Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-o...Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic consultation was performed. Clinical examination revealed a firm 25 mm mass on the medial part of the left breast with skin involvement. A biopsy was performed and analysis result came back in favor of a cellular type myofibroblastoma showing a fibrous component consisting of spindle cells with a herringbone arrangement. Anatomopathological results concluded to a dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor population strongly positive for CD34 expression. The search for a rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of the lesions with margins greater than 2 cm, on which the prognosis mainly depends. Micrographic surgery and oncoplastic breast surgery are of major interest in this location.展开更多
BACKGROUND Mammary-type myofibroblastoma(MTMF)is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation.Although 160 cases of MTMF have been reported in the literature since 2001,no cases of...BACKGROUND Mammary-type myofibroblastoma(MTMF)is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation.Although 160 cases of MTMF have been reported in the literature since 2001,no cases of infarction or atypical mitosis have been reported so far.Herein,we report an unusual case of MTMF in the pelvic cavity,which mimicked some malignant features,including infarction,atypical mitosis,infiltrative growth,and prominent cytologic atypia,making it difficult to ascertain whether the tumor was benign.CASE SUMMARY A 49-year-old man complained of pain and discomfort in the right buttock for more than 4 mo and did not receive any treatment.Nuclear magnetic resonance imaging(MRI)showed a 13-cm-sized mass in his right pelvic cavity.Histologically significant differences were atypical mitosis figures and multiple necrotic foci in the tumor.In addition,smooth muscle and skeletal muscle were invaded within and at the edge of the tumor.These morphologic features are often reminiscent of malignant tumors and therefore pose a diagnostic challenge to pathologists.The tumor cells were strongly positive for both cluster of differentiation 34 and desmin,and the loss of retinoblastoma 1 shown by immunohistochemical and fluorescence in situ hybridization results confirmed the pathological diagnosis of MTMF.Currently,the patient is alive and in good condition without tumor recurrence or metastasis after 2.5 years of follow-up by telephone and MRI.CONCLUSION The two pseudo-malignant characteristics of infarction and atypical mitosis broaden the morphological lineage of MTMF,a rare mesenchymal tumor.展开更多
In July 2006, a 32-year old female patient was found to have a 3 ×3 cm^2 neoplasm in the left lateral wall of her bladder. There was superficial necrosis and bleeding. Previously she had received a cystoscopy in ...In July 2006, a 32-year old female patient was found to have a 3 ×3 cm^2 neoplasm in the left lateral wall of her bladder. There was superficial necrosis and bleeding. Previously she had received a cystoscopy in another hospital because of painless gross hematuria and anemia. A partial resection of the bladder was conducted because attempts of medical hemostasis were unsatisfactory. Pathological examination indicated that the lesion was a spindle cell tumor of the bladder （Fig. 1）. Since the tumor cells had encroached into the smooth muscle, there was extensive cellular proliferation in the muscle layer and pathologic karyokinesis could be seen, suggestive of a malignant myofibroblastoma. The lateral and basilar cutting edges were oositive.展开更多
Myofibroblastoma of the breast(MFB)is a rare benign mesenchymal tumor of the breast.A case of giant breast myofibroblastic tumor,which is rarely reported in literature,was recently diagnosed in our department.We also ...Myofibroblastoma of the breast(MFB)is a rare benign mesenchymal tumor of the breast.A case of giant breast myofibroblastic tumor,which is rarely reported in literature,was recently diagnosed in our department.We also analyzed the clinicopathological features of MFB to improve the understanding of the tumor and avoid misdiagnosis.展开更多
