An acoustic dipole radiation model for magnetoacoustic tomography with magnetic induction （MAT-MI） is pro- posed, based on the analyses of one-dimensional tissue vibration, three-dimensional acoustic dipole radiatio...An acoustic dipole radiation model for magnetoacoustic tomography with magnetic induction （MAT-MI） is pro- posed, based on the analyses of one-dimensional tissue vibration, three-dimensional acoustic dipole radiation and acoustic waveform detection with a planar piston transducer. The collected waveforms provide information about the conductiv- ity boundaries in various vibration intensities and phases due to the acoustic dipole radiation pattern. Combined with the simplified back projection algorithm, the conductivity configuration of the measured layer in terms of shape and size can be reconstructed with obvious border stripes. The numerical simulation is performed for a two-layer cylindrical phantom model and it is also verified by the experimental results of MAT-MI for a tissue-like sample phantom. The proposed model suggests a potential application of conductivity differentiation and provides a universal basis for the further study of conductivity reconstruction for MAT-MI.展开更多
Based on the acoustic radiation theory of a dipole source, the influence of the transducer reception pattern is studied for magnetoacoustic tomography with magnetic induction（MAT-MI）. Numerical studies are conducted...Based on the acoustic radiation theory of a dipole source, the influence of the transducer reception pattern is studied for magnetoacoustic tomography with magnetic induction（MAT-MI）. Numerical studies are conducted to simulate acoustic pressures, waveforms, and reconstructed images with unidirectional, omnidirectional, and strong directional transducers.With the analyses of equivalent and projection sources, the influences of the model dimension and the layer effect are qualitatively analyzed to evaluate the performance of MAT-MI. Three-dimensional simulation studies show that the strong directional transducer with a large radius can reduce the influences of equivalent sources, projection sources, and the layer effect effectively, resulting in enhanced pressure and improved image contrast, which is beneficial for boundary pressure extraction in conductivity reconstruction. The reconstructed conductivity contrast images present the conductivity boundaries as stripes with different contrasts and polarities, representing the values and directions of the conductivity changes of the scanned layer. The favorable results provide solid evidence for transducer selection and suggest potential practical applications of MAT-MI in biomedical imaging.展开更多
Magneto–acoustic tomography with magnetic induction（MAT-MI） is a multiphysics coupled imaging technique that is combined with electrical impedance tomography and ultrasound imaging. In order to study the influence ...Magneto–acoustic tomography with magnetic induction（MAT-MI） is a multiphysics coupled imaging technique that is combined with electrical impedance tomography and ultrasound imaging. In order to study the influence of adding magnetic nanoparticles as a contrast agent for MAT-MI on its physical process, firstly, we analyze and compare the electromagnetic and acoustical properties of MAT-MI theoretically before and after adding magnetic nanoparticles, and then construct a two-dimensional（2 D） planar model. Under the guidance of space-time separation theory, we determine the reasonable simulation conditions and solve the electromagnetic field and sound field physical processes in the two modes by using the finite element method. The magnetic flux density, sound pressure distribution, and related one-dimensional（1 D）, 2 D, and three-dimensional（3 D） images are obtained. Finally, we make a qualitative and quantitative analysis based on the theoretical and simulation results. The research results show that the peak time of the time item separated from the sound source has a corresponding relationship with the peak time of the sound pressure signal. At this moment, MAMPTMI produces larger sound pressure signals, and the sound pressure distribution of the MAMPT-MI is more uniform, which facilitates the detection and completion of sound source reconstruction. The research results may lay the foundation for the MAT-MI of magnetically responsive nanoparticle in subsequent experiments and even clinical applications.展开更多
