Infectious diseases have always been a major cause of mobility and mortality,early and accurate diagnosis is important for their management.However,current clinical diagnosis for bacterial infection still remains trou...Infectious diseases have always been a major cause of mobility and mortality,early and accurate diagnosis is important for their management.However,current clinical diagnosis for bacterial infection still remains troublesome.Recently,many attempts on molecular imaging have been made for prompt bacteria detection,especially for early and precise disease diagnosis.Among them,maltohexaose-based probes serve as a superb candidate due to the bacteria-specific maltodextrin transport pathway.These probes can visualize bacterial foci with unparalleled sensitivity and specificity.Such metabolism-based targeting strategy offers a powerful delivery platform for imaging and theranostic agents,providing good translational potential for developing antibacterial agents.展开更多
基金supported by the National Key Research and Development Program of China(Nos.2018YFA0107301 and 2017YFA0205201)the National Natural Science Foundation of China(Nos.81422023,U1705281,and U1505221)+1 种基金the Fundamental Research Funds for the Central Universities(Nos.20720160065 and 20720190088)the Program for New Century Excellent Talents in University,China(No.NCET-13-0502)。
文摘Infectious diseases have always been a major cause of mobility and mortality,early and accurate diagnosis is important for their management.However,current clinical diagnosis for bacterial infection still remains troublesome.Recently,many attempts on molecular imaging have been made for prompt bacteria detection,especially for early and precise disease diagnosis.Among them,maltohexaose-based probes serve as a superb candidate due to the bacteria-specific maltodextrin transport pathway.These probes can visualize bacterial foci with unparalleled sensitivity and specificity.Such metabolism-based targeting strategy offers a powerful delivery platform for imaging and theranostic agents,providing good translational potential for developing antibacterial agents.