In 2001, Laskin et al firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They propo...In 2001, Laskin et al firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They proposed the term ＂superficial cervicovaginal myofibroblastoma （SCVM）＂ to highlight the unique features of this tumor： the superficial subepithelial location and myofibroblastic differentiation of the minor cells. SCVM appears less well recognized with only three additional reports have been documented in the English literatures.24 In this study, we described four new cases of SCVM to further characterize the clinical and pathological features of this rare entity.展开更多
肌纤维母细胞瘤(myofibroblastoma,MFB)伴黏液样变性是一种少见的间叶源性良性肿瘤。1例42岁女性MFB患者,发现右侧腹股沟无痛性肿块1年,肿块表面光滑,切面灰褐、实性、质中,呈结节状。镜下见肿瘤背景黏液丰富,瘤细胞圆形或短梭形排列成...肌纤维母细胞瘤(myofibroblastoma,MFB)伴黏液样变性是一种少见的间叶源性良性肿瘤。1例42岁女性MFB患者,发现右侧腹股沟无痛性肿块1年,肿块表面光滑,切面灰褐、实性、质中,呈结节状。镜下见肿瘤背景黏液丰富,瘤细胞圆形或短梭形排列成不规则条束状,胞质丰富、嗜酸性,部分细胞核空泡明显。免疫组织化学染色示:肿瘤细胞白细胞分化抗原34(cluster of differentiation 34,CD34)、结蛋白(desmin)呈弥漫阳性,平滑肌肌动蛋白(smooth muscle actin,SMA)、白细胞分化抗原56(cluster of differentiation 56,CD56)、成红细胞转化特异性相关基因(erythroblast transformation-specific related gene,ERG)部分阳性,细胞核相关抗原Ki-67增殖指数约为5%。荧光原位杂交(fluorescence in situ hybridization,FISH)检测示:视网膜母细胞瘤蛋白1(retinoblastoma protein 1,RB1)基因缺失阳性,核受体亚家族4成员3(nuclear receptor subfamily 4 group a member 3,NR4A3)基因和尤文肉瘤断裂区域1(Ewing sarcoma breakpoint region 1,EWSR1)基因阴性。手术切除后随访3~24个月,患者无肿瘤局部复发和远处转移。MFB伴黏液样变性的诊断及鉴别诊断主要依靠临床病理特征、免疫组织化学及基因检测,治疗以单纯手术切除为主,预后好,无明显的复发风险。展开更多
目的为了提高脾脏炎性肌纤维母细胞瘤的诊断水平,探讨多模态影像学的价值。方法回顾分析本院1例成人脾炎性肌纤维母细胞瘤(inflammatory pseudotumor of spleen,SIMT)患者的影像资料,包括彩色超声、CT平扫及增强、MRI平扫,并复习文献。...目的为了提高脾脏炎性肌纤维母细胞瘤的诊断水平,探讨多模态影像学的价值。方法回顾分析本院1例成人脾炎性肌纤维母细胞瘤(inflammatory pseudotumor of spleen,SIMT)患者的影像资料,包括彩色超声、CT平扫及增强、MRI平扫,并复习文献。结果脾脏内数枚肿块,以低回声为主,回声不均,边界尚清,形态规整,内见少许血流信号。CT平扫为等密度,其内见小片状低密度区;增强后呈轻度至中度不均匀强化。MRI表现:T1WI上低或等信号,T2WI序列及T2WI抑脂序列为等及高信号,病灶周围见完整包膜,DWI图为等及高信号,信号不均匀。病理学及免疫组化结果为SIMT;EB病毒(+)。结论SIMT临床表现缺乏特异性,最终需病理学确诊。多模态影像学检查对脾炎性肌纤维母细胞瘤有很高的诊断和鉴别诊断价值。展开更多
文摘Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic consultation was performed. Clinical examination revealed a firm 25 mm mass on the medial part of the left breast with skin involvement. A biopsy was performed and analysis result came back in favor of a cellular type myofibroblastoma showing a fibrous component consisting of spindle cells with a herringbone arrangement. Anatomopathological results concluded to a dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor population strongly positive for CD34 expression. The search for a rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of the lesions with margins greater than 2 cm, on which the prognosis mainly depends. Micrographic surgery and oncoplastic breast surgery are of major interest in this location.
文摘BACKGROUND Mammary-type myofibroblastoma(MTMF)is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation.Although 160 cases of MTMF have been reported in the literature since 2001,no cases of infarction or atypical mitosis have been reported so far.Herein,we report an unusual case of MTMF in the pelvic cavity,which mimicked some malignant features,including infarction,atypical mitosis,infiltrative growth,and prominent cytologic atypia,making it difficult to ascertain whether the tumor was benign.CASE SUMMARY A 49-year-old man complained of pain and discomfort in the right buttock for more than 4 mo and did not receive any treatment.Nuclear magnetic resonance imaging(MRI)showed a 13-cm-sized mass in his right pelvic cavity.Histologically significant differences were atypical mitosis figures and multiple necrotic foci in the tumor.In addition,smooth muscle and skeletal muscle were invaded within and at the edge of the tumor.These morphologic features are often reminiscent of malignant tumors and therefore pose a diagnostic challenge to pathologists.The tumor cells were strongly positive for both cluster of differentiation 34 and desmin,and the loss of retinoblastoma 1 shown by immunohistochemical and fluorescence in situ hybridization results confirmed the pathological diagnosis of MTMF.Currently,the patient is alive and in good condition without tumor recurrence or metastasis after 2.5 years of follow-up by telephone and MRI.CONCLUSION The two pseudo-malignant characteristics of infarction and atypical mitosis broaden the morphological lineage of MTMF,a rare mesenchymal tumor.