Due to the unique magnetic, mechanical and thermal properties, magnetic nanoparticles(MNPs) have comprehensive applications as the contrast and therapeutic agents in biomedical imaging and magnetic hyperthermia. The l...Due to the unique magnetic, mechanical and thermal properties, magnetic nanoparticles(MNPs) have comprehensive applications as the contrast and therapeutic agents in biomedical imaging and magnetic hyperthermia. The linear and nonlinear magnetoacoustic responses determined by the magnetic properties of MNPs have attracted more and more attention in biomedical engineering. By considering the relaxation time of MNPs, we derive the formulae of second harmonic magnetoacoustic responses(2H-MARs) for a cylindrical MNP solution model based on the mechanical oscillations of MNPs in magnetoacoustic tomography with magnetic induction(MAT-MI). It is proved that only the second harmonic magnetoacoustic oscillations can be generated by MNPs under an alternating magnetic excitation. The acoustic pressure of the 2H-MAR is proportional to the square of the magnetic field intensity and exhibits a linear increase with the concentration of MNPs. Numerical simulations of the 2H-MAR are confirmed by the experimental measurements for various magnetic field intensities and solution concentrations using a laser vibrometer. The favorable results demonstrate the feasibility of the harmonic measurements without the fundamental interference of the electromagnetic excitation, and suggest a new harmonic imaging strategy of MAT-MI for MNPs with enhanced spatial resolution and improved signal-to-noise ratio in biomedical applications.展开更多
As a kind of multi-physics imaging approach integrating the advantages of electrical impedance tomography and ul- trasound imaging with the improved spatial resolution and image contrast, magneto-acoustic tomography w...As a kind of multi-physics imaging approach integrating the advantages of electrical impedance tomography and ul- trasound imaging with the improved spatial resolution and image contrast, magneto-acoustic tomography with magnetic induction （MAT-MI） is demonstrated to have the capability of electrical impedance contrast imaging for biological tissues with conductivity differences. By being detected with a strong directional transducer, abrupt pressure change is proved to be generated by the gradient of the induced Lorentz force along the force direction at conductivity boundary. A simplified boundary normal pressure （BNP）-based conductivity reconstruction algorithm is proposed and the formula for conductivity distribution inside the object with the clear physical meaning of pressure derivative, is derived. Numerical simulations of acoustic pressure and conductivity reconstruction are conducted based on a 2-layer eccentric cylindrical phantom model using Hilbert transform. The reconstructed two-dimensional conductivity images accord well with the model, thus success- fully making up the deficiency of only imaging conductivity boundary in traditional MAT-MI. The proposed method is also demonstrated to have a spatial resolution of one wavelength. This study provides a new method of reconstructing accurate electrical conductivity and suggests the potential applications of MAT-MI in imaging biological tissues with conductivity difference.展开更多
This paper focuses on the key issues of information processing in the new sensing technology-electromagnetic induction tomography and depth theoretical study and experimental simulation have been conducted.In this stu...This paper focuses on the key issues of information processing in the new sensing technology-electromagnetic induction tomography and depth theoretical study and experimental simulation have been conducted.In this study,Labview is used to drive the data acquisition card to control the signal generation and acquisition,and Matlab is used to achieve algorithms such as Fast Fourier Transformation (FFT) algorithm,relevant law algorithm and the classical method algorithm.The simulation results show this software system enables successful digital phase identification and the phase difference resolution of 0.10 can be achieved,which is consistent with theoretical analysis.It can also be seen that software system based on Labview and Matlab is a successful method to identify the phase difference in magnetic induction tomography system,which can meet the measurement needs of sensor nodes,laying the basis for the further development of medical IoT study.展开更多
基金Project supported by the National Basic Research Program of China （Grant No. 2011CB707900）, the National Natural Science Foundation of China （Grant No. 10974098）, the Natural Science Foundation of Jiangsu Province, China （Grant No. BK2009407）, and the Specialized Research Fund for Doctoral Program of High Education of China （Grant No. 20093207120003）.
文摘An acoustic dipole radiation model for magnetoacoustic tomography with magnetic induction （MAT-MI） is pro- posed, based on the analyses of one-dimensional tissue vibration, three-dimensional acoustic dipole radiation and acoustic waveform detection with a planar piston transducer. The collected waveforms provide information about the conductiv- ity boundaries in various vibration intensities and phases due to the acoustic dipole radiation pattern. Combined with the simplified back projection algorithm, the conductivity configuration of the measured layer in terms of shape and size can be reconstructed with obvious border stripes. The numerical simulation is performed for a two-layer cylindrical phantom model and it is also verified by the experimental results of MAT-MI for a tissue-like sample phantom. The proposed model suggests a potential application of conductivity differentiation and provides a universal basis for the further study of conductivity reconstruction for MAT-MI.
