Wild Nutrition’s Food-Grown® Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult Population: A Double-Blind, Randomised, Placebo-Controlled Study

Background: Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown® magnesium in enhancing sleep quality and duration, as well as overall well-being. Methods: Eighty participants were randomly assigned to receive either 80 mg of Food-Grown® magnesium or a placebo (microcrystalline cellulose) daily for 8 weeks. Participants completed questionnaires assessing sleep quality, daytime drowsiness, quality of life, anxiety, and stress levels. Additionally, participants maintained daily sleep diaries and wore wrist-worn actigraphy devices. The primary outcome measured was the change in sleep quality and duration. Results: Seventy-one participants fulfilled all study requirements (35 in the active group and 36 in the placebo group). Magnesium supplementation significantly improved reported sleep quality, with the active group showing a 32% increase compared to 16% in the placebo group (p = 0.034). Moreover, magnesium supplementation led to a decrease in reported stress scores at week 8 compared to the placebo group (3.7 ± 2.6 vs. 5.5 ± 3.1, respectively). Both the magnesium and placebo groups exhibited significant increases in reported sleep duration and reductions in time to fall asleep, sleep disturbance, sleep latency, sleep medication usage, and total Pittsburgh Sleep Quality Index score at week 8 compared to baseline. Conclusion: Magnesium supplementation notably enhanced sleep quality and reduced stress levels compared to the placebo group. These findings highlight the potential of magnesium as a beneficial supplement for improving sleep quality and overall well-being.

A FLOW STRESS MODEL FOR AZ61 MAGNESIUM ALLOY

The flow stress behaviors of AZ61 alloy has been investigated at temperature rangefrom 523 to 673K with the strain rates of 0.001-1s^(-1). It is found that the averageactivation energy, strain rate sensitive exponent and stress exponent are different atvarious deformation conditions changing from 143.6 to 176.3kJ/mol, 0.125 to 0.167and 6 to 8 respectively. A flow stress model for AZ61 alloy is derived by analyzingthe stress data based on hot compression test. It is demonstrated that the flow stressmodel including strain hardening exponent and strain softening exponent is suitableto predicate the flow stress. The prediction of the flow stress of AZ61 alloy has shownto be good agreement with the test data. The maximum differences of the peak stressescalculated by the model and obtained by experiment is less than 8%.

Behavior of Stress Corrosion Cracking in a Magnesium Alloy

Slow strain rate testing （SSRT） was employed to study the stress corrosion cracking （SCC） behavior of ZE41 magnesium alloy in 0.01 M NaCl solution. Smooth tensile specimens with different thicknesses were strained dynamically in both longitudinal and transverse direction under permanent immersions at a strain rate of 10-6 s-1. It is found that ZE41 magnesium alloy is susceptible to SCC in 0.01 M NaCl solution. The SCC susceptibility of the thinner specimen is lower than that of the thicker specimen. Also, the longitudinal specimens are slightly more susceptible to SCC than the transverse specimens. The SCC mechanism of magnesium alloy is attributed to the combination of anodic dissolution with hydrogen embrittlement.

Flow stress and softening behavior of wrought magnesium alloy AZ31B at elevated temperature

The flow stress and softening behavior of AZ31B magnesium alloy in hot compression were investigated. The relationship of flow stress, temperature and strain rate was appropriately described with the exponential form of Zener Hollemen parameter during steady state deformation of alloy at 573723 K, 0.015s -1 . Dynamic recrystallization is the softening mechanism of AZ31B in hot compression. The flow curves of alloy have almost no peak value at 723 K and lower strain rate, presenting feature of geometric dynamic recrystallization.

Microstructure and Flow Stress of Mg-12Gd-3Y-0.5Zr Magnesium Alloy

The microstructure and flow stress of the Mg-12Gd-3Y-0.5Zr magnesium alloy was investigated by compression test at temperatures ranging from 350 to 500 ~C and the strain rates ranging from 0.01 to 20 s-1. The flow stress of the magnesium alloy increased with strain rate and decreased with deformation temperature. Flow stress can be expressed in terms of the Zener-Hollomon parameter Z, which describes the combined influence of the strain rate and temperature using an Arrhenius function.The values of the deformation activation energy were estimated to be 245.9 and 171.5 kJ/mol at deformation temperatures below 400 ℃ and above 400 ℃, respectively. Two constitutive equations were developed to quantify the effect of the deformation conditions on the flow stress of the magnesium alloy. The effects of deformation temperature and strain rate on the microstriucture of the magnesium alloy were also examined and quantified by measuring the volume fraction of dYnahaically recrystallized grain Xd. Xd increased with increasing of deformation temperature. When the deformation temperature was below 475 ℃, X4 decreased with strain rate until it reached 0.15 s-1, then it increased again. When the deformation temperature was above 475 ℃, X4 increased with strain rate.

