相比于传统雷达系统,感知雷达能够通过对复杂多变的电磁环境感知自适应调整雷达发射波形,以适应当前的环境,实现推理和判决的优化,从而获得系统性能的大幅提升。从感知雷达的思想出发,研究了杂波环境下的波形自适应选择问题,提出了一种...相比于传统雷达系统,感知雷达能够通过对复杂多变的电磁环境感知自适应调整雷达发射波形,以适应当前的环境,实现推理和判决的优化,从而获得系统性能的大幅提升。从感知雷达的思想出发,研究了杂波环境下的波形自适应选择问题,提出了一种基于修正概率数据关联(modified probabilistic data association,MPDA)的波形自适应选择目标跟踪算法。采用MPDA算法建立和更新杂波下目标的航迹,利用修正的Riccati方程估计下一时刻的滤波协方差矩阵,并推导了相应的波形优化准则函数。仿真表明,该算法降低了密集杂波条件下的滤波误差,相比于未采用波形优化的PDA和MPDA算法,显著提高了跟踪性能。展开更多
Diabetic wound healing has become a serious healthcare challenge.The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular f...Diabetic wound healing has become a serious healthcare challenge.The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue necrosis.To solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to ROS.This F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)NPs.In addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound healing.Therefore,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration.展开更多
文摘相比于传统雷达系统,感知雷达能够通过对复杂多变的电磁环境感知自适应调整雷达发射波形,以适应当前的环境,实现推理和判决的优化,从而获得系统性能的大幅提升。从感知雷达的思想出发,研究了杂波环境下的波形自适应选择问题,提出了一种基于修正概率数据关联(modified probabilistic data association,MPDA)的波形自适应选择目标跟踪算法。采用MPDA算法建立和更新杂波下目标的航迹,利用修正的Riccati方程估计下一时刻的滤波协方差矩阵,并推导了相应的波形优化准则函数。仿真表明,该算法降低了密集杂波条件下的滤波误差,相比于未采用波形优化的PDA和MPDA算法,显著提高了跟踪性能。
文摘Diabetic wound healing has become a serious healthcare challenge.The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue necrosis.To solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to ROS.This F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)NPs.In addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound healing.Therefore,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration.
