Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of the...Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.展开更多
Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes wer...Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, (()~1H) NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H_2O)_2]Cl_2·H_2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity ( R _1) of the Gd-complex was determined by INVREC Au program.展开更多
Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modi...Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.展开更多
Six new aminocarboxylic ligands were synthesized by reactions of EDTA (ethylenediaminetetraacetic acid) dianhydride or DTPA (dlethylenetriaminepenta-acetic acid) dianhydride and ethyl ester of serine,threonine and tyr...Six new aminocarboxylic ligands were synthesized by reactions of EDTA (ethylenediaminetetraacetic acid) dianhydride or DTPA (dlethylenetriaminepenta-acetic acid) dianhydride and ethyl ester of serine,threonine and tyrosine. Their paramagnetic metal complexes were also synthesized.All ligands and paramagnetic metal complexes were characterized by IR spectra,IH NMR and elemental analyses.Relaxivity study showed that the metal complexes had higher relaxation effectiveness as compared to corresponding unmodified metal complexes. Imaging study of gadolinium complex of tyrosine ethyl ester modified DTPA in mice demonstrated that this metal complex could apparently increase the signal intensity of MR images.展开更多
Mn-TCPP-CSn（n=6,1 1,20） as a type of potential magnetic resonance imaging（MRI） contrast agents were synthesized via manganese（Ⅱ） meso-tetra（4-carboxyphenyl） porphyrin（Mn-TCPP） modified with chitosan oligosa...Mn-TCPP-CSn（n=6,1 1,20） as a type of potential magnetic resonance imaging（MRI） contrast agents were synthesized via manganese（Ⅱ） meso-tetra（4-carboxyphenyl） porphyrin（Mn-TCPP） modified with chitosan oligosaccharides（CSn）.Experimental data of infared（IR）,UV-Vis,MS,inductively coupled plasma-atomic emission spectrometer（ICP-AES） and size exclusion chromatography evidenced the formation of Mn-TCPP-CSn-The stability results show that Mn-TCPP-CSn in aqueous solution was stable enough to prevent Mn（Ⅱ） ions from leaking.The magnetic properties in vitro indicate that Mn-TCPP-CS20 possesses higher longitudinal relaxivity（r1=10.38 L·mmol^-1·s^-1） in aqueous solution than unmodified porphyrin Mn-TCPPNa4[manganese（Ⅱ） meso-tetra（4-carboxyphenyl） porphyrin,tetrasodium salt]（r1=5.10 L·mmol^-1·s^-1） and the commercial contrast agent Gd-DTPA（r1=4.05 L·mmol^-1·s^-1）.The preliminary T1-weighted flash image studies in vitro show that the contrast and the imaging signal of Mn-TCPP-CSn were superior to those of Mn-TCPPNa4 and Gd-DTPA under the same conditions.The 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） assay shows that Mn-TCPP-CSn has a good biocompatibility.In addition,the thermodynamical parameters（ΔH〈0,ΔS〈0,ΔG〈0） of Mn-TCPP-CSn bound to bovine serum albumin（BSA） show that Mn-TCPP-CSn could bind to BSA spontaneously,where the binding complex was stabilized mainly by van der Waals interactions and hydrogen bonds.These results suggest that Mn-TCPP-CSn have the advantage of becoming a potential MRI contrast agent.展开更多
Accurate diagnosis of hepatocellular carcinoma(HCC) in the early stage is vital for its treatment.Contrast-enhanced dynamic magnetic resonance imaging(MRI) performed in the presence of extracellular contrast agents su...Accurate diagnosis of hepatocellular carcinoma(HCC) in the early stage is vital for its treatment.Contrast-enhanced dynamic magnetic resonance imaging(MRI) performed in the presence of extracellular contrast agents such as gadolinium chelates is considered as a useful approach for detecting and characterizing focal liver lesions.However,the sensitivity and specificity of conventional MRI contrast agents are far from satisfaction for the detection and characterization of benign and malignant focal liver lesions in the early stage.The novel molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue are highly desired.The development of nanotechnology provides an unprecedented opportunity for the diagnostic detection rate of HCC and cell-surface receptor-targeted nanotechnology improves the specificity of the detection of focal liver lesions.In order to maximize lesion detection and characterization,novel gadolinium chelates loaded nanovectors including the solid lipid nanoparticles,nanocomplexes and polymeric nanoparticles have been used as biocompatible molecular MRI contrast agent.In this review,the characterization and the advantages/disadvantages of these Gd-loaded novel nanovectors used as molecular MRI contrast agents were discussed.Furthermore,liver target nanovectors aimed at improving the diagnostic accuracy of liver MRI by targeting additional features of focal liver lesions were highlighted.展开更多
