在1842年的一篇医学文献中,首次提到声带反向运动疾病（paradoxic vocal fold movement discorder,PVFMD）,被描述为＂癔症性喉炎＂。1869年,由Mackenzie首次在喉镜下直接观察到声带的这种反常性运动,他认为声门关闭与患者的喘鸣直接相...在1842年的一篇医学文献中,首次提到声带反向运动疾病（paradoxic vocal fold movement discorder,PVFMD）,被描述为＂癔症性喉炎＂。1869年,由Mackenzie首次在喉镜下直接观察到声带的这种反常性运动,他认为声门关闭与患者的喘鸣直接相关。PVFMD患者平时的声带运动是正常的,表现为间歇性的声带收缩引起呼吸困难和喉部紧缩感。展开更多
Natural gas hydrate is widely distributed in continental slope sediments and permafrost,taken as a potential energy resource due to its gigantic amount.To develop the technologies for the industrial exploitation of na...Natural gas hydrate is widely distributed in continental slope sediments and permafrost,taken as a potential energy resource due to its gigantic amount.To develop the technologies for the industrial exploitation of natural gas hydrate,several production tests were carried out in permafrost and marine hydrate reservoirs,e.g.tests in permafrost hydrate reservoirs in Mackenzie Delta and Alaskan North Slope(Boswell et al.,2017)in the Antarctic,and those in marine hydrate reservoirs in Nankai Trough,offshore Japan(Yamamoto et al.,2014,2018),and South China Sea(SCS)(Li et al.,2018;Ye et al.,2020).As encouraged by the results obtained from the production tests,more tests are planned to develop technology for industrial exploitation of natural gas hydrate(Collett et al.,2022).Although production test can be conducted in permafrost hydrate reservoir for cost efficiency,generally it is thought industrial exploitation will be realized in marine hydrate reservoir because it is estimated with over 90%of hydrate resource.展开更多
The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cut...The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive dressing onto the skin, above probes, before anti-IgE injection. Histamine levels were assessed by an EIA method. In order to compare the different corticosteroids, AUC was calculated allowing an estimation of the amount of released histamine for 60 min of ex vivo cutaneous microdialysis. Diflucortolone 0.1% and micronized betamethasone dipropionate 0.05% are considered as corticosteroids with high potency in MacKenzie classification. Betamethasone dipropionate associated with propylene glycol 0.05%, belongs to a stronger class in Mackenzie classification. Our results showed that the decrease in histamine release was more important with difluocortolone than with both of these corticosteroids. Therefore there was no correlation between the vasoconstrictor potency of topical corticosteroids and their ability to inhibit histamine release.展开更多
Energy Daily,2017-03-03尽管资本投资达到历史最高纪录,但据英国石油和天然气活动调查发现,很少有项目按时交付运营和不超出预算的。英国石油和天然气局（OGA）发布了到2016年为止的石油和天然气活动的5年审查。审查发现,不到25%的石...Energy Daily,2017-03-03尽管资本投资达到历史最高纪录,但据英国石油和天然气活动调查发现,很少有项目按时交付运营和不超出预算的。英国石油和天然气局（OGA）发布了到2016年为止的石油和天然气活动的5年审查。审查发现,不到25%的石油和天然气项目按时交付,大部分比计划晚10个月运行。展开更多
文摘在1842年的一篇医学文献中,首次提到声带反向运动疾病（paradoxic vocal fold movement discorder,PVFMD）,被描述为＂癔症性喉炎＂。1869年,由Mackenzie首次在喉镜下直接观察到声带的这种反常性运动,他认为声门关闭与患者的喘鸣直接相关。PVFMD患者平时的声带运动是正常的,表现为间歇性的声带收缩引起呼吸困难和喉部紧缩感。
文摘Natural gas hydrate is widely distributed in continental slope sediments and permafrost,taken as a potential energy resource due to its gigantic amount.To develop the technologies for the industrial exploitation of natural gas hydrate,several production tests were carried out in permafrost and marine hydrate reservoirs,e.g.tests in permafrost hydrate reservoirs in Mackenzie Delta and Alaskan North Slope(Boswell et al.,2017)in the Antarctic,and those in marine hydrate reservoirs in Nankai Trough,offshore Japan(Yamamoto et al.,2014,2018),and South China Sea(SCS)(Li et al.,2018;Ye et al.,2020).As encouraged by the results obtained from the production tests,more tests are planned to develop technology for industrial exploitation of natural gas hydrate(Collett et al.,2022).Although production test can be conducted in permafrost hydrate reservoir for cost efficiency,generally it is thought industrial exploitation will be realized in marine hydrate reservoir because it is estimated with over 90%of hydrate resource.
文摘The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive dressing onto the skin, above probes, before anti-IgE injection. Histamine levels were assessed by an EIA method. In order to compare the different corticosteroids, AUC was calculated allowing an estimation of the amount of released histamine for 60 min of ex vivo cutaneous microdialysis. Diflucortolone 0.1% and micronized betamethasone dipropionate 0.05% are considered as corticosteroids with high potency in MacKenzie classification. Betamethasone dipropionate associated with propylene glycol 0.05%, belongs to a stronger class in Mackenzie classification. Our results showed that the decrease in histamine release was more important with difluocortolone than with both of these corticosteroids. Therefore there was no correlation between the vasoconstrictor potency of topical corticosteroids and their ability to inhibit histamine release.
