BACKGROUND Mature teratoma is a common benign ovarian germ cell tumor,accounting for about 20%of ovarian tumors.The malignant transformation of this tumor is less than 2%.The most common type is squamous cell carcinom...BACKGROUND Mature teratoma is a common benign ovarian germ cell tumor,accounting for about 20%of ovarian tumors.The malignant transformation of this tumor is less than 2%.The most common type is squamous cell carcinoma,followed by adenocarcinoma.Malignant transformation of colonic mature teratoma is extremely rare.We here report a case of malignant transformation of primary mature teratoma of the colon.The type of malignant transformation was adenocarcinoma.CASE SUMMARY A 63-year-old woman was admitted to our hospital due to persistent pain in her right lower abdomen for 1 mo,and she had no nausea,vomiting,blood in the stools,or other symptoms.Preoperative colonoscopy showed uplift of the sigmoid colon mucosa and submucosa.The biopsy showed squamous epithelium.However,contrast-enhanced computed tomography of abdomen and pelvis showed a localized thickening of the sigmoid wall,suggesting colon cancer.Endoscopic ultrasonography(EUS)revealed that the structure of the intestinal wall at the base of the lesion was destroyed,and the boundary between the lesion and the surroundings was unclear.According to the findings of the EUS,the patient did not undergo endoscopic submucosal dissection,but underwent radical resection of the tumor.Histologically,squamous epithelium was seen on the mucosal surface of the colon wall,cartilage and glands were seen under the epithelium,and adenocarcinoma was seen on the muscular layer and serous surface.The final pathological diagnosis was malignant teratoma of the colon.We have followed up the patient for 2 mo since the operation,and the patient recovered well.CONCLUSION This case suggests the possibility of mature teratoma in the colon and recognition of malignant types,and it should not be considered as an exclusively ovarian tumor.展开更多
We discuss an extremely rare case of ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. Radiological examinations showed a cystic tumor sandwiched between the pancreas and left kidney. Surge...We discuss an extremely rare case of ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. Radiological examinations showed a cystic tumor sandwiched between the pancreas and left kidney. Surgery was scheduled because the tumor seemed to have originated from the pancreas. En-block resection of the tumor with distal pancreatectomy, splenectomy, and left adrenalectomy was performed. In terms of macroscopic appearance, the tumor mainly consisted of a unilocular cystic mass, but the presence of a smaller, solid mass was also noted within the tumor. Histopathologic examination confirmed that the cystic mass was consistent with a mature cystic teratoma of the retroperitoneum, and in addition, a ganglioneuroblastoma was evident in the solid component. Histopathologically, the ganglioneuroblastomatous area was intimately associated with dermoid tissue of the mature cystic teratoma, thus this case was diagnosedto be a mature cystic teratoma with malignant transformation. To best of our knowledge, this is the first reported case of ganglioneuroblastoma arising in a mature cystic teratoma.展开更多
Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs. It has an aggressive nature and shows resistance to conventional treatments, however, its clinical features ...Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs. It has an aggressive nature and shows resistance to conventional treatments, however, its clinical features are not well known because of the small number or reported cases. We report G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma. An 80-year-old woman underwent suboptimal surgical excision of stage IIIC ovarian cancer. Prior to the treatment, the patient presented severe granulocytosis and elevated serum G-CSF concentration. With the help of histopathological and immunohistochemical studies, we diagnosed this case to be a poorly differentiated squamous cell carcinoma developed in ovarian mature cystic teratoma, which highly expressed G-CSF. During radiation therapy, the patient died from rapid growth of residual tumor and peritoneal dissemination 2 months after surgery. This is the first case of G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma, and its prognosis was very poor.展开更多