Macromolecular ligands with liver-targeting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetria-minepentaacetic acid monopyridoxamine group (...Macromolecular ligands with liver-targeting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetria-minepentaacetic acid monopyridoxamine group (DTPA-PM) into poly-α, β-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) and poly-α, β-[N-(2-aminoethyl)-L-aspartamide] (PAEA). The macromolecular ligands thus obtained were further complexed with gadolinium chloride to give macromolecular MRI contrast agents with different Gd(III) contents. These macromolecular ligands and their gadolinium complexes were characterized by1H NMR, IR, UV and elementary analysis. Relaxivity studies showed that these polyaspartamide gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging of the liver in rats and experimental data of biodistribution in mice indicate that these macromolecular MRI contrast agents containing pyridoxamine exhibit liver-targeting property.展开更多
Accurate diagnosis of hepatocellular carcinoma （HCC） in the early stage is vital for its treatment. Contrast-enhanced dynamic magnetic resonance imaging （MRI） performed in the presence of extracellular contrast ag...Accurate diagnosis of hepatocellular carcinoma （HCC） in the early stage is vital for its treatment. Contrast-enhanced dynamic magnetic resonance imaging （MRI） performed in the presence of extracellular contrast agents such as gadolinium chelates is considered as a useful approach for detecting and characterizing focal liver lesions. However, the sensitivity and specificity of conventional MRI contrast agents are far from satisfaction for the detection and characterization of benign and malignant focal liver lesions in the early stage. The novel molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue are highly desired. The development of nanotechnology provides an unprecedented opportunity for the diagnostic detection rate of HCC and cell-surface receptor-targeted nanotechnology improves the specificity of the detection of focal liver lesions. In order to maximize lesion detection and characterization, novel gadolinium chelates loaded nanovectors including the solid lipid nanoparticles, nanocomplexes and polymeric nanoparticles have been used as biocompatible molecular MRI contrast agent. In this review, the characterization and the advantages/disadvantages of these Gd-loaded novel nanovectors used as molecular MRI contrast agents were discussed. Furthermore, liver target nanovectors aimed at improving the diagnostic accuracy of liver MR1 by tar~etin~ additional features of focal liver lesions were highlighted.展开更多
X-ray single crystal analysis of a new paramagnetic manganese（Ⅱ） complex with DTPA-BpABA （a DTPAbisamide derivative）, Mn（DTPA-BpABA）·4H2O, shows that four oxygen atoms and three nitrogen atoms from the lig...X-ray single crystal analysis of a new paramagnetic manganese（Ⅱ） complex with DTPA-BpABA （a DTPAbisamide derivative）, Mn（DTPA-BpABA）·4H2O, shows that four oxygen atoms and three nitrogen atoms from the ligand coordinate to Mn（Ⅱ） cation, forming a seven-coordinate distorted pentagonal bipyramid polyhedron. In the crystal, the carboxyl groups and the nitrogen atoms extensively form hydrogen bonds with the lattice water molecules, building a 3D-network. The relaxometric study indicates that the R1 value of the paramagnetic manganese（Ⅱ）complex is 5.12 mmol·L·s^-1. The higher R1 value means that this complex may find an application in magnetic resonance imaging （MRI） technique.展开更多
Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents ...Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 L.mmol(-1).s(-1) vs. 5.2, 2.8 and 1.7 L.mmol(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.展开更多
Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of t...Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.展开更多
Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based ...Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based on gadolinium ion are developing fast in the last decade since they play an important role in physiological and pathology process in living system. This minireview would highlight recent progress in metal responsive gadolinium-based MRI contrast agent.展开更多
基金Project supported by the Chinese Academy of Sciences and the State Sciences and Technology Commission of China.
文摘Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.
文摘Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, (()~1H) NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H_2O)_2]Cl_2·H_2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity ( R _1) of the Gd-complex was determined by INVREC Au program.
