Liposarcoma of the breast is a very rare malignant tumor. It can clinically manifest as a palpable breast mass and mimic primary breast cancer. We report an unusual case of a 51-year-old female who presented with an a...Liposarcoma of the breast is a very rare malignant tumor. It can clinically manifest as a palpable breast mass and mimic primary breast cancer. We report an unusual case of a 51-year-old female who presented with an asymptomatic right breast mass, which was histologically diagnosed as well differentiated liposarcoma arisen within malignant phyllodes tumor. The patient underwent breast conserving surgery, received no adjuvant treatment and is disease-free after 2 years. Radiological and histopathological features are presented and described in detail. Data from the literature are presented and therapy recommendations discussed.展开更多
BACKGROUND Multiple primary malignant tumors(MPMTs)are rare type of cancer,especially when solid tumors are the first and lymphoma is the second primary malignancy.We report a patient with heterochronous MPMTs consist...BACKGROUND Multiple primary malignant tumors(MPMTs)are rare type of cancer,especially when solid tumors are the first and lymphoma is the second primary malignancy.We report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma(DLBCL).CASE SUMMARY We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide(50 mg per day)and an extended-release implant of goserelin(1/28 d).Seven years later,rectal DLBCL with lung metastases was found.CONCLUSION Although rare,the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.展开更多
合成磁共振成像(synthetic magnetic resonance imaging, Sy MRI)是一种新兴的磁共振定量弛豫技术,可以量化组织的弛豫时间和质子密度,仅通过一次扫描就能同时获得多种定量弛豫图,直接用于组织定量分析,为临床提供更多有价值的诊断信息...合成磁共振成像(synthetic magnetic resonance imaging, Sy MRI)是一种新兴的磁共振定量弛豫技术,可以量化组织的弛豫时间和质子密度,仅通过一次扫描就能同时获得多种定量弛豫图,直接用于组织定量分析,为临床提供更多有价值的诊断信息。Sy MRI最先应用于颅脑疾病诊断以及脑实质发育情况检测等。随着Sy MRI技术发展及恶性肿瘤发病率不断升高,Sy MRI技术亦逐渐被应用到临床常见恶性肿瘤的影像诊断中。本文对Sy MRI技术的基本原理及其在乳腺癌、恶性胶质瘤、前列腺癌、直肠癌、膀胱癌、子宫内膜癌、宫颈癌等常见恶性肿瘤中的研究进展进行综述,以期为恶性肿瘤的鉴别诊断及分型、诊疗规划和预后评估等提供依据及参考。展开更多
目的利用公共数据库探讨不同手术方式对Ⅰ期恶性乳腺叶状肿瘤患者生存的影响。方法选取1988年1月1日至2016年12月31日在美国国家癌症研究所建立的SEER数据库进行登记的630例恶性乳腺叶状肿瘤女性患者作为研究对象,按照手术方式将其分为...目的利用公共数据库探讨不同手术方式对Ⅰ期恶性乳腺叶状肿瘤患者生存的影响。方法选取1988年1月1日至2016年12月31日在美国国家癌症研究所建立的SEER数据库进行登记的630例恶性乳腺叶状肿瘤女性患者作为研究对象,按照手术方式将其分为保乳手术组(n=391)及乳房全切组(n=239)。比较两组患者的临床资料,采用Kaplan-Meier曲线分析两组患者的乳腺癌特异性生存期(breast cancer special survival,BCSS)和总生存期(overall survival,OS),采用单因素及多因素Cox回归模型分析患者BCSS和OS的风险比。结果单因素及多因素Cox回归分析结果显示,婚姻状况、种族、诊断时间、手术偏侧并非患者BCSS的影响因素(P>0.05),而年龄和手术方式是患者BCSS的影响因素(P<0.05),多因素分析风险比分别为5.406[95%置信区间(confidence interval,CI):2.221~13.159,P<0.001]、3.385(95%CI:1.670~6.861,P=0.001)。Kaplan-Meier曲线分析结果显示,行保乳手术的患者BCSS显著优于行乳房全切术的患者(P<0.05)。婚姻状况、种族、诊断时间、手术偏侧并非患者OS的影响因素(P>0.05),年龄和手术方式是患者OS的影响因素(P<0.05)。多因素分析风险比分别为6.657(95%CI:3.362~13.181)、1.889(95%CI:1.143~3.124),差异均有统计学意义(P<0.05)。Kaplan-Meier分析结果显示,行保乳手术的患者OS显著优于行乳房全切手术的患者(P<0.05)。结论在确保能够完整切除病灶、切缘阴性的前提下,Ⅰ期恶性乳腺叶状肿瘤的患者可以考虑优先选择保乳手术。展开更多
目的:分析乳腺分叶状肿瘤(phyllodes tumor of the breast,PTB)超声造影的图像特征及其与病理的相关性。方法:回顾性分析42例经手术或穿刺活检病理证实为PTB的患者,总结并分析乳腺叶状肿瘤超声造影的图像特征,比较良恶性的组间差异。结...目的:分析乳腺分叶状肿瘤(phyllodes tumor of the breast,PTB)超声造影的图像特征及其与病理的相关性。方法:回顾性分析42例经手术或穿刺活检病理证实为PTB的患者,总结并分析乳腺叶状肿瘤超声造影的图像特征,比较良恶性的组间差异。结果:42例叶状肿瘤中良性21例,交界性5例,恶性16例,造影的图像特征:恶性及交界性叶状肿瘤结节呈高增强,造影剂分布不均匀、可见部分充盈缺损、边缘呈放射状或蟹足样增强、增强后范围较二维增大,与良性叶状肿瘤的图像特征差异有统计学意义(P<0.05)。结论:乳腺叶状肿瘤的超声造影图像多样,对其性质的判断有一定的提示作用。展开更多
文摘Liposarcoma of the breast is a very rare malignant tumor. It can clinically manifest as a palpable breast mass and mimic primary breast cancer. We report an unusual case of a 51-year-old female who presented with an asymptomatic right breast mass, which was histologically diagnosed as well differentiated liposarcoma arisen within malignant phyllodes tumor. The patient underwent breast conserving surgery, received no adjuvant treatment and is disease-free after 2 years. Radiological and histopathological features are presented and described in detail. Data from the literature are presented and therapy recommendations discussed.
