期刊文献+
共找到4,847篇文章
< 1 2 243 >
每页显示 20 50 100
A Fault-Tolerant Mobility-Aware Caching Method in Edge Computing
1
作者 Yong Ma Han Zhao +5 位作者 Kunyin Guo Yunni Xia Xu Wang Xianhua Niu Dongge Zhu Yumin Dong 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期907-927,共21页
Mobile Edge Computing(MEC)is a technology designed for the on-demand provisioning of computing and storage services,strategically positioned close to users.In the MEC environment,frequently accessed content can be dep... Mobile Edge Computing(MEC)is a technology designed for the on-demand provisioning of computing and storage services,strategically positioned close to users.In the MEC environment,frequently accessed content can be deployed and cached on edge servers to optimize the efficiency of content delivery,ultimately enhancing the quality of the user experience.However,due to the typical placement of edge devices and nodes at the network’s periphery,these components may face various potential fault tolerance challenges,including network instability,device failures,and resource constraints.Considering the dynamic nature ofMEC,making high-quality content caching decisions for real-time mobile applications,especially those sensitive to latency,by effectively utilizing mobility information,continues to be a significant challenge.In response to this challenge,this paper introduces FT-MAACC,a mobility-aware caching solution grounded in multi-agent deep reinforcement learning and equipped with fault tolerance mechanisms.This approach comprehensively integrates content adaptivity algorithms to evaluate the priority of highly user-adaptive cached content.Furthermore,it relies on collaborative caching strategies based onmulti-agent deep reinforcement learningmodels and establishes a fault-tolerancemodel to ensure the system’s reliability,availability,and persistence.Empirical results unequivocally demonstrate that FTMAACC outperforms its peer methods in cache hit rates and transmission latency. 展开更多
关键词 Mobile edge networks mobility fault tolerance cooperative caching multi-agent deep reinforcement learning content prediction
下载PDF
Mobility and dynamic erosion process of granular flow:insights from numerical investigation using material point method
2
作者 YU Fangwei SU Lijun +1 位作者 LI Xinpo ZHAO Yu 《Journal of Mountain Science》 SCIE CSCD 2024年第8期2713-2738,共26页
In order to understand the dynamics of granular flow on an erodible base soil,in this paper,a series of material point method-based granular column collapse tests were conducted to investigate numerically the mobility... In order to understand the dynamics of granular flow on an erodible base soil,in this paper,a series of material point method-based granular column collapse tests were conducted to investigate numerically the mobility and dynamic erosion process of granular flow subjected to the complex settings,i.e.,the aspect ratio,granular mass,friction and dilatancy resistance,gravity and presence of water.A set of power scaling laws were proposed to describe the final deposit characteristics of granular flow by the relations of the normalized run-out distance and the normalized final height of granular flow against the aspect ratio,being greatly affected by the complex geological settings,e.g.,granular mass,the friction and dilatancy resistance of granular soil,and presence of water in granular flow.An index of the coefficient of friction of granular soil was defined as a ratio of the target coefficient of friction over the initial coefficient of friction to quantify the scaling extent of friction change(i.e.,friction strengthening or weakening).There is a characteristic aspect ratio of granular column corresponding to the maximum mobility of granular flow with the minimum index of the apparent coefficient of friction.The index of the repose coefficient of friction of granular flow decreased gradually with the increase in aspect ratio because higher potential energy of granular column at a larger aspect ratio causes a larger kinetic energy of granular soil to weaken the friction of granular soil as a kind of velocity-related friction weakening.An increase in granular mass reduces gradually the indexes of the apparent and repose coefficients of friction of granular soil to enhance the mobility of granular flow.The mobility of granular flow increases gradually with the decrease in friction angle or increase in dilatancy angle of granular soil.However,the increase of gravity accelerates granular flow but showing the same final deposit profile without any dependence on gravity.The mobility of granular flow increases gradually by lowering the indexes of the apparent and repose coefficients of friction of granular flow while changing the surroundings,in turn,the dry soil,submerged soil and saturated soil,implying a gradually increased excessive mobility of granular flow with the friction weakening of granular soil.Presence of water in granular flow may be a potential catalyzer to yield a long run-out granular flow,as revealed in comparison of water-absent and water-present granular flows.In addition,the dynamic erosion and entrainment of based soil induced by granular flow subjected to the complex geological settings,i.e.,the aspect ratio,granular mass,gravity,friction and dilatancy resistance,and presence of water,were comprehensively investigated as well. 展开更多
