采用自制的高比表面MSU介孔分子筛为载体,制备了系列歧化催化剂,对其进行XRD、N2吸附-脱附、H2-TPR和29Si MAS NMR表征,并评价了其1-丁烯歧化反应性能。结果显示高比表面载体和合适的WO3负载量有利于提高活性组分在载体表面的分散度,从...采用自制的高比表面MSU介孔分子筛为载体,制备了系列歧化催化剂,对其进行XRD、N2吸附-脱附、H2-TPR和29Si MAS NMR表征,并评价了其1-丁烯歧化反应性能。结果显示高比表面载体和合适的WO3负载量有利于提高活性组分在载体表面的分散度,从而抑制了烯烃双键异构化反应,提高歧化反应的活性和选择性。在400℃、0.5MPa,1-丁烯的质量空速为10h-1的反应条件下,1-丁烯自动歧化反应的转化率可达50%,目标产物(乙烯+丙烯+己烯)选择性达80%以上。展开更多
The intrinsic kinetics of oxidative dehydrogenation of propane with CO2 has been investigated over Cr/MSU-1 catalyst in a fixed bed reactor. Without limitations of both internal and external diffusion, intrinsic kinet...The intrinsic kinetics of oxidative dehydrogenation of propane with CO2 has been investigated over Cr/MSU-1 catalyst in a fixed bed reactor. Without limitations of both internal and external diffusion, intrinsic kinetic data were obtained under the following conditions： 490-530 °C, space velocity of 3600？6000 mL·h-1·g-1 and 3/1 molar ratio for CO2/C3H8 under normal pressure. Based on Langmuir-Hinshelwood mechanism, the kinetic models were established, and they were validated by statistical analysis. The parameters were estimated using Simplex Method combined with Universal Global Optimization Algorithm. The model, taking the surface reaction process as the rate-determining step, is the best one in agreement with the experimental data.展开更多
急性痛风是一种常见的自身炎症性关节炎,由滑膜关节软组织内单钠尿酸盐(monosodium urate,MSU)晶体沉积引起,尿酸盐通过半胱天冬酶(caspase)激活单核巨噬细胞分泌白细胞介素-1β(interleukin-1β,IL-1β),从而介导痛风性炎症反应。由于...急性痛风是一种常见的自身炎症性关节炎,由滑膜关节软组织内单钠尿酸盐(monosodium urate,MSU)晶体沉积引起,尿酸盐通过半胱天冬酶(caspase)激活单核巨噬细胞分泌白细胞介素-1β(interleukin-1β,IL-1β),从而介导痛风性炎症反应。由于痛风常见的一些合并症,目前首选治疗药物的使用受到许多限制。2016年更新的欧洲风湿病防治联合会(European League Against Rheumatism,EULAR)指南建议对急性痛风频繁发作以及难以使用常规疗法治疗的患者使用IL-1受体拮抗剂(interleukin-1 receptor antagonist,IL-1Ra)。阿那白滞素(anakinra)是一种重组非糖基化的人IL-1Ra,目前已被美国食品药品管理局(FDA)批准上市,并用于治疗类风湿关节炎等疾病多年,相比于其他IL-1Ra,anakinra的性价比更高。近年来anakinra治疗急性痛风的研究日益增多,研究结果支持其在治疗急性痛风发作中的有效性。本文就其对急性痛风的作用与治疗研究作一综述。展开更多
文摘采用自制的高比表面MSU介孔分子筛为载体,制备了系列歧化催化剂,对其进行XRD、N2吸附-脱附、H2-TPR和29Si MAS NMR表征,并评价了其1-丁烯歧化反应性能。结果显示高比表面载体和合适的WO3负载量有利于提高活性组分在载体表面的分散度,从而抑制了烯烃双键异构化反应,提高歧化反应的活性和选择性。在400℃、0.5MPa,1-丁烯的质量空速为10h-1的反应条件下,1-丁烯自动歧化反应的转化率可达50%,目标产物(乙烯+丙烯+己烯)选择性达80%以上。
基金supported by the National Natural Science Foundation of China (No. 21006109)the Postdoctoral Science Foundation of China (No. 20080430581)the CASKC Wang Post-Doctoral Fellowship
文摘The intrinsic kinetics of oxidative dehydrogenation of propane with CO2 has been investigated over Cr/MSU-1 catalyst in a fixed bed reactor. Without limitations of both internal and external diffusion, intrinsic kinetic data were obtained under the following conditions： 490-530 °C, space velocity of 3600？6000 mL·h-1·g-1 and 3/1 molar ratio for CO2/C3H8 under normal pressure. Based on Langmuir-Hinshelwood mechanism, the kinetic models were established, and they were validated by statistical analysis. The parameters were estimated using Simplex Method combined with Universal Global Optimization Algorithm. The model, taking the surface reaction process as the rate-determining step, is the best one in agreement with the experimental data.
文摘急性痛风是一种常见的自身炎症性关节炎,由滑膜关节软组织内单钠尿酸盐(monosodium urate,MSU)晶体沉积引起,尿酸盐通过半胱天冬酶(caspase)激活单核巨噬细胞分泌白细胞介素-1β(interleukin-1β,IL-1β),从而介导痛风性炎症反应。由于痛风常见的一些合并症,目前首选治疗药物的使用受到许多限制。2016年更新的欧洲风湿病防治联合会(European League Against Rheumatism,EULAR)指南建议对急性痛风频繁发作以及难以使用常规疗法治疗的患者使用IL-1受体拮抗剂(interleukin-1 receptor antagonist,IL-1Ra)。阿那白滞素(anakinra)是一种重组非糖基化的人IL-1Ra,目前已被美国食品药品管理局(FDA)批准上市,并用于治疗类风湿关节炎等疾病多年,相比于其他IL-1Ra,anakinra的性价比更高。近年来anakinra治疗急性痛风的研究日益增多,研究结果支持其在治疗急性痛风发作中的有效性。本文就其对急性痛风的作用与治疗研究作一综述。
