Effect of magnetic flow and external forcing current on mixed bursting in the pre-Botzinger complex

The pre-Botzinger complex(pre-BotC) in mammalian brainstem is essential for the generation of respiratory rhythms.Most dynamic studies on the pre-BotC neuron have been focused on its firing activities modulated by the ion conductances rather than that by the electromagnetic radiation or the external forcing current. In this paper, by adding the electromagnetic radiation and external forcing current to Park and Rubin’s model, we mainly investigate the influences of those two factors on the mixed bursting(MB) of single pre-BotC neuron. First, we explore how the variation of external forcing current affects the MB patterns of the system with non-vanishing magnetic flux. We classify the MB patterns and show their dynamic mechanism through fast-slow decomposition and bifurcation analysis. Then, by modifying the feedback coefficient, we further analyze the sole effect of electromagnetic radiation on the firing activities of the system. Our results may be instructive in understanding the dynamical behavior of pre-BotC neuron.

4D flow MRI 在法洛四联症术后评估中的应用进展

Cardiovascular dysfunction may occur in patients with repaired tetralogy of Fallot(rTOF),and postoperative follow-up is very important.The emergence of four-dimensional flow MRI(4D flow MRI)provides more quantitative parameters of hemodynamics and cardiac function,which is helpful for clinicians to know the condition of patients with rTOF.This article reviews the application progress of 4D flow MRI in postoperative evaluation of tetralogy of Fallot.

MHD Stability Analysis and Flow Controls of Liquid Metal Free Surface Film Flows as Fusion Reactor PFCs

Numerical and experimental investigation results on the magnetohydrodynamics（MHD） film flows along flat and curved bottom surfaces are summarized in this study. A simplified modeling has been developed to study the liquid metal MHD film state, which has been validated by the existing experimental results. Numerical results on how the inlet velocity（V）, the chute width（W） and the inlet film thickness（d0） affect the MHD film flow state are obtained. MHD stability analysis results are also provided in this study. The results show that strong magnetic fields make the stable V decrease several times compared to the case with no magnetic field,especially small radial magnetic fields（Bn） will have a significant impact on the MHD film flow state. Based on the above numerical and MHD stability analysis results flow control methods are proposed for flat and curved MHD film flows. For curved film flow we firstly proposed a new multi-layers MHD film flow system with a solid metal mesh to get the stable MHD film flows along the curved bottom surface. Experiments on flat and curved MHD film flows are also carried out and some firstly observed results are achieved.

Depth to the bottom of magnetic layer in South America and its relationship to Curie isotherm,Moho depth and seismicity behavior

We have estimated the DBML（depth to the bottom of the magnetic layer） in South America from the inversion of magnetic anomaly data extracted from the EMAG2 grid. The results show that the DBML values, interpreted as the Curie isotherm, vary between -10 and -60 km. The deepest values（〉-45） are mainly observed forming two anomalous zones in the central part of the Andes Cordillera. To the east of the Andes, in most of the stable cratonic area of South America, intermediate values（between -25 and-45 km） are predominant. The shallowest values（〈-25 km） are present in northwestern corner of South America, southern Patagonia, and in a few sectors to the east of the Andes Cordillera. Based on these results, we estimated the heat flow variations along the study area and found a very good correlation with the DBML. Also striking is the observation that the thermal anomalies of low heat flow are closely related to segments of flat subduction, where the presence of a cold and thick subducting oceanic slab beneath the continent, with a virtual absence of hot mantle wedge, leads to a decrease in the heat transfer from the deeper parts of the system.After comparing our results with the Moho depths reported by other authors, we have found that the Curie isotherm is deeper than Moho in most of the South American Platform（northward to -20°S）, which is located in the stable cratonic area at the east of the Andes. This is evidence that the lithospheric mantle here is magnetic and contributes to the long wavelength magnetic signal. Also, our results support the hypothesis that the Curie isotherm may be acting as a boundary above which most of the crustal seismicity is concentrated. Below this boundary the occurrence of seismic events decreases dramatically.

