the three software programs, SAMtools performed with the highest sensitivity and specificity on Bowtie 2 alignments. These results, however, are likely to vary among species, and we therefore propose a series of best practices for SNP calling in polyploids.展开更多
In the present paper the properties of morphisms in effect algebras are discussed. The conditions for the morphisms in effect algebras to be join-preservation and meet-preservation are given. From the categorical poin...In the present paper the properties of morphisms in effect algebras are discussed. The conditions for the morphisms in effect algebras to be join-preservation and meet-preservation are given. From the categorical point of view, some properties of ideals, filters and congruence relations under morphisms are obtained.展开更多
Let H3 be the 9-dimensional Taft Hopf algebra,let r(H3)be the corresponding Green ring of H3,and let Aut(R(H3))be the automorphism group of Green algebra R(H3)=R■Zr(H3)over the real number fieldR.We prove that the qu...Let H3 be the 9-dimensional Taft Hopf algebra,let r(H3)be the corresponding Green ring of H3,and let Aut(R(H3))be the automorphism group of Green algebra R(H3)=R■Zr(H3)over the real number fieldR.We prove that the quotient group Aut(R(H3))/T1 is isomorphic to the direct product of the dihedral group of order 12 and the cyclic group of order 2,where T1 is the isomorphism class which contains the identity map and is isomorphic to a group G={(c,d)∈R^(2)∣∣(c,d)≠(−1/3,−1/6)}with multiplication given by(c1,d1)⋅(c2,d2)=(c1+c2+2c1c2−4d1d2+2c1d2+2d1c2,d1+d2−2c1c2−2d1d2+4c1d2+4d1c2).展开更多
The automorphism group of G is determined, where G is a nonabelian p-group given by a central extension as 1→Zpm→G→Zp×…×Zp→1 such that its derived subgroup has order p.
In this paper we study finite morphisms of projective and compact K■hler manifolds, in particular,positivity properties of the associated vector bundle,deformation theory and ramified endomorphisms.
morphism. Harmonic morphisms may be characterized as harmonic mappings which are horizontally weakly conformal. In recent years a substantial progress has been made in the field of harmonic morphism, for example, refs...morphism. Harmonic morphisms may be characterized as harmonic mappings which are horizontally weakly conformal. In recent years a substantial progress has been made in the field of harmonic morphism, for example, refs. [ 3—7]. In ref. [4], Baird and Wood proved the following: (ⅰ) Any non-constant harmonic morphism from (S^3, g_(can)) to a Riemann展开更多
Let k be the algebraic closure of a finite field F_q and A be a finite dimensional k-algebra with a Frobenius morphism F.In the present paper we establish a relation between the stable module category of the repetitiv...Let k be the algebraic closure of a finite field F_q and A be a finite dimensional k-algebra with a Frobenius morphism F.In the present paper we establish a relation between the stable module category of the repetitive algebra of A and that of the repetitive algebra of the fixed-point algebra A^F.As an application,it is shown that the derived category of A^F is equivalent to the subcategory of F-stable objects in the derived category of A when A has a finite global dimension.展开更多
Let X be a smooth projective curve of genus g 2 over an algebraically closed field k of characteristic p>0,and F:X→X(1)the relative Frobenius morphism.Let M s X(r,d)(resp.M ss X(r,d))be the moduli space of(resp.se...Let X be a smooth projective curve of genus g 2 over an algebraically closed field k of characteristic p>0,and F:X→X(1)the relative Frobenius morphism.Let M s X(r,d)(resp.M ss X(r,d))be the moduli space of(resp.semi-)stable vector bundles of rank r and degree d on X.We show that the set-theoretic map S ss Frob:M ss X(r,d)→M ss X(1)(rp,d+r(p-1)(g-1))induced by[E]→[F(E)]is a proper morphism.Moreover,the induced morphism S s Frob:M s X(r,d)→M s X(1)(rp,d+r(p-1)(g-1))is a closed immersion.As an application,we obtain that the locus of moduli space M s X(1)(p,d)consisting of stable vector bundles whose Frobenius pull backs have maximal Harder-Narasimhan polygons is isomorphic to the Jacobian variety Jac X of X.展开更多
We produce p-harmonic morphisms by conformal foliations and Clifford systems. First, we give a useful criterion for a foliation on an m-dimensional Riemannian manifold locally generated by conformal fields to produce ...We produce p-harmonic morphisms by conformal foliations and Clifford systems. First, we give a useful criterion for a foliation on an m-dimensional Riemannian manifold locally generated by conformal fields to produce p-harmonic morphisms. By using this criterion we manufacture conformal foliations, with codimension not equal to p, which are locally the fibres of p-harmonic morphisms. Then we give a new approach for the construction of p-harmonic morphisms from R^m／{0} to R^n. By the well-known representation of Clifford algebras, we find an abundance of the new 2/3 （m ＋ 1）-harmonic morphism Ф： R^m／{0} → R^n where m = 2κδ（n - 1）.展开更多
文摘This paper aims to determine the possible role of estrogen receptor-β （ERβ） gene Rsal polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited： in vitro fertilization （IVF） group, including 374 couples who underwent conventional IVF; intracytoplasmic sperm injection （ICSI） group, including 294 couples who underwent an ICSI procedure using ejaculated sperm; and azoospermic group, consisting of 197 couples who underwent ICSI using either testis or epididymis sperm. Rsal polymorphism in the ERβ gene was detected by polymerase chain reaction （PCR）-restriction fragment length polymorphism technique; fertilization and high-quality embryo rates were evaluated for each group. In each group, no significant differences were found in the overall rates of fertilization and high-quality embryos among GG, AG and AA genotypes. However, the proportion of cycles possessing a satisfactory high-quality embryo rate with the AA genotype was significantly lower than that in the wild-type GG genotype from each group. These results demonstrated that sperm possessing the ERβ RsalA genotype may have reduced fertilization ability and decreased early embryonic developmental potential, which could directly or indirectly contribute to the low fertilization rate and early embryonic developmental arrest in some cases.
