Differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning

BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically different.Therefore,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and speed.AIM To develop a method to identify CD and ITB with high accuracy,specificity,and speed.METHODS A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or ITB.Paraffin wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential diagnosis.RESULTS The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and ITB.CONCLUSION Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB.

Decoding degeneration:the implementation of machine learning for clinical detection of neurodegenerative disorders

Machine learning represents a growing subfield of artificial intelligence with much promise in the diagnosis,treatment,and tracking of complex conditions,including neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.While no definitive methods of diagnosis or treatment exist for either disease,researchers have implemented machine learning algorithms with neuroimaging and motion-tracking technology to analyze pathologically relevant symptoms and biomarkers.Deep learning algorithms such as neural networks and complex combined architectures have proven capable of tracking disease-linked changes in brain structure and physiology as well as patient motor and cognitive symptoms and responses to treatment.However,such techniques require further development aimed at improving transparency,adaptability,and reproducibility.In this review,we provide an overview of existing neuroimaging technologies and supervised and unsupervised machine learning techniques with their current applications in the context of Alzheimer’s and Parkinson’s diseases.

Comparison and development of machine learning for thalidomideinduced peripheral neuropathy prediction of refractory Crohn’s disease in Chinese population

BACKGROUND Thalidomide is an effective treatment for refractory Crohn’s disease(CD).However,thalidomide-induced peripheral neuropathy(TiPN),which has a large individual variation,is a major cause of treatment failure.TiPN is rarely predictable and recognized,especially in CD.It is necessary to develop a risk model to predict TiPN occurrence.AIM To develop and compare a predictive model of TiPN using machine learning based on comprehensive clinical and genetic variables.METHODS A retrospective cohort of 164 CD patients from January 2016 to June 2022 was used to establish the model.The National Cancer Institute Common Toxicity Criteria Sensory Scale(version 4.0)was used to assess TiPN.With 18 clinical features and 150 genetic variables,five predictive models were established and evaluated by the confusion matrix receiver operating characteristic curve(AUROC),area under the precision-recall curve(AUPRC),specificity,sensitivity(recall rate),precision,accuracy,and F1 score.RESULTS The top-ranking five risk variables associated with TiPN were interleukin-12 rs1353248[P=0.0004,odds ratio(OR):8.983,95%confidence interval(CI):2.497-30.90],dose(mg/d,P=0.002),brainderived neurotrophic factor(BDNF)rs2030324(P=0.001,OR:3.164,95%CI:1.561-6.434),BDNF rs6265(P=0.001,OR:3.150,95%CI:1.546-6.073)and BDNF rs11030104(P=0.001,OR:3.091,95%CI:1.525-5.960).In the training set,gradient boosting decision tree(GBDT),extremely random trees(ET),random forest,logistic regression and extreme gradient boosting(XGBoost)obtained AUROC values>0.90 and AUPRC>0.87.Among these models,XGBoost and GBDT obtained the first two highest AUROC(0.90 and 1),AUPRC(0.98 and 1),accuracy(0.96 and 0.98),precision(0.90 and 0.95),F1 score(0.95 and 0.98),specificity(0.94 and 0.97),and sensitivity(1).In the validation set,XGBoost algorithm exhibited the best predictive performance with the highest specificity(0.857),accuracy(0.818),AUPRC(0.86)and AUROC(0.89).ET and GBDT obtained the highest sensitivity(1)and F1 score(0.8).Overall,compared with other state-of-the-art classifiers such as ET,GBDT and RF,XGBoost algorithm not only showed a more stable performance,but also yielded higher ROC-AUC and PRC-AUC scores,demonstrating its high accuracy in prediction of TiPN occurrence.CONCLUSION The powerful XGBoost algorithm accurately predicts TiPN using 18 clinical features and 14 genetic variables.With the ability to identify high-risk patients using single nucleotide polymorphisms,it offers a feasible option for improving thalidomide efficacy in CD patients.

