Malignant neoplasms represent a significant global health threat.To address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic nanoplatforms.Iron oxide nanoparticles(NP...Malignant neoplasms represent a significant global health threat.To address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic nanoplatforms.Iron oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high self-metabolism.Their ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such applications.Various methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting molecules.Multifunctional systems can be created by combining Fe_(3)O_(4) NPs with polymers.By combining various therapeutic approaches,more effective biomedical materials can be developed.This paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.12272253,82103147,12202302,31800684,and 11802197)the Natural Science Foundation of Shanxi Province,China(Grant Nos.202203021221047,20210302124007,and 20210302124405)+3 种基金the Shanxi Scholarship Council of China(HGKY2019037)the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SX-AT008 and 2021SX-AT009)the Central Guidance on Local Science and Technology Development Fund of Shanxi Province(YDZJSX2021A021)the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20220006)is also acknowledged with gratitude.
文摘Malignant neoplasms represent a significant global health threat.To address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic nanoplatforms.Iron oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high self-metabolism.Their ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such applications.Various methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting molecules.Multifunctional systems can be created by combining Fe_(3)O_(4) NPs with polymers.By combining various therapeutic approaches,more effective biomedical materials can be developed.This paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.
