The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Co...The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care.展开更多
Starting from China's macro-economic policy level and combining with the status of foreign trade in China, major problems in the development of foreign trade are analyzed under the background of expanding domestic...Starting from China's macro-economic policy level and combining with the status of foreign trade in China, major problems in the development of foreign trade are analyzed under the background of expanding domestic demand, which is guided by the macro-economy, international finance, international trade and other related disciplines. Problems are mainly the inflation, the reduction of import, the trade protection, the increase in export costs, the reduction of export, the scale shrinkage of foreign trade, the speculation of short-term hot money, and the increase in risk of economic fluctuation. Finally, corresponding countermeasures are put forward, such as actively coping with the appreciation of the RMB, effectively increasing the anti-risk ability of RMB, firmly maintaining the currency stability of RMB, reducing the international trade friction, transforming the growth model of foreign trade, promoting the industrial and products upgrading of foreign trade, enhancing the benefits of foreign trade, forming an effective price competition mechanism, increasing the support in trade, improving the environment for trade development, correctly dealing with the relationship between government and foreign trade enterprise, controlling inflation, and restricting hot money speculation.展开更多
基金partly supported by Florida Department of Health Cancer Research Chair FundingNIH fund-ing (CA150190,HL 70567 and CA78383,and Mayo Clinic Pancreatic Cancer SPORE P50 CA102701 Pilot Project) to DMNCI training grant 1T32 CA148073 (to DM) Pre-doctoral fellowship to NJ
文摘The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care.
文摘Starting from China's macro-economic policy level and combining with the status of foreign trade in China, major problems in the development of foreign trade are analyzed under the background of expanding domestic demand, which is guided by the macro-economy, international finance, international trade and other related disciplines. Problems are mainly the inflation, the reduction of import, the trade protection, the increase in export costs, the reduction of export, the scale shrinkage of foreign trade, the speculation of short-term hot money, and the increase in risk of economic fluctuation. Finally, corresponding countermeasures are put forward, such as actively coping with the appreciation of the RMB, effectively increasing the anti-risk ability of RMB, firmly maintaining the currency stability of RMB, reducing the international trade friction, transforming the growth model of foreign trade, promoting the industrial and products upgrading of foreign trade, enhancing the benefits of foreign trade, forming an effective price competition mechanism, increasing the support in trade, improving the environment for trade development, correctly dealing with the relationship between government and foreign trade enterprise, controlling inflation, and restricting hot money speculation.