Rapid, accurate and serotype independent pipeline for in silico epitope mapping of SARS-CoV-2 antigens: a combined machine learning and Chou’s pseudo amino acid composition method

Here,a new integrated machine learning and Chou’s pseudo amino acid composition method has been proposed for in silico epitope mapping of severe acute respiratorysyndrome-like coronavirus antigens.For this,a training dataset including 266 linear B-cell epitopes,1,267 T-cell epitopes and 1,280 non-epitopes were prepared.The epitope sequences were then converted to numerical vectors using Chou’s pseudo amino acid composition method.The vectors were then introduced to the support vector machine,random forest,artificial neural network,and K-nearest neighbor algorithms for the classification process.The algorithm with the highest performance was selected for the epitope mapping procedure.Based on the obtained results,the random forest algorithm was the most accurate classifier with an accuracy of 0.934 followed by K-nearest neighbor,artificial neural network,and support vector machine respectively.Furthermore,the efficacies of predicted epitopes by the trained random forest algorithm were assessed through their antigenicity potential as well as affinity to human B cell receptor and MHC-I/II alleles using the VaxiJen score and molecular docking,respectively.It was also clear that the predicted epitopes especially the B-cell epitopes had high antigenicity potentials and good affinities to the protein targets.According to the results,the suggested method can be considered for developing specific epitope predictor software as well as an accelerator pipeline for designing serotype independent vaccine against the virus.

售货机升降系统S型速度控制策略

在传统三闭环控制方式下,售货机升降接货系统易因启停过程中加速度突变产生冲击,导致系统运行不平稳。针对这一问题,文中对传统升降系统加减速控制策略进行改进,加入前馈和微分负反馈,提出一种S型速度曲线控制算法。根据路径规划判别条件将S型速度曲线分为七段式、六段式和四段式3种,并给出各路径约束条件下的参数求解方法和具体执行流程。将该算法运用到升降控制系统中进行仿真和实际工况测试,实验结果表明,与传统三闭环控制相比,文中所提控制策略可以提高售货机升降系统运行的平稳性,减小冲击,使速度曲线更加柔和,并能够保持较好的跟踪性能。

经验小波变换和改进S变换结合的电能质量检测与识别方法

为分析不确定干扰因素影响下的实际电力网络电能质量问题,提出一种经验小波变换(EWT)和改进S变换相结合的电能质量检测与识别方法。该方法一方面利用EWT联合归一化直接正交(NDQ)算法和奇异值分解(SVD)算法准确提取调幅-调频分量的频率、幅值和时间参数,另一方面考虑到EWT算法在高噪声环境下瞬时幅值波动的问题,引入改进S变换提取高噪声干扰下的电能质量扰动时频信息,最后,基于EWT和改进S变换提取的扰动特征向量,利用基于改进粒子群优化算法(IPSO)优化支持向量机(SVM)的电能质量扰动识别分类器实现扰动类型的精确识别。仿真和实验表明所提方法在复合扰动识别分类时平均识别准确率为93.23%,且能够准确识别4种实测扰动信号。

Reliability Evaluation of Machine Center Components Based on Cascading Failure Analysis

In order to rectify the problems that the com- ponent reliability model exhibits deviation, and the evalu- ation result is low due to the overlook of failure propagation in traditional reliability evaluation of machine center components, a new reliability evaluation method based on cascading failure analysis and the failure influ- enced degree assessment is proposed. A direct graph model of cascading failure among components is established according to cascading failure mechanism analysis and graph theory. The failure influenced degrees of the system components are assessed by the adjacency matrix and its transposition, combined with the Pagerank algorithm. Based on the comprehensive failure probability function and total probability formula, the inherent failure proba- bility function is determined to realize the reliability evaluation of the system components. Finally, the method is applied to a machine center, it shows the following： 1） The reliability evaluation values of the proposed method are at least 2.5% higher than those of the traditional method; 2） The difference between the comprehensive and inherent reliability of the system component presents a positive correlation with the failure influenced degree ofthe system component, which provides a theoretical basis for reliability allocation of machine center system.

