目的观察肿瘤转移相关基因Mta1(metastasis associated gene 1)及其蛋白在头颈部鳞状细胞癌中的表达,并探讨其临床意义。方法对86例头颈部鳞状细胞癌组织和20例头颈部正常组织用逆转录-PCR(RT-PCR)方法检测Mta1 m RNA表达,用免疫组化检...目的观察肿瘤转移相关基因Mta1(metastasis associated gene 1)及其蛋白在头颈部鳞状细胞癌中的表达,并探讨其临床意义。方法对86例头颈部鳞状细胞癌组织和20例头颈部正常组织用逆转录-PCR(RT-PCR)方法检测Mta1 m RNA表达,用免疫组化检测Mta1蛋白表达。结果 Mta1 m RNA在86例头颈部鳞状细胞癌组织中平均表达水平(1.72±0.56)%与头颈部正常组织(0.93±0.68)%比较,差异具有显著性(P<0.01);Mta1蛋白在头颈部鳞状细胞癌组织阳性率(65.12%,56/86)与对照组(15%,3/20)比较,差异具有显著性(P<0.01)。Mta1 m RNA及其蛋白在下咽癌、鼻咽癌、颈部皮肤鳞癌、淋巴结癌、扁桃体癌中平均表达水平及阳性率分别与头颈部正常组织比较,差异具有显著性(P<0.01);Mta1 m RNA及蛋白在头颈部鳞状细胞癌中表达及阳性率与高分化、中分化及低分化等分化程度呈正相关(P<0.05)。结论 Mta1 m RNA及其蛋白表达与头颈部鳞状细胞癌浸润转移关系密切,提示该基因可成为预测头颈部鳞状细胞癌转移和预后有价值的指标之一。展开更多
The relationship between ENSO and Indian Ocean Dipole was discussed by using the data set of sea temperature from Scripps Institute of Oceanography, the air temperature at 1000hPa from the NCEP reanalysis data and the...The relationship between ENSO and Indian Ocean Dipole was discussed by using the data set of sea temperature from Scripps Institute of Oceanography, the air temperature at 1000hPa from the NCEP reanalysis data and the Nino3 index from the Climate Prediction Center （CPC） of U.S.A. during the period from 1955 to 2001. The results show that there exists a Dipole on the maximum temperature anomalous level （MTAL） in the Indian Ocean, which close relates to ENSO in the Pacific Ocean. During El Nino periods there are good relationships between ENSO and Indian Ocean Dipole which maximum correlation occurring when ENSO leads by one month, but in La Nina periods the relationship is not so good. The distribution of Dipole in Indian Ocean is from northeast to southwest, which one （west） pole in 65°E - 75°E, 6°S - 10°S and the other in 85°E - 95°E, 2°N - 6°N, which is different from that defined by Saij. The correlation coefficients of Nino3 index with temperature anomalies in the west/east poles on the MTAL are over 0.4 - 0.15, respectively. It is a main sea temperature system in the tropical Indian Ocean. However, in the surface layer from sea surface to the depth of 20 m - 30 m there is no such a dipole with opposite sea temperature anomalies in the NE and SW of tropical Indian Ocean. The SSTA in the NE might be influenced by the sensible exchange process because the evolution of sea and 1 000 hPa air temperature anomaly time series of the NE of tropical Indian Ocean is quite similar except those during 1962 - 1963 and 1986. The periods of Indian Ocean Dipole are shorter than that of ENSO, and about 1 to 6-year.展开更多
文摘目的观察肿瘤转移相关基因Mta1(metastasis associated gene 1)及其蛋白在头颈部鳞状细胞癌中的表达,并探讨其临床意义。方法对86例头颈部鳞状细胞癌组织和20例头颈部正常组织用逆转录-PCR(RT-PCR)方法检测Mta1 m RNA表达,用免疫组化检测Mta1蛋白表达。结果 Mta1 m RNA在86例头颈部鳞状细胞癌组织中平均表达水平(1.72±0.56)%与头颈部正常组织(0.93±0.68)%比较,差异具有显著性(P<0.01);Mta1蛋白在头颈部鳞状细胞癌组织阳性率(65.12%,56/86)与对照组(15%,3/20)比较,差异具有显著性(P<0.01)。Mta1 m RNA及其蛋白在下咽癌、鼻咽癌、颈部皮肤鳞癌、淋巴结癌、扁桃体癌中平均表达水平及阳性率分别与头颈部正常组织比较,差异具有显著性(P<0.01);Mta1 m RNA及蛋白在头颈部鳞状细胞癌中表达及阳性率与高分化、中分化及低分化等分化程度呈正相关(P<0.05)。结论 Mta1 m RNA及其蛋白表达与头颈部鳞状细胞癌浸润转移关系密切,提示该基因可成为预测头颈部鳞状细胞癌转移和预后有价值的指标之一。
基金supported by the National Natural Science Foundation of China, (No. 40976015)National Basic Research Program of China under Grant No. (2010CB950302)
文摘The relationship between ENSO and Indian Ocean Dipole was discussed by using the data set of sea temperature from Scripps Institute of Oceanography, the air temperature at 1000hPa from the NCEP reanalysis data and the Nino3 index from the Climate Prediction Center （CPC） of U.S.A. during the period from 1955 to 2001. The results show that there exists a Dipole on the maximum temperature anomalous level （MTAL） in the Indian Ocean, which close relates to ENSO in the Pacific Ocean. During El Nino periods there are good relationships between ENSO and Indian Ocean Dipole which maximum correlation occurring when ENSO leads by one month, but in La Nina periods the relationship is not so good. The distribution of Dipole in Indian Ocean is from northeast to southwest, which one （west） pole in 65°E - 75°E, 6°S - 10°S and the other in 85°E - 95°E, 2°N - 6°N, which is different from that defined by Saij. The correlation coefficients of Nino3 index with temperature anomalies in the west/east poles on the MTAL are over 0.4 - 0.15, respectively. It is a main sea temperature system in the tropical Indian Ocean. However, in the surface layer from sea surface to the depth of 20 m - 30 m there is no such a dipole with opposite sea temperature anomalies in the NE and SW of tropical Indian Ocean. The SSTA in the NE might be influenced by the sensible exchange process because the evolution of sea and 1 000 hPa air temperature anomaly time series of the NE of tropical Indian Ocean is quite similar except those during 1962 - 1963 and 1986. The periods of Indian Ocean Dipole are shorter than that of ENSO, and about 1 to 6-year.
