Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in whi...Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain.展开更多
快动眼睡眠行为障碍(rapid eye movement sleep behavior disorder,RBD)是以快动眼睡眠(rapid eye movement sleep,REM)期骨骼肌失迟缓缺失引起的临床表现,它可作为单一疾病发生,也可作为α-突触核蛋白病中的先驱症状而存在,同时影响疾...快动眼睡眠行为障碍(rapid eye movement sleep behavior disorder,RBD)是以快动眼睡眠(rapid eye movement sleep,REM)期骨骼肌失迟缓缺失引起的临床表现,它可作为单一疾病发生,也可作为α-突触核蛋白病中的先驱症状而存在,同时影响疾病的进展和程度。但关于RBD的发病机制仍不清楚,随着影像学技术的发展,脑干及黑质纹状体功能在RBD中的作用日益受到关注,脑干作为睡眠管理中心在RBD发病机制中尤显重要。本文就最近几年国外的主要神经影像学进展进行综述。展开更多
基金supported in part by the National Basic Research Program of China,No.81300766(to XSM)the Cultivation and Innovation Fund from the First Affiliated Hospital of Jinan University,China,No.802168(to XSM)+2 种基金the fund of Leading Talents of Guangdong Province,China,No.87014002(to KFS)the fund of Ningxia Key Research and Development Program(Yinchuan,Ningxia Hui Autonomous Region,China)Programme of Introducing Talents of Discipline to Universities,China,No.B14036(to KFS)
文摘Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain.
文摘快动眼睡眠行为障碍(rapid eye movement sleep behavior disorder,RBD)是以快动眼睡眠(rapid eye movement sleep,REM)期骨骼肌失迟缓缺失引起的临床表现,它可作为单一疾病发生,也可作为α-突触核蛋白病中的先驱症状而存在,同时影响疾病的进展和程度。但关于RBD的发病机制仍不清楚,随着影像学技术的发展,脑干及黑质纹状体功能在RBD中的作用日益受到关注,脑干作为睡眠管理中心在RBD发病机制中尤显重要。本文就最近几年国外的主要神经影像学进展进行综述。