Implementation of a Smartphone as a Wearable and Wireless Accelerometer and Gyroscope Platform for Ascertaining Deep Brain Stimulation Treatment Efficacy of Parkinson’s Disease through Machine Learning Classification

Parkinson’s disease manifests in movement disorder symptoms, such as hand tremor. There exists an assortment of therapy interventions. In particular deep brain stimulation offers considerable efficacy for the treatment of Parkinson’s disease. However, a considerable challenge is the convergence toward an optimal configuration of tuning parameters. Quantified feedback from a wearable and wireless system consisting of an accelerometer and gyroscope can be enabled through a novel software application on a smartphone. The smartphone with its internal accelerometer and gyroscope can record the quantified attributes of Parkinson’s disease and tremor through mounting the smartphone about the dorsum of the hand. The recorded data can be then wirelessly transmitted as an email attachment to an Internet derived resource for subsequent post-processing. The inertial sensor data can be consolidated into a feature set for machine learning classification. A multilayer perceptron neural network has been successfully applied to attain considerable classification accuracy between deep brain stimulation “On” and “Off” scenarios for a subject with Parkinson’s disease. The findings establish the foundation for the broad objective of applying wearable and wireless systems for the development of closed-loop optimization of deep brain stimulation parameters in the context of cloud computing with machine learning classification.

Enhancing Parkinson’s Disease Prediction Using Machine Learning and Feature Selection Methods

Several millions of people suffer from Parkinson’s disease globally.Parkinson’s affects about 1%of people over 60 and its symptoms increase with age.The voice may be affected and patients experience abnormalities in speech that might not be noticed by listeners,but which could be analyzed using recorded speech signals.With the huge advancements of technology,the medical data has increased dramatically,and therefore,there is a need to apply data mining and machine learning methods to extract new knowledge from this data.Several classification methods were used to analyze medical data sets and diagnostic problems,such as Parkinson’s Disease(PD).In addition,to improve the performance of classification,feature selection methods have been extensively used in many fields.This paper aims to propose a comprehensive approach to enhance the prediction of PD using several machine learning methods with different feature selection methods such as filter-based and wrapper-based.The dataset includes 240 recodes with 46 acoustic features extracted from3 voice recording replications for 80 patients.The experimental results showed improvements when wrapper-based features selection method was used with K-NN classifier with accuracy of 88.33%.The best obtained results were compared with other studies and it was found that this study provides comparable and superior results.

Speech Analysis for Diagnosis of Parkinson’s Disease Using Genetic Algorithm and Support Vector Machine

Parkinson’s disease (PD) is the most common disease of motor system degeneration that occurs when the dopamine-producing cells are damaged in substantia nigra. To detect PD, various signals have been investigated, including EEG, gait and speech. Since approximately 90 percent of the people with PD suffer from speech disorders, speech analysis is considered as the most common technique for this aim. This paper proposes a new algorithm for diagnosing of Parkinson’s disease based on voice analysis. In the first step, genetic algorithm (GA) is undertaken for selecting optimized features from all extracted features. Afterwards a network based on support vector machine (SVM) is used for classification between healthy and people with Parkinson. The dataset of this research is composed of a range of biomedical voice signals from 31 people, 23 with Parkinson’s disease and 8 healthy people. The subjects were asked to pronounce letter “A” for 3 seconds. 22 linear and non-linear features were extracted from the signals that 14 features were based on F0 (fundamental frequency or pitch), jitter, shimmer and noise to harmonics ratio, which are main factors in voice signal. Because changing in these factors is noticeable for the people with PD, optimized features were selected among them. Of the various numbers of optimized features, the data classification was investigated. Results show that the classification accuracy percent of 94.50 per 4 optimized features, the accuracy percent of 93.66 per 7 optimized features and the accuracy percent of 94.22 per 9 optimized features, could be achieved. It can be observed that the best classification accuracy may be achieved using Fhi (Hz), Fho (Hz), jitter (RAP) and shimmer (APQ5).