文摘Objectives Peroxisome proliferator-activated receptor-γ2（PPARγ2） variant Pro12Ala was demonstrated with risk of coronary heart disease （CHD） and type 2 diabetes mellitus （T2DM）. Another variant C-689T in the promoter was reported with lower receptor activity but lack of reports on association between C-689T and CHD or T2DM. Methods A total of 351 subjects without CHD and T2DM （controls） and 125 patients with CHD and T2DM （cases） were enrolled in our case-control study. Polymerase chain reaction-restricted fragments length polymorphism （PCR-RFLP） was used to detect Pro12Ala and C-689T polymorphisms. And effects on CHD merged with T2DM of the two polymorphisms were analyzed in individual and haplotype analyses. Results In the study, Pro12Pro, Pro12Ala and Ala12Ala genotype frequencies were 92.9%, 6.8% and 0.3% in controls; 92.8%, 7.2% and 0.0% in cases respectively whilst CC, CT and TT genotype frequencies were 93.4%, 6.3% and 0.3% in controls; 92.8%, 7.2% and 0.0% in cases respectively. Pro12Ala and C-689T polymorphisms were in strong linkage disequilibrium （D＇=0.81, P=0.000） and the observed haplotype frequency of Pro-C, Pro-T, Ala-C and Ala-T was 0.957, 0.006, 0.008 and 0.028 respectively. No significant associations were detected between the two polymorphisms and CHD merged with T2DM in either individual or haplotype analyses. In subjects with obesity [body mass index （BMI）≥25 kg/m^2], we found that both Pro12Ala and C-689T polymorphisms were associated with BMI. In haplotype analyses, we found that Pro12Ala and C-689T haplotypes had associations with systolic blood pressure in total population, with BMI, waist circle and total cholesterol（TC） in obesity subgroup and with fasting blood glucose and TC in males. Conclusions PPARγ2 Pro12Ala and C-689T polymorphisms and haplotypes affect the profiles of CHD merged with T2DM in Chinese Han people.
基金a Grant-in-Aid for Young Scientists from the Ministry of Education,Culture,Sports,Science and Technology of Japana Grant-in-Aid for Scientific Research from the Ministry of Health,Labour and Welfare of Japan
文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection.
文摘A certain variety of non-switched polynomials provides a uni-figure representation for a wide range of linear functional equations. This is properly adapted for the calculations. We reinterpret from this point of view a number of algorithms.
基金Supported by National Natural Science Foundation of China (Grant No. 10961021)Program of Science and Technique of Gansu Province (Grant No. 1010RJZA025)
文摘We consider the preservation property of the homomorphism and tensor product functors for quasi-isomorphisms and equivalences of complexes. Let X and Y be two classes of R-modules with Ext〉I（X,Y） = 0 for each object X ∈ X and each object Y ∈ Y. We show that if A,B ∈ C^（R） are X-complexes and U, V ∈ Cr（R） are Y-complexes, then U V Hom（A, U） Hom（A, Y）; A B Hom（B, U） Hom（A, U）. As an application, we give a sufficient condition for the Hom evaluation morphism being invertible.
文摘Understanding the relationship between genotype and phenotype is a major biological question and being able to predict phenotypes based on molecular genotypes is integral to molecular breeding. Whole- genome duplications have shaped the history of all flowering plants and present challenges to elucidating the relationship between genotype and phenotype, especially in neopolyploid species. Although single nucleotide polymorphisms （SNPs） have become popular tools for genetic mapping, discovery and appli- cation of SNPs in polyploids has been difficult. Here, we summarize common experimental approaches to SNP calling, highlighting recent polyploid successes. To examine the impact of software choice on these analyses, we called SNPs among five peanut genotypes using different alignment programs （BWA-mem and Bowtie 2） and variant callers （SAMtools, GATK, and Freebayes）. Alignments produced by Bowtie 2 and BWA-mem and analyzed in SAMtools shared 24.5% concordant SNPs, and SAMtools, GATK, and Freebayes shared 1.4% concordant SNPs. A subsequent analysis of simulated Brassica napus chromosome 1A and 1C genotypes demonstrated that, of the three software programs, SAMtools performed with the highest sensitivity and specificity on Bowtie 2 alignments. These results, however, are likely to vary among species, and we therefore propose a series of best practices for SNP calling in polyploids.
