meso-去甲二氢愈创木酸和Machilin A的合成

报道了一条合成内消旋去甲二氢愈创木酸(meso-NDGA)和Machilin A的新路线.此路线通过两次Stobbe缩合构建木脂素结构骨架,经官能团转换,合成了meso-NDGA和Machilin A.该路线操作简便、实用性强.

Total Synthesis of Machilin A

Machilin A, isolated from the bark and root of Machilus thunbergii Sieb. et Zucc., was synthesized in eight steps from piperonal, with the coupling reaction as a key step.