Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modi...Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.展开更多
Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based ...Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based on gadolinium ion are developing fast in the last decade since they play an important role in physiological and pathology process in living system. This minireview would highlight recent progress in metal responsive gadolinium-based MRI contrast agent.展开更多
Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of the...Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.展开更多
Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.The...Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.Then,three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm.The longitudinal relaxation rate r_(1) of the Gal-PEG-2000 is 11.097(mmol/L)^(-1)/s,and the ratio of r_(2)/r_(1) is as low as 2.53.The composite shows good liver and intestines MRI performances after being used in in vivo imaging,showing a good prospect of biological application.展开更多
Magnetic resonance imaging (MRI) is a clinical diagnostic modality, which has become popular in hospitals around the world. Approximately 30% of MRI exams include the use of contrast agents. The research progress of t...Magnetic resonance imaging (MRI) is a clinical diagnostic modality, which has become popular in hospitals around the world. Approximately 30% of MRI exams include the use of contrast agents. The research progress of the paramagnetic resonance imaging contrast agents was described briefly. Three important approaches in the soluble paramagnetic resonance imaging contrast agents design including nonionic, tissue-specific and macromolecular contrast agents were investigated. In addition, the problems in the research and development in future were discussed.展开更多
Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents ...Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 L.mmol(-1).s(-1) vs. 5.2, 2.8 and 1.7 L.mmol(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.展开更多
Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes wer...Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, (()~1H) NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H_2O)_2]Cl_2·H_2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity ( R _1) of the Gd-complex was determined by INVREC Au program.展开更多
Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of t...Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.21374061,81371703 and 81501571)the Marie Curie International Incoming Fellowship of the EU+2 种基金the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning“Shu Guang”project supported by Shanghai Municipal Education CommissionShanghai Education Development Foundation
文摘Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.
基金Foundation items： New Century Excellent lalents in University （Grant No. NCET-08-0334） and Independent Innovation Foundation of Shandong University （IIFSDU, Grant No. 2010JC019）.
基金supported by the Scientific Instrument Developing Project of the Chinese Academy of Sciences(Grant No.ZDKYYQ20180001)the National Natural Science Foundation of China(Grant No.21704099)the CAS Pioneer Hundred Talents Program and the Open Funds of the State Key Laboratory of Rare Earth Resource Utilization(Grant No.RERUY2017009)
文摘Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based on gadolinium ion are developing fast in the last decade since they play an important role in physiological and pathology process in living system. This minireview would highlight recent progress in metal responsive gadolinium-based MRI contrast agent.
基金Project supported by the Chinese Academy of Sciences and the State Sciences and Technology Commission of China.
文摘Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.
基金Project supported by the Natural Science Foundation of Gansu Province(20JR10RA511,2019B-084)。
文摘Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.Then,three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm.The longitudinal relaxation rate r_(1) of the Gal-PEG-2000 is 11.097(mmol/L)^(-1)/s,and the ratio of r_(2)/r_(1) is as low as 2.53.The composite shows good liver and intestines MRI performances after being used in in vivo imaging,showing a good prospect of biological application.
基金This work was supported by the National "863" High Technology Project and the National Natural Science Foundation of China (Grant No. 29874028).
文摘Magnetic resonance imaging (MRI) is a clinical diagnostic modality, which has become popular in hospitals around the world. Approximately 30% of MRI exams include the use of contrast agents. The research progress of the paramagnetic resonance imaging contrast agents was described briefly. Three important approaches in the soluble paramagnetic resonance imaging contrast agents design including nonionic, tissue-specific and macromolecular contrast agents were investigated. In addition, the problems in the research and development in future were discussed.
文摘Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 L.mmol(-1).s(-1) vs. 5.2, 2.8 and 1.7 L.mmol(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.
文摘Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, (()~1H) NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H_2O)_2]Cl_2·H_2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity ( R _1) of the Gd-complex was determined by INVREC Au program.
基金Supported by the National Natural Science Foundation of China(Nos. 20275011 and 10234070) the Program for PromotingUniversity Academic Excellence by the Ministry of Education of Taiwan of China(No. A-92-N-FA01-2-4-5) Foundation of StateKey Laboratory of Magnetic Resonance &Atomic and Molecular Physics(No. T12045).
文摘Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.