基金financially supported by the National Natural Science Foundation of China(Nos.21374061,81371703 and 81501571)the Marie Curie International Incoming Fellowship of the EU+2 种基金the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning“Shu Guang”project supported by Shanghai Municipal Education CommissionShanghai Education Development Foundation
文摘Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.
文摘Six new aminocarboxylic ligands were synthesized by reactions of EDTA (ethylenediaminetetraacetic acid) dianhydride or DTPA (dlethylenetriaminepenta-acetic acid) dianhydride and ethyl ester of serine,threonine and tyrosine. Their paramagnetic metal complexes were also synthesized.All ligands and paramagnetic metal complexes were characterized by IR spectra,IH NMR and elemental analyses.Relaxivity study showed that the metal complexes had higher relaxation effectiveness as compared to corresponding unmodified metal complexes. Imaging study of gadolinium complex of tyrosine ethyl ester modified DTPA in mice demonstrated that this metal complex could apparently increase the signal intensity of MR images.
基金Supported by the National Natural Science Foundation of China（Nos.21261008, 21302071, 21171076）, and the Cooperation Project of Hainan International Science and Technology, China（No.KJHZ2014-05）.
文摘Mn-TCPP-CSn（n=6,1 1,20） as a type of potential magnetic resonance imaging（MRI） contrast agents were synthesized via manganese（Ⅱ） meso-tetra（4-carboxyphenyl） porphyrin（Mn-TCPP） modified with chitosan oligosaccharides（CSn）.Experimental data of infared（IR）,UV-Vis,MS,inductively coupled plasma-atomic emission spectrometer（ICP-AES） and size exclusion chromatography evidenced the formation of Mn-TCPP-CSn-The stability results show that Mn-TCPP-CSn in aqueous solution was stable enough to prevent Mn（Ⅱ） ions from leaking.The magnetic properties in vitro indicate that Mn-TCPP-CS20 possesses higher longitudinal relaxivity（r1=10.38 L·mmol^-1·s^-1） in aqueous solution than unmodified porphyrin Mn-TCPPNa4[manganese（Ⅱ） meso-tetra（4-carboxyphenyl） porphyrin,tetrasodium salt]（r1=5.10 L·mmol^-1·s^-1） and the commercial contrast agent Gd-DTPA（r1=4.05 L·mmol^-1·s^-1）.The preliminary T1-weighted flash image studies in vitro show that the contrast and the imaging signal of Mn-TCPP-CSn were superior to those of Mn-TCPPNa4 and Gd-DTPA under the same conditions.The 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） assay shows that Mn-TCPP-CSn has a good biocompatibility.In addition,the thermodynamical parameters（ΔH〈0,ΔS〈0,ΔG〈0） of Mn-TCPP-CSn bound to bovine serum albumin（BSA） show that Mn-TCPP-CSn could bind to BSA spontaneously,where the binding complex was stabilized mainly by van der Waals interactions and hydrogen bonds.These results suggest that Mn-TCPP-CSn have the advantage of becoming a potential MRI contrast agent.
基金New Century Excellent Talents in University (Grant No.NCET-08-0334)Independent Innovation Foundation of Shandong University(IIFSDU,Grant No.2010JC019).
文摘Accurate diagnosis of hepatocellular carcinoma(HCC) in the early stage is vital for its treatment.Contrast-enhanced dynamic magnetic resonance imaging(MRI) performed in the presence of extracellular contrast agents such as gadolinium chelates is considered as a useful approach for detecting and characterizing focal liver lesions.However,the sensitivity and specificity of conventional MRI contrast agents are far from satisfaction for the detection and characterization of benign and malignant focal liver lesions in the early stage.The novel molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue are highly desired.The development of nanotechnology provides an unprecedented opportunity for the diagnostic detection rate of HCC and cell-surface receptor-targeted nanotechnology improves the specificity of the detection of focal liver lesions.In order to maximize lesion detection and characterization,novel gadolinium chelates loaded nanovectors including the solid lipid nanoparticles,nanocomplexes and polymeric nanoparticles have been used as biocompatible molecular MRI contrast agent.In this review,the characterization and the advantages/disadvantages of these Gd-loaded novel nanovectors used as molecular MRI contrast agents were discussed.Furthermore,liver target nanovectors aimed at improving the diagnostic accuracy of liver MRI by targeting additional features of focal liver lesions were highlighted.
