New Study Uncovers How Immune Tolerance to Food Is Maintained

Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.

Overall National Economy Maintained Stable in the First Two Months

In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.

China's Imports and Exports Have Maintained Rapid Growth

Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.

National Economy Maintained a Steady and Fast Growth in 2007

In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.

Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease

Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD.However,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD areunknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every 13weeks.Measurements included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the hippocampus.Patients were evaluated at baseline and after follow-up.The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time.Results The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale changes.The baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up.Moreover,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)changes.Conclusions DLPFC-iTBS maybe a feasible and easy-to-implement non-pharmacological intervention to slow down the progressive decline of overall cognition and quality of life in patients with AD,providing a new AD treatment option.Trial registration number NCT04754152.

AGRIS

AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.

Ancient IP Promotes Consumption Recovery

The Millennium City Park has boosted the recovery of consumption by injecting new life into historical resources and promoting cultural tourism.CHINA’S domestic tourism market has maintained strong recovery since last year.One highlight of this positive recovery is the Millennium City Park which made milestone achievements in its operations during the Spring Festival holiday from February 10 to 17,2024.

NEWS

The Chinese economy has maintained good recovery momentum,beginning the year on a solid note as the country’s macro policies took effect,official data showed on March 18.Given its solid performance in January and February,China has the conditions and support to achieve its full-year growth target of around 5 percent for 2024 through enhanced efforts,the National Bureau of Statistics(NBS)spokesperson Liu Aihua said.

National Economy Saw an Increase in the First Two Months

In the first two months of the year,the synergy of the macro policies continued to take effect,production and demands remained stable and saw an increase,employment and prices were generally steady,and the development quality was improving.The national economy maintained the momentum of recovery and growth and got off to a stable start.

Chronology of 50 Years of China-Malaysia Diplomatic Relations

This year marks the 50th anniversary of the establishment of diplomatic ties between China and Malaysia.Over the past half century,China and Malaysia have maintained close economic and trade ties and intensified people-to-people exchanges.China and Malaysia are important trade partners and enjoy complementary economic advantages.

Economic Upturn Boosts Confidence

As the eventful year of 2023 drew to a close,China’s decisive economic rebound over the preceding 11 months continued to propel steady recovery of the flagging global economy.Last November,China’s retail sales of consumer goods-a major gauge of consumption strength-maintained accelerated growth,evident in a registered year-on-year increase of 10.1 percent,according to National Bureau of Statistics(NBS)data published on December 15.During the January-November period,moreover,total retail sales of the country’s consumer goods swelled to RMB 42.79 trillion-a 7.2 percent increase over the previous year.

Bacterial diversity in soils subjected to long-term chemical fertilization can be more stably maintained with the addition of livestock manure than wheat straw

With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).

New pharmacological tools:the use of diterpenes to promote adult hippocampal neurogenesis

Tissue regeneration maintains homeostasis and preserves the functional features of each tissue.However,not all tissues show a strong repairing capacity.This is the case of the central nervous system.It is now well established that the generation of new functional neurons from stem cells in the adult brain occurs in specific regions of the brain of different species such as rodents,birds,primates,and humans(Eriksson et al.,1998).

MWCNT Doped Reverse-Mode Polymer Network Liquid Crystals with Frequency Response Property

Polymer-liquid crystals(PLCs)are common materials for smart windows.However,PLC smart windows usually require high driving voltage to maintain transparency.We synthesized a novel PLC smart film by doping multi-wall carbon nanotubes(MWCNTs)into a reverse-mode polymer network liquid crystal(R-PNLC).

Aging impairs the osteocytic regulation of collagen integrity and bone quality

Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by osteocytes.We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material properties.We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses PLR.The control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)bone.This relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical tests.The effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic mechanisms.This is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)neurons.These neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the SVZ.First,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate neuroblasts.The latter are cells that maintain a proliferative phenotype while in an immature phase.However,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

Partnership for Green Development

Despite their disagreements on some issues,China and Europe need to maintain high-level dialogues as the relationship is more important than ever before.

Achieving Common Development in Step with the Times

As long as China and the EU adhere to strategic consensuses,keep in step with the times,and maintain mutual trust,they will be able to ensure the prosperity and stability of both sides.

Speeds Up the Construction of a New Power System

"In 2023,China's photovoltaic industry continued to maintain a rapid development momentum,with an additional installed capacity of more than 216 GW,accounting for more than half of the global total.The cumulative installed capacity is close to 610 GW,which helps the installed capacity of renewable energy surpass that of thermal power historically.In 2023,the output value of the domestic photovoltaic manufacturing industry exceeded RMB1.75 trillion,a year-on-year increase of 17.1%,and the output of the four main industrial chains of polysilicon.

National Economy Witnessed Momentum in Recovery with Solid Progress in High-quality Development

In 2023,when faced with both the complex and grave international environment as well as the arduous tasks required to advance reform,promote development and maintain stability at home,the national economy witnessed momentum in recovery,supply and demand improved steadily,transformation and upgrades were solidly advanced,employment and prices were generally stable,people’s well-being was robustly and effectively guaranteed,steady progress was made in terms of pursuing high-quality development,and major expected targets were well achieved.