Machine learning enabling prediction in mechanical performance of Ti6Al4V fabricated by large-scale laser powder bed fusion via a stacking model

Determining appropriate process parameters in large-scale laser powder bed fusion(LPBF)additive manufacturing pose formidable challenges that necessitate advanced approaches to minimize trial-and-error during experimentation.This work proposed a data-driven approach based on stacking ensemble learning to predict the mechanical properties of Ti6Al4V alloy fabricated by large-scale LPBF for the first time.This method can adapt to the complexity of large-scale LPBF data distribution and exhibits a more generalized predictive capability compared to base models.Specifically,the stacking model utilized artificial neural network(ANN),gradient boosting regressor,kernel ridge regression,and elastic net as base models,with the Lasso model serving as the meta-model.Bayesian optimization and cross-validation were utilized for model optimization and training based on a limited data set,resulting in higher predictive accuracy compared to traditional artificial neural network model.The statistical analysis of the ANN and stacking models indicates that the stacking model exhibits superior performance on the test set,with a coefficient of determination value of 0.944,mean absolute percentage error of 2.51%,and root mean squared error of 27.64,surpassing that of the ANN model.All statistical metrics demonstrate superiority over those obtained from the ANN model.These results confirm that by integrating the base models,the stacking model exhibits superior predictive stability compared to individual base models alone,thereby providing a reliable assessment approach for predicting the mechanical properties of metal parts fabricated by the LPBF process.

Modeling and Analysis of Single Machine Scheduling Based on Noncooperative Game Theory

Considering the independent optimization requirement for each demander of modernmanufacture, we explore the application of noncooperative game in production scheduling research,and model scheduling problem as competition of machine resources among a group of selfish jobs.Each job has its own performance objective. For the single machine, multi-jobs and non-preemptivescheduling problem, a noncooperative game model is established. Based on the model, many prob-lems about Nash equilibrium solution, such as the existence, quantity, properties of solution space,performance of solution and algorithm are discussed. The results are tested by numerical example.

基于深度学习和广义S变换协同的风速预测

针对实测风速的非平稳性特点,提出一种基于深度学习和时频分析的风速混合预测方法。首先,采用经验模态分解(EMD)将风速分解为若干子层,由此得到趋势分量和脉动分量以降低风速的非线性。根据2个分量的时频特性,采用长短时记忆(LSTM)处理趋势分量,极限学习机(ELM)处理脉动分量。其次,引入广义S变换(GST)来获得预测过程中的时频特性。同时,采用改进的灰狼算法(IGWO)对GST、LSTM和ELM的参数进行优化。最后,以内蒙古某风场实测风速对所提模型进行验证,结果表明该模型具有较高的精度。

Preliminary Network Centric Therapy for Machine Learning Classification of Deep Brain Stimulation Status for the Treatment of Parkinson’s Disease with a Conformal Wearable and Wireless Inertial Sensor

The concept of Network Centric Therapy represents an amalgamation of wearable and wireless inertial sensor systems and machine learning with access to a Cloud computing environment. The advent of Network Centric Therapy is highly relevant to the treatment of Parkinson’s disease through deep brain stimulation. Originally wearable and wireless systems for quantifying Parkinson’s disease involved the use a smartphone to quantify hand tremor. Although originally novel, the smartphone has notable issues as a wearable application for quantifying movement disorder tremor. The smartphone has evolved in a pathway that has made the smartphone progressively more cumbersome to mount about the dorsum of the hand. Furthermore, the smartphone utilizes an inertial sensor package that is not certified for medical analysis, and the trial data access a provisional Cloud computing environment through an email account. These concerns are resolved with the recent development of a conformal wearable and wireless inertial sensor system. This conformal wearable and wireless system mounts to the hand with the profile of a bandage by adhesive and accesses a secure Cloud computing environment through a segmented wireless connectivity strategy involving a smartphone and tablet. Additionally, the conformal wearable and wireless system is certified by the FDA of the United States of America for ascertaining medical grade inertial sensor data. These characteristics make the conformal wearable and wireless system uniquely suited for the quantification of Parkinson’s disease treatment through deep brain stimulation. Preliminary evaluation of the conformal wearable and wireless system is demonstrated through the differentiation of deep brain stimulation set to “On” and “Off” status. Based on the robustness of the acceleration signal, this signal was selected to quantify hand tremor for the prescribed deep brain stimulation settings. Machine learning classification using the Waikato Environment for Knowledge Analysis (WEKA) was applied using the multilayer perceptron neural network. The multilayer perceptron neural network achieved considerable classification accuracy for distinguishing between the deep brain stimulation system set to “On” and “Off” status through the quantified acceleration signal data obtained by this recently developed conformal wearable and wireless system. The research achievement establishes a progressive pathway to the future objective of achieving deep brain stimulation capabilities that promote closed-loop acquisition of configuration parameters that are uniquely optimized to the individual through extrinsic means of a highly conformal wearable and wireless inertial sensor system and machine learning with access to Cloud computing resources.