关键词 Column collapse Granular flow Granular soil Material point method mobility Numerical tests
下载PDF
Enhanced magnetic anisotropy and high hole mobility in magnetic semiconductor Ga_(1-x-y)Fe_(x)Ni_(y)Sb
3
作者 Zhi Deng Hailong Wang +5 位作者 Qiqi Wei Lei Liu Hongli Sun Dong Pan Dahai Wei Jianhua Zhao 《Journal of Semiconductors》 EI CAS CSCD 2024年第1期16-21,共6页
(Ga,Fe)Sb is a promising magnetic semiconductor(MS)for spintronic applications because its Curie temperature(T_(C))is above 300 K when the Fe concentration is higher than 20%.However,the anisotropy constant Ku of(Ga,F... (Ga,Fe)Sb is a promising magnetic semiconductor(MS)for spintronic applications because its Curie temperature(T_(C))is above 300 K when the Fe concentration is higher than 20%.However,the anisotropy constant Ku of(Ga,Fe)Sb is below 7.6×10^(3)erg/cm^(3)when Fe concentration is lower than 30%,which is one order of magnitude lower than that of(Ga,Mn)As.To address this issue,we grew Ga_(1-x-y)Fe_(x)Ni_(y)Sb films with almost the same x(≈24%)and different y to characterize their magnetic and electrical transport properties.We found that the magnetic anisotropy of Ga_(0.76-y)Fe_(0.24)Ni_(y)Sb can be enhanced by increasing y,in which Ku is negligible at y=1.7%but increases to 3.8×10^(5)erg/cm^(3)at y=6.1%(T_(C)=354 K).In addition,the hole mobility(μ)of Ga_(1-x-y)Fe_(x)Ni_(y)Sb reaches 31.3 cm^(2)/(V∙s)at x=23.7%,y=1.7%(T_(C)=319 K),which is much higher than the mobility of Ga_(1-x)Fe_(x)Sb at x=25.2%(μ=6.2 cm^(2)/(V∙s)).Our results provide useful information for enhancing the magnetic anisotropy and hole mobility of(Ga,Fe)Sb by using Ni co-doping. 展开更多
关键词 magnetic semiconductor molecular beam epitaxy Fe-Ni co-doping magnetic anisotropy hole mobility
下载PDF
Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples
4
作者 Alongkorn Kurilung Suphitcha Limjiasahapong +9 位作者 Khwanta Kaewnarin Pattipong Wisanpitayakorn Narumol Jariyasopit Kwanjeera Wanichthanarak Sitanan Sartyoungkul Stephen Choong Chee Wong Nuankanya Sathirapongsasuti Chagriya Kitiyakara Yongyut Sirivatanauksorn Sakda Khoomrung 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第5期733-743,共11页
The collision cross-sections(CCS)measurement using ion mobility spectrometry(IMS)in combination with mass spectrometry(MS)offers a great opportunity to increase confidence in metabolite identification.However,owing to... The collision cross-sections(CCS)measurement using ion mobility spectrometry(IMS)in combination with mass spectrometry(MS)offers a great opportunity to increase confidence in metabolite identification.However,owing to the lack of sensitivity and resolution,IMS has an analytical challenge in studying the CCS values of very low-molecular-weight metabolites(VLMs250 Da).Here,we describe an analytical method using ultrahigh-performance liquid chromatography(UPLC)coupled to a traveling wave ion mobility-quadrupole-time-of-flight mass spectrometer optimized for the measurement of VLMs in human urine samples.The experimental CCS values,along with mass spectral properties,were reported for the 174 metabolites.The experimental data included the mass-to-charge ratio(m/z),retention time(RT),tandem MS(MS/MS)spectra,and CCS values.Among the studied metabolites,263 traveling wave ion mobility spectrometry(TWIMS)-derived CCS values(TWCCSN2)were reported for the first time,and more than 70%of these were CCS values of VLMs.The TWCCSN2 values were highly repeatable,with inter-day variations of<1%relative standard deviation(RSD).The developed method revealed excellent TWCCSN2 accuracy with a CCS difference(DCCS)within±2%of the reported drift tube IMS(DTIMS)and TWIMS CCS values.The complexity of the urine matrix did not affect the precision of the method,as evidenced by DCCS within±1.92%.According to the Metabolomics Standards Initiative,55 urinary metabolites were identified with a confidence level of 1.Among these 55 metabolites,53(96%)were VLMs.The larger number of confirmed compounds found in this study was a result of the addition of TWCCSN2 values,which clearly increased metabolite identification confidence. 展开更多