基金Acknowledgements The authors would like to thank Mr. Cao Guoqiang and Mr. Cao Wei (Department of Nuclear Medicine of Wuhan Union Hospital) for their assistance in the biodistribution experiment, Profs. Zheng Congyi and Mr. Qu Sanfu (College of Life Scien
文摘Macromolecular ligands with liver-targeting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetria-minepentaacetic acid monopyridoxamine group (DTPA-PM) into poly-α, β-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) and poly-α, β-[N-(2-aminoethyl)-L-aspartamide] (PAEA). The macromolecular ligands thus obtained were further complexed with gadolinium chloride to give macromolecular MRI contrast agents with different Gd(III) contents. These macromolecular ligands and their gadolinium complexes were characterized by1H NMR, IR, UV and elementary analysis. Relaxivity studies showed that these polyaspartamide gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging of the liver in rats and experimental data of biodistribution in mice indicate that these macromolecular MRI contrast agents containing pyridoxamine exhibit liver-targeting property.
基金Foundation items： New Century Excellent lalents in University （Grant No. NCET-08-0334） and Independent Innovation Foundation of Shandong University （IIFSDU, Grant No. 2010JC019）.
文摘Accurate diagnosis of hepatocellular carcinoma （HCC） in the early stage is vital for its treatment. Contrast-enhanced dynamic magnetic resonance imaging （MRI） performed in the presence of extracellular contrast agents such as gadolinium chelates is considered as a useful approach for detecting and characterizing focal liver lesions. However, the sensitivity and specificity of conventional MRI contrast agents are far from satisfaction for the detection and characterization of benign and malignant focal liver lesions in the early stage. The novel molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue are highly desired. The development of nanotechnology provides an unprecedented opportunity for the diagnostic detection rate of HCC and cell-surface receptor-targeted nanotechnology improves the specificity of the detection of focal liver lesions. In order to maximize lesion detection and characterization, novel gadolinium chelates loaded nanovectors including the solid lipid nanoparticles, nanocomplexes and polymeric nanoparticles have been used as biocompatible molecular MRI contrast agent. In this review, the characterization and the advantages/disadvantages of these Gd-loaded novel nanovectors used as molecular MRI contrast agents were discussed. Furthermore, liver target nanovectors aimed at improving the diagnostic accuracy of liver MR1 by tar~etin~ additional features of focal liver lesions were highlighted.
基金Project supported by the Municipal Natural Science Foundation of Beijing （No. 2022011）.
文摘X-ray single crystal analysis of a new paramagnetic manganese（Ⅱ） complex with DTPA-BpABA （a DTPAbisamide derivative）, Mn（DTPA-BpABA）·4H2O, shows that four oxygen atoms and three nitrogen atoms from the ligand coordinate to Mn（Ⅱ） cation, forming a seven-coordinate distorted pentagonal bipyramid polyhedron. In the crystal, the carboxyl groups and the nitrogen atoms extensively form hydrogen bonds with the lattice water molecules, building a 3D-network. The relaxometric study indicates that the R1 value of the paramagnetic manganese（Ⅱ）complex is 5.12 mmol·L·s^-1. The higher R1 value means that this complex may find an application in magnetic resonance imaging （MRI） technique.
文摘Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 L.mmol(-1).s(-1) vs. 5.2, 2.8 and 1.7 L.mmol(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.
基金Supported by the National Natural Science Foundation of China(Nos. 20275011 and 10234070) the Program for PromotingUniversity Academic Excellence by the Ministry of Education of Taiwan of China(No. A-92-N-FA01-2-4-5) Foundation of StateKey Laboratory of Magnetic Resonance &Atomic and Molecular Physics(No. T12045).
文摘Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.
基金supported by the Scientific Instrument Developing Project of the Chinese Academy of Sciences(Grant No.ZDKYYQ20180001)the National Natural Science Foundation of China(Grant No.21704099)the CAS Pioneer Hundred Talents Program and the Open Funds of the State Key Laboratory of Rare Earth Resource Utilization(Grant No.RERUY2017009)
文摘Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based on gadolinium ion are developing fast in the last decade since they play an important role in physiological and pathology process in living system. This minireview would highlight recent progress in metal responsive gadolinium-based MRI contrast agent.