基金Project supported by the National Basic Research Program of China(Grant No.2011CB707900)the National Natural Science Foundation of China(Grant Nos 11274176 and 11474166)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China
文摘Based on the acoustic radiation theory of a dipole source, the influence of the transducer reception pattern is studied for magnetoacoustic tomography with magnetic induction（MAT-MI）. Numerical studies are conducted to simulate acoustic pressures, waveforms, and reconstructed images with unidirectional, omnidirectional, and strong directional transducers.With the analyses of equivalent and projection sources, the influences of the model dimension and the layer effect are qualitatively analyzed to evaluate the performance of MAT-MI. Three-dimensional simulation studies show that the strong directional transducer with a large radius can reduce the influences of equivalent sources, projection sources, and the layer effect effectively, resulting in enhanced pressure and improved image contrast, which is beneficial for boundary pressure extraction in conductivity reconstruction. The reconstructed conductivity contrast images present the conductivity boundaries as stripes with different contrasts and polarities, representing the values and directions of the conductivity changes of the scanned layer. The favorable results provide solid evidence for transducer selection and suggest potential practical applications of MAT-MI in biomedical imaging.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51507171,and 61427806)
文摘Magneto–acoustic tomography with magnetic induction（MAT-MI） is a multiphysics coupled imaging technique that is combined with electrical impedance tomography and ultrasound imaging. In order to study the influence of adding magnetic nanoparticles as a contrast agent for MAT-MI on its physical process, firstly, we analyze and compare the electromagnetic and acoustical properties of MAT-MI theoretically before and after adding magnetic nanoparticles, and then construct a two-dimensional（2 D） planar model. Under the guidance of space-time separation theory, we determine the reasonable simulation conditions and solve the electromagnetic field and sound field physical processes in the two modes by using the finite element method. The magnetic flux density, sound pressure distribution, and related one-dimensional（1 D）, 2 D, and three-dimensional（3 D） images are obtained. Finally, we make a qualitative and quantitative analysis based on the theoretical and simulation results. The research results show that the peak time of the time item separated from the sound source has a corresponding relationship with the peak time of the sound pressure signal. At this moment, MAMPTMI produces larger sound pressure signals, and the sound pressure distribution of the MAMPT-MI is more uniform, which facilitates the detection and completion of sound source reconstruction. The research results may lay the foundation for the MAT-MI of magnetically responsive nanoparticle in subsequent experiments and even clinical applications.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11934009,11974187,and 11604156)。
文摘Due to the unique magnetic, mechanical and thermal properties, magnetic nanoparticles(MNPs) have comprehensive applications as the contrast and therapeutic agents in biomedical imaging and magnetic hyperthermia. The linear and nonlinear magnetoacoustic responses determined by the magnetic properties of MNPs have attracted more and more attention in biomedical engineering. By considering the relaxation time of MNPs, we derive the formulae of second harmonic magnetoacoustic responses(2H-MARs) for a cylindrical MNP solution model based on the mechanical oscillations of MNPs in magnetoacoustic tomography with magnetic induction(MAT-MI). It is proved that only the second harmonic magnetoacoustic oscillations can be generated by MNPs under an alternating magnetic excitation. The acoustic pressure of the 2H-MAR is proportional to the square of the magnetic field intensity and exhibits a linear increase with the concentration of MNPs. Numerical simulations of the 2H-MAR are confirmed by the experimental measurements for various magnetic field intensities and solution concentrations using a laser vibrometer. The favorable results demonstrate the feasibility of the harmonic measurements without the fundamental interference of the electromagnetic excitation, and suggest a new harmonic imaging strategy of MAT-MI for MNPs with enhanced spatial resolution and improved signal-to-noise ratio in biomedical applications.
基金supported by the National Natural Science Foundation of China(Grant Nos.11474166 and 11604156)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20161013)+1 种基金the Postdoctoral Science Foundation of China(Grant No.2016M591874)the Priority Academic Program Development of Jiangsu Provincial Higher Education Institutions,China
文摘As a kind of multi-physics imaging approach integrating the advantages of electrical impedance tomography and ul- trasound imaging with the improved spatial resolution and image contrast, magneto-acoustic tomography with magnetic induction （MAT-MI） is demonstrated to have the capability of electrical impedance contrast imaging for biological tissues with conductivity differences. By being detected with a strong directional transducer, abrupt pressure change is proved to be generated by the gradient of the induced Lorentz force along the force direction at conductivity boundary. A simplified boundary normal pressure （BNP）-based conductivity reconstruction algorithm is proposed and the formula for conductivity distribution inside the object with the clear physical meaning of pressure derivative, is derived. Numerical simulations of acoustic pressure and conductivity reconstruction are conducted based on a 2-layer eccentric cylindrical phantom model using Hilbert transform. The reconstructed two-dimensional conductivity images accord well with the model, thus success- fully making up the deficiency of only imaging conductivity boundary in traditional MAT-MI. The proposed method is also demonstrated to have a spatial resolution of one wavelength. This study provides a new method of reconstructing accurate electrical conductivity and suggests the potential applications of MAT-MI in imaging biological tissues with conductivity difference.
文摘This paper focuses on the key issues of information processing in the new sensing technology-electromagnetic induction tomography and depth theoretical study and experimental simulation have been conducted.In this study,Labview is used to drive the data acquisition card to control the signal generation and acquisition,and Matlab is used to achieve algorithms such as Fast Fourier Transformation (FFT) algorithm,relevant law algorithm and the classical method algorithm.The simulation results show this software system enables successful digital phase identification and the phase difference resolution of 0.10 can be achieved,which is consistent with theoretical analysis.It can also be seen that software system based on Labview and Matlab is a successful method to identify the phase difference in magnetic induction tomography system,which can meet the measurement needs of sensor nodes,laying the basis for the further development of medical IoT study.