关键词 Very low-molecular-weight metabolites Traveling wave ion mobility Collision cross-section Human urine
下载PDF
Mobility edges and localization characteristics in one-dimensional quasiperiodic quantum walk
5
作者 崔鑫辉 王慧敏 李志坚 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期156-160,共5页
We construct a one-dimensional quasiperiodic quantum walk to investigate the localization–delocalization transition.The inverse participation ratio and Lyapunov exponent are employed as two indexes to determine the m... We construct a one-dimensional quasiperiodic quantum walk to investigate the localization–delocalization transition.The inverse participation ratio and Lyapunov exponent are employed as two indexes to determine the mobility edge, a critical energy to distinguish the energy regions of extended and localized states. The analytical solution of mobility edge is obtained by the Lyapunov exponents in global theory, and the consistency of the two indexes is confirmed. We further study the dynamic characteristics of the quantum walk and show that the probabilities are localized to some specific lattice sites with time evolution. This phenomenon is explained by the effective potential of the Hamiltonian which corresponds to the phase in the coin operator of the quantum walk. 展开更多
关键词 quantum walk mobility edges QUASIPERIODICITY
下载PDF
High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation
6
作者 Hanki Kim Bum Jun Kim +4 位作者 Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi 《Neural Regeneration Research》 SCIE CAS 2025年第1期107-115,共9页
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the ex... High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1. 展开更多
关键词 central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 INFLAMMATION neural stem cells NEURODEVELOPMENT oligodendrocyte progenitor cells redox status REGENERATION
下载PDF
Privacy-Preserving Federated Mobility Prediction with Compound Data and Model Perturbation Mechanism
7
作者 Long Qingyue Wang Huandong +4 位作者 Chen Huiming Jin Depeng Zhu Lin Yu Li Li Yong 《China Communications》 SCIE CSCD 2024年第3期160-173,共14页
Human mobility prediction is important for many applications.However,training an accurate mobility prediction model requires a large scale of human trajectories,where privacy issues become an important problem.The ris... Human mobility prediction is important for many applications.However,training an accurate mobility prediction model requires a large scale of human trajectories,where privacy issues become an important problem.The rising federated learning provides us with a promising solution to this problem,which enables mobile devices to collaboratively learn a shared prediction model while keeping all the training data on the device,decoupling the ability to do machine learning from the need to store the data in the cloud.However,existing federated learningbased methods either do not provide privacy guarantees or have vulnerability in terms of privacy leakage.In this paper,we combine the techniques of data perturbation and model perturbation mechanisms and propose a privacy-preserving mobility prediction algorithm,where we add noise to the transmitted model and the raw data collaboratively to protect user privacy and keep the mobility prediction performance.Extensive experimental results show that our proposed method significantly outperforms the existing stateof-the-art mobility prediction method in terms of defensive performance against practical attacks while having comparable mobility prediction performance,demonstrating its effectiveness. 展开更多
关键词 federated learning mobility prediction PRIVACY
下载PDF
Influence of shale reservoir properties on shale oil mobility and its mechanism
8
作者 Jijun Li Hang You +6 位作者 Xinwen Zhang Suping Zhao Fujie Jiang Guoqi Feng Yue Su Yinwu Zhang Jiaheng Xue 《Energy Geoscience》 EI 2024年第4期212-223,共12页
Given the tremendous potential for continental shale oil in China,many oilfields in the central and eastern parts of the country are involved in the exploration and development of shale oil resources.Besides engineeri... Given the tremendous potential for continental shale oil in China,many oilfields in the central and eastern parts of the country are involved in the exploration and development of shale oil resources.Besides engineering factors,shale oil mobility is the key to determining its commercial viability.This study explores the Hetaoyuan Formation in the Biyang Depression as an example to determine the influence of reservoir properties on the movable oil volume and its mechanisms.Multiple techniques were used,including displacement nuclear magnetic resonance(NMR),low-temperature nitrogen adsorption(LTNA),X-ray diffraction(XRD)bulk mineral analysis,and scanning electron