文摘In July 2006, a 32-year old female patient was found to have a 3 ×3 cm^2 neoplasm in the left lateral wall of her bladder. There was superficial necrosis and bleeding. Previously she had received a cystoscopy in another hospital because of painless gross hematuria and anemia. A partial resection of the bladder was conducted because attempts of medical hemostasis were unsatisfactory. Pathological examination indicated that the lesion was a spindle cell tumor of the bladder （Fig. 1）. Since the tumor cells had encroached into the smooth muscle, there was extensive cellular proliferation in the muscle layer and pathologic karyokinesis could be seen, suggestive of a malignant myofibroblastoma. The lateral and basilar cutting edges were oositive.
基金The Beijing-Tianjin-Hebei Basic Research Cooperation Special Project(2019):"Visualized Stem Cell Targeted Tumor Therapy Techniques for Precise Diagnosis and Treatment of Tumors"Project Number:19JCZDJC65800(Z).
文摘Myofibroblastoma of the breast(MFB)is a rare benign mesenchymal tumor of the breast.A case of giant breast myofibroblastic tumor,which is rarely reported in literature,was recently diagnosed in our department.We also analyzed the clinicopathological features of MFB to improve the understanding of the tumor and avoid misdiagnosis.
文摘In 2001, Laskin et al firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They proposed the term ＂superficial cervicovaginal myofibroblastoma （SCVM）＂ to highlight the unique features of this tumor： the superficial subepithelial location and myofibroblastic differentiation of the minor cells. SCVM appears less well recognized with only three additional reports have been documented in the English literatures.24 In this study, we described four new cases of SCVM to further characterize the clinical and pathological features of this rare entity.
文摘肌纤维母细胞瘤(myofibroblastoma,MFB)伴黏液样变性是一种少见的间叶源性良性肿瘤。1例42岁女性MFB患者,发现右侧腹股沟无痛性肿块1年,肿块表面光滑,切面灰褐、实性、质中,呈结节状。镜下见肿瘤背景黏液丰富,瘤细胞圆形或短梭形排列成不规则条束状,胞质丰富、嗜酸性,部分细胞核空泡明显。免疫组织化学染色示:肿瘤细胞白细胞分化抗原34(cluster of differentiation 34,CD34)、结蛋白(desmin)呈弥漫阳性,平滑肌肌动蛋白(smooth muscle actin,SMA)、白细胞分化抗原56(cluster of differentiation 56,CD56)、成红细胞转化特异性相关基因(erythroblast transformation-specific related gene,ERG)部分阳性,细胞核相关抗原Ki-67增殖指数约为5%。荧光原位杂交(fluorescence in situ hybridization,FISH)检测示:视网膜母细胞瘤蛋白1(retinoblastoma protein 1,RB1)基因缺失阳性,核受体亚家族4成员3(nuclear receptor subfamily 4 group a member 3,NR4A3)基因和尤文肉瘤断裂区域1(Ewing sarcoma breakpoint region 1,EWSR1)基因阴性。手术切除后随访3~24个月,患者无肿瘤局部复发和远处转移。MFB伴黏液样变性的诊断及鉴别诊断主要依靠临床病理特征、免疫组织化学及基因检测,治疗以单纯手术切除为主,预后好,无明显的复发风险。
文摘目的为了提高脾脏炎性肌纤维母细胞瘤的诊断水平,探讨多模态影像学的价值。方法回顾分析本院1例成人脾炎性肌纤维母细胞瘤(inflammatory pseudotumor of spleen,SIMT)患者的影像资料,包括彩色超声、CT平扫及增强、MRI平扫,并复习文献。结果脾脏内数枚肿块,以低回声为主,回声不均,边界尚清,形态规整,内见少许血流信号。CT平扫为等密度,其内见小片状低密度区;增强后呈轻度至中度不均匀强化。MRI表现:T1WI上低或等信号,T2WI序列及T2WI抑脂序列为等及高信号,病灶周围见完整包膜,DWI图为等及高信号,信号不均匀。病理学及免疫组化结果为SIMT;EB病毒(+)。结论SIMT临床表现缺乏特异性,最终需病理学确诊。多模态影像学检查对脾炎性肌纤维母细胞瘤有很高的诊断和鉴别诊断价值。