Comparison of CWSI and T_(s)-T_(a)-VIs in moisture monitoring of dryland crops(sorghum and maize)based on UAV remote sensing

Monitoring agricultural drought using remote sensing data is crucial for precision irrigation in modern agriculture.Utilizing unmanned aerial vehicle(UAV)remote sensing,we explored the applicability of an empirical crop water stress index(CWSI)based on canopy temperature and three-dimensional drought indices(TDDI)constructed from surface temperature(T_(s)),air temperature(T_(a))and five vegetation indices(VIs)for monitoring the moisture status of dryland crops.Three machine learning algorithms(random forest regression(RFR),support vector regression,and partial least squares regression)were used to compare the performance of the drought indices for vegetation moisture content(VMC)estimation in sorghum and maize.The main results of the study were as follows:(1)Comparative analysis of the drought indices revealed that T_(s)-T_(a)-normalized difference vegetation index(TDDIn)and T_(s)-T_(a)-enhanced vegetation index(TDDIe)were more strongly correlated with VMC compared with the other indices.The indices exhibited varying sensitivities to VMC under different irrigation regimes;the strongest correlation observed was for the TDDIe index with maize under the fully irrigated treatment(r=-0.93).(2)Regarding spatial and temporal characteristics,the TDDIn,TDDIe and CWSI indices showed minimal differences Over the experimental period,with coefficients of variation were 0.25,0.18 and 0.24,respectively.All three indices were capable of effectively characterizing the moisture distribution in dryland maize and sorghum crops,but the TDDI indices more accurately monitored the spatial distribution of crop moisture after a rainfall or irrigation event.(3)For prediction of the moisture content of single crops,RFR models based on TDDIn and TDDIe estimated VMC most accurately(R^(2)>0.7),and the TDDIn-based model predicted VMC with the highest accuracy when considering multiple-crop samples,with R^(2)and RMSE of 0.62 and 14.26%,respectively.Thus,TDDI proved more effective than the CWSI in estimating crop water content.

GAN-DIRNet:A Novel Deformable Image Registration Approach for Multimodal Histological Images

Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of tissue.Convolutional neural network(CNN)and generative adversarial network(GAN)are pivotal inmedical image registration.However,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s disease.We argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator inGAN.In this study,we propose a novel multi-modal registration approach GAN-DIRNet based on GAN for deformable histological image registration.To begin with,the discriminators of two GANs are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific modalities.Additionally,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise results.Lastly,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s disease.Experimental results demonstrate that our proposed GAN-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types.

Using Machine Reading to Understand Alzheimer's and Related Diseases from the Literature

Purpose： This paper aims to better understand a large number of papers in the medical domain of Alzheimer＇s disease （AD） and related diseases using the machine reading approach. Design/methodology/approach： The study uses the topic modeling method to obtain an overview of the field, and employs open information extraction to further comprehend the field at a specific fact level. Findings： Several topics within the AD research field are identified, such as the Human Immunodeficiency Virus （HIV）/Acquired Immune Deficiency Syndrome （AIDS）, which can help answer the question of how A1DS/HIV and AD are very different yet related diseases. Research limitations： Some manual data cleaning could improve the study, such as removing incorrect facts found by open information extraction. Practical implications： This study uses the literature to answer specific questions on a scientific domain, which can help domain experts find interesting and meaningful relations among entities in a similar manner, such as to discover relations between AD and AIDS/HIV. Origlnality/value： Both the overview and specific information from the literature are obtained using two distinct methods in a complementary manner. This combination is novel because previous work has only focused on one of them, and thus provides a better way to understand an important scientific field using data-driven methods.