Analysis on flow stress of magnesium alloys during high temperature deformation

The flow stress of magnesium alloys during hot compression at different temperatures and strain rates was studied by experiments.Materials used were AZ91D alloys in as-cast,homogeneous treatment states,AZ31 and ZK60 alloys in as-cast state. The results show that the thermal simulation curves of different alloys differ from one another at the same deforming condition.The general curves of AZ31 and AZ91D alloys have the character of dynamic recrystallization.There are increase of true stress,drastic falling of true stress and increase of true stress in most curves of ZK60 alloy,while the other curves have the characteristics of dynamic recrystallization.From the analysis the reasonable deforming temperature should be selected from 523 to 673 K for AZ31 and the unhomogenized AZ91D alloy,from 473 to 673 K for the homogenized AZ91D alloy,and it was concluded to be 473 K or 673 K for ZK60 alloy.

Thermal-stress Simulation of Direct-chill Casting of AZ31 Magnesium Alloy Billets

Two-dimensional （2D） transient coupled finite element model was developed to compute the temperature and stress field in cast billets, so as to predict the defects of the I-type billets made from AZ31 magnesium alloy and find the causes and solutions for surface cracks and shrinkages during direct-chill （DC） casting process. Method of equivalent specific heat was used in the heat conduction equation. The boundary and initial conditions used for primary and secondary cooling were elucidated on the basis of the heat transfer during the solidification of the billet. The temperature and the thermal-stress fields were simulated with the thermal-structural coupled module of ANSYS software. The influences of casting parameters on the distributions of temperature and stress were studied, which helped optimize the parameters （at pouring temperature of 680 ℃, casting speed of 2 min/s, heat-transfer coefficient of the second cooling equals to 5 000 W/m^2.℃^-1）. The simulation results of thermal stress and strain fields reveal the formation mechanism of some casting defects, which is favourable for optimizing the casting parameters and obtain high quality billets. Some measures of controlling processes were taken to prevent the defects for direct-chill casting billets.

奥拉西坦联合丙戊酸镁对老年脑卒中后癫痫的治疗效果及氧化应激反应的作用研究

目的探究奥拉西坦联合丙戊酸镁对老年脑卒中后癫痫的治疗效果及氧化应激反应的作用。方法选取2021年8月—2022年9月黑龙江中医药大学附属第一医院收治的92例老年脑卒中后癫痫患者,随机分为研究组与对照组,每组46例。对照组口服丙戊酸镁缓释片治疗,研究组在对照组基础联合奥拉西坦治疗,维持治疗3个月。比较两组患者治疗前后癫痫发作频率、单次癫痫发作持续时间、日常活动能力、认知水平、氧化应激反应、药物毒性及随访6个月的复发结局。结果治疗前后研究组癫痫发作频率差值、单次癫痫发作持续时间差值、日常活动能力评分差值、韦氏智力量表中国修订版评分差值、血清超氧化物歧化酶差值、血清脂质过氧化物差值均高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。研究组6个月的复发率低于对照组(P<0.05)。结论奥拉西坦联合丙戊酸镁治疗老年脑卒中后癫痫,有助于提升抗癫痫效果,改善患者认知功能,减轻氧化应激损伤,且安全性良好。

挤压态WE71镁合金热压缩变形行为

通过热模拟实验研究了挤压态WE71镁合金在变形温度为653~773 K、应变速率为0.001~1 s^(-1)条件下的热压缩变形行为,并采用EBSD对热加工图中的失稳区和可加工区的微观组织、动态再结晶过程进行了分析。结果表明,WE71镁合金属于正应变速率敏感材料,峰值应力随变形温度的升高逐渐下降,随应变速率的增大逐渐升高;在653 K和0.1 s^(-1)条件下开始发生动态再结晶,随着应变速率的降低,动态再结晶分数增加且平均晶粒尺寸减小,随着变形温度的增加,动态再结晶分数增加,但变形温度过高会使平均晶粒尺寸有所增大。挤压态WE71镁合金的变形失稳区主要为低温、高应变速率条件,最佳热加工工艺条件为733 K≤T≤773 K,0.001 s^(-1)≤ε·≤0.01 s^(-1)。