The exploration of flow pattern in the superior vena cava of healthy adults:A 4D flow magnetic resonance imaging study

Our study sought to investigate the blood flow pattern in the superior vena cava(SVC)of healthy adults and to describe the development and characteristics of the flow pattern using 4D flow magnetic resonance imaging(MRI).4D flow MRI data with full coverage of SVC and brachiocephalic veins(BVs)were acquired with a 3-Testa MRI in thirty healthy adults(age:28.70±9.09).Hemodynamic parameters in the SVC,including velocity,velocity vector,flow visualization(pathlines,streamlines),flow waveform and energy loss,were obtained with specialized commercial post-processing software based on 4D flow MRI data.This study found that:(1)The SVC has a pulsating flow waveform with double peaks.(2)Based on BVs flow of the SVC pathline visualization,flow patterns could be divided into three development types:twining(n=14),untwining(n=)and no helical flow(n=7).(3)With the decreasing blood velocity,helical flow areas tended to gradually extend.(4)There were no significant differences in most hemodynamic parameters among the three types.The exploration of the blood flow characteristics of normal SVC may be the first step for capturing pathogenic features before the patients develop symptoms with a certain positive significance.The potential physiological significance of these phenomena deserves more exploration in future studies.

A brief report on MRI investigation of experimental traumatic brain injury

Traumatic brain injury is a major cause of death and disability. This is a brief report based on a symposium presentation to the 2014 Chinese Neurotrauma Association Meeting in San Francisco, USA. It covers the work from our laboratory in applying multimodal MRI to study experimental traumatic brain injury in rats with comparisons made to behavioral tests and histology. MRI protocols include structural, perfusion, manganese-enhanced, diffusion-tensor MRI, and MRI of blood-brain barrier integrity and cerebrovascular reactivity.

Darcy-Forchheimer mangetized flow based on differential type nanoliquid capturing Ohmic dissipation effects

Hydromagnetic nanoliquid establish an extraordinary category of nanoliquids that unveil both liquid and magnetic attributes.The interest in the utilization of hydromagnetic nanoliquids as a heat transporting medium stem from a likelihood of regulating its flow along with heat transportation process subjected to an externally imposed magnetic field.This analysis reports the hydromagnetic nanoliquid impact on differential type(second-grade)liquid from a convectively heated extending surface.The well-known Darcy-Forchheimer aspect capturing porosity characteristics is introduced for nonlinear analysis.Robin conditions elaborating heat-mass transportation effect are considered.In addition,Ohmic dissipation and suction/injection aspects are also a part of this research.Mathematical analysis is done by implementing the basic relations of fluid mechanics.The modeled physical problem is simplified through order analysis.The resulting systems(partial differential expressions)are rendered to the ordinary ones by utilizing the apposite variables.Convergent solutions are constructed employing homotopy algorithm.Pictorial and numeric result are addressed comprehensively to elaborate the nature of sundry parameters against physical quantities.The velocity profile is suppressed with increasing Hartmann number(magnetic parameter)whereas it is enhanced with increment in material parameter(second-grade).With the elevation in thermophoresis parameter,temperature and concentration of nanoparticles are accelerated.

The LIMMCAST Program at HZDR:Modelling of Fluid Flow and Transport Phenomena in the Continuous Casting Process

Model experiments with low melting point liquid metals are an important tool to investigate the flow structure and related transport processes in melt flows relevant for metallurgical applications.We present the new experimental facility LIMMCAST for modelling the continuous casting process of steel using the alloy SnBi at temperatures of 200-400℃.The parameters of the facility and the dimensions of the test sections will be given,and the possibilities for flow investigations in tundish,submerged entry nozzle and mould will be discussed.In addition,the smaller set-up Mini-LIMMCAST will be presented,which works with the room-temperature liquid alloy GaInSn.The main value of cold metal laboratory experiments consists in the capabilities to obtain quantitative flow measurements with a reasonable spatial and temporal resolution.New ultrasonic and electromagnetic techniques for measuring the velocity in liquid metal flows came up during the last decade allowing for a satisfying characterisation of flow quantities in the considered temperature range up to 400℃.First results from LIMMCAST and Mini-LIMMCAST will be presented covering the following phenomena:fully contacfless electromagnetic tomography of the flow in the mould,flow monitoring by a multitude of ultrasonic sensors,and analysis of the flow in the mould under the influence of an electromagnetic brake: intensification of the flow turbulence contrary to the expected flow damping,injection of argon bubbles through the stopper rod:occurrence of pressure oscillations.