Digital Disparities:How Artificial Intelligence Can Facilitate Anti-Black Racism in the U.S.Healthcare Sector

This paper delves into the intricate interplay between artificial intelligence(AI)systems and the perpetuation of Anti-Black racism within the United States medical industry.Despite the promising potential of AI to enhance healthcare outcomes and reduce disparities,there is a growing concern that these technologies may inadvertently/advertently exacerbate existing racial inequalities.Focusing specifically on the experiences of Black patients,this research investigates how the following AI components:medical algorithms,machine learning,and natural learning processes are contributing to the unequal distribution of medical resources,diagnosis,and health care treatment of those classified as Black.Furthermore,this review employs a multidisciplinary approach,combining insights from computer science,medical ethics,and social justice theory to analyze the mechanisms through which AI systems may encode and reinforce racial biases.By dissecting the three primary components of AI,this paper aims to present a clear understanding of how these technologies work,how they intersect,and how they may inherently perpetuate harmful stereotypes resulting in negligent outcomes for Black patients.Furthermore,this paper explores the ethical implications of deploying AI in healthcare settings and calls for increased transparency,accountability,and diversity in the development and implementation of these technologies.Finally,it is important that I prefer the following paper with a clear and concise definition of what I refer to as Anti-Black racism throughout the text.Therefore,I assert the following:Anti-Black racism refers to prejudice,discrimination,or antagonism directed against individuals or communities of African descent based on their race.It involves the belief in the inherent superiority of one race over another and the systemic and institutional practices that perpetuate inequality and disadvantage for Black people.Furthermore,I proclaim that this form of racism can be manifested in various ways,such as unequal access to opportunities,resources,education,employment,and fair treatment within social,economic,and political systems.It is also pertinent to acknowledge that Anti-Black racism is deeply rooted in historical and societal structures throughout the U.S.borders and beyond,leading to systemic disadvantages and disparities that impact the well-being and life chances of Black individuals and communities.Addressing Anti-Black racism involves recognizing and challenging both individual attitudes and systemic structures that contribute to discrimination and inequality.Efforts to combat Anti-Black racism include promoting awareness,education,advocacy for policy changes,and fostering a culture of inclusivity and equality.

Classification of the Priority of Auditing XBRL Instance Documents with Fuzzy Support Vector Machines Algorithm

Concluding the conformity of XBRL(eXtensible Business Reporting Language)instance documents law to the Benford's law yields different results before and after a company's financial distress.A new idea of applying the machine learning technique to redefine the way conventional auditors work is therefore proposed since the unacceptable conformity implies a large likelihood of a fraudulent document.Fuzzy support vector machines models are developed to implement such an idea.The dependent variable is a fuzzy variable quantifying the conformity of an XBRL instance document to the Benford's law;whereas,independent variables are financial ratios.The interval factor method is introduced to express the fuzziness in input data.It is found the range of a fuzzy support vector machines model is controlled by maximum and minimum dependent and independent variables.Therefore,defining any member function to describe the fuzziness in input data is unnecessary.The results of this study indicate that the price-to-book ratio versus equity ratio is suitable to classify the priority of auditing XBRL instance documents with the less than 30%misclassification rate.In conclusion,the machine learning technique may be used to redefine the way conventional auditors work.This study provides the main evidence of applying a future project of training smart auditors.

CHINA'S SEWING MACHINE INDUSTRY

China’s export of sewing machinesstarted in the 1950s.At that time theButterfly brand household sewingmachine produced by the Shanghai XiechangSewing Machine Factory and the Tiger brandsewing machine produced by the ShanghaiHuigong Sewing Machine Factory enjoyeda good reputation in Southeast Asia. Along with China’s reform and openingdrive and economic development,and on thebasis of changes in market demand,thesewing machine industry has conducted rapidadjustment to the product structure,withmore stress being placed on technicalintroduction and renovation.Under theleadership an support of the Ministry ofLight Industry,products have developed fromhousehold sewing machines to Industrialones.While meeting the domestic