microscopy(SEM),and the results suggest that large average pore diameter,high throat to pore ratio,single pore morphology,and small specific surface area can weaken the boundary layer effect and reduce the amount of adsorbed oil.Our observations reveal that compared to the dissolution pores and intergranular pores in brittle minerals,the intercrystalline pores in terrigenous clastic clay minerals are more affected by compaction.Furthermore,authigenic clay minerals notably block the intergranular pores in the interbedded sandstones.Clay minerals are identified as the main contributor to the specific surface area,with high clay mineral content enhancing the pore heterogeneity of the reservoir.Thus,positive shale oil mobility occurs in shale with a weak boundary layer effect,which is attributed to the high brittle mineral content,large average pore diameter,small specific surface area,single pore morphology,and reservoir homogeneity. 展开更多
关键词 Biyang depression Hetaoyuan formation Shale oil mobility Nuclear magnetic resonance
下载PDF
Comparative Analysis of Metro Passengers’Mobility Patterns and Jobs-housing Balance of Metropolitan
9
作者 HUANG Yiman ZHANG Anshu +1 位作者 SU Yuezhu SHI Wenzhong 《Journal of Geodesy and Geoinformation Science》 CSCD 2024年第2期1-17,共17页
The advent of the big data era has provided many types of transportation datasets,such as metro smart card data,for studying residents’mobility and understanding how their mobility has been shaped and is shaping the ... The advent of the big data era has provided many types of transportation datasets,such as metro smart card data,for studying residents’mobility and understanding how their mobility has been shaped and is shaping the urban space.In this paper,we use metro smart card data from two Chinese metropolises,Shanghai and Shenzhen.Five metro mobility indicators are introduced,and association rules are established to explore the mobility patterns.The proportion of people entering and exiting the station is used to measure the jobs-housing balance.It is found that the average travel distance and duration of Shanghai passengers are higher than those of Shenzhen,and the proportion of metro commuters in Shanghai is higher than that of Shenzhen.The jobs-housing spatial relationship in Shenzhen based on metro travel is more balanced than that in Shanghai.The fundamental reason for the differences between the two cities is the difference in urban morphology.Compared with the monocentric structure of Shanghai,the polycentric structure of Shenzhen results in more scattered travel hotspots and more diverse travel routes,which helps Shenzhen to have a better jobs-housing balance.This paper fills a gap in comparative research among Chinese cities based on transportation big data analysis.The results provide support for planning metro routes,adjusting urban structure and land use to form a more reasonable metro network,and balancing the jobs-housing spatial relationship. 展开更多
关键词 metro smart card data mobility patterns association rules jobs-housing balance
下载PDF
Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage
10
作者 Yue-Ying Wang Ke Li +5 位作者 Jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun Ji-Ping Qi Yue-Jia Song 《World Journal of Diabetes》 SCIE 2024年第9期1979-2001,共23页
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie... BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain. 展开更多
关键词 Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1
下载PDF
Dual mobility in primary total hip arthroplasty:A temptation from the devil or a blessing from above
11
作者 Raymond Klumpp Linda Boerci +1 位作者 Francesco Buonanotte Marco Zeppieri 《World Journal of Orthopedics》 2024年第6期512-519,共8页
Dual mobility(DM)bearings have gained significant attention in the field of total hip arthroplasty(THA)as a valid treatment option in cases of revision for instability after THA whereas its use in primary THA is still... Dual mobility(DM)bearings have gained significant attention in the field of total hip arthroplasty(THA)as a valid treatment option in cases of revision for instability after THA whereas its use in primary THA is still a matter of debate.This manuscript explores the pathology,incidence,diagnosis,treatment options,prognosis,ongoing studies in the literature,and future perspectives related to the use of DM bearings employed in primary THA.DM bearings are primarily designed to address one of the major concerns in THA:Instability of the prosthetic hip.Instability is both for the surgeon and the patient a devastating postoperative complication,leading to significant pain and subsequent apprehension by the patient and may require revision surgeries.The use of DM implants poses the worry of wear-related complications,such