Objective To study the incidence of malignant change, diagnosis and management of mature cystic teratomas in postmenopausal women.Methods Twenty cases of mature cystic teratoma in postmenopausal women admitted to ou...Objective To study the incidence of malignant change, diagnosis and management of mature cystic teratomas in postmenopausal women.Methods Twenty cases of mature cystic teratoma in postmenopausal women admitted to our hospital between January 1977 and January 1997 was retrospectively reviewed and evaluated.Results The number of postmenopausal patients with mature cystic teratoma (20) accounted for 7.6% of the total number of patients with benign ovarian teratomas (263). There were 3 cases of malignant change, which were squamous carcinoma, carcinosarcoma, and digestive gland epithelial carcinoma. The incidence of malignant change was 15%.Conclusion In postmenopausal women, mature ovarian cystic teratoma should be treated as lowly malignant and should be paid much attention.展开更多
目的探讨卵巢成熟性囊性畸胎瘤恶变(malignant transformation in mature cystic teratoma of the ovary,MTMCTO)的临床病理特征、治疗方式及影响预后的相关因素。方法回顾2015年1月1日至2019年12月31日在四川大学华西第二医院接受治疗...目的探讨卵巢成熟性囊性畸胎瘤恶变(malignant transformation in mature cystic teratoma of the ovary,MTMCTO)的临床病理特征、治疗方式及影响预后的相关因素。方法回顾2015年1月1日至2019年12月31日在四川大学华西第二医院接受治疗的18例MT-MCTO患者的临床病理及预后资料,结合文献复习,探讨该病的临床、病理特征,分析影响患者预后的相关因素。结果共纳入18例患者,发病时平均年龄48(19~74)岁,14例(77.8%)患者术前血清肿瘤标志物检测异常升高,其中12例(66.7%)患者糖链抗原19-9(CA19-9)升高(≥37.0kU/L)、2例(28.6%)患者术前影像学检查提示恶变可能性。15例(83.3%)患者行全面的分期手术,2例(11.1%)患者行保留生育功能的分期手术,1例(5.6%)患者因年龄大合并症多仅行子宫+双附件切除术。术后病理结果提示鳞癌9例(50.0%),黏液腺癌6例(33.3%),腺鳞癌1例(5.6%),透明细胞腺癌1例(5.6%),未分化多形性肉瘤1例(5.6%)。11例(61.1%)患者术后接受辅助化疗[博来霉素、依托泊苷、顺铂(BEP)或博来霉素、依托泊苷、顺铂/铂类联合紫杉醇(BEP/TP)方案]。平均随访时间57.4(49.3~65.4)个月,截止至2022年4月,平均无进展生存期(PFS)为63.0(48.9~77.1)个月,总生存期(OS)为63.5(49.9~77.1)个月,行肿瘤细胞减灭术的患者3年总体生存率显著低于行根治切除术组患者(0 vs.93.3%)。国际妇产科联盟(FIGO)ⅠC期及以上组3年总体生存率显著低于FIGOⅠA+ⅠB组(20%vs.100%)。结论MT-MCTO极其罕见,发病隐匿,术前血清肿瘤标志物尤其是CA19-9可能对其早期诊断有提示意义,患者的预后与FIGO分期密切相关。手术是MT-MCTO的核心治疗方式,但肿瘤细胞减灭术是否增加患者生存获益有待进一步研究。展开更多
文摘BACKGROUND Mature teratoma is a common benign ovarian germ cell tumor,accounting for about 20%of ovarian tumors.The malignant transformation of this tumor is less than 2%.The most common type is squamous cell carcinoma,followed by adenocarcinoma.Malignant transformation of colonic mature teratoma is extremely rare.We here report a case of malignant transformation of primary mature teratoma of the colon.The type of malignant transformation was adenocarcinoma.CASE SUMMARY A 63-year-old woman was admitted to our hospital due to persistent pain in her right lower abdomen for 1 mo,and she had no nausea,vomiting,blood in the stools,or other symptoms.Preoperative colonoscopy showed uplift of the sigmoid colon mucosa and submucosa.The biopsy showed squamous epithelium.However,contrast-enhanced computed tomography of abdomen and pelvis showed a localized thickening of the sigmoid wall,suggesting colon cancer.Endoscopic ultrasonography(EUS)revealed that the structure of the intestinal wall at the base of the lesion was destroyed,and the boundary between the lesion and the surroundings was unclear.According to the findings of the EUS,the patient did not undergo endoscopic submucosal dissection,but underwent radical resection of the tumor.Histologically,squamous epithelium was seen on the mucosal surface of the colon wall,cartilage and glands were seen under the epithelium,and adenocarcinoma was seen on the muscular layer and serous surface.The final pathological diagnosis was malignant teratoma of the colon.We have followed up the patient for 2 mo since the operation,and the patient recovered well.CONCLUSION This case suggests the possibility of mature teratoma in the colon and recognition of malignant types,and it should not be considered as an exclusively ovarian tumor.