基金Supported by Key Research and Development Projects in Hebei Province,No.21377795DNatural Science Foundation of Hebei Province,No.H2021307017.
文摘BACKGROUND Multiple primary malignant tumors(MPMTs)are rare type of cancer,especially when solid tumors are the first and lymphoma is the second primary malignancy.We report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma(DLBCL).CASE SUMMARY We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide(50 mg per day)and an extended-release implant of goserelin(1/28 d).Seven years later,rectal DLBCL with lung metastases was found.CONCLUSION Although rare,the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.
文摘合成磁共振成像(synthetic magnetic resonance imaging, Sy MRI)是一种新兴的磁共振定量弛豫技术,可以量化组织的弛豫时间和质子密度,仅通过一次扫描就能同时获得多种定量弛豫图,直接用于组织定量分析,为临床提供更多有价值的诊断信息。Sy MRI最先应用于颅脑疾病诊断以及脑实质发育情况检测等。随着Sy MRI技术发展及恶性肿瘤发病率不断升高,Sy MRI技术亦逐渐被应用到临床常见恶性肿瘤的影像诊断中。本文对Sy MRI技术的基本原理及其在乳腺癌、恶性胶质瘤、前列腺癌、直肠癌、膀胱癌、子宫内膜癌、宫颈癌等常见恶性肿瘤中的研究进展进行综述,以期为恶性肿瘤的鉴别诊断及分型、诊疗规划和预后评估等提供依据及参考。
文摘目的利用公共数据库探讨不同手术方式对Ⅰ期恶性乳腺叶状肿瘤患者生存的影响。方法选取1988年1月1日至2016年12月31日在美国国家癌症研究所建立的SEER数据库进行登记的630例恶性乳腺叶状肿瘤女性患者作为研究对象,按照手术方式将其分为保乳手术组(n=391)及乳房全切组(n=239)。比较两组患者的临床资料,采用Kaplan-Meier曲线分析两组患者的乳腺癌特异性生存期(breast cancer special survival,BCSS)和总生存期(overall survival,OS),采用单因素及多因素Cox回归模型分析患者BCSS和OS的风险比。结果单因素及多因素Cox回归分析结果显示,婚姻状况、种族、诊断时间、手术偏侧并非患者BCSS的影响因素(P>0.05),而年龄和手术方式是患者BCSS的影响因素(P<0.05),多因素分析风险比分别为5.406[95%置信区间(confidence interval,CI):2.221~13.159,P<0.001]、3.385(95%CI:1.670~6.861,P=0.001)。Kaplan-Meier曲线分析结果显示,行保乳手术的患者BCSS显著优于行乳房全切术的患者(P<0.05)。婚姻状况、种族、诊断时间、手术偏侧并非患者OS的影响因素(P>0.05),年龄和手术方式是患者OS的影响因素(P<0.05)。多因素分析风险比分别为6.657(95%CI:3.362~13.181)、1.889(95%CI:1.143~3.124),差异均有统计学意义(P<0.05)。Kaplan-Meier分析结果显示,行保乳手术的患者OS显著优于行乳房全切手术的患者(P<0.05)。结论在确保能够完整切除病灶、切缘阴性的前提下,Ⅰ期恶性乳腺叶状肿瘤的患者可以考虑优先选择保乳手术。
文摘目的:分析乳腺分叶状肿瘤(phyllodes tumor of the breast,PTB)超声造影的图像特征及其与病理的相关性。方法:回顾性分析42例经手术或穿刺活检病理证实为PTB的患者,总结并分析乳腺叶状肿瘤超声造影的图像特征,比较良恶性的组间差异。结果:42例叶状肿瘤中良性21例,交界性5例,恶性16例,造影的图像特征:恶性及交界性叶状肿瘤结节呈高增强,造影剂分布不均匀、可见部分充盈缺损、边缘呈放射状或蟹足样增强、增强后范围较二维增大,与良性叶状肿瘤的图像特征差异有统计学意义(P<0.05)。结论:乳腺叶状肿瘤的超声造影图像多样,对其性质的判断有一定的提示作用。