as accelerated polyethylene wear and osteolysis,which also pose challenges to long-term implant survival.This technique has seen a steady rise in recent years,with multiple studies reporting favorable outcomes.The incidence of their utilization varies among institutions and surgeons,reflecting differing preferences and patient populations.The diagnosis of instability and wear-related complications in THA often involves clinical assessment,imaging modalities such as X-rays,computed tomography scans,and sometimes advanced imaging techniques like magnetic resonance imaging.DM bearings can be considered as an option when patients present neurologic pathologies such as Parkinson's disease or recurrent dislocations after THA.DM bearings provide an additional articulation point within the implant,facilitating a greater range of motion and inherent stability.This design allows for reduced risk of dislocation and improved functional outcomes.Various implant manufacturers offer different designs and sizes of DM bearings to suit individual patient needs.Current literature suggests that the use of DM bearings in primary THA has demonstrated promising outcomes in terms of enhanced stability,reduced dislocation rates,and improved patient satisfaction.However,long-term studies with larger patient cohorts are necessary to establish the durability and longevity of these implants.Several ongoing studies are investigating the role of DM bearings in primary THA.These studies focus on evaluating longterm implant survivorship,assessing wear patterns,analyzing patient-reported outcomes,and comparing the effectiveness of DM bearings with traditional THA designs.The future of DM bearings in primary THA holds potential for further advancements.Research efforts are aimed at refining implant materials,optimizing designs,and studying the influence of surgical techniques on implant performance.Additionally,continued investigation into the long-term outcomes and cost-effectiveness of DM bearings will play a crucial role in shaping their future use.While further research is warranted,the current evidence supports their potential as a beneficial solution in improving surgical outcomes and patient satisfaction. 展开更多
关键词 Dual mobility First implant Hip arthroplasty Surgical technique Differential diagnosis
下载PDF
LiMo 2040 Sustainable urban Living and Mobility Concept-Elevator System
12
作者 Hugo Gabele Torben Ossendorf 《Journal of Civil Engineering and Architecture》 2024年第1期1-5,共5页
How can individual mobility in urban areas be maintained alongside scooters and cargo bikes if conventional vehicles are foreseeably no longer allowed to enter city centers?And how can urban living be combined with in... How can individual mobility in urban areas be maintained alongside scooters and cargo bikes if conventional vehicles are foreseeably no longer allowed to enter city centers?And how can urban living be combined with individual mobility in a sustainable and socially acceptable way?LiMo-2040 attempts to provide answers to these questions.It follows a holistic approach according to the criteria:As light,as compact and as simple(cost-effective)as possible.Modular e-vehicle concepts(consisting of vehicle cabin and chassis)are known,but have not yet been thought through to their logical conclusion.The LiMo cabin is not only a vehicle cabin,but also a component of a modern high-rise apartment.It therefore requires no parking space and combines urban living and individual mobility sustainably and cost-effectively.If a vehicle is needed,an app can be used to book a chassis that comes along autonomously and waits until the cabin,including its occupants,travels down a sophisticated rail system,docks and autonomously heads for the desired destination. 展开更多
关键词 MODULAR urban mobility SUSTAINABILITY ELEVATOR autonomous
下载PDF
Hmo1:A versatile member of the high mobility group box family of chromosomal architecture proteins
13
作者 Xin Bi 《World Journal of Biological Chemistry》 2024年第1期1-10,共10页
Eukaryotic chromatin consisting of nucleosomes connected by linker DNA is organized into higher order structures,which is facilitated by linker histone H1.Formation of chromatin compacts and protects the genome,but al... Eukaryotic chromatin consisting of nucleosomes connected by linker DNA is organized into higher order structures,which is facilitated by linker histone H1.Formation of chromatin compacts and protects the genome,but also hinders DNA transactions.Cells have evolved mechanisms to modify/remodel chromatin resulting in chromatin states suitable for genome functions.The high mobility group box(HMGB)proteins are non-histone chromatin architectural factors characterized by one or more HMGB motifs that bind DNA