文摘We discuss an extremely rare case of ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. Radiological examinations showed a cystic tumor sandwiched between the pancreas and left kidney. Surgery was scheduled because the tumor seemed to have originated from the pancreas. En-block resection of the tumor with distal pancreatectomy, splenectomy, and left adrenalectomy was performed. In terms of macroscopic appearance, the tumor mainly consisted of a unilocular cystic mass, but the presence of a smaller, solid mass was also noted within the tumor. Histopathologic examination confirmed that the cystic mass was consistent with a mature cystic teratoma of the retroperitoneum, and in addition, a ganglioneuroblastoma was evident in the solid component. Histopathologically, the ganglioneuroblastomatous area was intimately associated with dermoid tissue of the mature cystic teratoma, thus this case was diagnosedto be a mature cystic teratoma with malignant transformation. To best of our knowledge, this is the first reported case of ganglioneuroblastoma arising in a mature cystic teratoma.
文摘Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs. It has an aggressive nature and shows resistance to conventional treatments, however, its clinical features are not well known because of the small number or reported cases. We report G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma. An 80-year-old woman underwent suboptimal surgical excision of stage IIIC ovarian cancer. Prior to the treatment, the patient presented severe granulocytosis and elevated serum G-CSF concentration. With the help of histopathological and immunohistochemical studies, we diagnosed this case to be a poorly differentiated squamous cell carcinoma developed in ovarian mature cystic teratoma, which highly expressed G-CSF. During radiation therapy, the patient died from rapid growth of residual tumor and peritoneal dissemination 2 months after surgery. This is the first case of G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma, and its prognosis was very poor.
文摘Objective To study the incidence of malignant change, diagnosis and management of mature cystic teratomas in postmenopausal women.Methods Twenty cases of mature cystic teratoma in postmenopausal women admitted to our hospital between January 1977 and January 1997 was retrospectively reviewed and evaluated.Results The number of postmenopausal patients with mature cystic teratoma (20) accounted for 7.6% of the total number of patients with benign ovarian teratomas (263). There were 3 cases of malignant change, which were squamous carcinoma, carcinosarcoma, and digestive gland epithelial carcinoma. The incidence of malignant change was 15%.Conclusion In postmenopausal women, mature ovarian cystic teratoma should be treated as lowly malignant and should be paid much attention.
文摘目的探讨卵巢成熟性囊性畸胎瘤恶变(malignant transformation in mature cystic teratoma of the ovary,MTMCTO)的临床病理特征、治疗方式及影响预后的相关因素。方法回顾2015年1月1日至2019年12月31日在四川大学华西第二医院接受治疗的18例MT-MCTO患者的临床病理及预后资料,结合文献复习,探讨该病的临床、病理特征,分析影响患者预后的相关因素。结果共纳入18例患者,发病时平均年龄48(19~74)岁,14例(77.8%)患者术前血清肿瘤标志物检测异常升高,其中12例(66.7%)患者糖链抗原19-9(CA19-9)升高(≥37.0kU/L)、2例(28.6%)患者术前影像学检查提示恶变可能性。15例(83.3%)患者行全面的分期手术,2例(11.1%)患者行保留生育功能的分期手术,1例(5.6%)患者因年龄大合并症多仅行子宫+双附件切除术。术后病理结果提示鳞癌9例(50.0%),黏液腺癌6例(33.3%),腺鳞癌1例(5.6%),透明细胞腺癌1例(5.6%),未分化多形性肉瘤1例(5.6%)。11例(61.1%)患者术后接受辅助化疗[博来霉素、依托泊苷、顺铂(BEP)或博来霉素、依托泊苷、顺铂/铂类联合紫杉醇(BEP/TP)方案]。平均随访时间57.4(49.3~65.4)个月,截止至2022年4月,平均无进展生存期(PFS)为63.0(48.9~77.1)个月,总生存期(OS)为63.5(49.9~77.1)个月,行肿瘤细胞减灭术的患者3年总体生存率显著低于行根治切除术组患者(0 vs.93.3%)。国际妇产科联盟(FIGO)ⅠC期及以上组3年总体生存率显著低于FIGOⅠA+ⅠB组(20%vs.100%)。结论MT-MCTO极其罕见,发病隐匿,术前血清肿瘤标志物尤其是CA19-9可能对其早期诊断有提示意义,患者的预后与FIGO分期密切相关。手术是MT-MCTO的核心治疗方式,但肿瘤细胞减灭术是否增加患者生存获益有待进一步研究。