基金the National-Natural Science Foundation of China （No. 10331010） the Natural Science Foundation of Fujian Province of China （No, 2006J0221）.
文摘In the present paper the properties of morphisms in effect algebras are discussed. The conditions for the morphisms in effect algebras to be join-preservation and meet-preservation are given. From the categorical point of view, some properties of ideals, filters and congruence relations under morphisms are obtained.
基金Supported by the National Natural Science Foundation of China(Nos.11661014,11701499,11871063,and 11711530703)the Research Innovation Program Project of Academic Degree Graduate Students in Jiangsu(XKYCX17_029)the Excellent Doctoral Dissertation Foundation Project of Yangzhou University in 2018.
文摘Let H3 be the 9-dimensional Taft Hopf algebra,let r(H3)be the corresponding Green ring of H3,and let Aut(R(H3))be the automorphism group of Green algebra R(H3)=R■Zr(H3)over the real number fieldR.We prove that the quotient group Aut(R(H3))/T1 is isomorphic to the direct product of the dihedral group of order 12 and the cyclic group of order 2,where T1 is the isomorphism class which contains the identity map and is isomorphic to a group G={(c,d)∈R^(2)∣∣(c,d)≠(−1/3,−1/6)}with multiplication given by(c1,d1)⋅(c2,d2)=(c1+c2+2c1c2−4d1d2+2c1d2+2d1c2,d1+d2−2c1c2−2d1d2+4c1d2+4d1c2).
基金Project supported by NSFC （11371124, 11301150） and the Natural Science Foundation of Henan Province of China （142300410134, 162300410066）.
文摘The automorphism group of G is determined, where G is a nonabelian p-group given by a central extension as 1→Zpm→G→Zp×…×Zp→1 such that its derived subgroup has order p.
基金Project supported partially by the National Natural Science Foundation of China (Grant No. 19531050)the State Education Commission Foundation of China.
文摘Two non-existence theorems on harmonic polynomial morphisms between Euclidean spaces have been
文摘In this paper we study finite morphisms of projective and compact K■hler manifolds, in particular,positivity properties of the associated vector bundle,deformation theory and ramified endomorphisms.
文摘morphism. Harmonic morphisms may be characterized as harmonic mappings which are horizontally weakly conformal. In recent years a substantial progress has been made in the field of harmonic morphism, for example, refs. [ 3—7]. In ref. [4], Baird and Wood proved the following: (ⅰ) Any non-constant harmonic morphism from (S^3, g_(can)) to a Riemann
基金the National Natural Science Foundation of China (Grant No.10671016)the 985 Project of Beijing Normal University
文摘Let k be the algebraic closure of a finite field F_q and A be a finite dimensional k-algebra with a Frobenius morphism F.In the present paper we establish a relation between the stable module category of the repetitive algebra of A and that of the repetitive algebra of the fixed-point algebra A^F.As an application,it is shown that the derived category of A^F is equivalent to the subcategory of F-stable objects in the derived category of A when A has a finite global dimension.
基金supported by National Natural Science Foundation of China (Grant No. 11271275)
文摘Let X be a smooth projective curve of genus g 2 over an algebraically closed field k of characteristic p>0,and F:X→X(1)the relative Frobenius morphism.Let M s X(r,d)(resp.M ss X(r,d))be the moduli space of(resp.semi-)stable vector bundles of rank r and degree d on X.We show that the set-theoretic map S ss Frob:M ss X(r,d)→M ss X(1)(rp,d+r(p-1)(g-1))induced by[E]→[F(E)]is a proper morphism.Moreover,the induced morphism S s Frob:M s X(r,d)→M s X(1)(rp,d+r(p-1)(g-1))is a closed immersion.As an application,we obtain that the locus of moduli space M s X(1)(p,d)consisting of stable vector bundles whose Frobenius pull backs have maximal Harder-Narasimhan polygons is isomorphic to the Jacobian variety Jac X of X.
基金This work is supported by the National Natural Science Foundation of China(10471001)
文摘We produce p-harmonic morphisms by conformal foliations and Clifford systems. First, we give a useful criterion for a foliation on an m-dimensional Riemannian manifold locally generated by conformal fields to produce p-harmonic morphisms. By using this criterion we manufacture conformal foliations, with codimension not equal to p, which are locally the fibres of p-harmonic morphisms. Then we give a new approach for the construction of p-harmonic morphisms from R^m／{0} to R^n. By the well-known representation of Clifford algebras, we find an abundance of the new 2/3 （m ＋ 1）-harmonic morphism Ф： R^m／{0} → R^n where m = 2κδ（n - 1）.