in a sequence nonspecific fashion.They play a major role in chromatin dynamics.The Saccharomyces cerevisiae(yeast hereafter)HMGB protein Hmo1 contains two HMGB motifs.However,unlike a canonical HMGB protein that has an acidic C-terminus,Hmo1 ends with a lysine rich,basic,C-terminus,resembling linker histone H1.Hmo1 exhibits characteristics of both HMGB proteins and linker histones in its multiple functions.For instance,Hmo1 promotes transcription by RNA polymerases I and II like canonical HMGB proteins but makes chromatin more compact/stable like linker histones.Recent studies have demonstrated that Hmo1 destabilizes/disrupts nucleosome similarly as other HMGB proteins in vitro and acts to maintain a common topological architecture of genes in yeast genome.This minireview reviews the functions of Hmo1 and the underlying mechanisms,highlighting recent discoveries. 展开更多
关键词 Hmo1 High mobility group box proteins CHROMATIN Chromatin remodeling Gene regulation Ribosomal DNA Ribosomal protein genes DNA damage response Linker histone
下载PDF
Pig Reproductive and Respiratory Syndrome Virus (PRRSV) Does Not Attach to Boar Sperm;It Affects Only the Velocity Pattern and the Mobility Pattern
14
作者 Néstor Méndez Palacios Netzi Naidí Mendez Palacios +3 位作者 Felicitas Vázquez Flores José Alfredo Galicia Domínguez Edgar Guadalupe Beltrán Rosas Maximino Méndez Mendoza 《Journal of Biosciences and Medicines》 2024年第4期216-228,共13页
The purpose of the study was to evaluate the sperm viability of semen infected with PRRSV viral particles, observing the effect of the Virus on the motility of boar sperm. The work was carried out at the FMVZ-BUAP Gen... The purpose of the study was to evaluate the sperm viability of semen infected with PRRSV viral particles, observing the effect of the Virus on the motility of boar sperm. The work was carried out at the FMVZ-BUAP Genetics and Reproduction Laboratory. 5 stallions were used. Each sample contained 1 × 10<sup>6</sup> sperm, the PRRS virus strain was ATCC-VR-2332 (0, 10<sup>2</sup>, 10<sup>4</sup> and 10<sup>6</sup> copies of RNA/mL in triplicate), it was observed daily at the CASA;Hamilton Thorne<sup>®</sup>. Cells with MT (P < 0.05) on days 1, 3, 5, 7 and 10 of evaluation with 201 ± 7.3, 167 ± 10.1, 165 ± 14.6, 134 ± 8.2 and 120 ± 8.8, respectively. The % MP between control and virus concentrations (P ≥ 0.05). The LCV on day 1 and 7 PI at 10X<sup>2</sup> and 10X<sup>6</sup> (P < 0.05) vs control. In the Correlation Matrix, where it is observed that there is a correlation between VSL and VAP, VSL and VCL, VCL and ALH, VAP with ALH. There is a correlation of VSL and ALH, STR and ALH. In this study there were (P ≤ 0.01) in the VCL, in the concentrations (10<sup>2</sup>) 162.81 ± 10.65 and (10<sup>6</sup>) 177.12 ± 5.77 vs 193.04 ± 4.62 of control. This indicates that altering these parameters would be related to fertility and the PRRS virus affects the LCV. Regarding the VSL, it was observed that the sperm infected with viruses 10<sup>2</sup>, 10<sup>4</sup> and 10<sup>6</sup> of 48.00 ± 3.38, 49.88 ± 1.83 and 50.55 ± 2.24 Vs. 56.66 ± 1.68 of control respectively, the control would have greater possibilities of fertilizing the oocyte. In this study, it was found (P ≤ 0.01) in the VAP with 102 of 77.26 ± 5.16, 10<sup>4</sup> with 83.35 ± 2.41 and 10<sup>6</sup> with 81.29 ± 3.14 vs the control with 90.56 ± 2.07. Regarding the ALH there is (P < 0.05) a 10<sup>4</sup> with 8.70 ± .26 and 10<sup>6</sup> with 9.64 ± 0.23 vs control 8.50 ± 0.27. The presence of different concentrations of PRRSV in boar semen induces changes in different types of sperm motility. Infection of ejaculates with the PRRS virus affects sperm motility on days 1, 3, 5, 7, and 10 post-infections. 展开更多
关键词 PRRSV Boar Sperms Velocity Pattern and mobility Pattern
下载PDF
Improvement in Patient Mobility Following Short-Term Rehabilitation in Skilled Nursing Facilities
15
作者 Sean R. Silver Jaden A. Silver 《Open Journal of Therapy and Rehabilitation》 2024年第1期52-60,共9页
Background: Mobility in older adults can be impaired after acute illness or hospitalization, and the level of severity can be used as a predictor of one’s ability to return to independent living. Patients are often r... Background: Mobility in older adults can be impaired after acute illness or hospitalization, and the level of severity can be used as a predictor of one’s ability to return to independent living. Patients are often referred to skilled nursing facilities in hopes of improving their mobility. We wanted to prove that rehabilitative services at Skilled Nursing Facilities improve overall outcomes. Methods: We conducted a retrospective analysis of data from 4612 patients admitted for short-term rehabilitation