AIM: To determine whether cannabinoids suppressnoxious stimulu-evoked Fos protein-like immunoreac-tivity (FLI) through direct actions at the spinal level.METHODS: Rats were implanted with intrathecal(ith) catheters at...AIM: To determine whether cannabinoids suppressnoxious stimulu-evoked Fos protein-like immunoreac-tivity (FLI) through direct actions at the spinal level.METHODS: Rats were implanted with intrathecal(ith) catheters at least one week prior to evaluation inthe formalin test. Effects of the cannabinoid agonist,CP55,940 (80 μg ith) on formalin pain and FLI in ratspinal cord were compared with that of the prototypicnarcotic analgesic, morphine (20 μg ith). CP55, 940suppressed pain behavior and FLI induced by intra-plantar formalin. The cannabinoid suppressed Fos inthe neck region of the dorsal horn and in the ventralhorn,but not in the nucleus proprius. The efficacy ofthe cannabinoid in suppressing FLI in these laminae展开更多
文摘AIM: To determine whether cannabinoids suppressnoxious stimulu-evoked Fos protein-like immunoreac-tivity (FLI) through direct actions at the spinal level.METHODS: Rats were implanted with intrathecal(ith) catheters at least one week prior to evaluation inthe formalin test. Effects of the cannabinoid agonist,CP55,940 (80 μg ith) on formalin pain and FLI in ratspinal cord were compared with that of the prototypicnarcotic analgesic, morphine (20 μg ith). CP55, 940suppressed pain behavior and FLI induced by intra-plantar formalin. The cannabinoid suppressed Fos inthe neck region of the dorsal horn and in the ventralhorn,but not in the nucleus proprius. The efficacy ofthe cannabinoid in suppressing FLI in these laminae
