Bone marrow mesenchymal stem cells (MSCs) can differentiate into smooth muscle cells (SMCs) and have tremendous potential for cell therapy and tissue engineering. In this study, to understand the effects of TGF-β3 on...Bone marrow mesenchymal stem cells (MSCs) can differentiate into smooth muscle cells (SMCs) and have tremendous potential for cell therapy and tissue engineering. In this study, to understand the effects of TGF-β3 on rat bone marrow-derived MSCs and the underlying molecular mechanism of this differentiation process, we investigated that the changes of myocardin-related transcription factors (MRTFs) at the transcriptional level after rat MSCs were treated with TGF-β3. The results showed that TGF-β3 increased the expression of contractile genes, such as SM22, smooth muscle-myosin heavy chain (SM- MHC), SM-α-actin in MSCs. When TGF-β3 induced MSCs differentiation into SMCs, myocardin and MRTF-A were activated. The data indicated that TGF-β3 induced rat bone marrow-derived MSCs differentiation into SMCs by activating mypcardin and MRTF-A.展开更多
针对LTE建网初期覆盖不足的现状,提出了基于LTE网络的CSFB语音业务方案和实现办法。目前,CSFB回落方案采用3GPP R8重定向回落方案,同时要求终端支持缓读System Information 13系统消息功能以缩短呼叫建立时延、优化方案性能。总体来说,C...针对LTE建网初期覆盖不足的现状,提出了基于LTE网络的CSFB语音业务方案和实现办法。目前,CSFB回落方案采用3GPP R8重定向回落方案,同时要求终端支持缓读System Information 13系统消息功能以缩短呼叫建立时延、优化方案性能。总体来说,CSFB呼叫建立过程包括三个阶段:UE在LTE网络发起呼叫/被叫接收寻呼、UE在LTE网络指引下回落并搜索合适的W小区接入、UE读取W小区系统广播消息并建立语音通话。在CSFB部署过程中,因参数配置或者设备功能缺陷,将导致CSFB呼叫建立过程出现异常情况。解决了被叫语音用户由4G网络回落到3G网络过程中出现的"被叫关机"问题,对于今后的网络优化具有参考价值。展开更多
文摘Bone marrow mesenchymal stem cells (MSCs) can differentiate into smooth muscle cells (SMCs) and have tremendous potential for cell therapy and tissue engineering. In this study, to understand the effects of TGF-β3 on rat bone marrow-derived MSCs and the underlying molecular mechanism of this differentiation process, we investigated that the changes of myocardin-related transcription factors (MRTFs) at the transcriptional level after rat MSCs were treated with TGF-β3. The results showed that TGF-β3 increased the expression of contractile genes, such as SM22, smooth muscle-myosin heavy chain (SM- MHC), SM-α-actin in MSCs. When TGF-β3 induced MSCs differentiation into SMCs, myocardin and MRTF-A were activated. The data indicated that TGF-β3 induced rat bone marrow-derived MSCs differentiation into SMCs by activating mypcardin and MRTF-A.
文摘针对LTE建网初期覆盖不足的现状,提出了基于LTE网络的CSFB语音业务方案和实现办法。目前,CSFB回落方案采用3GPP R8重定向回落方案,同时要求终端支持缓读System Information 13系统消息功能以缩短呼叫建立时延、优化方案性能。总体来说,CSFB呼叫建立过程包括三个阶段:UE在LTE网络发起呼叫/被叫接收寻呼、UE在LTE网络指引下回落并搜索合适的W小区接入、UE读取W小区系统广播消息并建立语音通话。在CSFB部署过程中,因参数配置或者设备功能缺陷,将导致CSFB呼叫建立过程出现异常情况。解决了被叫语音用户由4G网络回落到3G网络过程中出现的"被叫关机"问题,对于今后的网络优化具有参考价值。