in a large nursing home chain in California. Our aim was to determine whether patients’ mobility scores, as measured by rehabilitative staff, significantly improved by time of discharge compared to their scores at admission. Mobility scores were rated from 1 to 6, with 1 being the most dependent on aid and 6 being the most independent, over a variety of tasks at admission and compared to scores at discharge. Pearson’s correlations were performed to determine if there were significant relationships in the data: the Pearson’s correlation coefficient was used to describe the relationships between patient admission to a skilled nursing facility and medical improvement upon discharge. Results: The study demonstrated a statistically significant improvement in patients’ mobility scores upon discharge, with Medicare insured patients showing on average 57% improvement and Managed Care insured patients showing on average 59% improvement. Additionally, admission scores appeared to be predictive of the patient’s outcome at discharge. Conclusions: The values and consistency of improvement support the use of acute rehabilitative services in skilled nursing facilities. An equation can be formulated that evaluates patients’ estimated mobility statuses upon discharge from facilities based on their conditions on their arrivals. With this, new interventions can be studied and compared to the current standard of care by using these measurements. They can determine if further improvements can be made to increase patient outcomes. 展开更多
关键词 mobility Skilled Nursing Facility Rehabilitative Services Independent Living Healthcare
下载PDF
Sustainable Urban Mobility: (A)Synchrony between Subway Systems
16
作者 Ana Paula Borba Gonçalves Barros 《Journal of Traffic and Transportation Engineering》 2024年第3期151-161,共11页
The present study analyses the differences between the subways systems of two cities, Lisbon (Portugal) and Brasília (Brazil), verifying the extent to which their subway systems are spatially integrated with the ... The present study analyses the differences between the subways systems of two cities, Lisbon (Portugal) and Brasília (Brazil), verifying the extent to which their subway systems are spatially integrated with the respective urban fabric-which would promote a better synchrony in terms of economy and sustainability. For interpreting the data, the methodology and tools of the Theory of the Social Logic of Space were used, by means of axial maps, researching the relationship between the constructed and empty (public spaces) areas of the urban structures. Based on the findings, meaningful differences between the subway systems and the configuration of urban spaces were observed, as a product of specific design matrixes. In Lisbon, the mobility associated to the subway seems to be encouraged by the integration of the system with the potential for movement provided by the urban tissue (making the secondary centralities articulated with the subway stations more dynamic). In Brasilia, however, there are several difficulties for such mobility, due to the predominant role of the empty spaces in the city which weakens the gathering potential of such areas, despite the fact that such articulation with secondary centralities is also present there. 展开更多
关键词 Urban mobility spatial configuration space syntax subway system.
下载PDF
Exploring the Promises and Challenges of Urban Air Mobility (UAM)
17
作者 Yusuf Karimli Aniello Daniele Marano 《Advances in Aerospace Science and Technology》 2024年第3期75-84,共10页
This paper is focused on a higher-level report of a new generation of Unmanned Aerial Vehicle (UAV) technologies. Starting from the structural scalability of civil tiltrotors, design strategy and requirements for UAVs... This paper is focused on a higher-level report of a new generation of Unmanned Aerial Vehicle (UAV) technologies. Starting from the structural scalability of civil tiltrotors, design strategy and requirements for UAVs, and advanced composite materials, the increased speed and productivity requirements for tiltrotors have spawned several investigations associated with proprotor aero elastic stability augmentation and aerodynamic performance enhancements. The research emphasized the Large Civil Tilt Rotor as the configuration with the best potential to meet the technology goals, and the design, including the challenges of the Large Civil Tilt Rotor (LCTR). The design presented was economically competitive, with the potential for substantial impact on the air transportation system. The research includes some manufacturers of helicopters, drones and tiltrotors carrying out design studies and production of prototypes, as well as research projects aimed at designing, manufacturing, qualifying, and flight-testing the new wing of the Next-Generation Civil Tiltrotor Technology Demonstrator. Promises of Vertical Take-off and Landing (VTOL) aircraft, UAVs, Digitalization of Urban Air Mobility (UAM), and the “U-space” concept are discussed in the paper. The eight SUMP principles and possibilities of future advancements are emphasized. 展开更多