镁在糖尿病肾病中的作用及机制

糖尿病肾病(DN)可导致严重的肾衰竭和终末期肾病,也是糖尿病患者高病死率的最主要原因。DN的发病机制主要涉及胰岛素抵抗、氧化应激以及炎症反应等。低镁可通过影响胰岛素受体导致胰岛素抵抗的发生,而元素镁缺乏可影响DN的发生发展,但具体机制目前尚未完全阐明。镁可通过间接影响胰岛素受体底物的敏感性改变胰岛素抵抗;镁还可通过改变线粒体功能、钙离子水平、自由基的积累促进炎症的发生;镁也可通过影响活性氧水平促进氧化应激的发生,这些因素最终导致DN的发生发展。因此,深入研究镁在DN中的作用及机制,可以为疾病的治疗提供新思路。

应力三轴度对AZ31镁合金断裂应变的影响

采用试验和有限元数值模拟相结合的方法,分析了应力三轴度对AZ31镁合金断裂应变的影响。对光滑试样和3组不同缺口半径的试样以0.5 mm/min的拉伸速度进行准静态拉伸试验。然后,选取三组试样数据建立了AZ31镁合金在室温下关于应力三轴度对断裂应变影响的模型。将建立的损伤模型代入ABAQUS有限元软件中进行模拟仿真,模拟结果与其余一组试验结果基本一致,验证了该模型的正确性。

磷酸对硫氧镁水泥流变性能的影响

硫氧镁水泥是一种性能优良的镁质胶凝材料,它具有质量轻、强度高、耐火性好等特点,因此具有广泛的应用前景。通过配制不同水灰比的水泥浆体,利用黏度计研究不同掺量的磷酸对硫氧镁水泥浆体流变性能的影响。实验结果表明,改变浆体水灰比可以调控其黏度的增长,磷酸的加入延缓了水泥浆体的水化,进而降低了水泥浆体的塑性黏度和屈服应力。利用Bingham模型可以很好地拟合添加磷酸前后水泥浆体的流变曲线。

铣削工艺参数对AZ31B已加工表面残余应力的影响

铣削工艺参数是影响工件已加工表面残余应力的重要因素。通过建立镁合金AZ31B铣削有限元模型对铣削工艺参数进行研究,在采用正交试验法对镁合金AZ31B铣削仿真的重要工艺参数进行优化的基础上,用极差法分析各项铣削工艺参数对AZ31B工件已加工表面残余应力的影响规律。结果表明:对镁合金AZ31B铣削过程的铣削速度、铣削深度及铣削路径三种工艺参数中,铣削路径对AZ31B工件已加工表面残余应力的影响最大,铣削速度次之,铣削深度最小;铣削速度在(30~50)m/min范围内,镁合金已加工表面残余应力随着铣削速度而增大;在铣削深度为(1~3)mm范围内,铣削深度对已加工表面残余应力的影响不大。

瑞巴派特联合铝镁加混悬液对应激性胃溃疡患者症状改善及睡眠质量效果研究

目的:分析应激性胃溃疡治疗中采取瑞巴派特联合铝镁加混悬液的治疗效果及对症状改善与睡眠质量的影响。方法:选取2022年1月至2023年9月福州市长乐区第二医院收治的应激性胃溃疡患者50例作为研究对象,按照随机数字表法分为对照组和观察组,每组25例。对照组采取常规治疗,观察组采取瑞巴派特联合铝镁加混悬液治疗,比较2组治疗后症状改善时间(上腹痛、反酸、腹胀、烧心),分析2组治疗前后睡眠情况、睡眠相关评分。结果:观察组治疗后临床症状改善时间较对照组更短,差异有统计学意义(P<0.05);治疗后比较观察组与对照组睡眠时长、闭眼至入睡时间、匹兹堡睡眠质量指数、阿森斯失眠量表评分可见前者较后者改善明显,差异有统计学意义(P<0.05)。结论:对应激性胃溃疡患者采取瑞巴派特联合铝镁加混悬液治疗可改善其临床症状,与常规治疗模式比较还能缓解其睡眠状态,延长睡眠时间,有助于身体康复,值得推广。

