当前电力营销业务已由单一的供电服务逐渐转变为碳交易、客户侧储能、多能供应、能效服务、分布式电源等综合能源服务,及时响应用户需求变得尤为重要。针对传统建设模式中存在的跨环节协作壁垒、业务需求响应不及时等问题,文章借鉴中台...当前电力营销业务已由单一的供电服务逐渐转变为碳交易、客户侧储能、多能供应、能效服务、分布式电源等综合能源服务,及时响应用户需求变得尤为重要。针对传统建设模式中存在的跨环节协作壁垒、业务需求响应不及时等问题,文章借鉴中台架构设计理念,首先提出一种公共共享服务研运一体化支撑平台(middle-platform service components,MSC),利用模型编排、服务编排、流程编排、界面编排进行微服务灵活实现及扩展;然后,结合架构资产统一管理以及MSC四编排引擎,基于多租户技术进行电力营销业务系统研运一体化建设;最后,通过在客户侧工单中心建设中的应用,证明该模式可为电力营销业务系统建设提供有效支撑。展开更多
Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increas...Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound repair.As a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy.Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair follicles.In addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix production.Additionally,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma repair.Through the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair.In conclusion,MSCderived EV-based therapies have important application prospects in wound repair.Here we provide a comprehensive overview of their current status,application potential,and associated drawbacks.展开更多
文摘当前电力营销业务已由单一的供电服务逐渐转变为碳交易、客户侧储能、多能供应、能效服务、分布式电源等综合能源服务,及时响应用户需求变得尤为重要。针对传统建设模式中存在的跨环节协作壁垒、业务需求响应不及时等问题,文章借鉴中台架构设计理念,首先提出一种公共共享服务研运一体化支撑平台(middle-platform service components,MSC),利用模型编排、服务编排、流程编排、界面编排进行微服务灵活实现及扩展;然后,结合架构资产统一管理以及MSC四编排引擎,基于多租户技术进行电力营销业务系统研运一体化建设;最后,通过在客户侧工单中心建设中的应用,证明该模式可为电力营销业务系统建设提供有效支撑。
基金supported by the National Key Research and Development Project Intergovernmental Cooperation in Science and Technology of China(2018YFE0126900)the Key R&D Program of Lishui City(2021ZDYF12)the National Natural Science Foundation of China(82271629)。
文摘Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or contusions.As such injuries are common to all human groups,they may at times represent a serious socioeconomic burden.Currently,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound repair.As a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy.Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair follicles.In addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix production.Additionally,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma repair.Through the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair.In conclusion,MSCderived EV-based therapies have important application prospects in wound repair.Here we provide a comprehensive overview of their current status,application potential,and associated drawbacks.