关键词 THERMODYNAMICS Aerospace Innovations Sustainable Energy Systems Fluid Dynamics Aeronautical Engineering Green Technology Digital Development of Engineering Urban Air mobility
下载PDF
High threshold voltage enhancement-mode GaN p-FET with Sirich LPCVD SiN_(x) gate insulator for high hole mobility 被引量:1
18
作者 Liyang Zhu Kuangli Chen +5 位作者 Ying Ma Yong Cai Chunhua Zhou Zhaoji Li Bo Zhang Qi Zhou 《Journal of Semiconductors》 EI CAS CSCD 2023年第8期78-86,共9页
In this work,the GaN p-MISFET with LPCVD-SiN_(x) is studied as a gate dielectric to improve device performance.By changing the Si/N stoichiometry of SiN_(x),it is found that the channel hole mobility can be effectivel... In this work,the GaN p-MISFET with LPCVD-SiN_(x) is studied as a gate dielectric to improve device performance.By changing the Si/N stoichiometry of SiN_(x),it is found that the channel hole mobility can be effectively enhanced with Si-rich SiN_(x) gate dielectric,which leads to a respectably improved drive current of GaN p-FET.The record high channel mobility of 19.4 cm2/(V∙s)was achieved in the device featuring an Enhancement-mode channel.Benefiting from the significantly improved channel mobility,the fabricated E-mode GaN p-MISFET is capable of delivering a decent-high current of 1.6 mA/mm,while simultaneously featuring a negative threshold-voltage(VTH)of–2.3 V(defining at a stringent criteria of 10μA/mm).The device also exhibits a well pinch-off at 0 V with low leakage current of 1 nA/mm.This suggests that a decent E-mode operation of the fabricated p-FET is obtained.In addition,the VTH shows excellent stability,while the threshold-voltage hysteresisΔVTH is as small as 0.1 V for a gate voltage swing up to–10 V,which is among the best results reported in the literature.The results indicate that optimizing the Si/N stoichiometry of LPCVD-SiN_(x) is a promising approach to improve the device performance of GaN p-MISFET. 展开更多
关键词 p-channel GaN p-FET LPCVD channel mobility hole mobility ENHANCEMENT-MODE
下载PDF
Flexible Large-Area Graphene Films of 50-600 nm Thickness with High Carrier Mobility 被引量:4
19
作者 Shiyu Luo Li Peng +13 位作者 Yangsu Xie Xiaoxue Cao Xiao Wang Xiaoting Liu Tingting Chen Zhanpo Han Peidong Fan Haiyan Sun Ying Shen Fan Guo Yuxing Xia Kaiwen Li Xin Ming Chao Gao 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第5期1-14,共14页
Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and o... Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms. 展开更多
关键词 Flexible large-area graphene nanofilm High carrier mobility Mid-infrared detection Electromagnetic interference shielding Heat transfer
下载PDF
Mobility-Aware Adaptive Beam Tracking for Vehicles in Mm Wave Communication Networks 被引量:1
20
作者 Jin Xu Ying Zhou +2 位作者 Jian Zhang Yuchong Tang Xiaofeng Tao 《China Communications》 SCIE CSCD 2023年第3期161-174,共14页
The millimeter wave(mm Wave)is a potential solution for high data rate communication due to its availability of large bandwidth.However,it is challenging to perform beam tracking in vehicular mm Wave communication sys... The millimeter wave(mm Wave)is a potential solution for high data rate communication due to its availability of large bandwidth.However,it is challenging to perform beam tracking in vehicular mm Wave communication systems due to high mobility and narrow beams.In this paper,an adaptive beam tracking algorithm is proposed to improve the network throughput performance while reducing the training signal overhead.In particular,based on the mobility prediction at base station(BS),a novel frame structure with dynamic bundled timeslot is designed.Moreover,an actor-critic reinforcement learning based algorithm is proposed to obtain the joint optimization of both beam width and the number of bundled timeslots,which makes the beam tracking adapt to the changing environment.Simulation results demonstrate that,compared with the traditional full scan and Kalman filter based beam tracking algorithms,our proposed algorithm can improve the time-averaged throughput by 11.34%and 24.86%respectively.With the newly designed frame structure,it also outperforms beam tracking with conventional frame structure,especially in scenarios with large range of vehicle speeds. 展开更多
关键词 adaptive beam tracking mobility predic-tion dynamic bundled timeslot variable beam width reinforcement learning actor-critic
下载PDF
上一页 1 2 243 下一页 到第
使用帮助 返回顶部