异甘草酸镁联合腺苷蛋氨酸治疗肝衰竭的效果及对氧化应激指标的影响

目的探讨异甘草酸镁联合腺苷蛋氨酸治疗肝衰竭的效果及对氧化应激指标的影响。方法选取2019年6月至2022年6月本院收治的100例肝衰竭患者作为研究对象,依据患者入院编号的奇偶性将其均分为对照组(奇数,50例)与观察组(偶数,50例)。对照组行常规方案治疗,观察组行异甘草酸镁联合腺苷蛋氨酸方案治疗。比较两组的治疗效果、肝功能指标、炎症指标及氧化应激指标。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的总胆红素(TBIL)、谷丙转氨酶(ALT)及碱性磷酸酶(AKP)水平均低于对照组,白蛋白(ALB)水平高于对照组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平均低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)、血浆皮质醇(Cor)水平低于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)水平高于对照组(P<0.05)。结论异甘草酸镁联合腺苷蛋氨酸不但可以显著提升肝衰竭患者的治疗效果,还有助于减轻炎症及氧化应激损伤,促进患者肝功能恢复。

新型钙镁硅复合无机材料对盐胁迫下小麦幼苗生长的影响

为确定新型钙镁硅复合无机材料(IM)对盐(NaCl)胁迫下小麦幼苗生长的影响,采用液培法,通过在营养液中添加IM,制备了ρ(IM)=3.15,6.30,9.45,12.60,15.75 g·L^(-1)的5种培养液,进行了不同添加量的IM对盐胁迫下小麦幼苗生长与生理特性影响的试验。结果表明:盐胁迫显著抑制了小麦幼苗的生长,添加IM能有效缓解小麦幼苗的盐胁迫效应,其中以ρ(IM)=12.60 g·L^(-1)的处理能显著促进盐胁迫下小麦幼苗的生长,降低盐胁迫下小麦幼苗根系与叶片的丙二醛质量摩尔浓度和超氧阴离子产生速率,增加叶片和根系的可溶性蛋白质量分数和抗氧化酶活性,并显著提高游离脯氨酸质量分数。

基于SPH方法的搅拌摩擦焊数值模拟研究

光滑粒子流体动力学(smoothed particle hydrodynamics,SPH)法是基于拉格朗日的一种无网格法,基于SPH方法使用ABAQUS软件进行AZ31B镁合金的搅拌摩擦焊数值模拟,通过改变搅拌头转速,研究残余应力和温度的分布。结果显示:焊缝两侧残余应力分布呈不对称,后退侧应力大于前进侧;应力曲线具有双峰特征,在焊接区域表现为拉应力;随着转速的增加,工件应力分布更加均匀;焊缝两侧的温度呈不对称分布,且前进侧高于后退侧,随着转速的增加,温度呈上升趋势;纵向温度曲线呈M形分布。模拟结果对实际焊接过程中焊接参数的选择具有一定参考意义。

拉贝洛尔联合硫酸镁治疗妊娠期高血压患者的效果

目的:观察拉贝洛尔联合硫酸镁治疗妊娠期高血压患者的效果。方法:选取2021年5月至2022年5月该院收治的90例妊娠期高血压患者进行前瞻性研究,按随机数字表法将其分为观察组和对照组各45例。对照组采用硫酸镁治疗,观察组在对照组基础上联合拉贝洛尔治疗,比较两组治疗前后血压水平、血管内皮功能指标[超氧化物歧化酶(SOD)、内皮素-1(ET-1)、一氧化氮(NO)]水平、氧化应激指标[丙二醛(MDA)、髓过氧化物酶(MPO)]水平,以及不良妊娠结局发生率和不良反应发生率。结果:治疗后,观察组舒张压、收缩压水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组SOD、NO水平均高于对照组,ET-1水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组MDA、MPO水平均低于对照组,差异有统计学意义(P<0.05);观察组不良妊娠结局发生率为2.22%(1/45),低于对照组的22.22%(10/45),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:拉贝洛尔联合硫酸镁治疗妊娠期高血压患者可降低血压水平,改善血管内皮功能指标水平,降低氧化应激指标水平和不良妊娠结局发生率,效果优于单纯硫酸镁治疗。

AA2195-AZ31B搅拌摩擦焊温度与残余应力场的数值模拟

针对AA2195铝锂合金和AZ31B镁合金,基于耦合欧拉拉格朗日(coupled eulerian-lagrangian,CEL)方法,结合有限元分析软件Abaqus,建立了搅拌摩擦焊对接过程的有限元模型。同时,对焊接过程中的动态温度场及焊后残余应力场的分布进行了研究。结果表明:焊缝区域应力以纵向应力为主,最大残余应力在AA2195铝锂合金侧。垂直于焊缝的截面纵向应力呈“M”形分布,最大值约为220 MPa,双峰之间存在倒“V”形。焊接过程中温度变化趋势与应力循环曲线负相关。此外,针对2 mm厚的AA2195铝锂合金和AZ31B镁合金板材进行了搅拌摩擦焊试验,用盲孔法对焊后残余应力进行测试,验证了模型的准确性。