Visualization study on fluid distribution and end effects in core flow experiments with low-field mri method

Core flow experiment is an important means of simulation experiments to evaluate the effect of displacing agent, but conventionally the internal characteristics in the core cannot be intuitively observed, and then some important information can not be directly acquired by experiments. In this paper, a visualization method was used to detect the water-flooding process by using an improved low field nuclear magnetic resonance imaging（MRI） device, and the images describing the distribution of oil and water were collected. The experimental results show that the distribution of oil and water can be visually detected in an appropriate range of core porosity, and the end effect in many mechanics experiments is found to exist also in natural core flow test, and the influence range is about 0.004 m from the end of a 0.05752 m length natural core. The results also indicate that MRI is an effective tool to study the real time fluid distribution in natural core.

Divergence and flutter instability of magneto-thermo-elastic C-BN hetero-nanotubes conveying fluid

On the basis of finite element analysis,an eigenvalue problem is performed to examine the vibrational characteristics of a hetero-nanotube made of carbon(C)and boron nitride(BN)nanotubes in magnetic and thermal environment.By incorporating the assumption of nonlocal elasticity theory,the size-dependent behavior of the considered structure is also taken into account.The obtained results demonstrate that the onset of the divergence and flutter instabilities may be postponed by exploiting a hetero-nanotube rather than a uniform one composed of carbon nanotube.Moreover,it is exhibited that,in the presence of fluid flow,the mode shape configuration of nanotubes may be different from those of classical modes and therefore the later one should not be utilized in the dynamic analysis of fluid-conveying tubes.Finally,it is shown that,as the temperature decreases,the natural frequencies of the system decrease in high temperature conditions and increase for the case of room temperature.

Mathematical Modeling of ESR Process for Hollow Ingot with Current Supplying Mould

With ificreasing demand for large cylindrical forgings, a new technology--electroslag remelting （ESR） for direct manufacture of hollow ingots rather than solid ingots has been developed. The main features of the process include a T-shaped current supplying mould （CSM）, double power supply, an ingot withdrawing system, a metal level automatic control system based on a level sensor using the electromagnetic eddy current method, and the exchange of a consumable multi-electrode. ANSYS software was used to calculate the fluid flow and heat transfer in the slag bath 1 and metal pool of this ESR hollow ingot process with its T-shaped CSM. The mathematmal model was Verified by measuring the geometry of the liquid metal pool as observed in the macrostructure of 4650 mm （external diameter）/ 4450 mm （internal diameter） hollow ingots by sulphur print method： the. observed shape and depth of the s!ag bath were consistent with the simulated results. Simulation of the ESR process can improve understanding of the process and allow better operating parameters to be selected.

Hydrodynamic behavior of magnetized fluidized beds with admixtures of Geldart-B magnetizable and nonmagnetizable particles

This work focuses on the hydrodynamic behavior of admixtures of Geldart-B magnetizable and non- magnetizable particles in a magnetized fluidized bed. The applied magnetic field was axial, uniform, and steady. In operating the beds, the magnetization-LAST mode was adopted under which four distinct flow regimes exist： fixed, magnetized-bubbling, partial segregation-bubbling, and total segregation-bubbling, The operational phase diagram was drawn to display the transitions between flow regimes in an intuitive manner. Only in the magnetized-bubbling regime could the magnetic field reduce the bubble size and improve fluidization quality. In the segregation-bubbling regimes, fluidization quality deteriorated as segregation developed. The segregation of the binary mixture was quantitatively studied by observing pressure drops in the local bed. Reasons for the improvement in fluidization quality as well as the occur- rence of segregation were analyzed. Furthermore. the flow regime transition under magnetization-LAST operation mode was different from that under magnetization-FIRST mode. The magnetically stabilized bed （MSB） flow regime, which could be easily created under magnetization-FIRST mode, could no longer be achieved under magnetization-LAST mode. With the admixture, the MSB was proved to be a metastable equilibrium state. Under the magnetization-LAST mode, the admixture bed reached directly the stable equilibrium state-bubbling with segregation.